WO2004089106A2 - Melange de tanin servant d'additif - Google Patents

Melange de tanin servant d'additif Download PDF

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Publication number
WO2004089106A2
WO2004089106A2 PCT/EP2004/050400 EP2004050400W WO2004089106A2 WO 2004089106 A2 WO2004089106 A2 WO 2004089106A2 EP 2004050400 W EP2004050400 W EP 2004050400W WO 2004089106 A2 WO2004089106 A2 WO 2004089106A2
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Prior art keywords
tannin
mixture
weight
powder
tannins
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PCT/EP2004/050400
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English (en)
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WO2004089106A3 (fr
Inventor
Luigi Marenchino
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Luigi Marenchino
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Publication of WO2004089106A2 publication Critical patent/WO2004089106A2/fr
Publication of WO2004089106A3 publication Critical patent/WO2004089106A3/fr

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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/111—Aromatic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/20—Inorganic substances, e.g. oligoelements
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/10—Feeding-stuffs specially adapted for particular animals for ruminants

Definitions

  • the present invention relates to a tannin-based 5 mixture, which may used in animal feeding, and generally for solutions having such physico-chemical properties as to allow the use thereof in several application fields .
  • the present invention relates to a it) tannin-based mixture which may be used in animal feed, and may assist, in ruminants, the passage of the amino acid component of rumen undigested proteins from the rumen to the whey, resulting in an increase of the nutritional quality of milk and of production
  • tannins are known in the tanning industry, the word itself "tannin" deriving from the prevailing use thereof in this field; due to their chemical properties of astringency, these molecules have been 0 always used in hide processing as they help to condense the proteins of the outermost layer of the hides to be tanned, thereby forming a barrier against microorganisms which affect the quality of the processed leather.
  • tannins that form 5 particular chemical complexes in solutions with tertiary ferric oxide are also used as adjuvants in the dyeing of processed leathers, as they take the currently typical color of the leather used in the clothing industry.
  • Natural and synthetic tannin mixtures are also known to be used in winemaking, as the chemical properties of astringency of polyflavonoids (which include tannins) , allow to precipitate the proteins which would otherwise be suspended in wine, and generate a turbidity which is not always desired by the final user of the wine product .
  • Some synthesis tannins are further used to improve the taste of wine, by giving it a fruity taste, sometimes with a slight vanilla aftertaste.
  • Plants include a variety of secondary compounds, including alkaloids, terpenes and phenols, and while these components do not seem to have a role in primary metabolism (e.g. in biosynthesis, biodegradation, and other energy conversions performed by the intermediary metabolism) , they do not have several biological activities in a range from toxicity to the mimicry of hormone effects, and may have a role in protecting the plants from herbivores and diseases .
  • the phenolic metabolism in plants is quite complex and generates a wide range of compounds, from flower pigments (anthocyanins) to the phenolic complexes of the plant cell wall (lignin) .
  • the group of phenolic compounds known as "tannins" is clearly different from the other secondary plant phenols in terms of chemical reactions and biological activities .
  • Tannins belong to a group of simple and complex phenolic compounds, polyphenols and flavonoids, mostly bonded with polyglucosides, which are often so amorphous, as to be generally defined as tannins in that they have astringent properties and may generate gallic acid and compounds thereof as aglycons, during degradation. Tannins are mainly of two types : condensed tannins and hydrolyzable tannins .
  • the former including for instance proanthocyanidins
  • polymeric flavonoids polymeric flavonoids
  • phe amino acid- derived heretocyclic rings
  • the latter are derivatives of gallic acid (3, 4, 5-trihydroxylbenzoic acid) , which may be esterified with a polyoyl core, and of galloyl groups, which may be further esterified or bonded to provide a more complex hydrolyzable tannin.
  • gallic acid 3, 4, 5-trihydroxylbenzoic acid
  • galloyl groups which may be further esterified or bonded to provide a more complex hydrolyzable tannin.
  • tannins are generally found in the external parts and in the internal tissues of plants (and mainly in the plant cell vacuole) before passing, after the death of plants, into the humin formation cycle.
  • All tannins are relatively resistant to digestion and fermentation and have, like most secondary metabolites of plants, the function of inhibiting animals' ability of eating the living parts of the plant or lessen, in deciduous plants, i.e. those that shed their leaves or are subjected to an important seasonal tissue change, the rot of fallen parts, such as to reduce the potential of infection that may extend to living parts of the plant, which infection is often caused by rot and fermentation of said dead parts, fallen to the base of the plant .
  • Tannins have the property of preventing organic matter putrefaction and have been often used in the field of tanning due to this ability, allowing them to prevent leather putrefaction, and to provide different leather colors, useful, amongst other things, for classification purposes.
  • tannins are associated to certain reagents, such as ferric chloride, potassium dichromate, and a mixture of wolframate and sodium acetate.
  • Tannins are extracted from oak or cinchona bark, from chestnut, sessile oak, quebracho wood, from sumac leaves, from dividivi, myrobalans fruits and from gall (pathogenic swelling produced by certain plants due to an attack by harmful microorganisms) , by water infusion and possible treatment with alcohol or ether
  • tannins were found to be unjustified, as this substance provides appreciable results in several fields of applications and particularly in the bio-food field
  • tannins were found to have an important role as adjuvants in the increase of productivity and improvement of quality of animal biological products, preferably ovine and bovine products, for instance in terms of protein content and as a growth promoter for these organisms
  • tannins complex proteins at a pH of 5 to 7 (the pH of the rumen) , thereby protecting them from microbial enzymes which are active in this first portion of the bovine digestive tract Subsequently, these complexes may easily dissociate in contact with gastric secretions, having a pH of 2 5-3.5 and in contact with pancreatic secretions, having a pH of 8 Therefore, high quality dietary proteins are protected, at least in part, from degradation in the rumen and can then be digested more effectively in the intestine, thereby by-passing a too fast degradation, which is useless and sometimes harmful as far as animal nutrition is concerned, as it may lead to the formation of ketone bodies, whose passage into blood contributes to a pH change therein, thereby obviously affecting the ma n buffer capacity of this tissue, also, the use of a tannin in this application provides the additional advantage of drastically reducing gas emissions, as explained hereafter, because it protects proteins from attacks, and
  • predetermined amounts of tannin to food was found to allow a greater amount of proteins (such as casein) to pass through the digestive tract of the animal without being changed by the digestive enzymes of the animal and to be available in the milk produced by the animal, in its meat and in other animal products .
  • proteins such as casein
  • tannins An important mode of action of tannins toward proteins is their own relative astringency, which allows them to stably bond proteins by creating layers of strongly bonded proteins, which are difficultly hydrolyzed; as mentioned above, this particular behavior of polyphenolic compounds (here tannins) is particularly interesting for the treatment of animal feed with these compounds, as it allows food proteins to pass through the digestive tract without being attacked by microorganisms (which are especially present in the rumen, for bovines) , to be more readily available for the anabolic processes of the animal organism designed for productions .
  • tannins Another mode of action of tannins is directed to isolated chemical elements, such as heavy metals, and all cations in general (this group also including macromolecules having one or more positive charges) ; due to their ability of bonding atoms and molecules having positive charges (+) thanks to the chemical clamping action of the carboxy group -COOH which, in certain pH conditions, has a negative charge, so that tannins may be used to chemically block the action of chemical elements which, l ke heavy metals, are widely known as chemical poisons
  • Another mode of action of tannins which was found to be of chief importance and interest, relates to the action of the tannin as a strong antioxidant, the antioxidant function of tannins mainly depends on their oxidation-reduction potential and on the relative stability of the aryl radicals generated during the oxidation-reduction reaction, as well as on the general ability of low-molecular-weight phenols of removing free radicals and mitigating hydroxyl radicals (which ability is fully extendable to polyphenols and particularly to condensed tannins which obviously
  • Tannin (particularly from quebracho and/or chestnut) in certain amounts is not toxic, on the contrary it was found to prevent bacterial activity, particularly of methanogen, i.e. methane producing bacteria.
  • Another interesting aspect is that the use of this product in such terms simplifies the work of the personnel that watches over housed livestock, thanks to the apparent improvement of working conditions, providing an advantage in terms of working times and a higher productivity.
  • a tannin mixture (particularly from quebracho and/or chestnut) may be used as an adjuvant in flocculation, as described hereafter and hence may have an additional antibacterial function.
  • Waste water treatment processes should follow a well defined cycle (which is not described in detail herein, as it is well known to those skilled in the art) , and should have, at each stage of the cycle, a well defined bacterial population; the undefined increase of a particular bacterial population against another (which populations should be in stable equilibrium throughout the cycle) may lead to a variation of the physico- chemical characteristics of the sludge, which may finally not have the characteristics required for the proper execution of the water treatment process.
  • a tannin mixture (particularly from quebracho and/or chestnut) , if used in appropriate amounts, prevents viral replication activities, and considerably reduces the virus' capacity of infecting target organisms; the use of such compounds in medicine as antiviral agents is of particular interest, the addition of 0.1 g of a tannin mixture (particularly from quebracho and/or chestnut) being found to drastically reduce the virulence of infectious agents as, thanks to its above mentioned astringent properties, the tannin mixture can bond the proteins of the virus capsid, thereby inhibiting the external mechanisms used by the virus to come in contact with the target cells, and actually preventing the viral attack on the cell and the inoculation of the cell with the viral genome, or even disgregating and/or separating the protein components of the capsid, to release the viral genome before target cell inoculation therewith
  • a tannin mixture (particularly from quebracho and/or chestnut) may be also used as an adjuvant in the flocculating action of flocculating agents, well-known in the art, in the sedimentation tanks of water treatment plants, or in any system whose operation requires an appropriate formation of organic or inorganic flocks, to be removed and/or collected in suitable containers or storage tanks
  • a tannin mixture has the multiple advantage of combining a considerable thickening, flocculation adjuvant capacity and a high antibacterial capacity, the addition of about 350 g of a tannin mixture per kg of colloidal sludge was found to increase the formation of organic flocks, and to improve the conditions of the flocculating sludge, by making it more suitable for waste water treatment (in the case of urban waste water treatment plants)
  • a tannin mixture (particularly from quebracho and/or chestnut) used in this field in the above described manner is of particular interest for environment protection, as it prevents or at least reduces the use of the chemical synthesis compounds that are commonly used for water treatment
  • a tannin mixture (particularly from quebracho and/or chestnut) may be further used as an adjuvant in the preparation of solutions, creams and medical products having antioxidant properties; the addition of 12.5 g of a tannin mixture (particularly from quebracho and/or chestnut) for the synthesis of 100 ml of a solution used for preparing antioxidant drugs, or creams having pharmacological antioxidant properties was found to produce an enhanced chemical activity as compared with the same preparations obtained with prior art methods; a particular biomedical interest was found in the use of tannic compounds that might help to prevent or block organic matter oxidation reactions, which are involved in a number of disturbances and diseases, such as cancer, cardiovascular anomalies, arthritis, and ageing, due not only to the simple use of tannins, but also and especially to the fact that the molecules used in the process are not artificially synthesized but are present in nature with a high antioxidant activity .
  • a tannin mixture (particularly from quebracho and/or chestnut) may be also used as an ingredient in the preparation of UV filtering oils and creams; the double bonds of tannic acids were found to promote the absorption of UV rays; this use of mixtures of tannins is of particular interest for medicine as it allows to synthesize lotions, ointments, oils for tanning and/or for creating a protective film on the skin, which can absorb, thanks to the double bonds of the tannic acid molecules, the UV energy that is harmful for epithelial cells with little melanophore concentration, which cannot provide an adequate protection to the epithelial tissue, and the underlying tissues, from the carcinogenic action of UV rays, preventing them from producing the well-known negative effects of mutagenesis, for instance on the genetic material that is inside the cells belonging to the epithelial tissue .
  • a tannin mixture (particularly from quebracho and/or chestnut) may be further used as in ingredient in the preparation of solutions to be used for preparing antiparasitic mixtures; the addition of 0.5 g of tannin powder to one liter of an antiparasitic solution was found to greatly reduce the palatability of plants susceptible to parasite attacks.
  • a tannin mixture (particularly from quebracho and/or chestnut) may be further used as an ingredient in the preparation of toothpastes, candies, chewing-gums and the like, for medical and non medical use thanks to the glucosyltransferase inhibiting action of tannins (mainly extracted f om quebracho) , glucosyltransferase being an enzyme produced by bacteria of the genus Streptococcus (particularly S. mutans and S. sobrinus) which, as is known, can synthesize insoluble and adhesive glucans from the sucrose that is found on the dental enamel after eating.
  • tannins mainly extracted f om quebracho
  • glucosyltransferase being an enzyme produced by bacteria of the genus Streptococcus (particularly S. mutans and S. sobrinus) which, as is known, can synthesize insoluble and adhesive glucans from the sucrose that is found on the dental enamel after eating.
  • the glucans synthesized from these bacteria adhere to the surface of teeth and act as a substrate for the growth of the bacteria that are in the mouth thereby forming the well-known bacterial plaque; then, the organic acids formed by the bacterial metabolism during organic matter degradation as food for bacteria lower the pH of the teeth thereby creating optimal conditions for tooth decay.
  • the inhibition of this enzyme is of particular interest for medicine because, as is well known, tooth decay can be only cured by rather invasive operations on the tooth, whereby an adequate prevention, e.g. by using these compounds, may help to avoid, as much as possible, the need of such dental operations, and to drastically improve the physical state of the tooth, which shall not be subject to scraping, drilling and final filling with amalgams that have been often turned out to be poisonous for the human organism.
  • a tannin mixture (particularly from quebracho and/or chestnut) may be further used in the preparation of building bricks, the grain size of extracted and prepared tannin powders being particularly suitable for being added to the mortar to be baked to provide the common building brick; the addition of about 500 g of a tannin mixture per kg of mortar has been found to provide bricks having a higher resistance to pyrolysis, hence a considerably increased safety factor, as compared with that of common bricks .
  • a tannin mixture (particularly from quebracho and/or chestnut) may be further used as an ingredient in the preparation of solutions to be used for the preparation of high energy environmentally friendly fuels; the addition of tannin powder to fuels was found to drastically reduce the waste production and the exhalation thereof in the environment after total or partial combustion of said fuel, to allow recovery of this waste and limit the mechanical and chemical damage caused by this waste to boilers, heating systems, piping, internal combustion engines; furthermore, the use of such tannin-based fuel is also advantageous in terms of an increased efficiency of the engine or system that uses it, and because it causes no danger for both man and the environment, whereas the use of the ashes thereof is desirable ad a further resource, e.g. for the preparation of 100% natural fertilizers, manures, mulches, which are especially useful for municipal waste composting.
  • Figure 1 shows a mode of action of tannic acids as chelating agents .
  • Figure 2 shows the mode of action of tannic acids in bonds with proteins and in enzyme inhibition.
  • Figure 3 is a diagram of the glucosyltransferase inhibition value of a quebracho extract .
  • Figure 1 shows a mode of action of tannic acids as chelating agents; typical tannic acid carboxy terminals are shown, which act as chemical clamps for seizing cations, e.g. bivalent cations like Hg++; this use of mixtures of tannins is of particular interest in medicine and environment protection in general, as the chemical clamps formed by carboxy acids have negative charges and are useful for bonding ions, particularly cations, e.g. heavy metals, which are known to be chemical poisons .
  • FIG. 2 shows the mode of action of tannic acids in their bonds with proteins and in enzyme inhibition; the figure shows tannins (1) , the tertiary structure of the protein (2) and some hydrophobic loops (3) .
  • the conformation of tannins (1) facilitates the insertion thereof in the hydrophobic loops (3) of the secondary and tertiary structure of the protein (2), which capacity of tannins, as mentioned above, allows these molecules to bond and agglomerate proteins, thereby causing a change in the physical conformation thereof, which involves a lower digestibility thereof, decreases the possible bacterial attack sites, and also inhibits enzyme proteins whose action is based on their typical spatial conformation.
  • FIG. 3 shows a diagram of the glucosyltransferase inhibiting action of quebracho extracted tannins; this diagram shows that the glucosyltransferase inhibition level directly depends on the molecular weight of polyflavonoids, the inhibiting action of polyflavonoids being higher as their molecular weight decreases .
  • the tannin extracted from quebracho bark is shown to have a higher inhibiting action if it has a molecular weight of 1000 to 1500, its IC50 (a concentration that inhibits 50% of glucosyltransferase enzyme molecules) being of 40 to 15/16 ug.
  • a first example considers the effect of tannin in the food for pigs .
  • the basic food composition comprises:
  • the food has been delivered to the pigs in two trances at fixed times .
  • the pigs were divided into two groups one of which was treated further with natural extract of chestnut as the tannin containing element of the food mixture .
  • Group 1 was not treated with the Natural chestnut extract while group 2 was treated with adding to the basic food mixture the natural extract of chestnut.
  • Each group was formed by small pigs treated from the birth to the weaning, adult pigs treated from beginning of the growth diet to the beginning of the
  • the following table also depicts the consumption index of food for a day form 30 to 60 Kg. of weight of the animal.
  • the increase of the dose does not compromise the production rate or growth rate referred to the quantity (weight of food) .
  • the tannin brought by the natural extract of chestnut was used for integrating the food for cattle.
  • the experiment was carried out as follows : a) the breed of the cattle was Frisona-Holstein spotted black; b) a total amount of 117 heads of cattle was considered of which 40 heads of cattle were used for the test 1 and test 2 and 20 heads of cattle were used or the control .
  • the head of cattle were chosen so that the groups were homogeneous relating to the parameters and the history of the animals ( weight, age, number of birth, time passed form the last birth, genealogic parameters form the LGN (National genealogic log) kind of insemination, genetic tests of the bulls used for the inseminations, number of insemination per birth and milk production parameters .
  • LGN National genealogic log
  • the way of dispensing food was equal for every animal .
  • the cattle was held in the same territory at 520 meters above see level no limitation was set to the water consumption.
  • the following experiment was carried out in order to evaluate the positive effects of tannin as additive of food for animals on their dejection. Particularly a balance of nitrogen was evaluated in combination of different kinds of forage and without any additive, with formic acid as additive and with natural chestnut extract as additive .
  • the total amount of retained nitrogen is remarkably higher when tannin in the form of natural extract of chestnut is added to the forage.
  • the quantity of ingested food was good for the forage treated with 2Kg and 3Kg of natural extract of chestnut per ton of forage.
  • the ingestion rate increases with tannin enriched food because the food is more tasty and the digesting apparatus works better and the animal is in a better health status .
  • the increasing ingested quantity for the food treated i.e. enriched with the natural chestnut extract as a tannin content enhancer is a sing that the animals has improved health and as it can be seen in the column relating to digestibility the food is better exploited
  • Admixing a natural chestnut extract to the basic food has the advantage of enriching the tannin content and of exerting a bacteriostatic action.
  • the action is not indiscriminate but directed specifically only to bacteria causing high fermentation and toxic fermentations .
  • the insilate forage is improved relatively to taste, aroma, colour water content, friability, fluidity.
  • the handling of food is improved due to avoiding formation of blocks and agglomerates which are to big..
  • the natural chestnut extract acidifies the ensiled forages with a dose of 2 to 3 Kg per ton of forage This without affecting too much the PH value with respect to the formic acid Indeed in reading the above table the PH value changes from 4,8 to 4,3 i e 10,4% lower and from 4,8 to 4,08 i e 15% lower that the PH values obtained by treating the forage with formic
  • the ingestion rate is near to the one of formic ac d (-3%) but there is less nitrogenated material which is not digestible from 8 to 3,7%)
  • the said values increase, namely with respect to the said natural forage the one treated with natural chestnut extract leads to an increase of 9% inn the ingestion rate, an increase of the digestibility of the dry substances of 1,8% and at the same time an increase of the nitrogentaed non digestible substances of 7,1%.
  • the nitrogen balance in treating the forage with the natural chestnut extract and thus with tannin, there is an increase of ingested nitrogen with respect to the natural forage, i.e. the non treated forage of about 15% and a reduction of the nitrogen in the urine of about 13,3% considering the natural, non treated forage and of 9,3% considering the forage treated with formic acid.
  • the percentage of nitrogen in the faeces is reduced of 1,2% when the forage is treated with the natural chestnut extract with respect to the forage treated with formic acid.
  • the retained nitrogen is more than double relatively to the non treated forage and also considerably increased relatively to the forage treated with formic acid.
  • the pasty waste material or the fibrous component of this waste material which has no appliance for example in the food industry may be treated in order to generate combustion material Treatment may consist in drying the pasty material or in extracting the fibrous material contained in the pasty waste material and forming pellets or granulates out of the said fibers
  • tannin may be added to combustion material such as for example in bricks or blocks of combustible material such as paper, wood or the like for example of blocks of compressed particles of combustible material such as wood
  • the tannin added to the combustible material can be in the form of liquid, granulates mixed and incorporated in the blocks of compressed particles of combustible material or of powder mixed to the compressed particles of combustible materials
  • the residual or waste material obtained in the process of extracting tannins has a residual amount of tannin of about 20% in weight, which is considerably higher than in the tannin content in the starting biologic material such as wood
  • the residual waste material is treated in order to form the combustible materials before any further chemical treatment is carried out on the said material.
  • the following tables indicates the composition of the residual substance after combustion of a combustible material obtained by drying pasty waste materials from the tannin extraction proceeding.
  • the second example relates to a combustible material formed by pellets of fibres extracted form the said waste material of the tannin extracting process .
  • the second combustible substance made of pellets of fibres isolated from the waste material of the tannin extracting process has the following analytic parameters
  • tannins as additive for combustible substances, particularly by using waste material of the tannin extracting process, the advantage is obtained that no toxic metals are present and no dioxin.
  • the ashes are "clean" .
  • the composition of the ashes is such that the ashes could be used in the natural agro-feed cycle. During combustion non PM.10 or dangerous gases are produced.
  • the said combustible substances show the maximum efficiency in the pyrolysis and there is also no difficulty in manipulation and storage.
  • the said combustible substances may be provided in powder form, granulate form pellets, liquids and in other different forms.
  • tannin rich or enriched combustibles masses of vegetal kind provides ambient compatible residuals .
  • This residuals can be distributes on the soil and their washing away does not damage the ambient and on the contrary they enrich the soil with valuable minerals . Due to their harmless this residual can be manipulated without any kind of special care by not specialized personal .
  • the tannin enriched combustibles and the tannins can be used for enriching less valuable combustibles .
  • tannins in a pure state, particularly in liquid form or masses with an enriched content of tannins can be used as improved thermal energy reservoir capable of absorbing a very high amount of thermal energy without being subjected to a chemical modification .
  • tannins can be subjected to very high temperatures (about 800°C) without being subject to chemical or physical degeneration or modification. This is due to their very high burning temperature .
  • the present invention considers also the use of tannins for at least enriching a fluid in a heating plant, which fluid has the function of accumulating heat by being heated form a heat source and of transporting and giving away heat to the ambient .
  • the liquid can be water in which an amout of tannin is solved or it is a concentrated tannin solution.
  • Tannin can be used particularly where the heat source is of natural kind as for example solar energy .
  • a tannin solution or tannin enriched water can be heated by solar energy at very high temperatures and is able to slowly give away the accumulated heat .
  • the heat transfer from the fluid to the ambient can last a long time and being so controllable .

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Animal Husbandry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Inorganic Chemistry (AREA)
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  • Medicines Containing Plant Substances (AREA)
  • Fodder In General (AREA)

Abstract

L'invention concerne de nouvelles applications pour des mélanges à base de tanin. La présente invention porte notamment sur des aliments pour animaux contenant un additif à base de tanin ou enrichis au tanin.
PCT/EP2004/050400 2003-04-07 2004-03-31 Melange de tanin servant d'additif WO2004089106A2 (fr)

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IT000016A ITSV20030016A1 (it) 2003-04-07 2003-04-07 Sostanze contenenti tannini o miscele di tannini.
ITSV2003A000016 2003-04-07

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FR2924900A1 (fr) * 2007-12-14 2009-06-19 Mathias Pierre Paul Axel Teule Melange d'extraits vegetaux pour l'amelioration de la qualite de l'eau d'aquariums et de bassins d'aquaculture d'organismes aquatiques d'eau douce.
CN102106481A (zh) * 2011-01-11 2011-06-29 中国科学院亚热带农业生态研究所 一种饲料添加剂单宁螯合锌的制备方法
EP2510808A1 (fr) * 2011-04-11 2012-10-17 T L Utilisation de tanins hydrolysables dans l'alimentation animale
CN104824119A (zh) * 2014-02-07 2015-08-12 毛罗萨维奥拉集团有限责任公司 栗单宁提取物作为抗氧化剂、抗微生物添加剂的用途和降低亚硝胺和真菌毒素的用途
EP2642874B1 (fr) * 2010-11-26 2019-06-12 Erber Aktiengesellschaft Additif pour produits alimentaires pour animaux
CN111889692A (zh) * 2020-07-09 2020-11-06 荆楚理工学院 一种单分散超细铜粉及其制备方法
WO2021187516A1 (fr) * 2020-03-18 2021-09-23 国立大学法人 東京大学 Promoteur de croissance animale et aliment pour bétail
CN114617195A (zh) * 2022-01-29 2022-06-14 华南农业大学 一种耐单宁乳酸菌和单宁混合添加提高青贮饲料品质的方法
WO2023222731A1 (fr) * 2022-05-17 2023-11-23 Srx Utilisation d'une composition pour préserver un récipient vinaire

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CN108164371B (zh) * 2018-02-28 2024-02-02 中国科学院南京土壤研究所 一种秸秆促腐方法及其在酸性土壤改良中的应用

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CN102106481A (zh) * 2011-01-11 2011-06-29 中国科学院亚热带农业生态研究所 一种饲料添加剂单宁螯合锌的制备方法
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CN104824119A (zh) * 2014-02-07 2015-08-12 毛罗萨维奥拉集团有限责任公司 栗单宁提取物作为抗氧化剂、抗微生物添加剂的用途和降低亚硝胺和真菌毒素的用途
EP2904910B1 (fr) * 2014-02-07 2019-05-15 Gruppo Mauro Saviola S.r.l. L'utilisation d'extrait de tannins de châtaigniers comme antioxidant, additif antimicrobien et afin de réduire les nitrosamines et les mycotoxines.
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WO2021187516A1 (fr) * 2020-03-18 2021-09-23 国立大学法人 東京大学 Promoteur de croissance animale et aliment pour bétail
CN111889692A (zh) * 2020-07-09 2020-11-06 荆楚理工学院 一种单分散超细铜粉及其制备方法
CN111889692B (zh) * 2020-07-09 2022-10-14 荆楚理工学院 一种单分散超细铜粉及其制备方法
CN114617195A (zh) * 2022-01-29 2022-06-14 华南农业大学 一种耐单宁乳酸菌和单宁混合添加提高青贮饲料品质的方法
WO2023222731A1 (fr) * 2022-05-17 2023-11-23 Srx Utilisation d'une composition pour préserver un récipient vinaire
FR3135622A1 (fr) * 2022-05-17 2023-11-24 Srx Composition pour préserver un récipient vinaire.

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