WO2003050107A1 - Nouveaux derives d'acide piperidino-quinolone carboxylique substitue en position 7, chiraux, a action antimicrobienne a large spectre et ciblage triple, preparation, compositions contenant ces derives et leur utilisation en tant que medicaments - Google Patents

Nouveaux derives d'acide piperidino-quinolone carboxylique substitue en position 7, chiraux, a action antimicrobienne a large spectre et ciblage triple, preparation, compositions contenant ces derives et leur utilisation en tant que medicaments Download PDF

Info

Publication number
WO2003050107A1
WO2003050107A1 PCT/IN2002/000232 IN0200232W WO03050107A1 WO 2003050107 A1 WO2003050107 A1 WO 2003050107A1 IN 0200232 W IN0200232 W IN 0200232W WO 03050107 A1 WO03050107 A1 WO 03050107A1
Authority
WO
WIPO (PCT)
Prior art keywords
amino
oxo
dihydro
quinoline
fluoro
Prior art date
Application number
PCT/IN2002/000232
Other languages
English (en)
Inventor
Noel J. De Souza
Mahesh V. Patel
Prasad K. Deshpande
Yati Chugh
Milind C Shukla
Original Assignee
Wockhardt Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/128,996 external-priority patent/US6964966B2/en
Application filed by Wockhardt Limited filed Critical Wockhardt Limited
Priority to AU2002361493A priority Critical patent/AU2002361493A1/en
Priority to JP2003551131A priority patent/JP2005511743A/ja
Priority to EP02796957A priority patent/EP1453824A1/fr
Priority to CA002468190A priority patent/CA2468190A1/fr
Publication of WO2003050107A1 publication Critical patent/WO2003050107A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne de nouveaux dérivés d'acide pipéridino-quinolone carboxylique substitué en position 7, chiraux, à action antimicrobienne à large spectre et ciblage triple, des isomères optiques, des diastéréomères ou énantiomères, des sels pharmaceutiquement acceptables, des hydrates, des promédicaments, des polymorphes et des pseudopolymorphes de ces dérivés, ainsi que leur préparation, des composés contenant ces dérivés et leur utilisation.
PCT/IN2002/000232 2001-12-13 2002-12-12 Nouveaux derives d'acide piperidino-quinolone carboxylique substitue en position 7, chiraux, a action antimicrobienne a large spectre et ciblage triple, preparation, compositions contenant ces derives et leur utilisation en tant que medicaments WO2003050107A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU2002361493A AU2002361493A1 (en) 2001-12-13 2002-12-12 New generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
JP2003551131A JP2005511743A (ja) 2001-12-13 2002-12-12 新世代の三重標的化したキラルな広域スペクトラム抗菌性の７位置換ピペリジノ−キノロンカルボン酸誘導体、その調製方法、組成物、および医薬としての使用
EP02796957A EP1453824A1 (fr) 2001-12-13 2002-12-12 Nouveaux derives d'acide piperidino-quinolone carboxylique substitue en position 7, chiraux, a action antimicrobienne a large spectre et ciblage triple, preparation, compositions contenant ces derives et leur utilisation en tant que medicaments
CA002468190A CA2468190A1 (fr) 2001-12-13 2002-12-12 Nouveaux derives d'acide piperidino-quinolone carboxylique substitue en position 7, chiraux, a action antimicrobienne a large spectre et ciblage triple, preparation, compositions contenant ces derives et leur utilisation en tant que medicaments

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US34116501P 2001-12-13 2001-12-13
US60/341,165 2001-12-13
US10/128,996 2002-04-23
US10/128,996 US6964966B2 (en) 2001-04-25 2002-04-23 Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
PCT/IN2002/000111 WO2002085886A2 (fr) 2001-04-25 2002-04-24 Nouvelle generation de derives chiraux d'acide piperidino-quinolone carboxylique substitue en 7, a triple cible et a large spectre antimicrobien, leur preparation, leurs compositions et leur utilisation comme medicaments
INPCT/IN02/00111 2002-04-24

Publications (1)

Publication Number Publication Date
WO2003050107A1 true WO2003050107A1 (fr) 2003-06-19

Family

ID=27271958

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2002/000232 WO2003050107A1 (fr) 2001-12-13 2002-12-12 Nouveaux derives d'acide piperidino-quinolone carboxylique substitue en position 7, chiraux, a action antimicrobienne a large spectre et ciblage triple, preparation, compositions contenant ces derives et leur utilisation en tant que medicaments

Country Status (4)

Country Link
EP (1) EP1453824A1 (fr)
JP (1) JP2005511743A (fr)
AU (1) AU2002361493A1 (fr)
WO (1) WO2003050107A1 (fr)

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005026145A2 (fr) * 2003-09-12 2005-03-24 Warner-Lambert Company Llc Agents antibacteriens a base de quinolone
WO2005066154A2 (fr) * 2003-11-20 2005-07-21 Wockhardt Limited Nouveaux polymorphes d'enantiomeres racemiques, dextrogyres et levogyres de sels de chlorhydrate et de mesylate d'acide 1-cyclopropyl-6-fluoro-8-methoxy-7-(4-amino-3,3-dimethylpiperidin-1-yl)-1,4-dihydro-4-oxo-quinoline-3-carboxylique
WO2009046383A1 (fr) * 2007-10-05 2009-04-09 Cylene Pharmaceuticals, Inc. Analogues de quinolone et procédés associés
US7569563B2 (en) 2005-06-30 2009-08-04 Aicuris Gmbh & Co. Hk Substituted quinolones II
US7867992B2 (en) 2004-07-21 2011-01-11 Aicuris Gmbh & Co. Kg Substituted quinolones
US7902227B2 (en) 2007-07-27 2011-03-08 Janssen Pharmaceutica Nv. C-7 isoxazolinyl quinolone / naphthyridine derivatives useful as antibacterial agents
US7977349B2 (en) 2006-02-09 2011-07-12 Aicuris Gmbh & Co. Kg Substituted quinolones III
RU2547835C1 (ru) * 2014-03-06 2015-04-10 Федеральное государственное бюджетное учреждение науки Институт органического синтеза им. И.Я. Постовского Уральского отделения Российской академии наук Азолоазиниевые соли фторхинолонов, обладающие антибактериальным и противовирусным действием
WO2018011017A1 (fr) 2016-07-11 2018-01-18 Bayer Pharma Aktiengesellschaft Amides de l'acide 1-pyridyl-naphthyridin-3-carboxylique substitués en position 7, et leur utilisation
EP3296298A1 (fr) 2016-09-14 2018-03-21 Bayer Pharma Aktiengesellschaft 1-aryl-naphtyridin-3-ylcarboxamides substitués en position 7 et leur utilisation
WO2018050510A1 (fr) 2016-09-14 2018-03-22 Bayer Aktiengesellschaft Amides de l'acide 1-aryl-naphthyridine-3-carboxylique substitués en position 7 et leur utilisation
US9957282B2 (en) 2015-12-14 2018-05-01 Senhwa Biosciences, Inc. Crystalline forms of quinolone analogs and their salts
US10435403B2 (en) 2015-06-09 2019-10-08 Bayer Pharma Aktiengesellschaft Positive allosteric modulators of muscarinic M2 receptor
US10857156B2 (en) 2015-11-20 2020-12-08 Senhwa Biosciences, Inc. Combination therapy of tetracyclic quinolone analogs for treating cancer
US11524012B1 (en) 2018-02-15 2022-12-13 Senhwa Biosciences, Inc. Quinolone analogs and their salts, compositions, and method for their use

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009107571A1 (fr) * 2008-02-27 2009-09-03 住友化学株式会社 Procédé permettant la résolution optique d'un carbamate d'alkylpipéridin-3-yle et produit intermédiaire associé
JP2009256337A (ja) * 2008-03-26 2009-11-05 Sumitomo Chemical Co Ltd ピペリジン−３−イルカーバメート化合物の製造方法

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4399134A (en) * 1980-11-10 1983-08-16 Otsuka Pharmaceutical Co., Ltd. Pyrroloquinoline and benzoquinolizine compounds and antimicrobial compositions
US4894458A (en) * 1986-03-17 1990-01-16 Kyorin Pharmaceutical Co., Ltd. Quinolonecarboxylic acid derivatives and their preparation
WO1997031000A1 (fr) * 1996-02-21 1997-08-28 Darwin Discovery Limited Quinolones et leur utilisation therapeutique
WO2000018404A1 (fr) * 1998-09-30 2000-04-06 Alcon Laboratories, Inc. Compositions antibiotiques pour le traitement des yeux, des oreilles et du nez
WO2000068229A2 (fr) * 1999-05-07 2000-11-16 Wockhardt Limited Acides carboxyliques de benzoquinolizine antibacteriens optiquement purs, procedes, compositions et procedes de traitement
WO2001085728A2 (fr) * 2000-05-08 2001-11-15 Wockhardt Limited Piperidino-benzo [i, j] quinolizines a substitution de piperidino en 8 chirales antibacteriennes, procedes, compositions et methodes de traitement
WO2002009758A2 (fr) * 2000-08-01 2002-02-07 Wockhardt Limited Inhibiteurs de pompes d'efflux cellulaire de microbes

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4399134A (en) * 1980-11-10 1983-08-16 Otsuka Pharmaceutical Co., Ltd. Pyrroloquinoline and benzoquinolizine compounds and antimicrobial compositions
US4894458A (en) * 1986-03-17 1990-01-16 Kyorin Pharmaceutical Co., Ltd. Quinolonecarboxylic acid derivatives and their preparation
WO1997031000A1 (fr) * 1996-02-21 1997-08-28 Darwin Discovery Limited Quinolones et leur utilisation therapeutique
WO2000018404A1 (fr) * 1998-09-30 2000-04-06 Alcon Laboratories, Inc. Compositions antibiotiques pour le traitement des yeux, des oreilles et du nez
WO2000068229A2 (fr) * 1999-05-07 2000-11-16 Wockhardt Limited Acides carboxyliques de benzoquinolizine antibacteriens optiquement purs, procedes, compositions et procedes de traitement
WO2001085728A2 (fr) * 2000-05-08 2001-11-15 Wockhardt Limited Piperidino-benzo [i, j] quinolizines a substitution de piperidino en 8 chirales antibacteriennes, procedes, compositions et methodes de traitement
WO2002009758A2 (fr) * 2000-08-01 2002-02-07 Wockhardt Limited Inhibiteurs de pompes d'efflux cellulaire de microbes

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHU, DANIEL T. W. ET AL: "Synthesis and structure-activity relationships of novel arylfluoroquinolone antibacterial agents", J. MED. CHEM. (1985), 28(11), 1558-64, XP001061840 *
JAEN-OLTRA, JOSE ET AL: "Artificial neural network applied to prediction of fluorquinolone antibacterial activity by topological methods", JOURNAL OF MEDICINAL CHEMISTRY (2000), 43(6), 1143-1148, XP002212820 *
SUTO, MARK J. ET AL: "Fluoroquinolones: relationships between structural variations, mammalian cell cytotoxicity and antimicrobial activity", J. MED. CHEM. (1992), 35(25), 4745-50, XP001094135 *

Cited By (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005026145A3 (fr) * 2003-09-12 2005-06-16 Warner Lambert Co Agents antibacteriens a base de quinolone
WO2005026145A2 (fr) * 2003-09-12 2005-03-24 Warner-Lambert Company Llc Agents antibacteriens a base de quinolone
WO2005066154A2 (fr) * 2003-11-20 2005-07-21 Wockhardt Limited Nouveaux polymorphes d'enantiomeres racemiques, dextrogyres et levogyres de sels de chlorhydrate et de mesylate d'acide 1-cyclopropyl-6-fluoro-8-methoxy-7-(4-amino-3,3-dimethylpiperidin-1-yl)-1,4-dihydro-4-oxo-quinoline-3-carboxylique
WO2005066154A3 (fr) * 2003-11-20 2005-10-27 Prasad Keshav Deshpande Nouveaux polymorphes d'enantiomeres racemiques, dextrogyres et levogyres de sels de chlorhydrate et de mesylate d'acide 1-cyclopropyl-6-fluoro-8-methoxy-7-(4-amino-3,3-dimethylpiperidin-1-yl)-1,4-dihydro-4-oxo-quinoline-3-carboxylique
US7538221B2 (en) 2003-11-20 2009-05-26 The Company Of Wockhardt Limited Polymorphs of racemic, dextrorotatory, and levorotatory enantioners of 1-cyclopropyl-6-fluoro-8-methoxy-7-(4-amino-3,3-dimethylpiperidin-1-yl)-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid hydrochloride and mesylate salts
US7867992B2 (en) 2004-07-21 2011-01-11 Aicuris Gmbh & Co. Kg Substituted quinolones
US7569563B2 (en) 2005-06-30 2009-08-04 Aicuris Gmbh & Co. Hk Substituted quinolones II
US7977349B2 (en) 2006-02-09 2011-07-12 Aicuris Gmbh & Co. Kg Substituted quinolones III
US7902227B2 (en) 2007-07-27 2011-03-08 Janssen Pharmaceutica Nv. C-7 isoxazolinyl quinolone / naphthyridine derivatives useful as antibacterial agents
CN101888780B (zh) * 2007-10-05 2014-08-13 生华生物科技股份有限公司 喹诺酮类似物及其相关方法
US7928100B2 (en) 2007-10-05 2011-04-19 Cylene Pharmaceuticals, Inc. Quinolone analogs and methods related thereto
CN101888780A (zh) * 2007-10-05 2010-11-17 赛林药物股份有限公司 喹诺酮类似物及其相关方法
WO2009046383A1 (fr) * 2007-10-05 2009-04-09 Cylene Pharmaceuticals, Inc. Analogues de quinolone et procédés associés
US8853234B2 (en) 2007-10-05 2014-10-07 Senhwa Biosciences, Inc. Quinolone analogs and methods related thereto
RU2547835C1 (ru) * 2014-03-06 2015-04-10 Федеральное государственное бюджетное учреждение науки Институт органического синтеза им. И.Я. Постовского Уральского отделения Российской академии наук Азолоазиниевые соли фторхинолонов, обладающие антибактериальным и противовирусным действием
US10435403B2 (en) 2015-06-09 2019-10-08 Bayer Pharma Aktiengesellschaft Positive allosteric modulators of muscarinic M2 receptor
US11229654B2 (en) 2015-11-20 2022-01-25 Senhwa Biosciences, Inc. Combination therapy of tetracyclic quinolone analogs for treating cancer
US10857156B2 (en) 2015-11-20 2020-12-08 Senhwa Biosciences, Inc. Combination therapy of tetracyclic quinolone analogs for treating cancer
US9957282B2 (en) 2015-12-14 2018-05-01 Senhwa Biosciences, Inc. Crystalline forms of quinolone analogs and their salts
US10519154B2 (en) 2016-07-11 2019-12-31 Bayer Pharma Aktiengesellschaft 7-substituted 1-pyridyl-naphthyridine-3-carboxylic acid amides and use thereof
WO2018011017A1 (fr) 2016-07-11 2018-01-18 Bayer Pharma Aktiengesellschaft Amides de l'acide 1-pyridyl-naphthyridin-3-carboxylique substitués en position 7, et leur utilisation
WO2018050510A1 (fr) 2016-09-14 2018-03-22 Bayer Aktiengesellschaft Amides de l'acide 1-aryl-naphthyridine-3-carboxylique substitués en position 7 et leur utilisation
EP3296298A1 (fr) 2016-09-14 2018-03-21 Bayer Pharma Aktiengesellschaft 1-aryl-naphtyridin-3-ylcarboxamides substitués en position 7 et leur utilisation
US10927109B2 (en) 2016-09-14 2021-02-23 Bayer Aktiengesellschaft 7-substituted 1-aryl-naphthyridine-3-carboxylic acid amides and use thereof
US11472803B2 (en) 2016-09-14 2022-10-18 Bayer Aktiengesellschaft 7-substituted 1-aryl-naphthyridine-3-carboxylic acid amides and use thereof
US11524012B1 (en) 2018-02-15 2022-12-13 Senhwa Biosciences, Inc. Quinolone analogs and their salts, compositions, and method for their use

Also Published As

Publication number Publication date
AU2002361493A1 (en) 2003-06-23
JP2005511743A (ja) 2005-04-28
EP1453824A1 (fr) 2004-09-08

Similar Documents

Publication Publication Date Title
US7626032B2 (en) Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
US6964966B2 (en) Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
EP1015445B1 (fr) Quinolones antimicrobiennes, compositions et utilisations de celles-ci
JP5153329B2 (ja) （ｒ／ｓ）リファマイシン誘導体、その調製、および医薬組成物
EP1453824A1 (fr) Nouveaux derives d'acide piperidino-quinolone carboxylique substitue en position 7, chiraux, a action antimicrobienne a large spectre et ciblage triple, preparation, compositions contenant ces derives et leur utilisation en tant que medicaments
KR101490222B1 (ko) 항균성 퀴놀린 유도체
JP6552550B2 (ja) 抗菌性ピペリジニル置換３，４−ジヒドロ−１ｈ−［１，８］−ナフチリジノン類
KR101307717B1 (ko) 트리―, 테트라― 치환―3―아미노피롤리딘 유도체
CA2417799A1 (fr) Inhibiteurs de pompes d'efflux cellulaire de microbes
US7019143B2 (en) Antimicrobial quinolones, their compositions and uses
WO2018165614A1 (fr) Inhibiteurs de pompe à efflux bactérien
JP2017222646A (ja) 抗菌性ホモピペリジニル置換３，４−ジヒドロ−１ｈ−［１，８］−ナフチリジノン類
WO2001085728A2 (fr) Piperidino-benzo [i, j] quinolizines a substitution de piperidino en 8 chirales antibacteriennes, procedes, compositions et methodes de traitement
US6509349B1 (en) Antimicrobial 2-pyridones, their compositions and uses
US6608078B2 (en) Antibacterial chiral 8-(substituted piperidino)-benzo [i,j] quinolizines, processes, compositions and methods of treatment
KR20160003244A (ko) 퀴놀론 유도체
IE65175B1 (en) 7-(2-methyl-4-aminopyrrolidin-1-yl) naphthyridine and quinoline compounds
CA2468190A1 (fr) Nouveaux derives d'acide piperidino-quinolone carboxylique substitue en position 7, chiraux, a action antimicrobienne a large spectre et ciblage triple, preparation, compositions contenant ces derives et leur utilisation en tant que medicaments
CA2869453A1 (fr) Derives de quinoleine antibacteriens
Bhawsar et al. WCK 1152, WCK 1153: Discovery and structure activity relationship for the treatment of resistant pneumococcal and staphylococcal respiratory infections
WO2005066154A2 (fr) Nouveaux polymorphes d'enantiomeres racemiques, dextrogyres et levogyres de sels de chlorhydrate et de mesylate d'acide 1-cyclopropyl-6-fluoro-8-methoxy-7-(4-amino-3,3-dimethylpiperidin-1-yl)-1,4-dihydro-4-oxo-quinoline-3-carboxylique
WO2005030752A1 (fr) Derive d'acide 8-cyanoquinolone-carboxylique

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SC SD SE SG SK SL TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LU MC NL PT SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 274/MUMNP/2004

Country of ref document: IN

WWE Wipo information: entry into national phase

Ref document number: 2002796957

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2468190

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2003551131

Country of ref document: JP

WWP Wipo information: published in national office

Ref document number: 2002796957

Country of ref document: EP