WO2003089456A2 - Peptide inhibitors of protein kinase c - Google Patents

Peptide inhibitors of protein kinase c Download PDF

Info

Publication number
WO2003089456A2
WO2003089456A2 PCT/US2003/012541 US0312541W WO03089456A2 WO 2003089456 A2 WO2003089456 A2 WO 2003089456A2 US 0312541 W US0312541 W US 0312541W WO 03089456 A2 WO03089456 A2 WO 03089456A2
Authority
WO
WIPO (PCT)
Prior art keywords
seq
peptide
peptides
pkc
isozyme
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2003/012541
Other languages
English (en)
French (fr)
Other versions
WO2003089456A3 (en
Inventor
Daria Mochly-Rosen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leland Stanford Junior University
Original Assignee
Leland Stanford Junior University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to AU2003234185A priority Critical patent/AU2003234185C1/en
Priority to JP2003586176A priority patent/JP2005523326A/ja
Priority to CA2482598A priority patent/CA2482598C/en
Priority to EP03728494A priority patent/EP1501532A4/en
Priority to US10/513,003 priority patent/US7393835B2/en
Application filed by Leland Stanford Junior University filed Critical Leland Stanford Junior University
Publication of WO2003089456A2 publication Critical patent/WO2003089456A2/en
Publication of WO2003089456A3 publication Critical patent/WO2003089456A3/en
Anticipated expiration legal-status Critical
Priority to US11/879,414 priority patent/US7833984B2/en
Priority to AU2009201760A priority patent/AU2009201760B2/en
Priority to US13/101,540 priority patent/US8658594B2/en
Priority to US14/187,070 priority patent/US9365837B2/en
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45—Transferases (2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/18—Antioxidants, e.g. antiradicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids

Definitions

  • SEQ ID NO:51 is a fragment derived from SEQ ID N0.49.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
PCT/US2003/012541 2002-04-22 2003-04-22 Peptide inhibitors of protein kinase c Ceased WO2003089456A2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
AU2003234185A AU2003234185C1 (en) 2002-04-22 2003-04-22 Peptide inhibitors of protein kinase C
JP2003586176A JP2005523326A (ja) 2002-04-22 2003-04-22 プロテインキナーゼｃのペプチドインヒビター
CA2482598A CA2482598C (en) 2002-04-22 2003-04-22 Peptide inhibitors of protein kinase c
EP03728494A EP1501532A4 (en) 2002-04-22 2003-04-22 PEPTIDE INHIBITORS OF PROTEIN KINASE C
US10/513,003 US7393835B2 (en) 2002-04-22 2003-04-22 Peptide inhibitors of protein kinase C
US11/879,414 US7833984B2 (en) 2002-04-22 2007-07-16 Peptide inhibitors of protein kinase C
AU2009201760A AU2009201760B2 (en) 2002-04-22 2009-05-04 Peptide inhibitors of protein kinase C
US13/101,540 US8658594B2 (en) 2002-04-22 2011-05-05 Peptide inhibitors of protein kinase C
US14/187,070 US9365837B2 (en) 2002-04-22 2014-02-21 Peptide inhibitors of protein kinase C

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37453002P 2002-04-22 2002-04-22
US60/374,530 2002-04-22

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US10/421,503 Continuation US7507711B2 (en) 2002-04-22 2003-04-22 Peptide inhibitors of protein kinase C

Related Child Applications (4)

Application Number Title Priority Date Filing Date
US10513003 A-371-Of-International 2003-04-22
US10/513,003 A-371-Of-International US7393835B2 (en) 2002-04-22 2003-04-22 Peptide inhibitors of protein kinase C
US11/879,414 Continuation US7833984B2 (en) 2002-04-22 2007-07-16 Peptide inhibitors of protein kinase C
US12/214,104 Continuation US7939493B2 (en) 2002-04-22 2008-06-16 Peptide inhibitors of protein kinase C

Publications (2)

Publication Number Publication Date
WO2003089456A2 true WO2003089456A2 (en) 2003-10-30
WO2003089456A3 WO2003089456A3 (en) 2004-02-12

Family

ID=29251202

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2003/012541 Ceased WO2003089456A2 (en) 2002-04-22 2003-04-22 Peptide inhibitors of protein kinase c
PCT/US2003/012542 Ceased WO2003089457A2 (en) 2002-04-22 2003-04-22 Peptide inhibitors of protein kinase c ϝ for pain management

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/US2003/012542 Ceased WO2003089457A2 (en) 2002-04-22 2003-04-22 Peptide inhibitors of protein kinase c ϝ for pain management

Country Status (6)

Country Link
US (8) US7459424B2 (https=)
EP (3) EP1501533A4 (https=)
JP (5) JP2005527209A (https=)
AU (4) AU2003234185C1 (https=)
CA (3) CA2482598C (https=)
WO (2) WO2003089456A2 (https=)

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WO2007035782A3 (en) * 2005-09-19 2007-10-25 Kai Pharmaceuticals Inc Protein kinase c peptide modulators of angiogenesis
JP2008526987A (ja) * 2005-01-14 2008-07-24 フィラデルフィア・カレッジ・オブ・オステオパシック・メディスン 臓器のための灌流及び／又は保存溶液
US8785648B1 (en) 2010-08-10 2014-07-22 The Regents Of The University Of California PKC-epsilon inhibitors
WO2016003450A1 (en) 2014-07-01 2016-01-07 The Regents Of The University Of California Pkc-epsilon inhibitors
US9255124B2 (en) 2007-01-19 2016-02-09 Kai Pharmaceuticals, Inc. Modifications of peptide compositions to increase stability and delivery efficiency

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JP2005527209A (ja) * 2002-04-22 2005-09-15 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 疼痛管理のためのプロテインキナーゼＣγのペプチドインヒビター
US6933275B2 (en) * 2002-05-01 2005-08-23 The Board Of Trustees Of The Leland Stanford Junior University Protein kinase C peptides for use in withdrawal
WO2004084889A1 (en) * 2003-03-28 2004-10-07 Pfizer Inc. Use of protein kinase c inhibitor for suppressing sustained slow postsynaptic excitation (sspe) of enteric neurons
WO2004103266A2 (en) * 2003-05-16 2004-12-02 The Board Of Trustees Of The Leland Stanford Junior University Protein kinase c peptides for use in withdrawal
WO2005032575A1 (en) * 2003-10-02 2005-04-14 The Board Of Trustees Of The Leland Stanford Junior University Protein kinase c peptides for use in withdrawal
US8062891B2 (en) 2003-10-24 2011-11-22 Gencia Corporation Nonviral vectors for delivering polynucleotides to plants
US8507277B2 (en) * 2003-10-24 2013-08-13 Gencia Corporation Nonviral vectors for delivering polynucleotides
US8133733B2 (en) 2003-10-24 2012-03-13 Gencia Corporation Nonviral vectors for delivering polynucleotides to target tissues
US20090208478A1 (en) * 2003-10-24 2009-08-20 Gencia Corporation Transducible polypeptides for modifying metabolism
CA2543257C (en) 2003-10-24 2013-12-31 Gencia Corporation Methods and compositions for delivering polynucleotides
US20090123468A1 (en) 2003-10-24 2009-05-14 Gencia Corporation Transducible polypeptides for modifying metabolism
CA2549052A1 (en) * 2003-12-11 2005-06-30 The Board Of Trustees Of The Leland Stanford Junior University Isozyme-specific antagonists of protein kinase c
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EP2298792A3 (en) 2005-08-05 2011-10-19 Pharmagap Inc. Peptides targeted to protein kinase C isoforms and uses thereof
JP5276982B2 (ja) 2005-08-26 2013-08-28 ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティ オキシトシンの投与による頭痛の処置のための方法
JP2009531335A (ja) * 2006-03-30 2009-09-03 サルペップ バイオテクノロジー インコーポレイテッド 神経障害性疼痛の抑制および治療
US7741290B2 (en) * 2006-06-01 2010-06-22 The Board of Trustee of The Leland Stanford Juinior University Method of preventing progression of hypertension-induced heart failure with PKC peptides
KR20090117878A (ko) 2007-01-19 2009-11-13 카이 파마슈티컬즈 통증의 완화를 위한 엡실론 억제제 화합물의 사용 방법
US20090062208A1 (en) * 2007-02-06 2009-03-05 Mochly-Rosen Daria D Methods for maintaining blood-brain barrier integrity in hypertensive subjects using a delta-PKC inhibitor
JP2010523598A (ja) * 2007-04-06 2010-07-15 カイ・ファーマシューティカルズ・インコーポレイテッド 痛みの軽減のためのガンマ阻害剤化合物の使用方法
US20090137493A1 (en) * 2007-06-07 2009-05-28 Mochly-Rosen Daria D Inhibition of tumor metastases using protein kinase C (PKC) inhibitors
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CN103083643B (zh) * 2008-03-27 2015-01-07 雀巢产品技术援助有限公司 增加肽、肽模拟物和其他胃肠道转运蛋白底物吸收的方法
WO2010019965A1 (en) * 2008-08-15 2010-02-18 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for modulating epsilon protein kinase c-mediated cytoprotection
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KR101720961B1 (ko) 2009-02-27 2017-03-29 셀룰러 다이내믹스 인터내셔널, 인코포레이티드 다능성 세포의 분화
JP2012519710A (ja) * 2009-03-06 2012-08-30 アングストロム プハルマセウトイカルス インコーポレイテッド 細胞遊走を調整するための組成物、及び方法
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CA2958704A1 (en) 2014-08-25 2016-03-03 University Of Canberra Compositions for modulating cancer stem cells and uses therefor
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JP7093559B2 (ja) 2016-04-12 2022-06-30 トライジェミナ， インコーポレイテッド マグネシウム含有オキシトシン製剤および使用の方法
US12410143B2 (en) 2017-01-17 2025-09-09 Michael David FORREST Therapeutic inhibitors of the reverse mode of ATP synthase
BR112019028172A2 (pt) 2017-07-13 2020-10-06 Michael David Forrest moduladores terapêuticos do modo reverso da atp sintase
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JP2005527209A (ja) 2002-04-22 2005-09-15 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 疼痛管理のためのプロテインキナーゼＣγのペプチドインヒビター

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JP2008526987A (ja) * 2005-01-14 2008-07-24 フィラデルフィア・カレッジ・オブ・オステオパシック・メディスン 臓器のための灌流及び／又は保存溶液
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