WO2004024753A1 - Process for manufacturing crystals of growth hormone - Google Patents

Process for manufacturing crystals of growth hormone Download PDF

Info

Publication number
WO2004024753A1
WO2004024753A1 PCT/SE2003/001422 SE0301422W WO2004024753A1 WO 2004024753 A1 WO2004024753 A1 WO 2004024753A1 SE 0301422 W SE0301422 W SE 0301422W WO 2004024753 A1 WO2004024753 A1 WO 2004024753A1
Authority
WO
WIPO (PCT)
Prior art keywords
crystals
process according
functional derivatives
propanol
concentration
Prior art date
Application number
PCT/SE2003/001422
Other languages
English (en)
French (fr)
Inventor
Jonas Fransson
Mitra Mosharraf
Leena Lehtikari
Sinikka Uotila
Kalevi Visuri
Original Assignee
Pfizer Health Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Health Ab filed Critical Pfizer Health Ab
Priority to AU2003259002A priority Critical patent/AU2003259002A1/en
Priority to JP2004535333A priority patent/JP2006513986A/ja
Priority to CA002498525A priority patent/CA2498525A1/en
Priority to BR0314187-0A priority patent/BR0314187A/pt
Priority to MXPA05002826A priority patent/MXPA05002826A/es
Priority to EP03795535A priority patent/EP1539797A1/en
Publication of WO2004024753A1 publication Critical patent/WO2004024753A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormones [GH] (Somatotropin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/27—Growth hormone [GH] (Somatotropin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
PCT/SE2003/001422 2002-09-13 2003-09-12 Process for manufacturing crystals of growth hormone WO2004024753A1 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
AU2003259002A AU2003259002A1 (en) 2002-09-13 2003-09-12 Process for manufacturing crystals of growth hormone
JP2004535333A JP2006513986A (ja) 2002-09-13 2003-09-12 成長ホルモンの結晶を製造するための方法
CA002498525A CA2498525A1 (en) 2002-09-13 2003-09-12 Process for manufacturing crystals of growth hormone
BR0314187-0A BR0314187A (pt) 2002-09-13 2003-09-12 Processo para produzir cristais do hormÈnio do crescimento
MXPA05002826A MXPA05002826A (es) 2002-09-13 2003-09-12 Procedimiento para fabricar cristales de hormona de crecimiento.
EP03795535A EP1539797A1 (en) 2002-09-13 2003-09-12 Process for manufacturing crystals of growth hormone

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0202719-1 2002-09-13
SE0202719A SE0202719D0 (sv) 2002-09-13 2002-09-13 Process for mfg crystals of growth hormone

Publications (1)

Publication Number Publication Date
WO2004024753A1 true WO2004024753A1 (en) 2004-03-25

Family

ID=20288983

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SE2003/001422 WO2004024753A1 (en) 2002-09-13 2003-09-12 Process for manufacturing crystals of growth hormone

Country Status (8)

Country Link
EP (1) EP1539797A1 (sv)
JP (1) JP2006513986A (sv)
AU (1) AU2003259002A1 (sv)
BR (1) BR0314187A (sv)
CA (1) CA2498525A1 (sv)
MX (1) MXPA05002826A (sv)
SE (1) SE0202719D0 (sv)
WO (1) WO2004024753A1 (sv)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10470459B2 (en) 2014-05-28 2019-11-12 Ipabc Ltd Antimicrobial preparations, methods for preparing the same and uses thereof to combat microorganisms

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5148635B2 (ja) * 2007-03-05 2013-02-20 ロディア オペレーションズ 物質の結晶化を追跡する方法と対応する微小流体装置およびスクリーニング方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0398619A2 (en) * 1989-05-16 1990-11-22 Ethicon, Inc. Stabilized compositions containing epidermal growth factor
WO1992000998A1 (en) * 1990-07-13 1992-01-23 Novo Nordisk A/S Growth hormone crystals and a process for production of these gh-crystals
US5109117A (en) * 1990-06-26 1992-04-28 Monsanto Company Method of somatotropin naturation using urea and a soluble organic alcohol
US5734026A (en) * 1992-10-28 1998-03-31 Pharmacia & Upjohn Aktiebolag Process for manufacturing crystals of growth hormone and crystals thereby obtained
US5849704A (en) * 1991-12-20 1998-12-15 Novo Nordisk A/S Pharmaceutical formulation
EP0938902A1 (en) * 1998-02-04 1999-09-01 Jcr Pharmaceuticals Co., Ltd. Human growth hormone-containing aqueous pharamceutical composition

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0398619A2 (en) * 1989-05-16 1990-11-22 Ethicon, Inc. Stabilized compositions containing epidermal growth factor
US5109117A (en) * 1990-06-26 1992-04-28 Monsanto Company Method of somatotropin naturation using urea and a soluble organic alcohol
WO1992000998A1 (en) * 1990-07-13 1992-01-23 Novo Nordisk A/S Growth hormone crystals and a process for production of these gh-crystals
US5849704A (en) * 1991-12-20 1998-12-15 Novo Nordisk A/S Pharmaceutical formulation
US5734026A (en) * 1992-10-28 1998-03-31 Pharmacia & Upjohn Aktiebolag Process for manufacturing crystals of growth hormone and crystals thereby obtained
EP0938902A1 (en) * 1998-02-04 1999-09-01 Jcr Pharmaceuticals Co., Ltd. Human growth hormone-containing aqueous pharamceutical composition

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10470459B2 (en) 2014-05-28 2019-11-12 Ipabc Ltd Antimicrobial preparations, methods for preparing the same and uses thereof to combat microorganisms

Also Published As

Publication number Publication date
CA2498525A1 (en) 2004-03-25
JP2006513986A (ja) 2006-04-27
BR0314187A (pt) 2005-08-09
SE0202719D0 (sv) 2002-09-13
EP1539797A1 (en) 2005-06-15
AU2003259002A1 (en) 2004-04-30
MXPA05002826A (es) 2005-09-30

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