WO2003086080A1 - Procede et composition d'amelioration de la fertilite chez des humains et des animaux males et femelles - Google Patents
Procede et composition d'amelioration de la fertilite chez des humains et des animaux males et femelles Download PDFInfo
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- WO2003086080A1 WO2003086080A1 PCT/US2002/010854 US0210854W WO03086080A1 WO 2003086080 A1 WO2003086080 A1 WO 2003086080A1 US 0210854 W US0210854 W US 0210854W WO 03086080 A1 WO03086080 A1 WO 03086080A1
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- WIPO (PCT)
- Prior art keywords
- vitamins
- zinc
- selenium
- vitamin
- green tea
- Prior art date
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- 230000035558 fertility Effects 0.000 title claims abstract description 38
- 238000000034 method Methods 0.000 title claims description 15
- 230000036541 health Effects 0.000 title claims description 9
- 239000000203 mixture Substances 0.000 title description 7
- 241001465754 Metazoa Species 0.000 title description 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 56
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims abstract description 51
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims abstract description 48
- 235000016804 zinc Nutrition 0.000 claims abstract description 48
- 239000011701 zinc Substances 0.000 claims abstract description 48
- 229910052725 zinc Inorganic materials 0.000 claims abstract description 48
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims abstract description 46
- 235000011649 selenium Nutrition 0.000 claims abstract description 46
- 239000011669 selenium Substances 0.000 claims abstract description 46
- 229910052711 selenium Inorganic materials 0.000 claims abstract description 46
- 235000019165 vitamin E Nutrition 0.000 claims abstract description 42
- 239000011709 vitamin E Substances 0.000 claims abstract description 42
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims abstract description 40
- 244000269722 Thea sinensis Species 0.000 claims abstract description 39
- 235000009569 green tea Nutrition 0.000 claims abstract description 39
- 244000063464 Vitex agnus-castus Species 0.000 claims abstract description 38
- 235000009347 chasteberry Nutrition 0.000 claims abstract description 38
- 235000001667 Vitex agnus castus Nutrition 0.000 claims abstract description 34
- 235000019152 folic acid Nutrition 0.000 claims abstract description 31
- 239000011724 folic acid Substances 0.000 claims abstract description 31
- 239000003963 antioxidant agent Substances 0.000 claims abstract description 29
- 235000006708 antioxidants Nutrition 0.000 claims abstract description 29
- 229930003427 Vitamin E Natural products 0.000 claims abstract description 28
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims abstract description 28
- 229940046009 vitamin E Drugs 0.000 claims abstract description 27
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 claims abstract description 26
- 235000019158 vitamin B6 Nutrition 0.000 claims abstract description 26
- 239000011726 vitamin B6 Substances 0.000 claims abstract description 26
- 235000019154 vitamin C Nutrition 0.000 claims abstract description 23
- 239000011718 vitamin C Substances 0.000 claims abstract description 23
- 235000001014 amino acid Nutrition 0.000 claims abstract description 22
- 150000001413 amino acids Chemical class 0.000 claims abstract description 22
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 claims abstract description 20
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims abstract description 20
- 229960000304 folic acid Drugs 0.000 claims abstract description 20
- 229910052742 iron Inorganic materials 0.000 claims abstract description 20
- 235000019163 vitamin B12 Nutrition 0.000 claims abstract description 20
- 239000011715 vitamin B12 Substances 0.000 claims abstract description 20
- KSEBMYQBYZTDHS-HWKANZROSA-M (E)-Ferulic acid Natural products COC1=CC(\C=C\C([O-])=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-M 0.000 claims abstract description 19
- 229930064664 L-arginine Natural products 0.000 claims abstract description 19
- 235000014852 L-arginine Nutrition 0.000 claims abstract description 19
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims abstract description 19
- KSEBMYQBYZTDHS-HWKANZROSA-N ferulic acid Chemical compound COC1=CC(\C=C\C(O)=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-N 0.000 claims abstract description 19
- 235000001785 ferulic acid Nutrition 0.000 claims abstract description 19
- 229940114124 ferulic acid Drugs 0.000 claims abstract description 19
- KSEBMYQBYZTDHS-UHFFFAOYSA-N ferulic acid Natural products COC1=CC(C=CC(O)=O)=CC=C1O KSEBMYQBYZTDHS-UHFFFAOYSA-N 0.000 claims abstract description 19
- 239000011777 magnesium Substances 0.000 claims abstract description 19
- 229910052749 magnesium Inorganic materials 0.000 claims abstract description 19
- 235000001055 magnesium Nutrition 0.000 claims abstract description 19
- QURCVMIEKCOAJU-UHFFFAOYSA-N trans-isoferulic acid Natural products COC1=CC=C(C=CC(O)=O)C=C1O QURCVMIEKCOAJU-UHFFFAOYSA-N 0.000 claims abstract description 19
- 235000019156 vitamin B Nutrition 0.000 claims abstract description 19
- 239000011720 vitamin B Substances 0.000 claims abstract description 19
- 241000382455 Angelica sinensis Species 0.000 claims abstract description 14
- 239000009588 dong quai Substances 0.000 claims abstract description 14
- 229940014144 folate Drugs 0.000 claims abstract description 11
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 claims abstract description 10
- 229940088597 hormone Drugs 0.000 claims abstract description 8
- 239000005556 hormone Substances 0.000 claims abstract description 8
- 230000001850 reproductive effect Effects 0.000 claims abstract description 6
- 230000009933 reproductive health Effects 0.000 claims abstract description 6
- 210000000056 organ Anatomy 0.000 claims abstract description 5
- 230000016087 ovulation Effects 0.000 claims abstract description 5
- 239000000186 progesterone Substances 0.000 claims abstract description 5
- 229960003387 progesterone Drugs 0.000 claims abstract description 5
- 230000001737 promoting effect Effects 0.000 claims description 26
- 235000015872 dietary supplement Nutrition 0.000 claims description 6
- HNSUOMBUJRUZHJ-REVJHSINSA-N [(2r)-3-carboxy-2-hydroxypropyl]-trimethylazanium;(z)-4-hydroxy-4-oxobut-2-enoate Chemical compound OC(=O)\C=C/C(O)=O.C[N+](C)(C)C[C@H](O)CC([O-])=O HNSUOMBUJRUZHJ-REVJHSINSA-N 0.000 claims description 4
- 239000005515 coenzyme Substances 0.000 claims description 4
- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 claims description 3
- 235000017471 coenzyme Q10 Nutrition 0.000 claims description 3
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 claims description 3
- 229940110767 coenzyme Q10 Drugs 0.000 claims description 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 19
- 229940024606 amino acid Drugs 0.000 claims 17
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 16
- 239000013589 supplement Substances 0.000 claims 9
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims 8
- 229930003268 Vitamin C Natural products 0.000 claims 8
- -1 B12 Substances 0.000 claims 3
- 230000002708 enhancing effect Effects 0.000 claims 3
- 230000004936 stimulating effect Effects 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 abstract description 4
- 231100001238 environmental toxicant Toxicity 0.000 abstract description 4
- 102000009151 Luteinizing Hormone Human genes 0.000 abstract description 3
- 108010073521 Luteinizing Hormone Proteins 0.000 abstract description 3
- 230000032683 aging Effects 0.000 abstract description 3
- 230000003078 antioxidant effect Effects 0.000 abstract description 3
- 229940040129 luteinizing hormone Drugs 0.000 abstract description 3
- 230000004060 metabolic process Effects 0.000 abstract description 3
- 230000004899 motility Effects 0.000 abstract description 3
- 235000015097 nutrients Nutrition 0.000 abstract description 3
- 230000004792 oxidative damage Effects 0.000 abstract description 3
- 150000003254 radicals Chemical class 0.000 abstract description 3
- 210000004995 male reproductive system Anatomy 0.000 abstract description 2
- 230000003389 potentiating effect Effects 0.000 abstract description 2
- 230000000153 supplemental effect Effects 0.000 abstract 1
- 229930003231 vitamin Natural products 0.000 description 7
- 235000013343 vitamin Nutrition 0.000 description 7
- 239000011782 vitamin Substances 0.000 description 7
- 229940088594 vitamin Drugs 0.000 description 7
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- 208000000509 infertility Diseases 0.000 description 3
- 230000036512 infertility Effects 0.000 description 3
- 231100000535 infertility Toxicity 0.000 description 3
- 235000016709 nutrition Nutrition 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 229960001948 caffeine Drugs 0.000 description 2
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 description 2
- 235000005911 diet Nutrition 0.000 description 2
- 230000037213 diet Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- RZALONVQKUWRRY-FYZOBXCZSA-N 2,3-dihydroxybutanedioic acid;(3r)-3-hydroxy-4-(trimethylazaniumyl)butanoate Chemical compound OC(=O)C(O)C(O)C(O)=O.C[N+](C)(C)C[C@H](O)CC([O-])=O RZALONVQKUWRRY-FYZOBXCZSA-N 0.000 description 1
- 244000061176 Nicotiana tabacum Species 0.000 description 1
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 210000004246 corpus luteum Anatomy 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 235000012041 food component Nutrition 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 208000021267 infertility disease Diseases 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000002394 ovarian follicle Anatomy 0.000 description 1
- 230000027758 ovulation cycle Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000000391 smoking effect Effects 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/30—Copper compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4415—Pyridoxine, i.e. Vitamin B6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7135—Compounds containing heavy metals
- A61K31/714—Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/85—Verbenaceae (Verbena family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
Definitions
- This invention provides combinations of bioeffecting compounds for promoting fertility in men and women.
- the combinations include nutritional components that benefit fertility health. All the components have been studied separately, to determine their individual efficacy.
- the invention provides the first products to put these components together synergistically in women's and men's formulations.
- the invention provides combinations of beneficial bioeffecting compounds for promoting fertility in women.
- the invention provides a scientifically validated herbal/nutritional blend for women to improve infertility by helping to regulate the menstrual cycle and correct hormone imbalance (corpus luteum insufficiency) without increased chances of multiple births associated with drug therapy.
- the combination of amino acids, herbs, vitamins and minerals improves overall health and helps with many of the deficiencies that decrease fertility.
- Vitex agnus-castus (chasteberry)
- chasteberry The herb, Vitex agnus-castus (chasteberry) , enhances hormone balance in women by increasing luteinizing hormone and progesterone release and, therefore, ovulation frequency.
- the antioxidants, green tea, vitamin E, and selenium improve overall reproductive health.
- L-arginine an amino acid, stimulates the reproductive organs by improving circulation.
- Folic acid, vitamins B6 and B12, iron, zinc and magnesium help promote womens' fertility.
- the invention provides combinations of beneficial bioeffecting compounds for promoting fertility in men.
- Sperm are highly susceptible to free radical or oxidative damage from environmental toxicants and natural aging.
- Vitamins C and E, green tea, with or without coenzyme Q10 and selenium are all potent antioxidants that help improve sperm count and quality.
- Ferulic acid an antioxidant found in Dong Quai, also improves sperm quality.
- Zinc and B vitamins (B6, B12 and folate) are critical nutrients in male reproductive systems for hormone metabolism, sperm formation and motility.
- the amino acid, L-carnitine promotes formation of healthy sperm.
- L-carnitine fumarate is preferred.
- L-carnitine tartrate may be used.
- the invention provides synergistic action of the combinations .
- the two dietary supplements in male and female formulas are useful for men and women.
- the distinct combinations are taken by both members of a couple in which the female age is between 21 and 46.
- the distinct combinations are useful for couples who have tried for 6 months or more, up to three years, to become pregnant without success.
- patients take 2-4 capsules per day of the distinct formulas for three months.
- examples 1, 2, 3, provide preferred ranges of the combinations for men's formula considered in percent by weight :
- Example 2 Components Minimum % Maximum %
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Botany (AREA)
- Inorganic Chemistry (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Reproductive Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pregnancy & Childbirth (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Gynecology & Obstetrics (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Selon cette invention, dans un nouveau mélange complémentaire, l'herbe, Vitex agnus-castus (chasteberry), améliore l'équilibre hormonal par accroissement de l'hormone lutéinisante (LH) et la libération de progestérones, et donc la fréquence d'ovulation. Les antioxydants, le thé vert, la vitamine E et le sélénium améliorent l'ensemble de la santé de la reproduction. L-arginine, un acide aminé, stimule les organes reproducteurs par amélioration de la circulation. L'acide folique, les vitamines B6 et B12, le fer, le zinc et le magnésium favorisent la fertilité chez la femme. Un mélange de L-carnitine, d'antioxydants, d'acide folique, de zinc et de vitamines B permet d'augmenter la fertilité chez les hommes. L-carnitine, un acide aminé, améliore la motilité et la qualité du sperme. L'acide férulique, un antioxydant découvert dans le dong quai, permet également d'accroître la qualité du sperme. Les spermes sont très sensibles aux dommages d'oxydants et de radicaux libres provenant de substances toxiques environnementales et du vieillissement naturel. Les vitamines C et E, le thé vert, et le sélénium représentent tous des antioxydants puissants qui favorisent l'ensemble de la santé reproductive. Le zinc et les vitamines B (B6, B 12 et folate) constituent des nutriants essentiels pour les appareils reproductifs mâles, en matière de motilité et de formation du sperme du métabolisme hormonal.
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2002258727A AU2002258727A1 (en) | 2002-04-08 | 2002-04-08 | Method and composition for improving fertility health in female and male animals and humans |
| EP02728685A EP1496747A4 (fr) | 2002-04-08 | 2002-04-08 | Procede et composition d'amelioration de la fertilite chez des humains et des animaux males et femelles |
| CA002481603A CA2481603A1 (fr) | 2002-04-08 | 2002-04-08 | Procede et composition d'amelioration de la fertilite chez des humains et des animaux males et femelles |
| PCT/US2002/010854 WO2003086080A1 (fr) | 2002-04-08 | 2002-04-08 | Procede et composition d'amelioration de la fertilite chez des humains et des animaux males et femelles |
| JP2003583114A JP2005522486A (ja) | 2002-04-08 | 2002-04-08 | 動物のオスおよびメス、およびヒトにおける受精能の健康状態を改善するための方法および組成物 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2002/010854 WO2003086080A1 (fr) | 2002-04-08 | 2002-04-08 | Procede et composition d'amelioration de la fertilite chez des humains et des animaux males et femelles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2003086080A1 true WO2003086080A1 (fr) | 2003-10-23 |
Family
ID=29247959
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US2002/010854 WO2003086080A1 (fr) | 2002-04-08 | 2002-04-08 | Procede et composition d'amelioration de la fertilite chez des humains et des animaux males et femelles |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1496747A4 (fr) |
| JP (1) | JP2005522486A (fr) |
| AU (1) | AU2002258727A1 (fr) |
| CA (1) | CA2481603A1 (fr) |
| WO (1) | WO2003086080A1 (fr) |
Cited By (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005213147A (ja) * | 2004-01-27 | 2005-08-11 | Ryoko Kumai | 哺乳動物の精子の活性化剤及び活性化方法 |
| EP1714658A1 (fr) | 2005-04-21 | 2006-10-25 | Formquest Limited | Complément alimentaire comprenant une association d'agents antioxydants et de la carnitine ou un précurseur de la carnitine, comme aide à la fertilité chez l'homme et chez la femme |
| WO2007003007A1 (fr) * | 2005-07-05 | 2007-01-11 | Adelaide Fertility Centre Pty Ltd | Procédés et compositions pour augmenter les chances de grossesse |
| WO2007060368A1 (fr) * | 2005-11-28 | 2007-05-31 | Physcience | Composition phytohormonale et son utilisation comme substitutif hormonal |
| WO2007087667A3 (fr) * | 2006-02-03 | 2008-02-28 | Fapa Vital Anstalt | Préparation combinée destinée à améliorer la qualité du sperme |
| WO2008052432A1 (fr) * | 2006-10-27 | 2008-05-08 | Shengxian Huang | Médicament pour améliorer la qualité du sperme et traiter la stérilité chez l'homme |
| FR2908604A1 (fr) * | 2006-11-16 | 2008-05-23 | Physcience Soc Par Actions Sim | Complement alimentaire pour la prevention ou la lutte contre la chute des cheveux, l'acne, l'hirsutisme et la secretion sudorale apocrine excessive. |
| DE102007053369A1 (de) * | 2007-11-09 | 2009-07-02 | Alzchem Trostberg Gmbh | Verwendung einer eine Kreatin-Komponente enthaltende Zusammensetzung zur Verbesserung der männlichen Fruchtbarkeit |
| EP2135621A1 (fr) * | 2008-06-18 | 2009-12-23 | Roberto Fasani | Formulations combinées pour le traitement de l'infertilité masculine |
| FR2961697A1 (fr) * | 2010-06-23 | 2011-12-30 | Granions Lab Des | Composition pour la reduction du stress oxydatif dans le cas d'une hypofertilite masculine et utilisation |
| CN101879184B (zh) * | 2009-05-07 | 2012-01-18 | 浙江医药股份有限公司新昌制药厂 | 用于提高生殖能力的药物组合物及其制备方法和应用 |
| FR2964834A1 (fr) * | 2010-09-21 | 2012-03-23 | Marc Cohen | Composition anti-oxydante destinee a prevenir l'infertilite chez l'homme |
| AT510761A1 (de) * | 2010-12-09 | 2012-06-15 | Gonadosan Gmbh | Verwendung einer ubiquinon-komponente und ein kombinationspräparat zur verbesserung der weiblichen fertilität |
| WO2013024067A1 (fr) * | 2011-08-12 | 2013-02-21 | Lohmann Animal Health Gmbh | Utilisation des antioxydants pour améliorer la santé animale |
| WO2015082180A1 (fr) * | 2013-12-05 | 2015-06-11 | Sigma-Tau Industrire Farmaceutiche Riunite S.P.A. | Composition utile pour favoriser la fertilite feminine |
| RU2686334C2 (ru) * | 2017-08-31 | 2019-04-25 | Общество с ограниченной ответственностью "ЦитоНИР" (ООО "ЦитоНИР") | Ректальное лекарственное средство коррекции нарушений сперматогенеза при мужской инфертильности |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102228565B (zh) * | 2011-05-13 | 2013-05-15 | 潮州市泽润制药有限公司 | 一种穗花牡荆提取物的制备方法及其用途 |
| RU2616521C1 (ru) * | 2016-02-10 | 2017-04-17 | Общество с ограниченной ответственностью "ОКТАВА ХОЛДИНГ" | Композиция для улучшения репродуктивной функции человека |
| RU2665636C2 (ru) * | 2017-02-15 | 2018-09-03 | Общество с ограниченной ответственностью "ОКТАВА ХОЛДИНГ" | Композиция для улучшения мужской репродуктивной функции |
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| US4000276A (en) * | 1972-09-29 | 1976-12-28 | Kanebo, Ltd. | Cosmetic composition containing vitamin e orotate |
| US6242012B1 (en) * | 1999-10-19 | 2001-06-05 | Thomas Newmark | Herbal composition for promoting hormonal balance in women and methods of using same |
| US6338862B1 (en) * | 2001-03-26 | 2002-01-15 | Sarfaraz K Niazi | Composition and method of use in treating sexual dysfunction using cGMP-specific phosphodiesterase type 5 inhibitors |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US5308627A (en) * | 1990-08-07 | 1994-05-03 | Umbdenstock Jr Anthony J | Nutritional supplement for optimizing cellular health |
| JPH0840923A (ja) * | 1994-07-28 | 1996-02-13 | Masatoshi Nakano | 栄養補助剤 |
| JP4653269B2 (ja) * | 1999-02-23 | 2011-03-16 | 太陽化学株式会社 | テアニン含有組成物 |
| US6261607B1 (en) * | 1999-10-19 | 2001-07-17 | Thomas Newmark | Composition for promoting prostate health containing selenium and herbal extracts |
-
2002
- 2002-04-08 AU AU2002258727A patent/AU2002258727A1/en not_active Abandoned
- 2002-04-08 CA CA002481603A patent/CA2481603A1/fr not_active Abandoned
- 2002-04-08 EP EP02728685A patent/EP1496747A4/fr not_active Withdrawn
- 2002-04-08 WO PCT/US2002/010854 patent/WO2003086080A1/fr active Application Filing
- 2002-04-08 JP JP2003583114A patent/JP2005522486A/ja active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4000276A (en) * | 1972-09-29 | 1976-12-28 | Kanebo, Ltd. | Cosmetic composition containing vitamin e orotate |
| US6242012B1 (en) * | 1999-10-19 | 2001-06-05 | Thomas Newmark | Herbal composition for promoting hormonal balance in women and methods of using same |
| US6338862B1 (en) * | 2001-03-26 | 2002-01-15 | Sarfaraz K Niazi | Composition and method of use in treating sexual dysfunction using cGMP-specific phosphodiesterase type 5 inhibitors |
Non-Patent Citations (1)
| Title |
|---|
| See also references of EP1496747A4 * |
Cited By (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005213147A (ja) * | 2004-01-27 | 2005-08-11 | Ryoko Kumai | 哺乳動物の精子の活性化剤及び活性化方法 |
| EP1714658A1 (fr) | 2005-04-21 | 2006-10-25 | Formquest Limited | Complément alimentaire comprenant une association d'agents antioxydants et de la carnitine ou un précurseur de la carnitine, comme aide à la fertilité chez l'homme et chez la femme |
| FR2884692A1 (fr) * | 2005-04-21 | 2006-10-27 | Formquest Ltd | Complement alimentaire comprenant une association d'agents antioxydants et de carnitine, obtenue par synthese endogene ou exogene, comme aide a la fertilite chez l'homme et chez la femme |
| WO2007003007A1 (fr) * | 2005-07-05 | 2007-01-11 | Adelaide Fertility Centre Pty Ltd | Procédés et compositions pour augmenter les chances de grossesse |
| WO2007060368A1 (fr) * | 2005-11-28 | 2007-05-31 | Physcience | Composition phytohormonale et son utilisation comme substitutif hormonal |
| FR2893848A1 (fr) * | 2005-11-28 | 2007-06-01 | Physcience Soc Par Actions Sim | Composition phytohormonale et son utilisation comme substitut hormonal |
| WO2007087667A3 (fr) * | 2006-02-03 | 2008-02-28 | Fapa Vital Anstalt | Préparation combinée destinée à améliorer la qualité du sperme |
| EA015422B1 (ru) * | 2006-02-03 | 2011-08-30 | Фапа Витал Анштальт | Комбинированный препарат для улучшения качества сперматозоидов |
| US9623042B2 (en) | 2006-02-03 | 2017-04-18 | Fapa Vital Anstalt | Combination preparation for improving sperm quality |
| WO2008052432A1 (fr) * | 2006-10-27 | 2008-05-08 | Shengxian Huang | Médicament pour améliorer la qualité du sperme et traiter la stérilité chez l'homme |
| FR2908604A1 (fr) * | 2006-11-16 | 2008-05-23 | Physcience Soc Par Actions Sim | Complement alimentaire pour la prevention ou la lutte contre la chute des cheveux, l'acne, l'hirsutisme et la secretion sudorale apocrine excessive. |
| DE102007053369A1 (de) * | 2007-11-09 | 2009-07-02 | Alzchem Trostberg Gmbh | Verwendung einer eine Kreatin-Komponente enthaltende Zusammensetzung zur Verbesserung der männlichen Fruchtbarkeit |
| EP2135621A1 (fr) * | 2008-06-18 | 2009-12-23 | Roberto Fasani | Formulations combinées pour le traitement de l'infertilité masculine |
| EP2502635A1 (fr) * | 2008-06-18 | 2012-09-26 | Roberto Fasani | Formulations combinées pour le traitement de la stérilité masculine |
| CN101879184B (zh) * | 2009-05-07 | 2012-01-18 | 浙江医药股份有限公司新昌制药厂 | 用于提高生殖能力的药物组合物及其制备方法和应用 |
| FR2961697A1 (fr) * | 2010-06-23 | 2011-12-30 | Granions Lab Des | Composition pour la reduction du stress oxydatif dans le cas d'une hypofertilite masculine et utilisation |
| FR2964834A1 (fr) * | 2010-09-21 | 2012-03-23 | Marc Cohen | Composition anti-oxydante destinee a prevenir l'infertilite chez l'homme |
| AT510761A1 (de) * | 2010-12-09 | 2012-06-15 | Gonadosan Gmbh | Verwendung einer ubiquinon-komponente und ein kombinationspräparat zur verbesserung der weiblichen fertilität |
| AT13410U1 (de) * | 2010-12-09 | 2013-12-15 | Gonadosan Gmbh | Verwendung einer Ubiquinon-Komponente und ein Kombinationspräparat zur Verbesserung der weiblichen Fertilität |
| WO2013024067A1 (fr) * | 2011-08-12 | 2013-02-21 | Lohmann Animal Health Gmbh | Utilisation des antioxydants pour améliorer la santé animale |
| WO2015082180A1 (fr) * | 2013-12-05 | 2015-06-11 | Sigma-Tau Industrire Farmaceutiche Riunite S.P.A. | Composition utile pour favoriser la fertilite feminine |
| CN105792818A (zh) * | 2013-12-05 | 2016-07-20 | 希格马托制药工业公司 | 用于促进女性生育力的组合物 |
| EA028998B1 (ru) * | 2013-12-05 | 2018-01-31 | Альфасигма С.П.А. | Композиция, применимая для активации женской репродуктивной способности |
| TWI633882B (zh) * | 2013-12-05 | 2018-09-01 | 義大利商阿爾法西格瑪公司 | 適用於提高女性生育力的組合物 |
| US10076541B2 (en) | 2013-12-05 | 2018-09-18 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Composition useful as a dietary supplement |
| CN105792818B (zh) * | 2013-12-05 | 2019-07-12 | 希格马托制药工业公司 | 用于促进女性生育力的组合物 |
| RU2686334C2 (ru) * | 2017-08-31 | 2019-04-25 | Общество с ограниченной ответственностью "ЦитоНИР" (ООО "ЦитоНИР") | Ректальное лекарственное средство коррекции нарушений сперматогенеза при мужской инфертильности |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2002258727A1 (en) | 2003-10-27 |
| EP1496747A4 (fr) | 2008-01-09 |
| JP2005522486A (ja) | 2005-07-28 |
| EP1496747A1 (fr) | 2005-01-19 |
| CA2481603A1 (fr) | 2003-10-23 |
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