CN108186882A - 皮肤抑菌中药组合物及其制备方法 - Google Patents
皮肤抑菌中药组合物及其制备方法 Download PDFInfo
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- CN108186882A CN108186882A CN201810102797.4A CN201810102797A CN108186882A CN 108186882 A CN108186882 A CN 108186882A CN 201810102797 A CN201810102797 A CN 201810102797A CN 108186882 A CN108186882 A CN 108186882A
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Abstract
本发明涉及一种皮肤抑菌中药组合物及其制备方法。原料包括樟脑、艾叶、蜈蚣、大黄、荆芥、花椒、全蝎、蒺藜、金银花、石蒜、蛇床子、槐花、大飞扬草、三百草、石榴皮、五味子、黄精、野菊花、半枝莲、松香、冰片、白芍、薄荷、夜交藤、苍术、川椒、车前草、马兰根、斑蝥、地肤子、白鲜皮和青黛。制备方法:将各原料组分洗净后粉碎,之后用水提取,过滤并收集滤液;将滤液浓缩成浸膏,得到中药组合物。本发明中药组合物具有优异的清热除湿、消风止痒、消疹清凉以及祛除体内外湿热之邪等功效,其能够显著改善皮肤癣症、痤疮、冻疮等病症,且安全无毒副作用;此外,本发明提供的中药组合物使用方便,成本较低,具有很好的商业前景。
Description
技术领域
本发明涉及中草药技术领域,具体涉及一种皮肤抑菌中药组合物及其制备方法。
背景技术
皮肤病,尤其是由真菌引起的癣症、皮炎,油脂性皮肤人容易发的痤疮,冻疮等病症,使患者痒痛难忍,带来皮肉痛苦,既影响正常的工作,又影响社交活动的正常进行,特别是痤疮给患者脸上留下色斑和疤痕甚至影响到就业找工作,更是在精神上带来痛苦。
人体表面覆盖的皮肤和粘膜作为人体抵抗外部致病微生物侵袭的防线,创伤发生时易被感染,进而引发瘙痒、红肿、疼痛等各种问题。目前市场上销售的皮肤病药物种类很多,但效果多不甚理想,或者有明显的刺激性,使用不舒适;而且大多含皮质类固醇激素成分,使用后容易产生皮肤角化发硬、脱皮、粗糙开裂、褐色素沉着、皮肤弹性变差等问题。
基于此,研究一种新型的、安全无毒副作用且可以有效的防治各类皮肤病的光谱类药物具有非常重要的意义。
发明内容
针对现有技术中的缺陷,本发明旨在提供一种皮肤抑菌中药组合物及其制备方法。本发明提供的中药组合物具有优异的清热除湿、消风止痒、消疹清凉以及祛除体内外湿热之邪等功效,其能够显著改善皮肤癣症、痤疮、冻疮等病症,且安全无毒副作用;此外,本发明提供的中药组合物使用方便,成本较低,具有很好的商业前景。
为此,本发明提供如下技术方案:
第一方面,本发明提供一种皮肤抑菌中药组合物,原料组分按重量份计,包括:樟脑20~30重量份、艾叶50~70重量份、蜈蚣10~20重量份、大黄10~20重量份、荆芥30~60重量份、花椒5~10重量份、全蝎5~10重量份、蒺藜10~150重量份、金银花20~25重量份、石蒜10~20重量份、蛇床子5~10重量份、槐花5~10重量份、大飞扬草20~30重量份、三百草10~15重量份、石榴皮10~15重量份、五味子30~50重量份、黄精10~15重量份、野菊花40~60重量份、半枝莲10~15重量份、松香10~20重量份、冰片10~20重量份、白芍10~20重量份、薄荷10~15重量份、夜交藤10~20重量份、苍术5~10重量份、川椒10~20重量份和车前草10~20重量份。
优选地,原料组分还包括:马兰根10~25重量份、斑蝥10~15重量份、地肤子10~15重量份、白鲜皮10~15重量份和青黛20~25重量份。
优选地,该中药组合物由下述原料组分制成:樟脑25重量份、艾叶60重量份、蜈蚣15重量份、大黄15重量份、荆芥50重量份、花椒8重量份、全蝎8重量份、蒺藜50重量份、金银花23重量份、石蒜15重量份、蛇床子8重量份、槐花8重量份、大飞扬草25重量份、三百草12重量份、石榴皮13重量份、五味子40重量份、黄精12重量份、野菊花50重量份、半枝莲13重量份、松香15重量份、冰片16重量份、白芍15重量份、薄荷12重量份、夜交藤18重量份、苍术8重量份、川椒15重量份、车前草15重量份、马兰根20重量份、斑蝥13重量份、地肤子12重量份、白鲜皮12重量份和青黛23重量份。
优选地,该中药组合物由下述原料组分制成:樟脑30重量份、艾叶50重量份、蜈蚣10重量份、大黄20重量份、荆芥30重量份、花椒10重量份、全蝎5重量份、蒺藜150重量份、金银花20重量份、石蒜20重量份、蛇床子5重量份、槐花10重量份、大飞扬草20重量份、三百草15重量份、石榴皮10重量份、五味子50重量份、黄精10重量份、野菊花60重量份、半枝莲10重量份、松香20重量份、冰片10重量份、白芍20重量份、薄荷10重量份、夜交藤20重量份、苍术5重量份、川椒20重量份、车前草10重量份、马兰根25重量份、斑蝥10重量份、地肤子15重量份、白鲜皮10重量份和青黛25重量份。
第二方面,本发明提供一种中药组合物的制备方法,包括以下步骤:按照配比称取各原料组分,将其洗净后粉碎至200~300目,之后用水进行提取,过滤,收集滤液;将滤液浓缩成70℃时相对密度为1.10~1.20的浸膏,得到中药组合物。
优选地,提取为回流提取,且回流提取的温度为75℃~85℃,提取次数为1~3次,每次提取的时间为150min~300min。
优选地,回流提取时,加入的水量为原料组分总质量的10~20倍。
需要说明的是,上述方法制备的中药组合物可根据需要进一步制备成药学上可接受的剂型。此外,以上述中药组合物为活性成分制成的药物也属于本发明的保护范围。通过将上述中药组合物,直接制备或者加入药学上可接受的辅料后制备,可制成任何药学上可接受的剂型。以外用制剂为例包括:溶液剂、贴剂、酒剂、酊剂、凝胶剂、搽剂、气雾剂、喷雾剂、软膏剂、栓剂和涂膜剂。上述各种剂型的药物均可以按照药学领域的常规方法制备。在临床应用中,本发明提供的中药组合物的用量一般为每次3g,每天三次。
第三方面,本发明提供的中药组合物在制备皮肤抑菌药物和/或药物添加剂中的应用。
本发明的上述技术方案相比现有技术具有以下优点:
(1)申请人经过大量研究发现:本发明提供的中药组合物具有优异的清热除湿、消风止痒、消疹清凉以及祛除体内外湿热之邪等功效,其能够显著改善皮肤癣症、痤疮、冻疮等病症,且安全无毒副作用;此外,本发明提供的中药组合物使用方便,成本较低,具有很好的商业前景。
(2)采用本发明提供的制备方法,能够在最大限度的保留各原料药活性成分的同时,可以把各原料药材中的有效成分充分释放出来,从而使最终制备得到的中药组合物不仅具有很好的药效,且易于吸收,进而快速达到改善脂肪肝的目的。
本发明的附加方面和优点将在下面的描述中部分给出,部分将从下面的描述中变得明显,或通过本发明的实践了解到。
具体实施方式
下面将对本发明技术方案的实施例进行详细的描述。以下实施例仅用于更加清楚的说明本发明的技术方案,因此只作为实例,而不能以此来限制本发明的保护范围。
下述实施例中的实验方法,如无特殊说明,均为常规方法。
下述实施例中所用的试验材料,如无特殊说明,均为自常规试剂商店购买得到的。
以下实施例中的定量试验,均设置三次重复实验,数据为三次重复实验的平均值或平均值±标准差。
下述实施例中所用的樟脑、艾叶、蜈蚣、大黄、荆芥、花椒、全蝎、蒺藜、金银花、石蒜、蛇床子、槐花、大飞扬草、三百草、石榴皮、五味子、黄精、野菊花、半枝莲、松香、冰片、白芍、薄荷、夜交藤、苍术、川椒、车前草、马兰根、斑蝥、地肤子、白鲜皮和青黛均符合中国药典(2016年版)一部正文各药材项下的有关规定。投料前,通过鉴定,各味药材实物与名称相符,质量符合标准。
本发明提供一种皮肤抑菌中药组合物,其特征在于,原料组分按重量份计,包括:樟脑20~30重量份、艾叶50~70重量份、蜈蚣10~20重量份、大黄10~20重量份、荆芥30~60重量份、花椒5~10重量份、全蝎5~10重量份、蒺藜10~150重量份、金银花20~25重量份、石蒜10~20重量份、蛇床子5~10重量份、槐花5~10重量份、大飞扬草20~30重量份、三百草10~15重量份、石榴皮10~15重量份、五味子30~50重量份、黄精10~15重量份、野菊花40~60重量份、半枝莲10~15重量份、松香10~20重量份、冰片10~20重量份、白芍10~20重量份、薄荷10~15重量份、夜交藤10~20重量份、苍术5~10重量份、川椒10~20重量份和车前草10~20重量份。其中,原料组分优选还包括:马兰根10~25重量份、斑蝥10~15重量份、地肤子10~15重量份、白鲜皮10~15重量份和青黛20~25重量份。
另外,针对本发明的中药组合物,本发明专门设计了制备方法,包括以下步骤:
按照配比称取各原料组分,将其洗净后粉碎至200~300目,之后用水进行提取,过滤,收集滤液;将滤液浓缩成70℃时相对密度为1.10~1.20的浸膏,得到中药组合物。其中,提取为回流提取,且回流提取的温度为75℃~85℃,提取次数为1~3次,每次提取的时间为150min~300min;且回流提取时,加入的水量为原料组分总质量的10~20倍。
下面结合具体实施方式进行说明:
实施例一
本实施例提供一种皮肤抑菌中药组合物,由下述原料组分制备而成:樟脑25重量份、艾叶60重量份、蜈蚣15重量份、大黄15重量份、荆芥50重量份、花椒8重量份、全蝎8重量份、蒺藜50重量份、金银花23重量份、石蒜15重量份、蛇床子8重量份、槐花8重量份、大飞扬草25重量份、三百草12重量份、石榴皮13重量份、五味子40重量份、黄精12重量份、野菊花50重量份、半枝莲13重量份、松香15重量份、冰片16重量份、白芍15重量份、薄荷12重量份、夜交藤18重量份、苍术8重量份、川椒15重量份和车前草15重量份。
按上述原料组分,采用本发明的制备方法,制备中药组合物:
按照配比称取各原料组分,将其洗净后粉碎至300目,之后用水进行提取,过滤,收集滤液;将滤液浓缩成70℃时相对密度为1.15的浸膏,得到中药组合物。其中,回流提取的温度为80℃,加入的水量为原料组分总质量的15倍,提取次数为3次,每次提取的时间为200min。
实施例二
本实施例提供一种皮肤抑菌中药组合物,由下述原料组分制备而成:樟脑30重量份、艾叶50重量份、蜈蚣10重量份、大黄20重量份、荆芥30重量份、花椒10重量份、全蝎5重量份、蒺藜150重量份、金银花20重量份、石蒜20重量份、蛇床子5重量份、槐花10重量份、大飞扬草20重量份、三百草15重量份、石榴皮10重量份、五味子50重量份、黄精10重量份、野菊花60重量份、半枝莲10重量份、松香20重量份、冰片10重量份、白芍20重量份、薄荷10重量份、夜交藤20重量份、苍术5重量份、川椒20重量份和车前草10重量份。
按上述原料组分,采用本发明的制备方法,制备中药组合物:
按照配比称取各原料组分,将其洗净后粉碎至300目,之后用水进行回流提取,过滤,收集滤液;将滤液浓缩成70℃时相对密度为1.20的浸膏,得到中药组合物。其中,回流提取的温度为75℃,加入的水量为原料组分总质量的20倍,提取次数为3次,每次提取的时间为300min。
实施例三
本实施例提供一种皮肤抑菌中药组合物,由下述原料组分制备而成:樟脑25重量份、艾叶60重量份、蜈蚣15重量份、大黄15重量份、荆芥50重量份、花椒8重量份、全蝎8重量份、蒺藜50重量份、金银花23重量份、石蒜15重量份、蛇床子8重量份、槐花8重量份、大飞扬草25重量份、三百草12重量份、石榴皮13重量份、五味子40重量份、黄精12重量份、野菊花50重量份、半枝莲13重量份、松香15重量份、冰片16重量份、白芍15重量份、薄荷12重量份、夜交藤18重量份、苍术8重量份、川椒15重量份、车前草15重量份、马兰根20重量份、斑蝥13重量份、地肤子12重量份、白鲜皮12重量份和青黛23重量份。
按上述原料组分,采用本发明的制备方法,制备中药组合物:
按照配比称取各原料组分,将其洗净后粉碎至300目,之后用水进行提取,过滤,收集滤液;将滤液浓缩成70℃时相对密度为1.15的浸膏,得到中药组合物。其中,回流提取的温度为80℃,加入的水量为原料组分总质量的15倍,提取次数为3次,每次提取的时间为200min。
实施例四
本实施例提供一种皮肤抑菌中药组合物,由下述原料组分制备而成:樟脑30重量份、艾叶50重量份、蜈蚣10重量份、大黄20重量份、荆芥30重量份、花椒10重量份、全蝎5重量份、蒺藜150重量份、金银花20重量份、石蒜20重量份、蛇床子5重量份、槐花10重量份、大飞扬草20重量份、三百草15重量份、石榴皮10重量份、五味子50重量份、黄精10重量份、野菊花60重量份、半枝莲10重量份、松香20重量份、冰片10重量份、白芍20重量份、薄荷10重量份、夜交藤20重量份、苍术5重量份、川椒20重量份、车前草10重量份、马兰根25重量份、斑蝥10重量份、地肤子15重量份、白鲜皮10重量份和青黛25重量份。
按上述原料组分,采用本发明的制备方法,制备中药组合物:
按照配比称取各原料组分,将其洗净后粉碎至300目,之后用水进行回流提取,过滤,收集滤液;将滤液浓缩成70℃时相对密度为1.20的浸膏,得到中药组合物。其中,回流提取的温度为75℃,加入的水量为原料组分总质量的20倍,提取次数为3次,每次提取的时间为300min。
另外,为了更好的评价各实施例的功效,进行以下实验:
一、毒性试验
选2~3kg的白色家兔40只(雌雄各20只),家兔背部去毛露出外表皮,去毛范围3cm×3cm,取本发明中药组合物5g,涂抹在家兔的外表皮上,每日两次;观察15天,间隔5天后重做一次过敏试验,两次试验后观察,外表皮上未发现红斑;家兔食欲、呼吸、肤色均无任何异常。由此证明,本发明提供的中药组合物外用时皮肤反应正常,无致敏性现象。
二、体外抑菌试验
取1g本发明提供的化妆品,接种痤疮丙酸杆菌,使产品中痤疮丙酸杆菌的浓度达到1×106CFU/g,每6天取样,采用平板计数法检测产品中菌落数,结果如下表1所示。由此可见,6天后,痤疮丙酸杆菌的总菌数能维持在60CFU/g以下,由此证明本发明制备的化妆品可以有效的抑制痤疮丙酸杆菌的生长。
表1各实施例抑菌效果列表,各菌种单位为CFU/g
三、临床试验
根据本发明技术方案得到的中药组合物具有优异的改善皮肤癣症、痤疮、冻疮等作用,下面是几个使用本产品的病例:
1、陈某,男,30岁,油性皮肤,经常发痤疮。患者经常挤痤疮中的堵塞毛孔的脂肪粒,使得满背的痤疮包块又红又肿,反复发作。试用本发明中药组合物涂抹背部痤疮,一天两次,10天后痤疮红肿消退,包块消失,且观察半年无复发。
2、孙某,女,25岁,脸部严重痤疮反复发炎,发炎处红肿、胀痛难忍,涂抹/内服市售药物数年无效果。试用本发明中药组合物涂抹脸部痤疮,一天两次,7天后痤疮红肿消退,且观察两年无复发。
3、张某,女,49岁,绝经后皮肤干燥,出现黄褐斑和皱纹,使用市售诸多护肤品无明显改善。试用本发明中药组合物涂抹面部皮肤,皮肤细腻光滑,且黄褐斑变淡。
当然,除了实施例一至实施例四列举的情况,其他原料组分的种类和重量百分比、制备过程中的条件和参数等也是可以的。
本发明提供的中药组合物具有优异的清热除湿、消风止痒、消疹清凉以及祛除体内外湿热之邪等功效,其能够显著改善皮肤癣症、痤疮、冻疮等病症,且安全无毒副作用;此外,本发明提供的中药组合物使用方便,成本较低,具有很好的商业前景。
在本说明书的描述中,需要理解的是,参考术语“一个实施例”、“一些实施例”、“示例”、“具体示例”、或“一些示例”等的描述意指结合该实施例或示例描述的具体特征、结构、材料或者特点包含于本发明的至少一个实施例或示例中。在本说明书中,对上述术语的示意性表述不必须针对的是相同的实施例或示例。而且,描述的具体特征、结构、材料或者特点可以在任一个或多个实施例或示例中以合适的方式结合。此外,在不相互矛盾的情况下,本领域的技术人员可以将本说明书中描述的不同实施例或示例以及不同实施例或示例的特征进行结合和组合。
尽管上面已经示出和描述了本发明的实施例,可以理解的是,上述实施例是示例性的,不能理解为对本发明的限制,本领域的普通技术人员在本发明的范围内可以对上述实施例进行变化、修改、替换和变型。
Claims (8)
1.一种皮肤抑菌中药组合物,其特征在于,原料组分按重量份计,包括:
樟脑20~30重量份、艾叶50~70重量份、蜈蚣10~20重量份、大黄10~20重量份、荆芥30~60重量份、花椒5~10重量份、全蝎5~10重量份、蒺藜10~150重量份、金银花20~25重量份、石蒜10~20重量份、蛇床子5~10重量份、槐花5~10重量份、大飞扬草20~30重量份、三百草10~15重量份、石榴皮10~15重量份、五味子30~50重量份、黄精10~15重量份、野菊花40~60重量份、半枝莲10~15重量份、松香10~20重量份、冰片10~20重量份、白芍10~20重量份、薄荷10~15重量份、夜交藤10~20重量份、苍术5~10重量份、川椒10~20重量份和车前草10~20重量份。
2.根据权利要求1所述的皮肤抑菌中药组合物,其特征在于,还包括:
马兰根10~25重量份、斑蝥10~15重量份、地肤子10~15重量份、白鲜皮10~15重量份和青黛20~25重量份。
3.根据权利要求2所述的皮肤抑菌中药组合物,其特征在于,由下述原料组分制成:
樟脑25重量份、艾叶60重量份、蜈蚣15重量份、大黄15重量份、荆芥50重量份、花椒8重量份、全蝎8重量份、蒺藜50重量份、金银花23重量份、石蒜15重量份、蛇床子8重量份、槐花8重量份、大飞扬草25重量份、三百草12重量份、石榴皮13重量份、五味子40重量份、黄精12重量份、野菊花50重量份、半枝莲13重量份、松香15重量份、冰片16重量份、白芍15重量份、薄荷12重量份、夜交藤18重量份、苍术8重量份、川椒15重量份、车前草15重量份、马兰根20重量份、斑蝥13重量份、地肤子12重量份、白鲜皮12重量份和青黛23重量份。
4.根据权利要求2所述的皮肤抑菌中药组合物,其特征在于,由下述原料组分制成:
樟脑30重量份、艾叶50重量份、蜈蚣10重量份、大黄20重量份、荆芥30重量份、花椒10重量份、全蝎5重量份、蒺藜150重量份、金银花20重量份、石蒜20重量份、蛇床子5重量份、槐花10重量份、大飞扬草20重量份、三百草15重量份、石榴皮10重量份、五味子50重量份、黄精10重量份、野菊花60重量份、半枝莲10重量份、松香20重量份、冰片10重量份、白芍20重量份、薄荷10重量份、夜交藤20重量份、苍术5重量份、川椒20重量份、车前草10重量份、马兰根25重量份、斑蝥10重量份、地肤子15重量份、白鲜皮10重量份和青黛25重量份。
5.权利要求1~4任一项所述的中药组合物的制备方法,其特征在于,包括以下步骤:
按照配比称取各原料组分,将其洗净后粉碎至200~300目,之后用水进行提取,过滤,收集滤液;将所述滤液浓缩成70℃时相对密度为1.10~1.20的浸膏,得到所述中药组合物。
6.权利要求5所述的中药组合物的制备方法,其特征在于:
所述提取为回流提取,且所述回流提取的温度为75℃~85℃,提取次数为1~3次,每次提取的时间为150min~300min。
7.权利要求6所述的中药组合物的制备方法,其特征在于:
所述回流提取时,加入的水量为所述原料组分总质量的10~20倍。
8.权利要求1~4任一项所述的中药组合物在制备皮肤抑菌药物和/或药物添加剂中的应用。
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CN110755477A (zh) * | 2019-11-29 | 2020-02-07 | 中国科学院新疆理化技术研究所 | 一种小裂叶荆芥精油和石榴皮有效组分组合物的用途 |
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CN110755477A (zh) * | 2019-11-29 | 2020-02-07 | 中国科学院新疆理化技术研究所 | 一种小裂叶荆芥精油和石榴皮有效组分组合物的用途 |
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