MXPA05002826A - Procedimiento para fabricar cristales de hormona de crecimiento. - Google Patents

Procedimiento para fabricar cristales de hormona de crecimiento.

Info

Publication number
MXPA05002826A
MXPA05002826A MXPA05002826A MXPA05002826A MXPA05002826A MX PA05002826 A MXPA05002826 A MX PA05002826A MX PA05002826 A MXPA05002826 A MX PA05002826A MX PA05002826 A MXPA05002826 A MX PA05002826A MX PA05002826 A MXPA05002826 A MX PA05002826A
Authority
MX
Mexico
Prior art keywords
crystals
functional derivatives
growth hormone
manufacturing
propanol
Prior art date
Application number
MXPA05002826A
Other languages
English (en)
Inventor
Kalevi Visuri
Original Assignee
Pfizer Health Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Health Ab filed Critical Pfizer Health Ab
Publication of MXPA05002826A publication Critical patent/MXPA05002826A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/61Growth hormones [GH] (Somatotropin)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/27Growth hormone [GH] (Somatotropin)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/10Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Se provee un procedimiento para fabricar cristales de hormona de crecimiento (GH), o derivados funcionales de la misma, que comprende los siguientes pasos: (a) preparar una solucion acuosa de GH, o derivados funcionales de la misma, que comprenda 2-propanol, (b) incubar la solucion preparada en el paso (a) para cristalizar dicha GH, o derivados funcionales de la misma, y (c) aislar los cristales formados en el paso (b); se provee tambien un uso novedoso de 2-propanol como un agente de cristalizacion para fabricar cristales de GH, o derivados funcionales de la misma; ademas, se proveen cristales obtenibles mediante el procedimiento y las composiciones farmaceuticas que comprenden los cristales; los cristales son utiles como un medicamento, en la fabricacion de dicho medicamento, y en un metodo para tratar a un mamifero, incluyendo un humano.
MXPA05002826A 2002-09-13 2003-09-12 Procedimiento para fabricar cristales de hormona de crecimiento. MXPA05002826A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0202719A SE0202719D0 (sv) 2002-09-13 2002-09-13 Process for mfg crystals of growth hormone
PCT/SE2003/001422 WO2004024753A1 (en) 2002-09-13 2003-09-12 Process for manufacturing crystals of growth hormone

Publications (1)

Publication Number Publication Date
MXPA05002826A true MXPA05002826A (es) 2005-09-30

Family

ID=20288983

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05002826A MXPA05002826A (es) 2002-09-13 2003-09-12 Procedimiento para fabricar cristales de hormona de crecimiento.

Country Status (8)

Country Link
EP (1) EP1539797A1 (es)
JP (1) JP2006513986A (es)
AU (1) AU2003259002A1 (es)
BR (1) BR0314187A (es)
CA (1) CA2498525A1 (es)
MX (1) MXPA05002826A (es)
SE (1) SE0202719D0 (es)
WO (1) WO2004024753A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5148635B2 (ja) * 2007-03-05 2013-02-20 ロディア オペレーションズ 物質の結晶化を追跡する方法と対応する微小流体装置およびスクリーニング方法
GB201409451D0 (en) 2014-05-28 2014-07-09 Ipabc Ltd Antimicrobial preparations, methods for preparing the same and uses thereof to combat microorganisms

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5130298A (en) * 1989-05-16 1992-07-14 Ethicon, Inc. Stabilized compositions containing epidermal growth factor
US5109117A (en) * 1990-06-26 1992-04-28 Monsanto Company Method of somatotropin naturation using urea and a soluble organic alcohol
DK168790D0 (es) * 1990-07-13 1990-07-13 Novo Nordisk As
US5849704A (en) * 1991-12-20 1998-12-15 Novo Nordisk A/S Pharmaceutical formulation
SE9302278D0 (sv) * 1992-10-28 1993-07-02 Kabi Pharmacia Ab Growth hormone
JP3723857B2 (ja) * 1998-02-04 2005-12-07 日本ケミカルリサーチ株式会社 ヒト成長ホルモン含有水性医薬組成物

Also Published As

Publication number Publication date
AU2003259002A1 (en) 2004-04-30
BR0314187A (pt) 2005-08-09
SE0202719D0 (sv) 2002-09-13
EP1539797A1 (en) 2005-06-15
WO2004024753A1 (en) 2004-03-25
JP2006513986A (ja) 2006-04-27
CA2498525A1 (en) 2004-03-25

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal