WO2003074716A3 - Procedes de production d'acides gras insatures - Google Patents

Procedes de production d'acides gras insatures Download PDF

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Publication number
WO2003074716A3
WO2003074716A3 PCT/EP2003/002011 EP0302011W WO03074716A3 WO 2003074716 A3 WO2003074716 A3 WO 2003074716A3 EP 0302011 W EP0302011 W EP 0302011W WO 03074716 A3 WO03074716 A3 WO 03074716A3
Authority
WO
WIPO (PCT)
Prior art keywords
fatty acids
unsaturated fatty
production
methods
transgenic expression
Prior art date
Application number
PCT/EP2003/002011
Other languages
German (de)
English (en)
Other versions
WO2003074716A2 (fr
Inventor
Andreas Renz
Martijn Gipmans
Ivo Feussner
Original Assignee
Basf Plant Science Gmbh
Andreas Renz
Martijn Gipmans
Ivo Feussner
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Plant Science Gmbh, Andreas Renz, Martijn Gipmans, Ivo Feussner filed Critical Basf Plant Science Gmbh
Priority to AU2003208769A priority Critical patent/AU2003208769A1/en
Publication of WO2003074716A2 publication Critical patent/WO2003074716A2/fr
Publication of WO2003074716A3 publication Critical patent/WO2003074716A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0083—Miscellaneous (1.14.99)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C12N15/8247—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6436—Fatty acid esters
    • C12P7/6445—Glycerides
    • C12P7/6472—Glycerides containing polyunsaturated fatty acid [PUFA] residues, i.e. having two or more double bonds in their backbone

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Plant Pathology (AREA)
  • Nutrition Science (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Fats And Perfumes (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Cosmetics (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

L'invention concerne des procédés de production d'acides gras insaturés, de préférence d'acides gras conjugués polyinsaturés, tels que l'acide linolique conjugué (CLA), par expression transgénique de désaturases provenant d'insectes de l'ordre des lépidoptères. L'invention concerne également des cassettes d'expression transgénique servant à l'expression transgénique de désaturases provenant d'insectes de l'ordre des lépidoptères, ainsi que les organismes transgéniques transformés avec celles-ci.
PCT/EP2003/002011 2002-03-01 2003-02-27 Procedes de production d'acides gras insatures WO2003074716A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003208769A AU2003208769A1 (en) 2002-03-01 2003-02-27 Methods for the production of unsaturated fatty acids

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10208812A DE10208812A1 (de) 2002-03-01 2002-03-01 Verfahren zur Herstellung von ungesättigten Fettsäuren
DE10208812.8 2002-03-01

Publications (2)

Publication Number Publication Date
WO2003074716A2 WO2003074716A2 (fr) 2003-09-12
WO2003074716A3 true WO2003074716A3 (fr) 2003-12-24

Family

ID=27740519

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2003/005788 WO2003074715A2 (fr) 2002-03-01 2003-02-27 Methode de production d'acides gras insatures
PCT/EP2003/002011 WO2003074716A2 (fr) 2002-03-01 2003-02-27 Procedes de production d'acides gras insatures

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/US2003/005788 WO2003074715A2 (fr) 2002-03-01 2003-02-27 Methode de production d'acides gras insatures

Country Status (8)

Country Link
EP (1) EP1527182A4 (fr)
JP (1) JP2006503546A (fr)
CN (1) CN1656226A (fr)
AU (2) AU2003208769A1 (fr)
BR (1) BR0307938A (fr)
CA (1) CA2477858A1 (fr)
DE (1) DE10208812A1 (fr)
WO (2) WO2003074715A2 (fr)

Families Citing this family (21)

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Publication number Priority date Publication date Assignee Title
ES2421440T3 (es) * 2004-02-27 2013-09-02 Basf Plant Science Gmbh Método para preparar ácidos grasos poliinsaturados en plantas transgénicas
DE102005052551A1 (de) * 2005-11-02 2007-05-16 Rothamsted Res Harpenden Verfahren zur Herstellung von y-Linolensäure und/oder Stearidonsäure in transgenen Brassicaceae und Linaceae
DK1976877T4 (en) 2005-11-30 2017-01-16 Abbvie Inc Monoclonal antibodies to amyloid beta protein and uses thereof
PL1954718T3 (pl) 2005-11-30 2015-04-30 Abbvie Inc Przeciwciała skierowane przeciwko A globulomerowi, ich reszty wiążące antygeny, odpowiednie hybrydomy, kwasy nukleinowe, wektory, komórki gospodarze, sposoby wytwarzania tych przeciwciał, kompozycje zawierające te przeciwciała, zastosowania tych przeciwciał i sposoby stosowania tych przeciwciał
CN101617039A (zh) * 2006-10-20 2009-12-30 代表亚利桑那大学的亚利桑那校董会 经修饰的蓝细菌
US8455626B2 (en) 2006-11-30 2013-06-04 Abbott Laboratories Aβ conformer selective anti-aβ globulomer monoclonal antibodies
PT2367950T (pt) * 2008-12-01 2017-07-06 Univ Saarland Produção de ácidos gordos ómega-3 por mixobactérias
JP5168511B2 (ja) * 2009-08-25 2013-03-21 独立行政法人農業生物資源研究所 種子特異的プロモーターおよびその利用
JP2013523182A (ja) 2010-04-15 2013-06-17 アボット・ラボラトリーズ アミロイドベータ結合タンパク質
US11236351B2 (en) 2010-05-17 2022-02-01 Dow Agrosciences Llc Production of DHA and other LC PUFAs in plants
EP2603524A1 (fr) 2010-08-14 2013-06-19 AbbVie Inc. Protéines de liaison bêta-amyloïdes
TW201307553A (zh) 2011-07-26 2013-02-16 Dow Agrosciences Llc 在植物中生產二十二碳六烯酸（ｄｈａ）及其他長鏈多元不飽和脂肪酸（ｌｃ－ｐｕｆａ）之技術
KR101540746B1 (ko) 2011-12-28 2015-08-03 대한민국 공액리놀레산(Ｃｏｎｊｕｇａｔｅｄ Ｌｉｎｏｌｅｉｃ Ａｃｉｄ, ＣＬＡ)의 생산방법
CN108138202B (zh) 2015-06-26 2023-05-16 丹麦科技大学 用于在酵母中产生蛾信息素的方法
WO2017087846A1 (fr) 2015-11-18 2017-05-26 Provivi, Inc. Micro-organismes destinés à la production de phéromones d'insectes et composés associés
AR110606A1 (es) 2016-06-06 2019-04-17 Provivi Inc Producción semi-biosintética de alcoholes grasos y aldehídos grasos
DE17825464T1 (de) 2016-12-16 2019-12-19 Danmarks Tekniske Universitet Verfahren zur herstellung von fettalkoholen und derivaten davon in hefe
US11434506B2 (en) 2016-12-16 2022-09-06 Danmarks Tekniske Universitet Production of desaturated fatty alcohols and desaturated fatty alcohol acetates in yeast
AR112543A1 (es) 2017-05-17 2019-11-13 Provivi Inc Microorganismos para la producción de feromonas de insectos y compuestos relacionados
EP3521439A1 (fr) * 2018-01-31 2019-08-07 Commissariat à l'Energie Atomique et aux Energies Alternatives Procédé de production de triacylglycérides et d'acides gras
CN116064266B (zh) * 2022-11-01 2024-06-14 四川大学 盐胁迫抗性增强的重组酿酒酵母菌及其构建方法与应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997018320A1 (fr) * 1995-11-14 1997-05-22 Loders Croklaan B.V. Procede de preparation de matieres presentant une forte teneur en acides gras polyinsatures a chaine longue
WO1999047135A1 (fr) * 1998-03-17 1999-09-23 Conlinco, Inc. Compositions a base d'acides linoleiques conjugues
WO2001000846A2 (fr) * 1999-06-30 2001-01-04 Dcv, Inc. D.B.A Bio-Technical Resources Linoleate isomerase

Family Cites Families (6)

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Publication number Priority date Publication date Assignee Title
US5876994A (en) * 1995-11-16 1999-03-02 Cornell Research Foundation, Inc. Pheromone desaturases
EP0915909B1 (fr) * 1997-05-05 2007-06-13 Dow AgroSciences LLC Toxines proteiques insecticides issues de xenorhabdus
AU4564399A (en) * 1998-06-12 1999-12-30 Abbott Laboratories Polyunsaturated fatty acids in plants
AU5785199A (en) * 1998-08-24 2000-03-14 Rutgers, The State University Of New Jersey Synthetic fatty acid desaturase gene for expression in plants
WO2001002591A1 (fr) * 1999-07-06 2001-01-11 Basf Plant Science Gmbh Plantes exprimant des genes de la δ6-desaturase; huiles contenant des acides gras polyinsatures extraites de ces plantes et procede de production d'acides gras insatures
AU2001263473A1 (en) * 2000-05-26 2001-12-11 Washington State University Research Foundation Palmitate desaturase gene

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997018320A1 (fr) * 1995-11-14 1997-05-22 Loders Croklaan B.V. Procede de preparation de matieres presentant une forte teneur en acides gras polyinsatures a chaine longue
WO1999047135A1 (fr) * 1998-03-17 1999-09-23 Conlinco, Inc. Compositions a base d'acides linoleiques conjugues
WO2001000846A2 (fr) * 1999-06-30 2001-01-04 Dcv, Inc. D.B.A Bio-Technical Resources Linoleate isomerase

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CAHOON EDGAR B ET AL: "Formation of conjugated DELTA8,DELTA10-double bonds by DELTA12-oleic-acid desaturase-related enzymes. Biosynthetic origin of calendic acid.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 276, no. 4, 26 January 2001 (2001-01-26), pages 2637 - 2643, XP002252846, ISSN: 0021-9258 *
CAHOON EDGAR B ET AL: "Production of fatty acid components of meadowfoam oil in somatic soybean embryos.", PLANT PHYSIOLOGY (ROCKVILLE), vol. 124, no. 1, September 2000 (2000-09-01), pages 243 - 251, XP002252847, ISSN: 0032-0889 *
FRITSCHE KATHRIN ET AL: "Isolation and characterization of a calendic acid producing (8,11)-linoleoyl desaturase.", FEBS LETTERS, vol. 462, no. 3, 3 December 1999 (1999-12-03), pages 249 - 253, XP002252849, ISSN: 0014-5793 *
KNIPPLE DOUGLAS C ET AL: "Cloning and functional expression of a cDNA encoding a pheromone gland-specific acyl-CoA DELTA11-desaturase of the cabbage looper moth, Trichoplusia ni.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 95, no. 26, 22 December 1998 (1998-12-22), Dec. 22, 1998, pages 15287 - 15292, XP002252850, ISSN: 0027-8424 *
LIU WEITIAN ET AL: "Gene characterized for membrane desaturase that produces (E)-11 isomers of mono- and diunsaturated fatty acids.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 99, no. 2, 22 January 2002 (2002-01-22), http://www.pnas.org January 22, 2002, pages 620 - 624, XP002252845, ISSN: 0027-8424 *
QIU XIAO ET AL: "Identification and analysis of a gene from Calendula officinalis encoding a fatty acid conjugase.", PLANT PHYSIOLOGY (ROCKVILLE), vol. 125, no. 2, February 2001 (2001-02-01), pages 847 - 855, XP002252848, ISSN: 0032-0889 *

Also Published As

Publication number Publication date
DE10208812A1 (de) 2003-09-11
AU2003219899A1 (en) 2003-09-16
CA2477858A1 (fr) 2003-09-12
CN1656226A (zh) 2005-08-17
EP1527182A4 (fr) 2005-12-21
WO2003074715A3 (fr) 2004-04-29
WO2003074716A2 (fr) 2003-09-12
AU2003208769A1 (en) 2003-09-16
AU2003208769A8 (en) 2003-09-16
WO2003074715A2 (fr) 2003-09-12
EP1527182A2 (fr) 2005-05-04
BR0307938A (pt) 2005-01-11
JP2006503546A (ja) 2006-02-02

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