WO2003070173A2 - Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof - Google Patents
Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof Download PDFInfo
- Publication number
- WO2003070173A2 WO2003070173A2 PCT/US2003/004596 US0304596W WO03070173A2 WO 2003070173 A2 WO2003070173 A2 WO 2003070173A2 US 0304596 W US0304596 W US 0304596W WO 03070173 A2 WO03070173 A2 WO 03070173A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- compound
- therapeutic agent
- mmol
- alkyl
- cell
- Prior art date
Links
- CUFLWHQNSBHRND-IPZFTDEOSA-N CC[C@H]([C@H]([C@@H]([C@@H](C)/C(/CC[C@](C)(C[C@@H](C)[C@@H]([C@H]1C)O)O)=N/OCC(c(c(O2)c3)cc(OC)c3OC)=CC2=O)O)O)OC1=O Chemical compound CC[C@H]([C@H]([C@@H]([C@@H](C)/C(/CC[C@](C)(C[C@@H](C)[C@@H]([C@H]1C)O)O)=N/OCC(c(c(O2)c3)cc(OC)c3OC)=CC2=O)O)O)OC1=O CUFLWHQNSBHRND-IPZFTDEOSA-N 0.000 description 1
- HUECCBIJAKZXMF-HNADRMDWSA-N CC[C@H]([C@](C)([C@@H]([C@@H](C)N(C)C[C@H](C)C[C@](C)([C@@H]([C@@H](C)C(C1C)=O)O[C@@H]([C@@H]2OC(CCC(OCC([C@@]34OC(C)(C)O[C@@H]3C[C@@H]([C@H](CCC([C@]3(C)C=C5)=CC5=O)[C@@]33F)[C@]4(C)CC3O)=O)=O)=O)O[C@H](C)CC2N(C)C)O)O)O)OC1=O Chemical compound CC[C@H]([C@](C)([C@@H]([C@@H](C)N(C)C[C@H](C)C[C@](C)([C@@H]([C@@H](C)C(C1C)=O)O[C@@H]([C@@H]2OC(CCC(OCC([C@@]34OC(C)(C)O[C@@H]3C[C@@H]([C@H](CCC([C@]3(C)C=C5)=CC5=O)[C@@]33F)[C@]4(C)CC3O)=O)=O)=O)O[C@H](C)CC2N(C)C)O)O)O)OC1=O HUECCBIJAKZXMF-HNADRMDWSA-N 0.000 description 1
- FTVZWXLVUZMRFJ-JGTBGLEXSA-N CC[C@H]([C@](C)([C@@H]([C@@H](C)N(C)C[C@H](C)C[C@](C)([C@@H]([C@@H](C)[C@@H]([C@H]1C)[O]([C@@H](C[C@@]2(C)OC)O[C@@H](C)[C@@H]2O)#C)O[C@@H]([C@@H]2O)O[C@H](C)CC2N(C)C(CN(C)CCO)=O)O)O)O)OC1=O Chemical compound CC[C@H]([C@](C)([C@@H]([C@@H](C)N(C)C[C@H](C)C[C@](C)([C@@H]([C@@H](C)[C@@H]([C@H]1C)[O]([C@@H](C[C@@]2(C)OC)O[C@@H](C)[C@@H]2O)#C)O[C@@H]([C@@H]2O)O[C@H](C)CC2N(C)C(CN(C)CCO)=O)O)O)O)OC1=O FTVZWXLVUZMRFJ-JGTBGLEXSA-N 0.000 description 1
- KXOYBUAWGXMWBO-HGIOQMIJSA-N CC[C@H]([C@](C=C)(/C(/O)=C(\C)/N(C)C[C@H](C)C[C@](C)([C@@H]([C@@H](C)[C@@H]([C@H]1C)O[C@@H](C[C@@]2(C)OC)O[C@@H](C)[C@@H]2O)OC([C@@H]2OC(CN(CC3)CCN3c(cc3)ccc3C(Nc3cc(Nc4nc(-c5cccnc5)ccn4)c(C)cc3)=O)=O)=[O][C@H](C)CC2N(C)C)[O](#C)#C)O)OC1=O Chemical compound CC[C@H]([C@](C=C)(/C(/O)=C(\C)/N(C)C[C@H](C)C[C@](C)([C@@H]([C@@H](C)[C@@H]([C@H]1C)O[C@@H](C[C@@]2(C)OC)O[C@@H](C)[C@@H]2O)OC([C@@H]2OC(CN(CC3)CCN3c(cc3)ccc3C(Nc3cc(Nc4nc(-c5cccnc5)ccn4)c(C)cc3)=O)=O)=[O][C@H](C)CC2N(C)C)[O](#C)#C)O)OC1=O KXOYBUAWGXMWBO-HGIOQMIJSA-N 0.000 description 1
- DEDSHQWIHDVFDR-BZNPZCIMSA-N CN(C)[C@@H](C[C@@H](C#C)O[C@H]1O)[C@H]1O Chemical compound CN(C)[C@@H](C[C@@H](C#C)O[C@H]1O)[C@H]1O DEDSHQWIHDVFDR-BZNPZCIMSA-N 0.000 description 1
- 0 C[C@@](C[C@]1(C)*)O[C@](C)[C@@]1O Chemical compound C[C@@](C[C@]1(C)*)O[C@](C)[C@@]1O 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
- A61K47/552—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds one of the codrug's components being an antibiotic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/555—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound pre-targeting systems involving an organic compound, other than a peptide, protein or antibody, for targeting specific cells
- A61K47/556—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound pre-targeting systems involving an organic compound, other than a peptide, protein or antibody, for targeting specific cells enzyme catalyzed therapeutic agent [ECTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/66—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid the modifying agent being a pre-targeting system involving a peptide or protein for targeting specific cells
- A61K47/67—Enzyme prodrug therapy, e.g. gene directed enzyme drug therapy [GDEPT] or VDEPT
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5094—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for blood cell populations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Microbiology (AREA)
- Nanotechnology (AREA)
- Toxicology (AREA)
- Food Science & Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- General Engineering & Computer Science (AREA)
- Ecology (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Endocrinology (AREA)
- Medical Informatics (AREA)
- Crystallography & Structural Chemistry (AREA)
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/504,786 US20060099660A1 (en) | 2002-02-15 | 2003-02-14 | Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof |
EP03711061A EP1483579A4 (en) | 2002-02-15 | 2003-02-14 | CONJUGATES OF BIOLOGICALLY ACTIVE COMPOUNDS, METHODS FOR THE PREPARATION AND USE OF CONJUGATES, FORMULATION AND PHARMACEUTICAL APPLICATIONS OBTAINED FROM SUCH CONJUGATES |
AU2003215245A AU2003215245A1 (en) | 2002-02-15 | 2003-02-14 | Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof |
HR20040849A HRP20040849A2 (en) | 2002-02-15 | 2004-09-15 | Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof |
US12/157,937 US8357506B2 (en) | 2002-02-15 | 2008-06-12 | Method of identifying improved conjugates of biologically active compounds |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US35758902P | 2002-02-15 | 2002-02-15 | |
US60/357,589 | 2002-02-15 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10504786 A-371-Of-International | 2003-02-14 | ||
US12/157,937 Continuation US8357506B2 (en) | 2002-02-15 | 2008-06-12 | Method of identifying improved conjugates of biologically active compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2003070173A2 true WO2003070173A2 (en) | 2003-08-28 |
WO2003070173A3 WO2003070173A3 (en) | 2003-12-04 |
Family
ID=27757644
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2003/004596 WO2003070173A2 (en) | 2002-02-15 | 2003-02-14 | Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof |
Country Status (5)
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1482957A1 (en) * | 2002-02-15 | 2004-12-08 | Sympore GmbH | Antibiotic conjugates |
EP1483277A2 (en) * | 2002-02-15 | 2004-12-08 | Sympore GmbH | Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof |
WO2004110452A1 (en) * | 2003-06-13 | 2004-12-23 | Novartis Ag | 2-aminopyrimidine derivatives as raf kinase inhibitors |
WO2006018698A2 (en) * | 2004-08-12 | 2006-02-23 | Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. | Use of cell-specific conjugates for treatment of inflammatory diseases of the gastrointestinal tract |
US7091187B2 (en) | 2002-07-08 | 2006-08-15 | Pliva-Istrazivacki Institut D.O.O. | Compounds, compositions and methods for treatment of inflammatory diseases and conditions |
US7091196B2 (en) | 2002-09-26 | 2006-08-15 | Rib-X Pharmaceuticals, Inc. | Bifunctional heterocyclic compounds and methods of making and using same |
US7109176B2 (en) | 2002-07-08 | 2006-09-19 | Pliva-Istrazivacki Institut D.O.O. | Nonsteroidal anti-inflammatory substances, compositions and methods for their use |
WO2006136586A2 (en) * | 2005-06-22 | 2006-12-28 | Complex Biosystems Gmbh | N, n-bis- (2-hydroxyethyl) glycine amide as linker in polymer conjugated prodrugs |
US7157433B2 (en) | 2002-07-08 | 2007-01-02 | Glaxosmithkline Istrazivacki Centar Zagreb | Compounds, compositions as carriers for steroid/nonsteroid anti-inflammatory; antienoplastic and antiviral active molecules |
WO2007093840A2 (en) * | 2006-02-15 | 2007-08-23 | Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. | Use of cell-specific conjugates for treatment of inflammatory diseases of the gastrointestinal tract |
CN101619085A (zh) * | 2009-08-11 | 2010-01-06 | 沈阳药科大学 | 红霉素衍生物及其作为肿瘤细胞增殖抑制剂的用途 |
US7767797B1 (en) | 2004-09-30 | 2010-08-03 | Synovo Gmbh | Macrocyclic compounds and methods of use thereof |
US8202843B2 (en) | 2004-02-27 | 2012-06-19 | Rib-X Pharmaceuticals, Inc. | Macrocyclic compounds and methods of making and using the same |
CN104710488A (zh) * | 2015-03-11 | 2015-06-17 | 江南大学 | 一种泰拉霉素的半抗原和完全抗原的合成方法 |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1483579A4 (en) * | 2002-02-15 | 2006-07-12 | Merckle Gmbh | CONJUGATES OF BIOLOGICALLY ACTIVE COMPOUNDS, METHODS FOR THE PREPARATION AND USE OF CONJUGATES, FORMULATION AND PHARMACEUTICAL APPLICATIONS OBTAINED FROM SUCH CONJUGATES |
HRP20030324A2 (en) * | 2003-04-24 | 2005-02-28 | Pliva-Istra�iva�ki institut d.o.o. | Compounds of antiinflammatory effect |
US9050378B2 (en) * | 2003-12-10 | 2015-06-09 | Board Of Regents, The University Of Texas System | N2S2 chelate-targeting ligand conjugates |
WO2007012464A1 (en) * | 2005-07-26 | 2007-02-01 | Merckle Gmbh | Macrolide conjugates of pyrrolizine and indolizine compounds as inhibitors of 5-lipooxygenase and cyclooxygenase |
US9895449B2 (en) | 2010-05-25 | 2018-02-20 | Syndevrx, Inc. | Polymer-conjugated MetAP2 inhibitors, and therapeutic methods of use thereof |
WO2011150022A2 (en) | 2010-05-25 | 2011-12-01 | Syndevrx, Inc. | Polymer-conjugated metap2 inhibitors, and therapeutic methods of use thereof |
US20130137831A1 (en) * | 2010-05-25 | 2013-05-30 | John S. Petersen | Optimized drug conjugates |
DK2984085T3 (da) | 2013-04-10 | 2019-10-21 | Syndevrx Inc | Modificerede eller polymerkonjugerede fumagillol metap2-hæmmere til anvendelse i behandling af fedme |
KR20180093995A (ko) | 2015-12-10 | 2018-08-22 | 신데브알엑스, 인크. | 푸마길롤 유도체 및 그의 다형체 |
US10646463B2 (en) | 2016-01-11 | 2020-05-12 | Syndevrx, Inc. | Treatment for tumors driven by metabolic dysfunction |
CN113453721A (zh) | 2018-10-26 | 2021-09-28 | 辛德弗雷克斯公司 | Metap2抑制剂的生物标志物及其应用 |
KR20220003555A (ko) | 2019-04-18 | 2022-01-10 | 아주라 오프탈믹스 엘티디 | 안구 장애의 치료를 위한 화합물 및 방법 |
WO2022084738A2 (en) * | 2020-10-21 | 2022-04-28 | Azura Ophthalmics Ltd. | Compounds and methods for the treatment of ocular disorders |
US11459351B1 (en) * | 2021-04-05 | 2022-10-04 | Azura Ophthalmics Ltd. | Compounds and methods for the treatment of ocular disorders |
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- 2003-02-14 EP EP03711061A patent/EP1483579A4/en not_active Withdrawn
- 2003-02-14 US US10/504,786 patent/US20060099660A1/en not_active Abandoned
- 2003-02-14 US US10/367,624 patent/US20040005641A1/en not_active Abandoned
- 2003-02-14 WO PCT/US2003/004596 patent/WO2003070173A2/en not_active Application Discontinuation
- 2003-02-14 AU AU2003215245A patent/AU2003215245A1/en not_active Abandoned
-
2004
- 2004-09-15 HR HR20040849A patent/HRP20040849A2/xx not_active Application Discontinuation
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2007
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EP1483277A2 (en) * | 2002-02-15 | 2004-12-08 | Sympore GmbH | Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof |
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EP1482957A4 (en) * | 2002-02-15 | 2006-07-19 | Merckle Gmbh | ANTIBIOTIC CONJUGATES |
EP1482957A1 (en) * | 2002-02-15 | 2004-12-08 | Sympore GmbH | Antibiotic conjugates |
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US7091187B2 (en) | 2002-07-08 | 2006-08-15 | Pliva-Istrazivacki Institut D.O.O. | Compounds, compositions and methods for treatment of inflammatory diseases and conditions |
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US8461120B2 (en) | 2004-09-30 | 2013-06-11 | Synovo Gmbh | Macrocyclic compounds pounds and methods of use thereof |
US7767797B1 (en) | 2004-09-30 | 2010-08-03 | Synovo Gmbh | Macrocyclic compounds and methods of use thereof |
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US8980242B2 (en) | 2005-06-22 | 2015-03-17 | Ascendis Pharma Gmbh | Aliphatic prodrug linker |
WO2007093840A3 (en) * | 2006-02-15 | 2008-02-14 | Glaxosmithkline Zagreb | Use of cell-specific conjugates for treatment of inflammatory diseases of the gastrointestinal tract |
WO2007093840A2 (en) * | 2006-02-15 | 2007-08-23 | Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. | Use of cell-specific conjugates for treatment of inflammatory diseases of the gastrointestinal tract |
CN101619085A (zh) * | 2009-08-11 | 2010-01-06 | 沈阳药科大学 | 红霉素衍生物及其作为肿瘤细胞增殖抑制剂的用途 |
CN104710488A (zh) * | 2015-03-11 | 2015-06-17 | 江南大学 | 一种泰拉霉素的半抗原和完全抗原的合成方法 |
Also Published As
Publication number | Publication date |
---|---|
US20080145343A1 (en) | 2008-06-19 |
AU2003215245A1 (en) | 2003-09-09 |
EP1483579A2 (en) | 2004-12-08 |
US8357506B2 (en) | 2013-01-22 |
US20090093014A1 (en) | 2009-04-09 |
US20060099660A1 (en) | 2006-05-11 |
WO2003070173A3 (en) | 2003-12-04 |
EP1483579A4 (en) | 2006-07-12 |
HRP20040849A2 (en) | 2005-08-31 |
AU2003215245A8 (en) | 2003-09-09 |
US20040005641A1 (en) | 2004-01-08 |
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