WO2004037019A1 - Compositions de metal capables de supprimer l'oxygene actif - Google Patents

Compositions de metal capables de supprimer l'oxygene actif Download PDF

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Publication number
WO2004037019A1
WO2004037019A1 PCT/JP2002/011145 JP0211145W WO2004037019A1 WO 2004037019 A1 WO2004037019 A1 WO 2004037019A1 JP 0211145 W JP0211145 W JP 0211145W WO 2004037019 A1 WO2004037019 A1 WO 2004037019A1
Authority
WO
WIPO (PCT)
Prior art keywords
active oxygen
gold
platinum
oxygen radical
foil
Prior art date
Application number
PCT/JP2002/011145
Other languages
English (en)
Japanese (ja)
Inventor
Kazuyoshi Okubo
Original Assignee
Takaoka Shoji Inc.
Motomura, Michiyo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takaoka Shoji Inc., Motomura, Michiyo filed Critical Takaoka Shoji Inc.
Priority to AU2002343768A priority Critical patent/AU2002343768A1/en
Priority to PCT/JP2002/011145 priority patent/WO2004037019A1/fr
Publication of WO2004037019A1 publication Critical patent/WO2004037019A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
    • A23L3/34—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
    • A23L3/3409—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of gases, e.g. fumigation; Compositions or apparatus therefor
    • A23L3/3418—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of gases, e.g. fumigation; Compositions or apparatus therefor in a controlled atmosphere, e.g. partial vacuum, comprising only CO2, N2, O2 or H2O
    • A23L3/3427—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of gases, e.g. fumigation; Compositions or apparatus therefor in a controlled atmosphere, e.g. partial vacuum, comprising only CO2, N2, O2 or H2O in which an absorbent is placed or used
    • A23L3/3436—Oxygen absorbent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants

Definitions

  • the present invention relates to a metal composition having an ability to scavenge reactive oxygen radicals (Reactive Oxygen Radica1).
  • Background art Reactive Oxygen Radica1.
  • Active oxygen radicals also called simply active oxygen or free radicals, are reactive atoms and molecules with unstable unpaired electrons.
  • reactive oxygen radicals In general, super O key side (- 0 2 -), hydroxy radicals (HO *), hydrogen peroxide (H 2 0 2), 4 kinds of singlet oxygen 0 2) is referred to as reactive oxygen radicals.
  • hydroperoxy radicals (HOO *), peroxy radicals (L 00 *), alkoxy radicals (LO *) and the like are also broadly called active oxygen species and radical species.
  • active oxygen radicals are produced secondary and tertiary from active oxygen radicals.
  • active oxygen radicals which increase at an accelerated rate, cause damage to cells and DNA, peroxidation of lipids, and are involved in many diseases.
  • active oxygen radical scavengers have two aspects: elimination of active oxygen and generation of active oxygen.
  • the active oxygen radical scavenger which is a hydrogen (H *) donor, is converted into an active oxygen radical such as 0 *, HOOH, HO 0 *, and HO * (HOOH in the above equation). It donates two electrons (e-one) and reduces by two protons (H +) to eliminate active oxygen radicals.
  • the normal oxygen molecule O 2 two electrons (e-), donate two protons (H +), thereby generating an active oxygen Also involved in the process.
  • active oxygen radical scavengers and media such as aldehydes, amino acids, and peronic acid (acidic saccharides), which have poor direct working ability to process active oxygen radicals alone, are present at the same time. It was revealed that the active oxygen radical scavenger was superior to the active oxygen radical scavenger in eliminating the active oxygen than the active oxygen radical scavenger alone. In addition, it was revealed that there was a combination of active oxygen radical scavenger and mediae in the reaction to eliminate active oxygen radicals.
  • active oxygen radical X hereinafter sometimes simply referred to as “X” in the present specification
  • active oxygen radical scavenger Y hereinafter referred to as the “donor”
  • Y active oxygen radical scavenger
  • k Constant reflecting the active oxygen radical processing ability mainly by the combination of Y and Z
  • test substance if a faint luminescence phenomenon can be observed in the test substance under the coexistence of X and Y, it can be recognized that the test substance is a medium-Z. In addition, if a weak emission phenomenon can be observed in the test substance under the coexistence of X and Z, the test substance can be recognized as the active oxygen radical scavenger Y.
  • test substance is a substance consisting of the active oxygen radical X and the media Zi.
  • test substance is a substance consisting of the active oxygen radical X and the active oxygen radical force ranger Y. Can be.
  • the phenomenon of the weak light emission (hereinafter, sometimes referred to as “XYZ-based weak light emission” in the present specification) is a basic phenomenon in an oxygen environment, and is a basic and universal phenomenon that occurs near us. This phenomenon is based on the elimination of the active oxygen radical X by converting it into light energy.
  • ⁇ works as a hydrogen ( ⁇ *) donor and ⁇ works as a mediator.
  • ⁇ can be said to be a second scavenger because even if the activity of ⁇ , called a scavenger, is high, light energy cannot be released without the presence of ⁇ .
  • the world of media in the ⁇ -based active oxygen-eliminated luminescence is a completely unknown world with no concept.
  • the skin, digestive organs, respiratory organs, heart, blood vessels, eyes, brain, bones, and genitalia of the body are all ⁇ , and play an important role as a mediator of hydrogen in active oxygen scavenging luminescence. Disclosure of the invention
  • the inventor of the present application has analyzed the components of various substances having the ability as a media, and as a result of diligent research, found that gold, platinum, silver, and copper have the ability as a media. After elucidation, the present invention was completed.
  • the metal composition having the active oxygen scavenging ability proposed by the present invention is made of one or more of gold, platinum, silver, and copper.
  • the metal composition of the present invention is 24 gold, 23.9 gold, 23.74 gold, 23.44 gold, 23.21 gold, 22.99 gold, 22.66 gold, 21.68 gold, 18.12 gold , 14.12 gold.
  • Table 1 shows the gold, silver and copper content ratios. Table 1 Content of gold, silver and copper
  • the shape of gold, platinum, silver, and copper is not particularly limited, but is preferably foil, flake, powder, or granule because the larger the surface area, the higher the capacity of the media becomes. However, if the particle size is reduced, the surface area increases, but in consideration of the cost, foil or flake is more preferable.
  • the thickness should be about 0.1 to 0.3 zm, which is the intermediate product of foil or about 0.1 to 0.3 zm obtained by further hammering the supernatant. I like it.
  • the content ratio by weight of gold to platinum is preferably 0.01 to 100 with respect to platinum 1.
  • the weight ratio of gold to platinum if the amount of gold is less than 0.01 with respect to platinum 1, it is not preferable because the effect of gold is hardly observed, and conversely, it exceeds 100. Because the effect of platinum is not produced, it is unfavorable.
  • the active oxygen-eliminated luminescence as Z by XY was observed, but the active oxygen-eliminated luminescence as Y by XZ, the active oxygen-eliminated luminescence as XZ by Y, and the XY as XY by Z. No active oxygen-quenched luminescence was observed. Therefore, the gold leaf is recognized as the medial oxygen Z, but it is not the active oxygen radical scavenger Y, but the active oxygen radical X and the media oxygen Z, but not the active oxygen radical X. It was found that it was not a substance consisting of the active oxygen radical scavenger Y.
  • Example 2 Flaky 24 gold foil, flaky 23.9 gold foil, flaky 18.12 gold foil, flaky 14.12 gold foil, flaky 100% platinum foil, flaky 100% silver foil, flaky 100% The active oxygen-eliminated luminescence as Z by XY was measured for each of the copper foil and the flaky aluminum foil.
  • Petri dish 5 is flaked 24 gold leaf
  • Petri dish 6 is flaked 23.9 gold leaf
  • Petri dish 7 is flaked 18.12 gold foil
  • Petri dish 8 is flaked 14.12 gold foil
  • Petri dish 9 is flaked 100% platinum foil
  • Petri dish 10 is flaked 1 ⁇ 0% silver foil
  • the Petri dish 11 was a flaky 100% copper foil
  • the Petri dish 12 was a flaky aluminum foil.
  • the faint emission of the dish 5-12 is detected by the CCD camera performs Fuotonkau down computing, further from the light emission luminance displayed by performing the image processing, the brightness of the active oxygen scavenging emission as Z by XY (cd / m 2 ).
  • the metal composition of the present invention has a capability as a media, and has excellent active oxygen scavenging ability, and is therefore useful for maintaining and recovering human health and physical condition. Therefore, the metal composition of the present invention is highly versatile and is expected to be widely used as a raw material for cosmetics, pharmaceuticals, health foods and general foods.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Biochemistry (AREA)
  • Nutrition Science (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne des compositions de métal possédant une capacité sous forme de substance Z, qui peut à peine supprimer un radical oxygène actif par elle-même, mais qui favorise l'effet de suppression de radical oxygène actif lorsqu'elle coexiste avec un capteur de radical oxygène actif et, qui possède une capacité de suppression d'oxygène actif élevée. L'objet susmentionné est obtenu grâce à des compositions métalliques capables supprimer l'oxygène actif. Ces compositions comprennent un ou plusieurs métaux sélectionnés parmi l'or, le platine, l'argent et le cuivre. Ces compositions métalliques sont des produits aux applications variées qui peuvent être utilisés à des fins diverses telles que pour des matériaux destinés à des produits cosmétiques, des médicaments, des aliments diététiques et des aliments ordinaires.
PCT/JP2002/011145 2002-10-28 2002-10-28 Compositions de metal capables de supprimer l'oxygene actif WO2004037019A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2002343768A AU2002343768A1 (en) 2002-10-28 2002-10-28 Metal compositions capable of removing active oxygen
PCT/JP2002/011145 WO2004037019A1 (fr) 2002-10-28 2002-10-28 Compositions de metal capables de supprimer l'oxygene actif

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP2002/011145 WO2004037019A1 (fr) 2002-10-28 2002-10-28 Compositions de metal capables de supprimer l'oxygene actif

Publications (1)

Publication Number Publication Date
WO2004037019A1 true WO2004037019A1 (fr) 2004-05-06

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PCT/JP2002/011145 WO2004037019A1 (fr) 2002-10-28 2002-10-28 Compositions de metal capables de supprimer l'oxygene actif

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AU (1) AU2002343768A1 (fr)
WO (1) WO2004037019A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1598071A4 (fr) * 2003-02-20 2006-04-26 Shetech Co Ltd Agent de decomposition d'un anion superoxyde
EP1656840A1 (fr) * 2004-11-08 2006-05-17 Fuji Photo Film Co., Ltd. Agent pour l'élimination de l'oxygène et méthode de production

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991011117A2 (fr) * 1990-02-05 1991-08-08 Board Of Regents, The University Of Texas System Complements alimentaires comprenant des vitamines et des sels mineraux
JPH1160493A (ja) * 1997-08-18 1999-03-02 Eiichi Tsukiji 活性酸素を起因とする疾患の治療および予防薬又はその原料
JPH11346715A (ja) * 1998-06-09 1999-12-21 Otsuka Yakuhin Kogyo Kk 白金族コロイド溶液を配合した食品の製造方法
WO2001036337A1 (fr) * 1999-11-18 2001-05-25 Phild Co., Ltd. Procede et dispositif de preparation d'une eau contenant des particules d'or ultrafines dissoutes

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991011117A2 (fr) * 1990-02-05 1991-08-08 Board Of Regents, The University Of Texas System Complements alimentaires comprenant des vitamines et des sels mineraux
JPH1160493A (ja) * 1997-08-18 1999-03-02 Eiichi Tsukiji 活性酸素を起因とする疾患の治療および予防薬又はその原料
JPH11346715A (ja) * 1998-06-09 1999-12-21 Otsuka Yakuhin Kogyo Kk 白金族コロイド溶液を配合した食品の製造方法
WO2001036337A1 (fr) * 1999-11-18 2001-05-25 Phild Co., Ltd. Procede et dispositif de preparation d'une eau contenant des particules d'or ultrafines dissoutes

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1598071A4 (fr) * 2003-02-20 2006-04-26 Shetech Co Ltd Agent de decomposition d'un anion superoxyde
US7838043B2 (en) 2003-02-20 2010-11-23 Apt Co., Ltd Superoxide anion decomposing agent
EP1656840A1 (fr) * 2004-11-08 2006-05-17 Fuji Photo Film Co., Ltd. Agent pour l'élimination de l'oxygène et méthode de production

Also Published As

Publication number Publication date
AU2002343768A8 (en) 2004-05-13
AU2002343768A1 (en) 2004-05-13

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