WO2003022294A2 - Extract obtainable from artemisia abrotanum l. (southernwood) - Google Patents

Extract obtainable from artemisia abrotanum l. (southernwood) Download PDF

Info

Publication number
WO2003022294A2
WO2003022294A2 PCT/EP2002/010203 EP0210203W WO03022294A2 WO 2003022294 A2 WO2003022294 A2 WO 2003022294A2 EP 0210203 W EP0210203 W EP 0210203W WO 03022294 A2 WO03022294 A2 WO 03022294A2
Authority
WO
WIPO (PCT)
Prior art keywords
aqueous
extract
percolation
parts
liquids
Prior art date
Application number
PCT/EP2002/010203
Other languages
German (de)
French (fr)
Other versions
WO2003022294A3 (en
Inventor
Josef Beuth
Horst Mayer
Hong Lioe Ko
Original Assignee
Josef Beuth
Horst Mayer
Ko P
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Josef Beuth, Horst Mayer, Ko P filed Critical Josef Beuth
Publication of WO2003022294A2 publication Critical patent/WO2003022294A2/en
Publication of WO2003022294A3 publication Critical patent/WO2003022294A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282—Artemisia, e.g. wormwood or sagebrush
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

Definitions

  • the present invention relates to an extract obtainable by percolation of above-ground parts of plants from Artemisia abrotanum L. (Eberraute) with aqueous or aqueous-alcoholic liquids, a process for its preparation, a medicament containing the extract according to the invention and certain indications of the medicament according to the invention.
  • the boar diamond Artemisia abrotanum
  • the boar diamond is a plant that is also native to Germany and is traditionally used as a medicinal plant in folk medicine. Teas or tinctures of this plant are usually used. Areas of application are treatment of weight loss and development disorders in children, non-specific chronic inflammation, skin diseases, rheumatism and gout.
  • an extract of the boar diamond is effective as a medicine against viral and bacterial infections.
  • the present invention therefore relates to an extract which can be obtained by percolating above-ground parts of Artemisia abrotanum L. plants (Eberraute) with aqueous or aqueous-alcoholic liquids, optionally followed by drying the extract obtained with aqueous or aqueous-alcoholic liquids.
  • aqueous or aqueous-alcoholic liquids By drying the liquid extract obtained by percolation, solid, in particular powder, can be obtained.
  • the latter can be mixed with carriers and formulated in conventional pharmaceutical preparations. These include e.g. Tablets, dragees, capsules.
  • liquid extracts are also suitable for use, but can also be mixed with liquids customary in pharmaceutical technology for the purpose of dilution or to facilitate administration.
  • the extract according to the invention is preferably obtainable by percolation of dried aerial parts of the mountain rose plants.
  • the process according to the invention for producing the extract of Artemisia abrotanum L. (Eberraute) according to the invention comprises the following steps:
  • the extraction is preferably carried out with hot liquids.
  • water or mixtures of ethanol / water are used as liquids in the process according to the invention.
  • Percolation is preferably carried out with dried
  • the invention also relates to a medicament containing the extract according to the invention.
  • the medicament according to the invention is particularly suitable for the treatment of viral and / or bacterial infectious diseases.
  • the invention furthermore relates to a use of the extract according to the invention for the production of a medicament for the treatment of viral and / or bacterial infectious diseases.
  • infectious diseases are based in particular on infections with herpes simplex I and II viruses, hepatitis B and C viruses, rota- / entero viruses, the cytomegalovirus, the Epstein-Barr virus, RS viruses, chlamydia, ureaplasmas , Legionella, mycoplasma or combinations thereof.
  • herpes simplex I and II viruses hepatitis B and C viruses
  • rota- / entero viruses the cytomegalovirus
  • the Epstein-Barr virus Epstein-Barr virus
  • RS viruses chlamydia
  • ureaplasmas ureaplasmas
  • Legionella mycoplasma or combinations thereof.
  • Dried boarwood plants were treated by percolation in a manner known per se.
  • the ratio of the parts of the boar diamond: extractant dried above ground was 4: 1 (w / w).
  • the extractant was water.
  • the extraction was carried out at temperatures between 80 ° C and 100 ° C for a period of up to 4 minutes.
  • Berber diamond extract according to Example 1 was administered for the treatment / prophylaxis of herpes simplex (H.s.) hand infections in carers at dialysis wards.
  • Dialysis nurses / nurses often suffer from herpes simplex hand infections, due to regular mandatory local disinfection measures.
  • the subjects (n 15) suffered from florid, recurrent hand infections and drank a cup of mountain rose extract twice a day. All subjects could not become virus-free with virus-free therapy using standard antiviral therapy.

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Organic Chemistry (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention relates to an extract that can be obtained by percolation of overground plant parts from Artemisia abrotanum L. (southernwood) with aqueous or aqueous-alcoholic liquids, optionally followed by the drying of the extract obtained with the aqueous or aqueous-alcoholic liquids. Said extract can be used as medicament in the treatment of infections.

Description

Extrakt erhältlich aus Artemisia abrotanum L. (Eberraute) Extract available from Artemisia abrotanum L. (Eberraute)
Die vorliegende Erfindung betrifft einen Extrakt erhältlich durch Perkolation oberirdischer Pflanzenteile von Artemisia abrotanum L. (Eberraute) mit wässrigen oder wässrig-alkoholischen Flüssigkeiten, ein Verfahren zu seiner Herstellung, ein Arzneimittel enthaltend den erfindungsgemäßen Extrakt sowie bestimmte Indikationen des erfindungsgemäßen Arzneimittels.The present invention relates to an extract obtainable by percolation of above-ground parts of plants from Artemisia abrotanum L. (Eberraute) with aqueous or aqueous-alcoholic liquids, a process for its preparation, a medicament containing the extract according to the invention and certain indications of the medicament according to the invention.
Die Eberraute, Artemisia abrotanum, ist eine auch in Deutschland heimische Pflanze, die in der Volksmedizin als Heilpflanze traditionell benutzt wird. Üblicherweise werden Tees oder Tinkturen dieser Pflanze verwendet. Anwendungsgebiete sind Behandlung von Abmagerung und Εntwicklungs- störungen bei Kindern, unspezifische chronische Entzündungen, Hauterkrankungen, Rheumatismus und Gicht.The boar diamond, Artemisia abrotanum, is a plant that is also native to Germany and is traditionally used as a medicinal plant in folk medicine. Teas or tinctures of this plant are usually used. Areas of application are treatment of weight loss and development disorders in children, non-specific chronic inflammation, skin diseases, rheumatism and gout.
Überraschenderweise wurde gefunden, dass ein Extrakt der Eberraute als Arzneimittel gegen virale und bakterielle Infektionen wirksam ist.Surprisingly, it has been found that an extract of the boar diamond is effective as a medicine against viral and bacterial infections.
Gegenstand der vorliegenden Erfindung ist daher ein Extrakt, der durch Perkolation oberirdischer Pflanzenteile von Artemisia abrotanum L. (Eberraute) mit wässrigen oder wässrig-alkoholischen Flüssigkeiten erhältlich ist, ggf. gefolgt von Trocknung des mit wässrigen oder wässrig-alkoholischen Flüssigkeiten gewonnenen Extraktes. Durch die Trocknung des durch Perkolation erhaltenen flüssigen Extraktes sind feste, insbesondere pulverförmige erhältlich. Letztere können mit Trägerstoffen vermischt und in üblichen galenischen Zubereitungen formuliert werden. Dazu gehören z.B. Tabletten, Dragees, Kapseln.The present invention therefore relates to an extract which can be obtained by percolating above-ground parts of Artemisia abrotanum L. plants (Eberraute) with aqueous or aqueous-alcoholic liquids, optionally followed by drying the extract obtained with aqueous or aqueous-alcoholic liquids. By drying the liquid extract obtained by percolation, solid, in particular powder, can be obtained. The latter can be mixed with carriers and formulated in conventional pharmaceutical preparations. These include e.g. Tablets, dragees, capsules.
Auch die flüssigen Extrakte sind zur Verwendung geeignet, können jedoch ebenfalls mit in der pharmazeutischen Technologie üblichen Flüssigkeiten vermischt werden zwecks Verdünnung oder Erleichterung der Administration.The liquid extracts are also suitable for use, but can also be mixed with liquids customary in pharmaceutical technology for the purpose of dilution or to facilitate administration.
Vorzugsweise ist der erfindungsgemäße Extrakt durch Perkolation getrockneter oberirdischer Teile der Eberrautenpflanzen erhältlich. Der erfindungsgemäße Extrakt wird bevorzugterweise so gewonnen, dass das Mengenverhältnis der oberirdisch getrockneten Teile der Eberraute : Extraktionsmittel = 2,5 - 5,5: 1 (w/w) beträgt, insbesondere 4:1 (w/w)The extract according to the invention is preferably obtainable by percolation of dried aerial parts of the mountain rose plants. The extract according to the invention is preferably obtained so that the quantitative ratio of Parts of the boar diamond dried above ground: extractant = 2.5 - 5.5: 1 (w / w), in particular 4: 1 (w / w)
Das erfindungsgemäße Verfahren zur Herstellung des erfindungsgemäßen Extrakts von Artemisia abrotanum L. (Eberraute) umfasst die folgenden Schritte:The process according to the invention for producing the extract of Artemisia abrotanum L. (Eberraute) according to the invention comprises the following steps:
- eine Perkolation von oberirdischen Pflanzenteilen von Artemisia abrotanum L. (Eberraute) mit wässrigen oder wässrig-alkoholischen Flüssigkeiten,a percolation of above-ground parts of plants from Artemisia abrotanum L. (Eberraute) with aqueous or aqueous-alcoholic liquids,
- ggf. gefolgt von einer Trocknung des mit wässrigen oder wässrig- alkoholischen Flüssigkeiten gewonnenen Extraktes. Vorzugsweise erfolgt die Extraktion mit heißen Flüssigkeiten. Als Flüssigkeiten werden im erfindungsgemäßen Verfahren insbesondere Wasser oder Gemische aus Ethanol/Wasser verwendet.- optionally followed by drying of the extract obtained with aqueous or aqueous-alcoholic liquids. The extraction is preferably carried out with hot liquids. In particular, water or mixtures of ethanol / water are used as liquids in the process according to the invention.
Die Perkolation erfolgt vorzugsweise mit getrocknetenPercolation is preferably carried out with dried
Eberrautenpflanzenteilen. Das Mengenverhältnis der oberirdisch getrockneten Teile der Eberraute : Extraktionsmittel beträgt 2,5 - 5,5:1 (w/w).Eberrautenpflanzenteilen. The quantitative ratio of the parts of the boar lozenge: extractant dried above ground is 2.5 - 5.5: 1 (w / w).
Gegenstand der Erfindung ist auch ein Arzneimittel enthaltend den erfindungsgemäßen Extrakt. Das erfindungsgemäße Arzneimittel ist insbesondere zur Behandlung von viralen und/oder bakteriellen Infektionserkrankungen geeignet.The invention also relates to a medicament containing the extract according to the invention. The medicament according to the invention is particularly suitable for the treatment of viral and / or bacterial infectious diseases.
Gegenstand der Erfindung ist des Weiteren eine Verwendung des erfindungsgemäßen Extraktes zur Herstellung eines Arzneimittels zur Behandlung von viralen und/oder bakteriellen Infektionserkrankungen.The invention furthermore relates to a use of the extract according to the invention for the production of a medicament for the treatment of viral and / or bacterial infectious diseases.
Die Infektionserkrankungen beruhen insbesondere auf Infektionen mit Herpes Simplex I- und II-Viren, Hepatitis B- und C-Viren, Rota-/Entero-Viren, dem Cytomegalie-Virus, dem Epstein-Barr-Virus, RS-Viren, Chlamydien, Ureaplasmen, Legionellen, Mykoplasmen oder Kombinationen davon. Beispiel 1:The infectious diseases are based in particular on infections with herpes simplex I and II viruses, hepatitis B and C viruses, rota- / entero viruses, the cytomegalovirus, the Epstein-Barr virus, RS viruses, chlamydia, ureaplasmas , Legionella, mycoplasma or combinations thereof. Example 1:
Getrocknete Eberrautenpflanzen wurden mittels Perkolation in an sich bekannter Weise behandelt. Das Verhältnis der oberirdisch getrockneten Teile der Eberraute : Extraktionsmittel betrug 4: 1 (w/w). Das Extraktionsmittel war Wasser. Die Extraktion erfolgte bei Temperaturen zwischen 80°C und 100°C für eine Zeitdauer bis 4 Minuten.Dried boarwood plants were treated by percolation in a manner known per se. The ratio of the parts of the boar diamond: extractant dried above ground was 4: 1 (w / w). The extractant was water. The extraction was carried out at temperatures between 80 ° C and 100 ° C for a period of up to 4 minutes.
Beispiel 2:Example 2:
Eberrauten Extrakt nach Beispiel 1 wurde zur Therapie/Prophylaxe von Herpes simplex (H.s.) Handinfektionen bei Pflegern/Innen auf Dialysestationen verabreicht. Dialyseschwestern/-pfleger leiden gehäuft an Herpes simplex Handinfektionen, bedingt durch regelmäßige obligate lokale Desinfektionsmaßnahmen. Die Probanden/Innen (n = 15) litten unter floriden rekurrierenden Handinfektionen und tranken 2-mal täglich eine Tasse Eberrauten Extrakt. Alle Probanden/Innen konnten durch antivirale Standardtherapie nicht virus-symptomfrei werden.Berber diamond extract according to Example 1 was administered for the treatment / prophylaxis of herpes simplex (H.s.) hand infections in carers at dialysis wards. Dialysis nurses / nurses often suffer from herpes simplex hand infections, due to regular mandatory local disinfection measures. The subjects (n = 15) suffered from florid, recurrent hand infections and drank a cup of mountain rose extract twice a day. All subjects could not become virus-free with virus-free therapy using standard antiviral therapy.
Alle Probanden/Innen mit floriden H.s. Infektionen (n = 15) konnten den Heilungsprozess durch Eberrauten Extrakt forcieren (verglichen mit antiviraler Therapie in früheren Krankheitsepisoden) und die Rezidivrate deutlich senken. Auffällig war insbesondere, dass die rezidivfreie Zeit signifikant verlängert werden konnte, bzw. dass Rezidive in einem Teilkollektiv der Probanden/Innen (n = 8; ca. 53%) über Jahre nicht mehr auftraten. Dieser Befund ist ein Indiz für die antivirale Aktivität (gegen Herpes simplex Viren) von Eberrauten Extrakten. All subjects with florid H.s. Infections (n = 15) were able to accelerate the healing process with rue extract (compared to antiviral therapy in previous episodes of the disease) and significantly reduce the recurrence rate. It was particularly noticeable that the recurrence-free period could be significantly extended, or that recurrences in a sub-collective of the test subjects (n = 8; approx. 53%) did not occur for years. This finding is an indication of the antiviral activity (against herpes simplex viruses) of barbeque extracts.

Claims

Patentansprüche claims
1. Extrakt erhältlich durch Perkolation oberirdischer Pflanzenteile von Artemisia abrotanum L. (Eberraute) mit wässrigen oder wässrig- alkoholischen Flüssigkeiten ggf. gefolgt von Trocknung des mit wässrigen oder wässrig-alkoholischen Flüssigkeiten gewonnenen Extraktes.1. Extract obtainable by percolation of above-ground parts of plants from Artemisia abrotanum L. (Eberraute) with aqueous or aqueous-alcoholic liquids, possibly followed by drying of the extract obtained with aqueous or aqueous-alcoholic liquids.
2. Extrakt nach Anspruch 1, dadurch gekennzeichnet, dass die Perkolation mit getrockneten Eberrautenpflanzenteilen erfolgt.2. Extract according to claim 1, characterized in that the percolation is carried out with dried parts of the rowan plant.
3. Extrakt nach Anspruch 1 und/oder 2, dadurch gekennzeichnet, dass das Mengenverhältnis der oberirdisch getrockneten Teile der Eberraute : Extraktionsmittel = 2,5 - 5,5: 1 (w/w) beträgt.3. Extract according to claim 1 and / or 2, characterized in that the quantitative ratio of the above-ground dried parts of the boar diamond: extracting agent = 2.5 - 5.5: 1 (w / w).
4. Verfahren zur Herstellung eines Extraktes von Artemisia abrotanum L. (Eberraute) wobei eine Perkolation von oberirdischen Pflanzenteilen von Artemisia abrotanum L. (Eberraute) erfolgt mit wässrigen oder wässrig- alkoholischen Flüssigkeiten, ggf. gefolgt von einer Trocknung des mit wässrigen oder wässrig- alkoholischen Flüssigkeiten gewonnenen Extraktes.4. Process for the production of an extract of Artemisia abrotanum L. (mountain rose) whereby percolation of above-ground parts of plants from Artemisia abrotanum L. (mountain rose) is carried out with aqueous or aqueous-alcoholic liquids, if appropriate followed by drying of the with aqueous or aqueous extract obtained from alcoholic liquids.
5. Verfahren nach Anspruch 4, wobei die Extraktion mit heissen Flüssigkeiten erfolgt.5. The method according to claim 4, wherein the extraction is carried out with hot liquids.
6. Verfahren nach Anspruch 4 und/oder 5, wobei die Flüssigkeiten Wasser oder Gemisch EtOH/Wasser sind.6. The method according to claim 4 and / or 5, wherein the liquids are water or EtOH / water mixture.
7. Verfahren nach mindestens einem der Ansprüche 4 bis 6, dadurch gekennzeichnet, dass die Perkolation mit getrockneten Eberrautenpflanzenteilen erfolgt.7. The method according to at least one of claims 4 to 6, characterized in that the percolation is carried out with dried mountain rose plant parts.
8. Verfahren nach mindestens einem der Ansprüche 4 bis 7, dadurch gekennzeichnet, dass das Mengenverhältnis der oberirdisch getrockneten Teile der Eberraute : Extraktionsmittel = 2,5 - 5,5: 1 (w/w) beträgt. 8. The method according to at least one of claims 4 to 7, characterized in that the quantitative ratio of the above-ground dried parts of the boar diamond: extracting agent = 2.5 - 5.5: 1 (w / w).
9. Arzneimittel enthaltend den Extrakt nach mindestens einem der Ansprüche 1 bis 3.9. Medicament containing the extract according to at least one of claims 1 to 3.
10. Verwendung des Extraktes nach mindestens einem der Ansprüche 1 bis 3 zur Herstellung eines Arzneimittels zur Behandlung von viralen und/oder bakteriellen Infektionserkrankungen.10. Use of the extract according to at least one of claims 1 to 3 for the manufacture of a medicament for the treatment of viral and / or bacterial infectious diseases.
11. Verwendung nach Anspruch 10 wobei die Infektionserkrankungen auf Infektionen mit Herpes simplex I- und II-Viren, Hepatitis B- und C-Viren, Rota-/Entero-Viren, dem Cytomegalie-Virus, dem Epstein-Barr-Virus, RS- Viren, Chlamydien,Ureaplasmen, Legionellen, Mykoplasmen oder Kombinationen davon beruhen. 11. Use according to claim 10, wherein the infectious diseases on infections with herpes simplex I and II viruses, hepatitis B and C viruses, Rota / Entero viruses, the cytomegalovirus, the Epstein-Barr virus, RS virus Viruses, chlamydia, ureaplasmas, legionella, mycoplasma or combinations thereof.
PCT/EP2002/010203 2001-09-11 2002-09-11 Extract obtainable from artemisia abrotanum l. (southernwood) WO2003022294A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10144765A DE10144765A1 (en) 2001-09-11 2001-09-11 Extract available from Artemisia abrotanum L. (Eberraute)
DE10144765.5 2001-09-11

Publications (2)

Publication Number Publication Date
WO2003022294A2 true WO2003022294A2 (en) 2003-03-20
WO2003022294A3 WO2003022294A3 (en) 2003-09-12

Family

ID=7698661

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/010203 WO2003022294A2 (en) 2001-09-11 2002-09-11 Extract obtainable from artemisia abrotanum l. (southernwood)

Country Status (2)

Country Link
DE (1) DE10144765A1 (en)
WO (1) WO2003022294A2 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2890312A1 (en) * 2005-09-02 2007-03-09 Limousine D Applic Biolog Dite Process for making principle active repulpant, useful to stimulate the synthesis and the storage of adipose tissue, comprises solubilizing entire plant powder of Artemisia abrotanum, separating the phases, filtering and sterilizing
WO2011140224A1 (en) * 2010-05-07 2011-11-10 Johnson & Johnson Consumer Companies, Inc. Extracts of southernwood and topical uses thereof
WO2011140226A3 (en) * 2010-05-07 2012-01-05 Johnson &Johnson Consumer Companies, Inc. Compositions comprising extracts of southernwood and an amine compound
WO2015030567A1 (en) * 2013-08-30 2015-03-05 Zamarripa Blas Juan Alberto Improvements to a complementary formulation for counteracting adverse effects of cancer treatments and of treatments for some viral diseases

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3000521A1 (en) * 1979-01-10 1980-07-24 Kitasato Inst SUBSTANCE WITH INTERFERON INDUCING ACTIVITY AND METHOD FOR THEIR PRODUCTION

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9104286D0 (en) * 1991-02-28 1991-04-17 Phytopharm Ltd Pharmaceutical compositions for the treatment of skin disorders
DE4131313A1 (en) * 1991-09-20 1993-03-25 Karl Konrad Medicament from camomile flowers - contains non-polar active agent obtd. by aq. extn. in presence of ascorbic acid

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3000521A1 (en) * 1979-01-10 1980-07-24 Kitasato Inst SUBSTANCE WITH INTERFERON INDUCING ACTIVITY AND METHOD FOR THEIR PRODUCTION

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DATABASE BIOSIS [Online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1989 ZHENG M: "AN EXPERIMENTAL STUDY OF THE ANTI-HSV-II ACTION OF 500 HERBAL DRUGS" Database accession no. PREV199089046061 XP002158932 & JOURNAL OF TRADITIONAL CHINESE MEDICINE, Bd. 9, Nr. 2, 1989, Seiten 113-116, ISSN: 0254-6272 *
DATABASE BIOSIS [Online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1995 BERGENDROFF OLA ET AL: "Spasmolytic flavonols from Artemisia abrotanum." Database accession no. PREV199598457072 XP002237541 & PLANTA MEDICA, Bd. 61, Nr. 4, 1995, Seiten 370-371, ISSN: 0032-0943 *
DATABASE BIOSIS [Online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1999 DULGER BASARAN ET AL: "Antimicrobial activity of Artemisia absinthium L." Database accession no. PREV199900284070 XP002237543 & TURKISH JOURNAL OF BIOLOGY, Bd. 23, Nr. 3, 1999, Seiten 377-384, ISSN: 1300-0152 *
DATABASE EMBASE [Online] ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL; 1990 CUBUKCU B ET AL: "In vitro antimalarial activity of crude extracts and compounds from Artemisia abrotanum L" Database accession no. EMB-1990364749 XP002237540 & PHYTOTHERAPY RESEARCH 1990 UNITED KINGDOM, Bd. 4, Nr. 5, 1990, Seiten 203-204, ISSN: 0951-418X *
DATABASE MEDLINE [Online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; Januar 1990 (1990-01) ZHENG M: "ÄExperimental study of 472 herbs with antiviral action against the herpes simplex virus]" Database accession no. NLM2161714 XP002237542 & ZHONG YI YAN JIU YUAN, ZHU BAN. CHINA JAN 1990, Bd. 10, Nr. 1, Januar 1990 (1990-01), Seiten 39-41, 46, ISSN: 0254-9034 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2890312A1 (en) * 2005-09-02 2007-03-09 Limousine D Applic Biolog Dite Process for making principle active repulpant, useful to stimulate the synthesis and the storage of adipose tissue, comprises solubilizing entire plant powder of Artemisia abrotanum, separating the phases, filtering and sterilizing
WO2011140224A1 (en) * 2010-05-07 2011-11-10 Johnson & Johnson Consumer Companies, Inc. Extracts of southernwood and topical uses thereof
WO2011140226A3 (en) * 2010-05-07 2012-01-05 Johnson &Johnson Consumer Companies, Inc. Compositions comprising extracts of southernwood and an amine compound
US8722113B2 (en) 2010-05-07 2014-05-13 Johnson & Johnson Consumer Companies, Inc. Compositions comprising extracts of southernwood and an amine compound
WO2015030567A1 (en) * 2013-08-30 2015-03-05 Zamarripa Blas Juan Alberto Improvements to a complementary formulation for counteracting adverse effects of cancer treatments and of treatments for some viral diseases

Also Published As

Publication number Publication date
WO2003022294A3 (en) 2003-09-12
DE10144765A1 (en) 2003-04-30

Similar Documents

Publication Publication Date Title
Paithankar et al. Phyllanthus niruri: A magic herb
Ansari et al. Adiantum capillus-veneris. L: Phytochemical constituents, traditional uses and pharmacological properties: A review
DE3705151A1 (en) WARTS
DE19953829C2 (en) Nasal spray (drops) for the treatment of fever, cold and its manufacture
CN106138241A (en) A kind of Chinese medicine composition of relieving itching and eliminating swelling and preparation method thereof after mosquito bite
CH699749B1 (en) Prepared mixture of spagyric and plants in propolis tincture for dry cough in children.
WO2003022294A2 (en) Extract obtainable from artemisia abrotanum l. (southernwood)
US20070212432A1 (en) Herbal Composition
CN101264136A (en) Chinese medicine preparation for treating wind-heat type common cold and preparation thereof
CN108186882A (en) Skin bacteriostatic Chinese medicinal composition and preparation method thereof
WO1994011009A1 (en) Composition for controlling dermatomycoses and their agents, as well as transpiration and bodily odours
WO2010025577A2 (en) Preparation for preventing and/or treating and/or avoiding the spreading of respiratory tract diseases
RU2311190C1 (en) Therapeutical and prophylactic drug for young agricultural animals and a method to prevent and treatment of viral respiratory diseases in calves using it
RU2032419C1 (en) Hepatoprotective preparation and process for producing same
CN110025705A (en) A kind of Chinese medicine composition and its preparation method and application for treating atopic dermatitis
RU2576238C1 (en) Herbal tea for treating functional disorders of the gall bladder at hypertonic-hyperkinetic type of dyskinesia
DE69919040T2 (en) USE OF A SYNERGISTIC COMPOSITION FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF LIVER DISEASES
Mahajan et al. Psychopharmacological evaluation of alkaloidal fraction of Desmodium gangeticum
EP1338303B1 (en) Detoxifying phytotherapeutic composition from two plant extracts and process for preparing the same
DE4244754C2 (en) Combating the pathogens of dermatomycoses in clothing
JP2004352680A (en) Composition for treatment of allergic disease
Lodhi et al. Evaluation of the Pharmacological Potential of Nyctanthes Arbor-Tristis Flowers Extract against Milk Induced Asthmatic Disorder in Swiss Albino Mice
Mulatu Identification of Artemisia afra for Access and Benefit Sharing activities
CN100522189C (en) Method for preparing broad-spectrum antiviral drug of nano total acid of chickweed as well as usage and chickweed acid A
SK8166Y1 (en) Herbal extract and its use

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BY BZ CA CH CN CO CR CU CZ DE DM DZ EC EE ES FI GB GD GE GH HR HU ID IL IN IS JP KE KG KP KR LC LK LR LS LT LU LV MA MD MG MN MW MX MZ NO NZ OM PH PL PT RU SD SE SG SI SK SL TJ TM TN TR TZ UA UG US UZ VC VN YU ZA ZM

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ UG ZM ZW AM AZ BY KG KZ RU TJ TM AT BE BG CH CY CZ DK EE ES FI FR GB GR IE IT LU MC PT SE SK TR BF BJ CF CG CI GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP