CA2417799A1 - Inhibiteurs de pompes d'efflux cellulaire de microbes - Google Patents
Inhibiteurs de pompes d'efflux cellulaire de microbes Download PDFInfo
- Publication number
- CA2417799A1 CA2417799A1 CA002417799A CA2417799A CA2417799A1 CA 2417799 A1 CA2417799 A1 CA 2417799A1 CA 002417799 A CA002417799 A CA 002417799A CA 2417799 A CA2417799 A CA 2417799A CA 2417799 A1 CA2417799 A1 CA 2417799A1
- Authority
- CA
- Canada
- Prior art keywords
- oxo
- dihydro
- carboxylic acid
- fluoro
- salts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
- A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
L'invention concerne des composés inhibiteurs de pompes d'efflux cellulaire de microbes. L'invention se rapporte également à des procédés de préparation desdits composés, des procédés d'utilisation de ces composés inhibiteurs de pompes d'efflux et des compositions pharmaceutiques contenant lesdits composés.
Applications Claiming Priority (13)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22220100P | 2000-08-01 | 2000-08-01 | |
US60/222,201 | 2000-08-01 | ||
US09/640,947 US6750224B1 (en) | 1999-05-07 | 2000-08-17 | Antibacterial optically pure benzoquinolizine carboxylic acids, processes, compositions and methods of treatment |
US09/640,947 | 2000-08-19 | ||
INPCT/IN00/00111 | 2000-11-21 | ||
IN0000111 | 2000-11-22 | ||
US28629101P | 2001-04-25 | 2001-04-25 | |
US60/286,291 | 2001-04-25 | ||
US09/850,669 US6608078B2 (en) | 2000-05-08 | 2001-05-07 | Antibacterial chiral 8-(substituted piperidino)-benzo [i,j] quinolizines, processes, compositions and methods of treatment |
US09/850,669 | 2001-05-07 | ||
INPCT/IN01/00100 | 2001-05-08 | ||
PCT/IN2001/000100 WO2001085728A2 (fr) | 2000-05-08 | 2001-05-08 | Piperidino-benzo [i, j] quinolizines a substitution de piperidino en 8 chirales antibacteriennes, procedes, compositions et methodes de traitement |
PCT/IN2001/000139 WO2002009758A2 (fr) | 2000-08-01 | 2001-07-31 | Inhibiteurs de pompes d'efflux cellulaire de microbes |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2417799A1 true CA2417799A1 (fr) | 2002-02-07 |
Family
ID=27517699
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002417799A Abandoned CA2417799A1 (fr) | 2000-08-01 | 2001-07-31 | Inhibiteurs de pompes d'efflux cellulaire de microbes |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1305048A2 (fr) |
AU (1) | AU2001280091A1 (fr) |
CA (1) | CA2417799A1 (fr) |
WO (1) | WO2002009758A2 (fr) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6608078B2 (en) | 2000-05-08 | 2003-08-19 | Wockhardt Limited | Antibacterial chiral 8-(substituted piperidino)-benzo [i,j] quinolizines, processes, compositions and methods of treatment |
WO2011101710A1 (fr) * | 2010-02-16 | 2011-08-25 | Wockhardt Research Centre | Inhibiteurs de pompe à écoulement |
US7098219B2 (en) | 2000-08-01 | 2006-08-29 | Wockhart Limited | Inhibitors of cellular efflux pumps of microbes |
US6964966B2 (en) * | 2001-04-25 | 2005-11-15 | Wockhardt Limited | Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments |
US6878713B2 (en) | 2001-04-25 | 2005-04-12 | Wockhardt Limited | Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments |
AU2002361493A1 (en) * | 2001-12-13 | 2003-06-23 | Wockhardt Limited | New generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments |
EP1918289A3 (fr) * | 2002-05-28 | 2009-08-19 | Wockhardt Limited | Forme cristalline de sel d'arginine de fluoroquinolone |
US6664267B1 (en) | 2002-05-28 | 2003-12-16 | Wockhardt Limited | Crystalline fluoroquinolone arginine salt form |
US7829543B2 (en) | 2003-01-07 | 2010-11-09 | Paratek Pharmaceuticals, Inc. | Substituted polyamines as inhibitors of bacterial efflux pumps |
GB2403653A (en) * | 2003-07-10 | 2005-01-12 | Secr Defence | Use of fluoroquinone antibiotics for the treatment of plague |
EP1660495B1 (fr) * | 2003-09-04 | 2007-07-11 | Wockhardt Limited | Arginine tetrahydrate d'acide benzoquinolizine-2-carboxylique |
WO2005026145A2 (fr) * | 2003-09-12 | 2005-03-24 | Warner-Lambert Company Llc | Agents antibacteriens a base de quinolone |
US7247634B2 (en) | 2004-01-13 | 2007-07-24 | Cumbre Pharmaceuticals Inc. | Rifamycin derivatives effective against drug-resistant microbes |
EP1723150A1 (fr) | 2004-01-13 | 2006-11-22 | Cumbre Pharmaceuticals Inc. | Derives de rifamycine imino efficaces contres des microbes pharmacoresistants |
US7994225B2 (en) | 2004-03-17 | 2011-08-09 | Rempex Pharmaceuticals, Inc. | Bacterial efflux pump inhibitors for the treatment of ophthalmic and otic infections |
WO2005089738A2 (fr) * | 2004-03-17 | 2005-09-29 | Mpex Pharmaceuticals, Inc. | Utilisation et administration d'inhibiteurs de pompe d'efflux de bacteries |
DE102004035203A1 (de) | 2004-07-21 | 2006-02-16 | Bayer Healthcare Ag | Substituierte Chinolone |
DE102005030524A1 (de) | 2005-06-30 | 2007-01-18 | Aicuris Gmbh & Co. Kg | Substituierte Chinolone II |
DE102006005861A1 (de) | 2006-02-09 | 2007-08-23 | Aicuris Gmbh & Co. Kg | Substituierte Chinolone III |
US9155792B2 (en) | 2006-02-13 | 2015-10-13 | Trustees Of Boston University | RecA inhibitors with antibiotic activity, compositions and methods of use |
ES2393802T3 (es) * | 2006-03-07 | 2012-12-28 | Wockhardt Limited | Profármacos del ácido benzoquinolizin-2-carboxílico |
AU2007225088B2 (en) * | 2006-03-13 | 2012-09-13 | Kyorin Pharmaceutical Co., Ltd | Aminoquinolones as GSK-3 inhibitors |
US20100234348A1 (en) * | 2006-08-04 | 2010-09-16 | Trustees Of Boston University | Compositions and methods for potentiating antibiotic activity |
US7902227B2 (en) | 2007-07-27 | 2011-03-08 | Janssen Pharmaceutica Nv. | C-7 isoxazolinyl quinolone / naphthyridine derivatives useful as antibacterial agents |
CA2699151A1 (fr) | 2007-09-11 | 2009-03-19 | Activx Biosciences, Inc. | Cyanoaminoquinolones et tetrazoloaminoquinolones en tant qu'inhibiteurs de gsk-3 |
CA2699152C (fr) | 2007-09-12 | 2015-11-24 | Activx Biosciences, Inc. | Aminoquinolones spirocycliques utilisees en tant qu'inhibiteurs de gsk-3 |
MX2011009414A (es) | 2009-03-11 | 2011-10-19 | Kyorin Seiyaku Kk | 7-cicloalquiloaminoquinolonas como inhibidores de gsk-3. |
TW201718506A (zh) | 2011-08-31 | 2017-06-01 | 大塚製藥股份有限公司 | 喹啉酮化合物 |
CN103183684B (zh) * | 2011-12-29 | 2015-11-18 | 杭州师范大学 | 一种喹喏酮内酯化合物及其制备方法和应用 |
CN109486739B (zh) * | 2018-11-23 | 2022-02-01 | 上海海洋大学 | 一种诱导副溶血性弧菌产生左氧氟沙星耐药性的方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU200917B (en) * | 1987-07-20 | 1990-09-28 | Chinoin Gyogyszer Es Vegyeszet | Process for producing pharmaceutical compositions comprising quinoline or naphthyridinecarboxylic acid and tetracycline derivatives as active ingredient |
US5753269A (en) * | 1995-12-27 | 1998-05-19 | Bayer Corporation | Otic microbial combinations |
-
2001
- 2001-07-31 AU AU2001280091A patent/AU2001280091A1/en not_active Abandoned
- 2001-07-31 EP EP01958373A patent/EP1305048A2/fr not_active Withdrawn
- 2001-07-31 WO PCT/IN2001/000139 patent/WO2002009758A2/fr not_active Application Discontinuation
- 2001-07-31 CA CA002417799A patent/CA2417799A1/fr not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1305048A2 (fr) | 2003-05-02 |
WO2002009758A3 (fr) | 2002-12-27 |
WO2002009758A2 (fr) | 2002-02-07 |
AU2001280091A1 (en) | 2002-02-13 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2417799A1 (fr) | Inhibiteurs de pompes d'efflux cellulaire de microbes | |
US7247634B2 (en) | Rifamycin derivatives effective against drug-resistant microbes | |
US5137892A (en) | Quinoline, naphthyridine and pyridobenzoxazine derivatives | |
US7626032B2 (en) | Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments | |
US7229996B2 (en) | Rifamycin derivatives | |
US7202246B2 (en) | Spiro-rifamycin derivatives targeting RNA polymerase | |
US7238694B2 (en) | Rifamycin imino derivatives effective against drug-resistant microbes | |
KR101307717B1 (ko) | 트리―, 테트라― 치환―3―아미노피롤리딘 유도체 | |
US6964966B2 (en) | Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments | |
MX2011010434A (es) | Hidroxitienoquinolonas y compuestos relacionados como agentes antiinfecciosos. | |
JP2005511743A (ja) | 新世代の三重標的化したキラルな広域スペクトラム抗菌性の7位置換ピペリジノ−キノロンカルボン酸誘導体、その調製方法、組成物、および医薬としての使用 | |
US5453422A (en) | Quinolone- and naphthyridone carboxylic acid derivatives, process for their production, antibacterial compositions and feed additives containing them | |
US6900225B2 (en) | Quinolonecarboxylic acid derivative | |
US7098219B2 (en) | Inhibitors of cellular efflux pumps of microbes | |
KR20180094042A (ko) | 7-옥소-6-(설포옥시)-1,6-디아자바이사이클로[3.2.1]옥탄-2-카르복사미드 함유 화합물 및 이의 세균 감염의 치료 용도 | |
US20120058989A1 (en) | Antibacterial fluoroquinolone analogs | |
EP0302371B1 (fr) | Composés de 7-(2-méthyl-4-aminopyrrolidinyl)naphthyridine et quinoléine | |
WO2010012138A1 (fr) | Dérivés de l'acide carboxylique de quinoline 7-[4-(aminométhyl)-4-fluoro-3-(alkoxyimino)pyrrolidin-1-yle] et leurs procédés de préparation | |
CA2468190A1 (fr) | Nouveaux derives d'acide piperidino-quinolone carboxylique substitue en position 7, chiraux, a action antimicrobienne a large spectre et ciblage triple, preparation, compositions contenant ces derives et leur utilisation en tant que medicaments |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Discontinued |