WO2003018837A3 - Verfahren und diagnosekit zur molekularen diagnostik pharmakologisch relevanter gene - Google Patents

Verfahren und diagnosekit zur molekularen diagnostik pharmakologisch relevanter gene Download PDF

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Publication number
WO2003018837A3
WO2003018837A3 PCT/EP2002/009386 EP0209386W WO03018837A3 WO 2003018837 A3 WO2003018837 A3 WO 2003018837A3 EP 0209386 W EP0209386 W EP 0209386W WO 03018837 A3 WO03018837 A3 WO 03018837A3
Authority
WO
WIPO (PCT)
Prior art keywords
diagnostic kit
oligonucleotides
molecular diagnosis
relevant genes
pharmacologically relevant
Prior art date
Application number
PCT/EP2002/009386
Other languages
English (en)
French (fr)
Other versions
WO2003018837A2 (de
Inventor
Stefanie Waschuetza
Eckart Schnakenberg
Michael Lustig
Original Assignee
Adnagen Ag
Stefanie Waschuetza
Eckart Schnakenberg
Michael Lustig
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10140651A external-priority patent/DE10140651A1/de
Priority claimed from DE2002119373 external-priority patent/DE10219373A1/de
Application filed by Adnagen Ag, Stefanie Waschuetza, Eckart Schnakenberg, Michael Lustig filed Critical Adnagen Ag
Publication of WO2003018837A2 publication Critical patent/WO2003018837A2/de
Publication of WO2003018837A3 publication Critical patent/WO2003018837A3/de

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B01J2219/00529—DNA chips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00608—DNA chips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Physiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Die vorliegende Erfindung betrifft ein Diagnose-Kit und ein Verfahren zur Bestimmung der Medikamentenverträglichkeit eines Menschen. Das Diagnose-Kit enthält mindestens zwei Paare Oligonukleotide (Reversprimer, Forwardprimer), wobei die beiden Oligonukleotide jedes Paares als Primer zur Amplifikation mittels Polymerasekettenreaktion jeweils eines der beiden komplementären Stränge eines gesuchten DNS-Abschnittes geeignet sind. Der jeweils einem Paar Oligonukleotide zugeordnete gesuchte DNS-Abschnitt ist dabei Teil des Gens eines der menschlichen Enzyme der Phase I und/oder Phase II des Entgiftungsstoffwechsels.
PCT/EP2002/009386 2001-08-24 2002-08-22 Verfahren und diagnosekit zur molekularen diagnostik pharmakologisch relevanter gene WO2003018837A2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE10140651A DE10140651A1 (de) 2001-08-24 2001-08-24 Verfahren zur chipbasierenden SNP-Diagnostik der N-Acetyltransferase 2 (NAT2) der in thiopurine S-Methyltransferase und des Cytochroms P450 3A4
DE10140651.7 2001-08-24
DE10219373.8 2002-04-30
DE2002119373 DE10219373A1 (de) 2002-04-30 2002-04-30 Verfahren und Diagnosekit zur molekularen Diagnostik pharmakologisch relevanter Gene

Publications (2)

Publication Number Publication Date
WO2003018837A2 WO2003018837A2 (de) 2003-03-06
WO2003018837A3 true WO2003018837A3 (de) 2004-01-08

Family

ID=26009961

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/009386 WO2003018837A2 (de) 2001-08-24 2002-08-22 Verfahren und diagnosekit zur molekularen diagnostik pharmakologisch relevanter gene

Country Status (1)

Country Link
WO (1) WO2003018837A2 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1308462C (zh) * 2003-09-22 2007-04-04 周宏灏 个体化用药基因型诊断芯片及其制造方法和应用方法
WO2006008632A2 (en) * 2004-07-15 2006-01-26 Council Of Scientific And Industrial Research Novel allelic variant of cyp2c19 associated with drug metabolism
FR2884257B1 (fr) * 2005-04-12 2010-11-26 Centre Regional De Lutte Contre Le Cancer Dangers Prevention des toxicites dues au 5-fluorouracile
CN107574239A (zh) * 2017-10-25 2018-01-12 广州和康医疗技术有限公司 一种检测硫嘌呤药物snp位点基因型的检测方法及试剂盒

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000024926A1 (en) * 1998-10-23 2000-05-04 Signalgene Detection of cyp1a1, cyp3a4, cyp2d6 and nat2 variants and therapeutic uses thereof
US6140054A (en) * 1998-09-30 2000-10-31 University Of Utah Research Foundation Multiplex genotyping using fluorescent hybridization probes
WO2001027327A2 (en) * 1999-10-08 2001-04-19 Protogene Laboratories, Inc. Method and apparatus for performing large numbers of reactions using array assembly
WO2001066804A2 (en) * 2000-03-09 2001-09-13 Protogene Laboratories, Inc. Methods for optimizing hybridization performance of polynucleotide probes and localizing and detecting sequence variations
WO2001073118A2 (en) * 2000-03-29 2001-10-04 Lgc (Teddington) Limited Hybridisation beacon and method of rapid sequence detection and discrimination

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6140054A (en) * 1998-09-30 2000-10-31 University Of Utah Research Foundation Multiplex genotyping using fluorescent hybridization probes
WO2000024926A1 (en) * 1998-10-23 2000-05-04 Signalgene Detection of cyp1a1, cyp3a4, cyp2d6 and nat2 variants and therapeutic uses thereof
WO2001027327A2 (en) * 1999-10-08 2001-04-19 Protogene Laboratories, Inc. Method and apparatus for performing large numbers of reactions using array assembly
WO2001066804A2 (en) * 2000-03-09 2001-09-13 Protogene Laboratories, Inc. Methods for optimizing hybridization performance of polynucleotide probes and localizing and detecting sequence variations
WO2001073118A2 (en) * 2000-03-29 2001-10-04 Lgc (Teddington) Limited Hybridisation beacon and method of rapid sequence detection and discrimination

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BLOEMEKE B ET AL: "IDENTIFICATION OF N-ACETYLTRANSFERASE 2 GENOTYPES BY CONTINUOUS MONITORING OF FLUOROGENIC HYBRIDIZATION PROBES", ANALYTICAL BIOCHEMISTRY, ORLANDO, FL, US, vol. 275, no. 1, 1999, pages 93 - 97, XP000874148, ISSN: 0003-2697 *
DEGUCHI T: "SEQUENCES AND EXPRESSION OF ALLELES OF POLYMORPHIC ARYLAMINE N-ACETYLTRANSFERASE OF HUMAN LIVER", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 267, no. 25, 1992, pages 18140 - 18147, XP002252774, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
WO2003018837A2 (de) 2003-03-06

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