WO2003022294A2 - Extrait obtenu a partir de artemisia abrotanum l. (aurone) - Google Patents

Extrait obtenu a partir de artemisia abrotanum l. (aurone) Download PDF

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Publication number
WO2003022294A2
WO2003022294A2 PCT/EP2002/010203 EP0210203W WO03022294A2 WO 2003022294 A2 WO2003022294 A2 WO 2003022294A2 EP 0210203 W EP0210203 W EP 0210203W WO 03022294 A2 WO03022294 A2 WO 03022294A2
Authority
WO
WIPO (PCT)
Prior art keywords
aqueous
extract
percolation
parts
liquids
Prior art date
Application number
PCT/EP2002/010203
Other languages
German (de)
English (en)
Other versions
WO2003022294A3 (fr
Inventor
Josef Beuth
Horst Mayer
Hong Lioe Ko
Original Assignee
Josef Beuth
Horst Mayer
Ko P
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Josef Beuth, Horst Mayer, Ko P filed Critical Josef Beuth
Publication of WO2003022294A2 publication Critical patent/WO2003022294A2/fr
Publication of WO2003022294A3 publication Critical patent/WO2003022294A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282—Artemisia, e.g. wormwood or sagebrush
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

Definitions

  • the present invention relates to an extract obtainable by percolation of above-ground parts of plants from Artemisia abrotanum L. (Eberraute) with aqueous or aqueous-alcoholic liquids, a process for its preparation, a medicament containing the extract according to the invention and certain indications of the medicament according to the invention.
  • the boar diamond Artemisia abrotanum
  • the boar diamond is a plant that is also native to Germany and is traditionally used as a medicinal plant in folk medicine. Teas or tinctures of this plant are usually used. Areas of application are treatment of weight loss and development disorders in children, non-specific chronic inflammation, skin diseases, rheumatism and gout.
  • an extract of the boar diamond is effective as a medicine against viral and bacterial infections.
  • the present invention therefore relates to an extract which can be obtained by percolating above-ground parts of Artemisia abrotanum L. plants (Eberraute) with aqueous or aqueous-alcoholic liquids, optionally followed by drying the extract obtained with aqueous or aqueous-alcoholic liquids.
  • aqueous or aqueous-alcoholic liquids By drying the liquid extract obtained by percolation, solid, in particular powder, can be obtained.
  • the latter can be mixed with carriers and formulated in conventional pharmaceutical preparations. These include e.g. Tablets, dragees, capsules.
  • liquid extracts are also suitable for use, but can also be mixed with liquids customary in pharmaceutical technology for the purpose of dilution or to facilitate administration.
  • the extract according to the invention is preferably obtainable by percolation of dried aerial parts of the mountain rose plants.
  • the process according to the invention for producing the extract of Artemisia abrotanum L. (Eberraute) according to the invention comprises the following steps:
  • the extraction is preferably carried out with hot liquids.
  • water or mixtures of ethanol / water are used as liquids in the process according to the invention.
  • Percolation is preferably carried out with dried
  • the invention also relates to a medicament containing the extract according to the invention.
  • the medicament according to the invention is particularly suitable for the treatment of viral and / or bacterial infectious diseases.
  • the invention furthermore relates to a use of the extract according to the invention for the production of a medicament for the treatment of viral and / or bacterial infectious diseases.
  • infectious diseases are based in particular on infections with herpes simplex I and II viruses, hepatitis B and C viruses, rota- / entero viruses, the cytomegalovirus, the Epstein-Barr virus, RS viruses, chlamydia, ureaplasmas , Legionella, mycoplasma or combinations thereof.
  • herpes simplex I and II viruses hepatitis B and C viruses
  • rota- / entero viruses the cytomegalovirus
  • the Epstein-Barr virus Epstein-Barr virus
  • RS viruses chlamydia
  • ureaplasmas ureaplasmas
  • Legionella mycoplasma or combinations thereof.
  • Dried boarwood plants were treated by percolation in a manner known per se.
  • the ratio of the parts of the boar diamond: extractant dried above ground was 4: 1 (w / w).
  • the extractant was water.
  • the extraction was carried out at temperatures between 80 ° C and 100 ° C for a period of up to 4 minutes.
  • Berber diamond extract according to Example 1 was administered for the treatment / prophylaxis of herpes simplex (H.s.) hand infections in carers at dialysis wards.
  • Dialysis nurses / nurses often suffer from herpes simplex hand infections, due to regular mandatory local disinfection measures.
  • the subjects (n 15) suffered from florid, recurrent hand infections and drank a cup of mountain rose extract twice a day. All subjects could not become virus-free with virus-free therapy using standard antiviral therapy.

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

La présente invention concerne un extrait obtenu par percolation de morceaux de végétaux aériens de Artemisia abrotanum L. (aurone) avec des liquides aqueux ou aqueux-alcooliques, éventuellement suivie du séchage de l'extrait obtenu avec les liquides aqueux ou aqueux-alcooliques. Cet extrait peut être utilisé en tant que produit pharmaceutique pour traiter des infections.
PCT/EP2002/010203 2001-09-11 2002-09-11 Extrait obtenu a partir de artemisia abrotanum l. (aurone) WO2003022294A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10144765A DE10144765A1 (de) 2001-09-11 2001-09-11 Extrakt erhältlich aus Artemisia abrotanum L. (Eberraute)
DE10144765.5 2001-09-11

Publications (2)

Publication Number Publication Date
WO2003022294A2 true WO2003022294A2 (fr) 2003-03-20
WO2003022294A3 WO2003022294A3 (fr) 2003-09-12

Family

ID=7698661

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/010203 WO2003022294A2 (fr) 2001-09-11 2002-09-11 Extrait obtenu a partir de artemisia abrotanum l. (aurone)

Country Status (2)

Country Link
DE (1) DE10144765A1 (fr)
WO (1) WO2003022294A2 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2890312A1 (fr) * 2005-09-02 2007-03-09 Limousine D Applic Biolog Dite Procede d'obtention d'un principe actif repulpant, principe actif obtenu et compositions cosmetiques l'incluant
WO2011140224A1 (fr) * 2010-05-07 2011-11-10 Johnson & Johnson Consumer Companies, Inc. Extraits d'aurone mâle et utilisations topiques de ceux-ci
WO2011140226A3 (fr) * 2010-05-07 2012-01-05 Johnson &Johnson Consumer Companies, Inc. Compositions comprenant des extraits d'aurone mâle et un composé amine
WO2015030567A1 (fr) * 2013-08-30 2015-03-05 Zamarripa Blas Juan Alberto Améliorations apportées à une formulation auxiliaire pour contrecarrer les effets indésirables de traitements contre le cancer et de traitements contre certaines maladies virales

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3000521A1 (de) * 1979-01-10 1980-07-24 Kitasato Inst Substanz mit interferon induzierender aktivitaet sowie verfahren zu ihrer herstellung

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9104286D0 (en) * 1991-02-28 1991-04-17 Phytopharm Ltd Pharmaceutical compositions for the treatment of skin disorders
DE4131313A1 (de) * 1991-09-20 1993-03-25 Karl Konrad Arzneimittel aus kamillenblueten

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3000521A1 (de) * 1979-01-10 1980-07-24 Kitasato Inst Substanz mit interferon induzierender aktivitaet sowie verfahren zu ihrer herstellung

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DATABASE BIOSIS [Online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1989 ZHENG M: "AN EXPERIMENTAL STUDY OF THE ANTI-HSV-II ACTION OF 500 HERBAL DRUGS" Database accession no. PREV199089046061 XP002158932 & JOURNAL OF TRADITIONAL CHINESE MEDICINE, Bd. 9, Nr. 2, 1989, Seiten 113-116, ISSN: 0254-6272 *
DATABASE BIOSIS [Online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1995 BERGENDROFF OLA ET AL: "Spasmolytic flavonols from Artemisia abrotanum." Database accession no. PREV199598457072 XP002237541 & PLANTA MEDICA, Bd. 61, Nr. 4, 1995, Seiten 370-371, ISSN: 0032-0943 *
DATABASE BIOSIS [Online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1999 DULGER BASARAN ET AL: "Antimicrobial activity of Artemisia absinthium L." Database accession no. PREV199900284070 XP002237543 & TURKISH JOURNAL OF BIOLOGY, Bd. 23, Nr. 3, 1999, Seiten 377-384, ISSN: 1300-0152 *
DATABASE EMBASE [Online] ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL; 1990 CUBUKCU B ET AL: "In vitro antimalarial activity of crude extracts and compounds from Artemisia abrotanum L" Database accession no. EMB-1990364749 XP002237540 & PHYTOTHERAPY RESEARCH 1990 UNITED KINGDOM, Bd. 4, Nr. 5, 1990, Seiten 203-204, ISSN: 0951-418X *
DATABASE MEDLINE [Online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; Januar 1990 (1990-01) ZHENG M: "ÄExperimental study of 472 herbs with antiviral action against the herpes simplex virus]" Database accession no. NLM2161714 XP002237542 & ZHONG YI YAN JIU YUAN, ZHU BAN. CHINA JAN 1990, Bd. 10, Nr. 1, Januar 1990 (1990-01), Seiten 39-41, 46, ISSN: 0254-9034 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2890312A1 (fr) * 2005-09-02 2007-03-09 Limousine D Applic Biolog Dite Procede d'obtention d'un principe actif repulpant, principe actif obtenu et compositions cosmetiques l'incluant
WO2011140224A1 (fr) * 2010-05-07 2011-11-10 Johnson & Johnson Consumer Companies, Inc. Extraits d'aurone mâle et utilisations topiques de ceux-ci
WO2011140226A3 (fr) * 2010-05-07 2012-01-05 Johnson &Johnson Consumer Companies, Inc. Compositions comprenant des extraits d'aurone mâle et un composé amine
US8722113B2 (en) 2010-05-07 2014-05-13 Johnson & Johnson Consumer Companies, Inc. Compositions comprising extracts of southernwood and an amine compound
WO2015030567A1 (fr) * 2013-08-30 2015-03-05 Zamarripa Blas Juan Alberto Améliorations apportées à une formulation auxiliaire pour contrecarrer les effets indésirables de traitements contre le cancer et de traitements contre certaines maladies virales

Also Published As

Publication number Publication date
WO2003022294A3 (fr) 2003-09-12
DE10144765A1 (de) 2003-04-30

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