SK8166Y1 - Herbal extract and its use - Google Patents

Abstract

Described is the herbal extract obtained by leaching a mixture of 32 herbs in a leaching medium containing 20 % by volume up to 50 % by volume ethanol and its use.

Description

Technical field

The technical solution concerns herbal extract and its use. The extract is suitable for use in medicine and for home treatment, in particular for the treatment of stomach complaints, for stimulating the non-specific immune system, for short-term prevention and for the treatment of common cold, as well as otorhinolaryngo logic, topical antiseptic, topical virostatic, topical antifungal and a dermatological

BACKGROUND OF THE INVENTION

Herbal extracts represent one of the oldest and most used ways of using medicinal plants. These are processed herbal drugs (dried root, leaves, leaves, etc.), and concentrated plant extracts obtained by extracting the drug with various solvents (water, alcohol, glycerol, etc.). The extracts may be liquid to dry (obtained by complete evaporation of the solvent).

Patent documents CN104906550 disclose medicinal compositions of 18 traditional Chinese herbs, which include a species of blackberry Rubus nutans in minority quantities. This dry herbal mixture is used to treat chronic gastritis. A disadvantage is the dry form of the formulation, which does not guarantee high efficacy of the formulation. Another patent document CN104815183 describes a mixture of herbs of one of the species of blackberry Rubus xanthocarpus, which contains a further 11 kinds of Chinese herbs. This composition is used to treat childhood diarrhea. It is prepared by boiling a mixture of herbs in water for 5 hours followed by filtration and evaporation of the filtrate to dryness. Such treatment causes degradation of the thermolabile bioactive substances in the formulation, thereby reducing the effectiveness of the formulation.

Ukrainian patent document UA94082 discloses herbal extract of Nettle and / or Tartar with optional addition of selenium or urea. The preparation is still exposed to the high-frequency electromagnetic field. The composition is used as an aid in the treatment of conditions such as HIV infections and AIDS.

Korean patent document KR20120027040 discloses an extract prepared from a combination of blackberry species Rubus idaeus and Rubusfructiosus with anti-influenza effects.

US2002012708 discloses the use of an artichoke herb extract which constitutes an essential component of the formulation, is in dry form, and optionally may also contain minor echinacea and / or nettle extracts. This preparation is administered as a support for conventional treatment of diseases caused by bacteria and viruses, for example Crohn's disease, pancreatitis, kidney, liver atrophy, jaundice or skin ulcers, or also for the treatment of viral diseases.

Czech Utility Model No. 27424 describes the gastric tincture of a mixture of five herbs, such as extracts of the Yellow Gentian Root, Duckweed, which are bitter digestive herbs. In addition to supporting herbs, it contains minority quantities of Raspberry, Ragwort and Chubet Benedict. However, this tincture is only used for stomach problems and has not been shown to have any other effects.

The essence of the technical solution

The object of the invention is to prepare a herbal extract which has a wide spectrum of effects not only when administered orally, but also when applied topically to the skin or mucosa of the patient.

A unique combination of herbs has been developed, i. j. a herbal mixture which is leached at ambient temperature, wherein the herbal extract obtained has a number of different therapeutic effects. This herbal extract can be used in the treatment of stomach problems, for stimulating the non-specific immune system, for the short-term prevention and treatment of common cold, also as an otorhinolaryngological, topical antiseptic, topical virostatic, topical antifungal and dermatologic.

Accordingly, the herbal extract according to the invention is based on the problem that the above-mentioned drawbacks and drawbacks are fulfilled and that in 1000 ml of the leaching medium containing 20% by volume of the brewing medium. up to 50 vol. %. at least 8,6 to 14,9 g of dry spring shoots of Nettle, at least 2,9 to 8,6 g of dry leaves of raspberry blackberry, at least 2,9 to 8,6 g of dry leaves of blackberry 4.1 g of dry leaves of Strawberry, at least 1.7 to 4.1 g of dry young growth of Norway spruce, at least 1.7 to 4.1 g of dry aerial part of the Willowherb in bloom, at least 1.1 to 3.5 g of the dry aerial part of the Mildewmoss in bloom, at least 1.1 to 3.5 g of dry Baza black flowers, at least 1.1 to 3.5 g of a dry mixture of flower and Alchemilla leaf,

SK 8166 Yl at least 1.1 to 3.5 g of dry leaves of Early Spearwort, at least 1.1 to 3.5 g of the dry aerial part of the Speedwell in flowering, at least 0.9 to 3.1 g of the dry aerial part of the Lipizzanum in bloom , at least 0.9 to 3.1 g of dry above ground part of lemon balm in bloom, at least 0.6 to 2.8 g of dry mixture of flower and leaf of Coltsfoot, at least 0.6 to 2.8 g of dry ground part of the plant common, at least 0.6 to 2.8 g dry flower Daisies, at least 0.6 to 2.8 g dry flower St. John's wort, at least 0.6 to 2.8 g dry flower Heart lime, at least 0.6 to 1 , 6 g dry flower Spring primrose, at least 0.6 to 1.6 g dry leaf of Replica, at least 0.6 to 1.6 g dry flower of calendula, at least 0.6 to 1.6 g dry flower of thorns, at least 0.6 to 1.6 g of dry overhead part of Peppermint Mint, at least 0.6 to 1.6 g of dry crown petals j or Rose of the centenary, at least 0,6 to 1,6 g of dry aerial part of Pea seed, at least 0,3 to 0,9 g of dry flower and leaf of Pamajoran, at least 0,3 to 0,9 g of dry flower and leaves Violet fragrant, at least 0,3 to 0,9 g dry flower Chamomile, at least 0,3 to 0,9 g dry flower White nipples, at least 0,3 to 0,6 g dry flower up to 0,5 g of dry flower of Divozel large flower and at least 2,4 to 4,4 g per pulverized crushed garlic clove paste.

A preferred embodiment of the invention is a herbal extract, wherein in 1000 ml of the digestion liquor containing 30% by volume of water. ethanol is leached:

11,5 g of dry stems of Nettle,

5.7 g dry leaves of Raspberry Blackberry,

5.7 g dry leaves Blackberry,

2,9 g dry leaves of Strawberry,

2,9 g dry young increments of Norway spruce,

2,9 g of dry above-ground part of small-flowered willow in bloom,

2.3 g of dry aerial part

2,3 g dry flowers Bazy black,

2,3 g of dry mixture of flower and Alchemilla leaf,

2,3 g of dry leaves of the scorpion,

2.3 g of the dry aerial part of the medicinal plant in flower,

2,0 g of dry aerial part of Grapevine in flower,

2,0 g dry aerial partMedovka in flower,

1.7 g dry mixture of flower and leaf of Coltsfoot,

1,7 g of dry aerial part of Mother's sip,

1,7 g dry flower Daisies,

1,7 g dry flower of St. John's wort,

1,7 g of dry linden flower,

1,1 g of dry flower

1,1 g dry leaf of Rape,

1,1 g of dry flower of Calendula,

1.1 g dry flower

1,1 g of dry aerial part of peppermint in bloom,

1,1 g of dry crown petals of Gallic Rose or Centennial Rose,

1,1 g of dry aerial partPresley beads,

0,6 g dry mixture of flower and leaf of Pamajoran,

0,6 g of dry mixture of flower and leaf Violet,

0,6 g dry flower of Camomile,

0,6 g dry flower White nipples,

0,4 g dry flower

0,3 g of dry flower of Divozel large flower a

3.4 g per pulverized crushed garlic clove paste.

A leaching medium containing an alcohol content, preferably ethanol, of 20% to 45% by volume, more preferably 30% by volume, is used for the extraction (extraction). up to 40% vol.

N E 8166 Yl

The term "mixture of flower and leaf" means a mixture that results from the separation of leaves and flowers from the stalks of the plants of a given herb. Preferably, the Alchemilla flower and leaf are mixed in a ratio of 2 vol. flower parts and 1 vol. part of the sheet. The same flower-to-foliage ratio is also beneficial for Coltsfoot.

In the case of Pamajorane, the preferred ratio in the mixture is 1 vol. part flower to 1 vol. part of the sheet. The same flower to leaf ratio is also beneficial for Violet Fragrant.

A great advantage of the herbal extract according to the invention is its versatility of use and wide effect especially in the prevention and treatment of infectious diseases. It is used orally and / or topically, either in the form of drops or in the form of a spray. For oral use, a small amount of extract is preferably dropped into water or tea. In the topical (topical) application of the extract according to the invention, preferably the affected skin or mucosa is rubbed or sprayed.

The herbal extract according to the invention can be used in the treatment of stomach complaints, for stimulating the non-specific immune system, for the short-term prevention or treatment of common cold, as well as an otorhinolaryngological, antiseptic, virostatic, autimycotic or dermatologic. nasopharyngitis, diseases caused by herpes viruses, preferably Herpes simplex; or diseases caused by papilloma viruses.

The prepared herbal extract is effective when administered orally in the form of drops for the treatment of acute and chronic gastritis. It enhances the overall immunity of the organism, in particular it is effective in preventing and treating colds, nasopharyngitis, bronchitis. It is also an effective otorhinolaryngologic, cervical, nasal and ear antiseptic. Topically administered herbal extract according to the invention, it is an effective virostatic, especially in the treatment of cold sores caused by Herpes simplex virus and recurrent Herpes labialis. The preparation has proven to be very useful in the treatment of skin infections caused by bacteria or in the treatment of local mycoses caused by fungi, molds and yeasts. The herbal extract according to the invention can also be used as a support for the treatment or prevention of dry, scaly, itchy and sensitive skin, for example atopic eczema.

An exemplary embodiment

Example 1

A dry herbal mixture is prepared according to Table 1.

Table 1

Herb name Collected part Amount (g) in dry herbal mixture House Nettle spring shoots 11.5 Raspberry blackberry foliage 5.7 Blackberry foliage 5.7 Strawberry foliage 2.9 Common spruce young additions 2.9 Willow Willow aerial part of the plant in bloom 2.9 Pulmonary medicine aerial part of the plant in bloom 2.3 elderberry flower 2.3 Alchemilka ordinary a 2: 1 mixture of flower and leaf 2.3 Skorocel kopijovitý a letter 2.3 Speedwell medical aerial part of the plant in bloom 2.3 Lipkavec pravý aerial part of the plant in bloom 2.0 Lemon balm aerial part of the plant in bloom 2.0 Coltsfoot healing a 2: 1 mixture of flower and leaf 1.7 Materina sip aboveground part of the plant 1.7 Daisy flower 1.7 St John's wort flower 1.7 Lipa srdcovitá flower 1.7 Primrose spring flower 1.1 Rape a letter 1.1

N E 8166 Yl

Garden nail flower 1.1 Hawthorn flower 1.1 Peppermint Mint aerial part of the plant in bloom 1.1 Gallic rose crown petals 1.1 Praslička roľná aboveground part of the plant 1.1 Pamajorán ordinary a 1: 1 mixture of flower and leaf 0.6 Violet fragrant a 1: 1 mixture of flower and leaf 0.6 Camomile flower 0.6 White nettle flower 0.6 Common ladder flower 0.4 Divozel veľkokvetý flower 0.3

3.4 g per pulverized garlic clove paste are added to the dry herb mixture, then this mixture is allowed to infuse in 1 liter of alcohol distillate with an ethanol content of 40% by volume. for 30 days. After the digestion time, the mixture is filtered. The leachate (filtrate) is still squeezed out of the mother cake and then allowed to stand in a glass container for 10 days to drain. Then it turns into a prepared glass.

Example 2

A dry herbal mixture is prepared according to Table 2.

Table 2

Herb name Collected part Amount (g) in dry herbal mixture House Nettle spring shoots 8.6 Raspberry blackberry foliage 2.9 Blackberry foliage 2.9 Strawberry foliage 1.7 Common spruce young additions 1.7 Willow Willow aerial part of the plant in bloom 1.7 Pulmonary medicine aerial part of the plant in bloom 1.1 elderberry flower 1.1 Alchemilka ordinary mixture of flower and leaf 1.1 Skorocel kopijovitý a letter 1.1 Speedwell medical aerial part of the plant in bloom 1.1 Iipkavec pravý aerial part of the plant in bloom 0.9 Lemon balm aerial part of the plant in bloom 0.9 Coltsfoot healing mixture of flower and leaf 0.6 Materina sip aboveground part of the plant 0.6 Daisy flower 0.6 St John's wort flower 0.6 Lipa srdcovitá flower 0.6 Primrose spring flower 0.6 Rape a letter 0.6 Garden nail flower 0.6 Hawthorn flower 0.6 Peppermint Mint aerial part of the plant in bloom 0.6 Rose rose crown flower petals 0.6 Praslička roľná aboveground part of the plant 0.6 Pamajorán ordinary mixture of flower and leaf 0.3

N E 8166 Yl

Violet fragrant mixture of flower and leaf 0.3 Camomile flower 0.3 White nettle flower 0.3 Common ladder flower 0.2 Divozel veľkokvetý flower 0.1

2.4 g per pulverized garlic clove paste are added to the dry herb mixture, then this mixture is allowed to infuse in 1 liter of distillate with an ethanol content of 50% by volume. for 20 days. After the digestion time, the mixture is filtered. Then the extract (filtrate) is stored in a glass container.

Example 3

A dry herbal mixture is prepared according to Table 3.

Table 3

Herb name Collected part Amount (g) in dry herbal mixture House Nettle spring shoots 14.9 Raspberry blackberry foliage 8.6 Blackberry foliage 8.6 Strawberry foliage 4.1 Common spruce young additions 4.1 Willow Willow the whole aerial part of the plant in bloom 4.1 Pulmonary medicine the whole aerial part of the plant in bloom 3.5 elderberry flower 3.5 Alchemilka ordinary mixture of flower and leaf 3.5 Skorocel kopijovitý a letter 3.5 Speedwell medical the whole aerial part of the plant in bloom 3.5 Lipkavec pravý the whole aerial part of the plant in bloom 3.1 Lemon balm the whole aerial part of the plant in bloom 3.1 Coltsfoot healing mixture of flower and leaf 2.8 Materina sip the whole aerial part of the plant 2.8 Daisy flower 2.8 St John's wort flower 2.8 Lipa srdcovitá flower 2.8 Primrose spring flower 1.6 Rape a letter 1.6 Garden nail flower 1.6 Hawthorn flower 1.6 Peppermint Mint the whole aerial part of the plant in bloom 1.6 Gallic rose crown flower petals 1.6 Praslička roľná the whole aerial part of the plant 1.6 Pamajorán ordinary mixture of flower and leaf 0.9 Violet fragrant mixture of flower and leaf 0.9 Camomile flower 0.9 White nettle flower 0.9 Common ladder flower 0.6 Divozel veľkokvetý flower 0.5

N E 8166 ΥΙ

4.4 g per pulverized garlic clove paste are added to the dry herb mixture, then this mixture is allowed to infuse in 1 liter of fermented plum distillate with an ethanol content of 20% by volume. for 40 days. After the leaching time, the soot filters. Then the extract is stored in a glass container.

Example 4

Clinical investigation of the effect of the herbal extract according to the technical solution prepared according to Example 1.

The study was conducted at the Private Skin Clinic DOSTE in Svidnik, SK.

Several groups of volunteers were selected. Prior to application, it was confirmed that people had no history of allergy to herbs, food or medicine. Probands were subjected to epicutaneous testing, all with negative results

Groups with internal (oral) use of herbal extract drops according to the technical solution, total of 35 subjects (16 women, 19 men, aged 21 - 59 years), dose twice daily 10 drops, time of use 1 month.

I. Group - relapsing Herpes simplex -10 follow-ups - 6 people did not recur cold sores within 14 months, although previously the frequency was at least once a month.

In 4 people, herpes occurred rarely 1 to 2 times during the year. They consider the effect of herbal extract to be very good.

Π. Group - relapsing verrucae vulgares - 6 subjects - no recurrence of vices in 5 subjects in 15 months, dose of 10 drops twice a day, use time of 1 month, one person interrupted observation for departure abroad, information is not available.

ΠΙ. The group - patients with meteosensitivity, frequent colds and problems with HCD - 9 persons, since the beginning of use significantly improved the body's defenses according to personal opinion, were neither cold nor cold in 16 months. Dose 2 drops daily 10 drops, time of use 1 month, after 6 months of repeated use.

IV. Group - patients with recurrent manifestations of psoriasis vulgaris - seasonal occurrence in the spring and autumn of 10 subjects, since the beginning of use significantly improved the body's defenses since the beginning of the use. Dose 2 drops daily 10 drops, time of use 1 month, after 6 months of repeated use. Local corticoid-free treatment, only emollients.

Groups with topical use of the herbal extract prepared according to Example 1, a total of 25 subjects (12 women, 13 men, ages 23-55), combating the affected skin areas 2 to 3 times a day until symptoms disappear.

V. Group - relapsing Herpes simplex - 10 subjects - no recurrence of cold sores in 7 subjects over 9 months, although previously the frequency was at least once a month.

In 3 subjects, herpes appeared 1 time within 6 months. They consider the effect of the herbal extract to be very good, spontaneously demanded by the patients because of the manifestations with and calming within 3 days.

VI. The group - relapsing verrucae vulgares - 6 subjects - no warts relapsed in all subjects within 15 months, healing within 12 days.

VH. The group - verrucae planes juvenile - 3 women - after a monthly application of the extract twice a day on the forehead and cheeks, the manifestations, previously unsuccessfully treated, disappeared, no recurrence was noted.

Oral use groups of herbal extract prepared according to Example 1, a total of 25 subjects (12 women, 13 men, ages 23-55), 10 drops twice daily, 1 month use time.

VHI. The group - patients meteo sensitive, frequent colds and problems with HCD - 6 persons, since the beginning of use significantly improved in all according to personal expression of the body's defense, when the first manifestations of scraping in the throat or rhinitis occurred. they had no health problems for 3 days.

IX. Patients after chemotherapy for breast cancer, digestive tract, respiratory tract, a total of 9 persons (5 women, 4 men, mean age 39-72 years). Dose 2 drops daily 10 drops, time of use 1 month, after 3 months re-use (total 3 times). All of the monitored persons had improved their health and mental condition after one month of use and there was no negative reaction.

From the observation of a small group of people with various health problems, the use of poly-composite herbal extract according to the technical solution proved to be very effective. Undesirable general or local manifestations did not occur in any of the subjects. The use of the herbal extract according to the invention is very comfortable and efficient.

Claims (4)

PROTECTION REQUIREMENTS 1. The herbal extract is obtained by leaching: 8.6 to 14.9 g of dry spring shoots of Nettle; 2.9 to 8.6 g dry leaves of Raspberry Blackberry; 2.9 to 8.6 g of dry leaves of Blackberry; 1.7 to 4.1 g dry leaves Strawberries; 1.7 to 4.1 g dry young increments of Norway spruce; 1.7 to 4.1 g of the dry aboveground part of the Willow Willow in bloom; 1.1 to 3.5 g of the dry aerial part of the Pulmonary arboreal in bloom; 1.1 to 3.5 g dry flowers Black Baza; 1.1 to 3.5 g of a dry blend of flower and Alchemilla leaf; 1.1 to 3.5 g of dry leaves of the scorpion; 1.1 to 3.5 g of the dry aerial part of Speedwell in bloom; 0.9 to 3.1 g of the dry aerial part of the Ladybug in bloom; 0.9 to 3.1 g of dry above ground part of Melissa in bloom; 0.6 to 2.8 g of a dry mixture of flower and leaf Coltsfoot; 0.6 to 2.8 g of dry aboveground part of the Material Thistle plant; 0.6 to 2.8 g of dry flower Daisies; 0.6 to 2.8 g of dry St. John's wort; 0.6 to 2.8 g of dry linden flower; 0,6 to 1,6 g of dry flower of primroses; 0.6 to 1.6 g dry leaf of Rape; 0.6 to 1.6 g of dry flower of Calendula; 0.6 to 1.6 g dry flowering Conch thistle; 0.6 to 1.6 g of dry overhead portion of Peppermint Mint; 0.6 to 1.6 g of dry crown petals of Gallic Rose or Centennial Rose; 0.6 to 1.6 g of the dry overhead part of Pea seed; 0.3 to 0.9 g dry mixture of flower and leaf of Pamajoran; 0.3 to 0.9 g dry blend of flower and violet leaf; 0.3 to 0.9 g dry flower of Camomile; 0.3 to 0.9 g dry flower White nipples; 0.3 to 0.6 g dry flower of the Ladder; 0.1 to 0.5 g of Divozel dry flower and 2.4 to 4.4 g per pulverized garlic clove paste in 1000 ml of leaching medium containing 20% vol. up to 50% vol. ethanol. The herbal extract of claim 1 is obtained by leaching: 11.5 g of dry spring shoots of Nettle; 5.7 g dry spring leaves Raspberry Blackberries; 5.7 g of dry spring leaves Blackberry; 2,9 g dry leaves Strawberries; 2,9 g dry young increments of Norway spruce; 2.9 g of dry, above-ground part of the Willow herb in bloom; 2.3 g of dry above-ground part of the Common Mildew in bloom; 2.3 g dry flowers Black Baza; 2.3 g of a dry blend of Alchemil flower and leaf; 2.3 g dry leaves of the scorpion; 2.3 g of dry aerial part of Speedwell in bloom; 2.0 g of dry above-ground part of the Ladybug in bloom; 2,0 g of dry aerial part of Melissa in bloom; 1.7 g dry mixture of flower and leaf Coltsfoot; 1.7 g of dry aerial part of the material sip; 1,7 g dry flower Daisies; 1,7 g dry flower St John's wort; 1.7 g of dry linden flower; 1,1 g dry flower Primrose spring; 1.1 g dry leaf of Rape; 1.1 g of dry flower of Calendula; 1.1 g of dry flowering Conch thistle; 1.1 g of dry aerial part of Peppermint Mint in bloom; 1.1 g of dry crown petals of Gallic Rose or Centennial Rose; 1.1 g of the dry overhead part of Pea seed; 0,6 g dry mixture of flower and leaf of Pamajorana; 0,6 g dry mixture of flower and leaf of violet; 0,6 g dry flower Camomile; 0,6 g dry flower White nipples; 0,4 g dry flower of the Ladder; 0.3 g of dry flower of Divozel grandiflorum and 3.4 g of crushed garlic clove paste in 1000 ml of leaching medium containing 30% vol. ethanol. The herbal extract according to any one of claims 1 to 2, characterized in that the leaching medium contains 30 to 40% by volume. ethanol. The herbal extract according to any one of claims 1 to 3, for use for oral and / or topical application. End of document