WO2004080381A3 - Poudre impregnee ameliorant la biodisponibilite et/ou la solubilite et procede de fabrication - Google Patents

Poudre impregnee ameliorant la biodisponibilite et/ou la solubilite et procede de fabrication Download PDF

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Publication number
WO2004080381A3
WO2004080381A3 PCT/FR2004/000541 FR2004000541W WO2004080381A3 WO 2004080381 A3 WO2004080381 A3 WO 2004080381A3 FR 2004000541 W FR2004000541 W FR 2004000541W WO 2004080381 A3 WO2004080381 A3 WO 2004080381A3
Authority
WO
WIPO (PCT)
Prior art keywords
solubility
production
active ingredient
impregnated powder
improving bioavailability
Prior art date
Application number
PCT/FR2004/000541
Other languages
English (en)
Other versions
WO2004080381A2 (fr
Inventor
Jerome Besse
Lawrence Besse
Myriam Alphonse
Original Assignee
Sarl Galenix Innovations
Jerome Besse
Lawrence Besse
Myriam Alphonse
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sarl Galenix Innovations, Jerome Besse, Lawrence Besse, Myriam Alphonse filed Critical Sarl Galenix Innovations
Priority to CA2518200A priority Critical patent/CA2518200C/fr
Priority to JP2006505704A priority patent/JP4901469B2/ja
Priority to BRPI0408065-3A priority patent/BRPI0408065A/pt
Priority to EP04717669A priority patent/EP1603538A2/fr
Priority to AU2004218859A priority patent/AU2004218859B2/en
Priority to MXPA05009440A priority patent/MXPA05009440A/es
Priority to US10/547,797 priority patent/US7569274B2/en
Publication of WO2004080381A2 publication Critical patent/WO2004080381A2/fr
Publication of WO2004080381A3 publication Critical patent/WO2004080381A3/fr
Priority to NO20054562A priority patent/NO20054562L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated
    • Y10T428/2993—Silicic or refractory material containing [e.g., tungsten oxide, glass, cement, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated
    • Y10T428/2993—Silicic or refractory material containing [e.g., tungsten oxide, glass, cement, etc.]
    • Y10T428/2995—Silane, siloxane or silicone coating
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated
    • Y10T428/2993—Silicic or refractory material containing [e.g., tungsten oxide, glass, cement, etc.]
    • Y10T428/2996—Glass particles or spheres
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated
    • Y10T428/2998—Coated including synthetic resin or polymer

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

L'invention concerne une poudre augmentant la biodisponibilité et/ou la solubilité d'au moins un principe actif comprenant un support solide, inerte, sous forme particulaire imprégné par un milieu liquide comprenant une phase hydrophobe et une phase hydrophile, au moins un tensioactif et au moins un principe actif, caractérisée en ce que le(s) principe(s) actif(s) est (sont) dissous dans l'une desdites phases hydrophile ou hydrophobe et sous forme de suspension dans l'autre desdites phases. Cette poudre imprégnée sert de base à diverses préparation dans le domaine pharmaceutique, parapharmaceutique, cosmétique, des compléments alimentaires et agroalimentaire.
PCT/FR2004/000541 2003-03-06 2004-03-05 Poudre impregnee ameliorant la biodisponibilite et/ou la solubilite et procede de fabrication WO2004080381A2 (fr)

Priority Applications (8)

Application Number Priority Date Filing Date Title
CA2518200A CA2518200C (fr) 2003-03-06 2004-03-05 Poudre impregnee ameliorant la biodisponibilite et/ou la solubilite et procede de fabrication
JP2006505704A JP4901469B2 (ja) 2003-03-06 2004-03-05 生物学的利用能および／または溶解度を増大させるための含浸粉末とその製造方法
BRPI0408065-3A BRPI0408065A (pt) 2003-03-06 2004-03-05 pó impregnado, processo de fabricação do mesmo e sua utilização
EP04717669A EP1603538A2 (fr) 2003-03-06 2004-03-05 Poudre impregnee ameliorant la biodisponibilite et/ou la solubilite et procede de fabrication
AU2004218859A AU2004218859B2 (en) 2003-03-06 2004-03-05 Impregnated powder improving bioavailability and/or solubility and method of production
MXPA05009440A MXPA05009440A (es) 2003-03-06 2004-03-05 Polvo impregnado que mejora la biodisponibilidad y/o solubilidad y metodo de produccion.
US10/547,797 US7569274B2 (en) 2003-03-06 2004-03-05 Impregnated powder improving bioavailability and/or solubility and method of production
NO20054562A NO20054562L (no) 2003-03-06 2005-10-04 Impregnert pulver som forbedrer biotilgjengelighet og/eller opploselighet og fremgangsmate for fremstilling derav

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0302802A FR2851918B1 (fr) 2003-03-06 2003-03-06 Poudre impregnee ameliorant la biodisponibilite et/ou la solubilite et procede de fabrication
FR03/02802 2003-03-06

Publications (2)

Publication Number Publication Date
WO2004080381A2 WO2004080381A2 (fr) 2004-09-23
WO2004080381A3 true WO2004080381A3 (fr) 2005-07-28

Family

ID=32865308

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2004/000541 WO2004080381A2 (fr) 2003-03-06 2004-03-05 Poudre impregnee ameliorant la biodisponibilite et/ou la solubilite et procede de fabrication

Country Status (11)

Country Link
US (1) US7569274B2 (fr)
EP (1) EP1603538A2 (fr)
JP (1) JP4901469B2 (fr)
AU (1) AU2004218859B2 (fr)
BR (1) BRPI0408065A (fr)
CA (1) CA2518200C (fr)
FR (1) FR2851918B1 (fr)
MX (1) MXPA05009440A (fr)
NO (1) NO20054562L (fr)
RU (1) RU2367412C2 (fr)
WO (1) WO2004080381A2 (fr)

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RU2309732C1 (ru) * 2006-03-13 2007-11-10 Олег Ильич Эпштейн Спрессованная твердая оральная форма лекарственного препарата и способ получения твердой оральной формы лекарственного препарата
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JP2000026283A (ja) * 1998-07-10 2000-01-25 Nisshin Oil Mills Ltd:The 油性組成物を含有した粉末組成物
WO2002083102A1 (fr) * 2001-02-23 2002-10-24 Cima Labs Inc. Emulsions en formes posologiques solides pour l'administration orale
WO2003051334A2 (fr) * 2001-12-19 2003-06-26 Remedia S.R.L. Composition pharmaceutique comprenant une double micro-emulsion huile/eau/huile incorporee dans un support solide

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Also Published As

Publication number Publication date
NO20054562D0 (no) 2005-10-04
MXPA05009440A (es) 2006-04-07
FR2851918A1 (fr) 2004-09-10
RU2367412C2 (ru) 2009-09-20
AU2004218859B2 (en) 2009-10-15
AU2004218859A1 (en) 2004-09-23
CA2518200A1 (fr) 2004-09-23
FR2851918B1 (fr) 2006-06-16
JP4901469B2 (ja) 2012-03-21
BRPI0408065A (pt) 2006-02-14
US7569274B2 (en) 2009-08-04
NO20054562L (no) 2005-12-01
WO2004080381A2 (fr) 2004-09-23
RU2005130989A (ru) 2006-08-10
CA2518200C (fr) 2013-04-30
JP2006519820A (ja) 2006-08-31
US20060182691A1 (en) 2006-08-17
EP1603538A2 (fr) 2005-12-14

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