MXPA05002826A - Procedimiento para fabricar cristales de hormona de crecimiento. - Google Patents
Procedimiento para fabricar cristales de hormona de crecimiento.Info
- Publication number
- MXPA05002826A MXPA05002826A MXPA05002826A MXPA05002826A MXPA05002826A MX PA05002826 A MXPA05002826 A MX PA05002826A MX PA05002826 A MXPA05002826 A MX PA05002826A MX PA05002826 A MXPA05002826 A MX PA05002826A MX PA05002826 A MXPA05002826 A MX PA05002826A
- Authority
- MX
- Mexico
- Prior art keywords
- crystals
- functional derivatives
- growth hormone
- manufacturing
- propanol
- Prior art date
Links
- 239000013078 crystal Substances 0.000 title abstract 7
- 102000018997 Growth Hormone Human genes 0.000 title abstract 6
- 108010051696 Growth Hormone Proteins 0.000 title abstract 6
- 239000000122 growth hormone Substances 0.000 title abstract 6
- 238000004519 manufacturing process Methods 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 abstract 6
- 239000003814 drug Substances 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Endocrinology (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Toxicology (AREA)
- Diabetes (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Abstract
Se provee un procedimiento para fabricar cristales de hormona de crecimiento (GH), o derivados funcionales de la misma, que comprende los siguientes pasos: (a) preparar una solucion acuosa de GH, o derivados funcionales de la misma, que comprenda 2-propanol, (b) incubar la solucion preparada en el paso (a) para cristalizar dicha GH, o derivados funcionales de la misma, y (c) aislar los cristales formados en el paso (b); se provee tambien un uso novedoso de 2-propanol como un agente de cristalizacion para fabricar cristales de GH, o derivados funcionales de la misma; ademas, se proveen cristales obtenibles mediante el procedimiento y las composiciones farmaceuticas que comprenden los cristales; los cristales son utiles como un medicamento, en la fabricacion de dicho medicamento, y en un metodo para tratar a un mamifero, incluyendo un humano.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0202719A SE0202719D0 (sv) | 2002-09-13 | 2002-09-13 | Process for mfg crystals of growth hormone |
PCT/SE2003/001422 WO2004024753A1 (en) | 2002-09-13 | 2003-09-12 | Process for manufacturing crystals of growth hormone |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA05002826A true MXPA05002826A (es) | 2005-09-30 |
Family
ID=20288983
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA05002826A MXPA05002826A (es) | 2002-09-13 | 2003-09-12 | Procedimiento para fabricar cristales de hormona de crecimiento. |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP1539797A1 (es) |
JP (1) | JP2006513986A (es) |
AU (1) | AU2003259002A1 (es) |
BR (1) | BR0314187A (es) |
CA (1) | CA2498525A1 (es) |
MX (1) | MXPA05002826A (es) |
SE (1) | SE0202719D0 (es) |
WO (1) | WO2004024753A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5148635B2 (ja) * | 2007-03-05 | 2013-02-20 | ロディア オペレーションズ | 物質の結晶化を追跡する方法と対応する微小流体装置およびスクリーニング方法 |
GB201409451D0 (en) | 2014-05-28 | 2014-07-09 | Ipabc Ltd | Antimicrobial preparations, methods for preparing the same and uses thereof to combat microorganisms |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5130298A (en) * | 1989-05-16 | 1992-07-14 | Ethicon, Inc. | Stabilized compositions containing epidermal growth factor |
US5109117A (en) * | 1990-06-26 | 1992-04-28 | Monsanto Company | Method of somatotropin naturation using urea and a soluble organic alcohol |
DK168790D0 (es) * | 1990-07-13 | 1990-07-13 | Novo Nordisk As | |
US5849704A (en) * | 1991-12-20 | 1998-12-15 | Novo Nordisk A/S | Pharmaceutical formulation |
SE9302278D0 (sv) * | 1992-10-28 | 1993-07-02 | Kabi Pharmacia Ab | Growth hormone |
JP3723857B2 (ja) * | 1998-02-04 | 2005-12-07 | 日本ケミカルリサーチ株式会社 | ヒト成長ホルモン含有水性医薬組成物 |
-
2002
- 2002-09-13 SE SE0202719A patent/SE0202719D0/xx unknown
-
2003
- 2003-09-12 WO PCT/SE2003/001422 patent/WO2004024753A1/en active Search and Examination
- 2003-09-12 BR BR0314187-0A patent/BR0314187A/pt not_active IP Right Cessation
- 2003-09-12 JP JP2004535333A patent/JP2006513986A/ja not_active Withdrawn
- 2003-09-12 MX MXPA05002826A patent/MXPA05002826A/es not_active Application Discontinuation
- 2003-09-12 AU AU2003259002A patent/AU2003259002A1/en not_active Abandoned
- 2003-09-12 EP EP03795535A patent/EP1539797A1/en not_active Ceased
- 2003-09-12 CA CA002498525A patent/CA2498525A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP2006513986A (ja) | 2006-04-27 |
SE0202719D0 (sv) | 2002-09-13 |
CA2498525A1 (en) | 2004-03-25 |
AU2003259002A1 (en) | 2004-04-30 |
BR0314187A (pt) | 2005-08-09 |
EP1539797A1 (en) | 2005-06-15 |
WO2004024753A1 (en) | 2004-03-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |