WO2003057205A3 - Combinaison d'inhibiteurs de mtp ou d'inhibiteurs de secretions apob avec des fibrates en vue d'une utilisation comme medicament - Google Patents

Combinaison d'inhibiteurs de mtp ou d'inhibiteurs de secretions apob avec des fibrates en vue d'une utilisation comme medicament Download PDF

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Publication number
WO2003057205A3
WO2003057205A3 PCT/EP2003/000057 EP0300057W WO03057205A3 WO 2003057205 A3 WO2003057205 A3 WO 2003057205A3 EP 0300057 W EP0300057 W EP 0300057W WO 03057205 A3 WO03057205 A3 WO 03057205A3
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WO
WIPO (PCT)
Prior art keywords
inhibitors
fibrates
drugs
combination
mtp
Prior art date
Application number
PCT/EP2003/000057
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German (de)
English (en)
Other versions
WO2003057205A2 (fr
Inventor
Leo Thomas
Michael Mark
Original Assignee
Boehringer Ingelheim Pharma
Leo Thomas
Michael Mark
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2002100633 external-priority patent/DE10200633A1/de
Priority claimed from DE10256184A external-priority patent/DE10256184A1/de
Application filed by Boehringer Ingelheim Pharma, Leo Thomas, Michael Mark filed Critical Boehringer Ingelheim Pharma
Priority to CA002471566A priority Critical patent/CA2471566A1/fr
Priority to JP2003557563A priority patent/JP2005525309A/ja
Priority to AU2003205570A priority patent/AU2003205570A1/en
Priority to EP03702391A priority patent/EP1465613A2/fr
Publication of WO2003057205A2 publication Critical patent/WO2003057205A2/fr
Publication of WO2003057205A3 publication Critical patent/WO2003057205A3/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
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    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
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    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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  • Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne d'une part, l'utilisation de fibrates en vue de réduire la toxicité hépatique des inhibiteurs de MTP et, d'autre part, des compositions pharmaceutiques renfermant un inhibiteur de MTP et un fibrate.
PCT/EP2003/000057 2002-01-10 2003-01-07 Combinaison d'inhibiteurs de mtp ou d'inhibiteurs de secretions apob avec des fibrates en vue d'une utilisation comme medicament WO2003057205A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002471566A CA2471566A1 (fr) 2002-01-10 2003-01-07 Combinaison d'inhibiteurs de mtp ou d'inhibiteurs de secretions apob avec des fibrates en vue d'une utilisation comme medicament
JP2003557563A JP2005525309A (ja) 2002-01-10 2003-01-07 医薬品としての使用のためのＭＴＰインヒビター又はａｐｏＢ分泌インヒビターとフィブレートの組み合わせ
AU2003205570A AU2003205570A1 (en) 2002-01-10 2003-01-07 Combination of mtp inhibitors or apob secretion inhibitors with fibrates for use as drugs
EP03702391A EP1465613A2 (fr) 2002-01-10 2003-01-07 Combinaison d'inhibiteurs de mtp ou d'inhibiteurs de secretions apob avec des fibrates en vue d'une utilisation comme medicament

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE10200633.4 2002-01-10
DE2002100633 DE10200633A1 (de) 2002-01-10 2002-01-10 Kombination von MTP Inhibitoren oder apoB-Sekretions-Inhibitoren mit Fibraten zur Verwendung als Arzneimittel
DE10256184A DE10256184A1 (de) 2002-12-02 2002-12-02 Kombination von MTP Inhibitoren oder apoB-Sekretions-Inhibitoren mit Fibraten zur Verwendung als Arzneimittel
DE10256184.2 2002-12-02

Publications (2)

Publication Number Publication Date
WO2003057205A2 WO2003057205A2 (fr) 2003-07-17
WO2003057205A3 true WO2003057205A3 (fr) 2004-04-01

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PCT/EP2003/000057 WO2003057205A2 (fr) 2002-01-10 2003-01-07 Combinaison d'inhibiteurs de mtp ou d'inhibiteurs de secretions apob avec des fibrates en vue d'une utilisation comme medicament

Country Status (9)

Country Link
EP (1) EP1465613A2 (fr)
JP (1) JP2005525309A (fr)
AR (1) AR038178A1 (fr)
AU (1) AU2003205570A1 (fr)
CA (1) CA2471566A1 (fr)
PE (1) PE20030924A1 (fr)
TW (1) TW200402292A (fr)
UY (1) UY27610A1 (fr)
WO (1) WO2003057205A2 (fr)

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WO2004056777A1 (fr) * 2002-12-20 2004-07-08 Pfizer Products Inc. Inhibiteurs de proteine microsomale de transfert de triglyceride
JP2007008816A (ja) * 2003-10-15 2007-01-18 Ube Ind Ltd 新規イソキノリン誘導体
AU2004309390B2 (en) 2003-12-22 2011-06-02 Gilead Sciences, Inc. Imidazo[4,5-c]pyridine compounds and methods of antiviral treatment
JP2008524335A (ja) 2004-12-21 2008-07-10 ギリアド サイエンシズ， インコーポレイテッド イミダゾ［４，５−ｃ］ピリジン化合物および抗ウイルス処置法
US20060241073A1 (en) * 2005-04-20 2006-10-26 Wanders Ronaldus J A Means and methods for counteracting fatty acid accumulation
NZ565470A (en) * 2005-07-29 2010-11-26 4Sc Ag Novel heterocyclic NF-kB inhibitors
ES2339298T3 (es) 2006-07-07 2010-05-18 Gilead Sciences, Inc. Compuesto de piridazina novedoso y uso del mismo.
JP5642922B2 (ja) * 2007-04-24 2014-12-17 サントリーホールディングス株式会社 複数の肝障害マーカーを指標とする肝障害の評価方法
TWI444379B (zh) * 2007-06-29 2014-07-11 Sunesis Pharmaceuticals Inc 有用於作為Ｒａｆ激酶抑制劑之化合物
UA99466C2 (en) 2007-07-06 2012-08-27 Гилиад Сайенсиз, Инк. Crystalline pyridazine compound
SG176628A1 (en) 2009-06-05 2012-01-30 Link Medicine Corp Aminopyrrolidinone derivatives and uses thereof
MA49566A (fr) 2017-07-11 2020-05-20 Vertex Pharma Carboxamides utilisés en tant qu'inhibiteurs des canaux sodiques
HRP20220331T1 (hr) 2018-03-08 2022-05-13 Incyte Corporation Spojevi aminopirazin diola kao inhibitori pi3k-y
US11046658B2 (en) 2018-07-02 2021-06-29 Incyte Corporation Aminopyrazine derivatives as PI3K-γ inhibitors

Citations (4)

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WO1998003069A1 (fr) * 1996-07-24 1998-01-29 Bristol-Myers Squibb Company Procede d'abaissement des taux de lipides seriques au moyen d'un inhibiteur de mtp combine a un autre medicament destine a abaisser le cholesterol
EP1099701A1 (fr) * 1999-11-10 2001-05-16 Pfizer Products Inc. Amides des acides 7-[(4'-trifluoromethyl-biphenyl-2-carbonyl)amino]-quinoleine-3 carboxyliques, et méthodes pour inhiber la sécretion de l'apolipoprotéine B
DE10033337A1 (de) * 2000-07-08 2002-01-17 Boehringer Ingelheim Pharma Biphenylcarbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel
WO2003004020A1 (fr) * 2001-07-05 2003-01-16 Boehringer Ingelheim Pharma Gmbh & Co. Kg Amides d'acide heteroarylcarboxylique, leur production et leur utilisation en tant qu'inhibiteurs de la proteine microsomale de transfert des triglycerides (mtp)

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SUDHOP T ET AL: "CHOLESTEROL ABSORPTION INHIBITORS FOR THE TREATMENT OF HYPERCHOLESTEROLAEMIA", DRUGS, ADIS INTERNATIONAL LTD, AT, vol. 62, no. 16, 2002, pages 2333 - 2347, XP008011717, ISSN: 0012-6667 *

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TW200402292A (en) 2004-02-16
CA2471566A1 (fr) 2003-07-17
JP2005525309A (ja) 2005-08-25
AU2003205570A1 (en) 2003-07-24
PE20030924A1 (es) 2003-12-17
UY27610A1 (es) 2003-08-29
EP1465613A2 (fr) 2004-10-13
AU2003205570A8 (en) 2003-07-24
WO2003057205A2 (fr) 2003-07-17
AR038178A1 (es) 2005-01-05

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