WO2001081621A3 - Verfahren, diagnose-kit und mikroarray zur bestimmung des rhesus-faktors - Google Patents

Verfahren, diagnose-kit und mikroarray zur bestimmung des rhesus-faktors Download PDF

Info

Publication number
WO2001081621A3
WO2001081621A3 PCT/EP2001/003301 EP0103301W WO0181621A3 WO 2001081621 A3 WO2001081621 A3 WO 2001081621A3 EP 0103301 W EP0103301 W EP 0103301W WO 0181621 A3 WO0181621 A3 WO 0181621A3
Authority
WO
WIPO (PCT)
Prior art keywords
diagnostic kit
microarray
determining
human
rhesus factor
Prior art date
Application number
PCT/EP2001/003301
Other languages
English (en)
French (fr)
Other versions
WO2001081621A2 (de
Inventor
Lutz Wehmeier
Cengiz Tamak
Stefanie Waschuetza
Original Assignee
Adnagen Ag
Lutz Wehmeier
Cengiz Tamak
Stefanie Waschuetza
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10049363A external-priority patent/DE10049363A1/de
Application filed by Adnagen Ag, Lutz Wehmeier, Cengiz Tamak, Stefanie Waschuetza filed Critical Adnagen Ag
Priority to AU2001242507A priority Critical patent/AU2001242507A1/en
Publication of WO2001081621A2 publication Critical patent/WO2001081621A2/de
Publication of WO2001081621A3 publication Critical patent/WO2001081621A3/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Die vorliegende Erfindung bezieht sich auf ein Verfahren, ein Diagnose-Kit, ein Mikroarray (z.B. DNS-Chip) sowie deren Verwendung zur Bestimmung des Rhesus-Faktors eines Menschen, insbesondere eines menschlichen Fötus zur Verwendung beispielsweise im Bereich der Medizin, insbesondere in der Pränatal-Diagnose. Das erfindungsgemässe Diagnose-Kit enthält mindestens ein Paar Oligonukleotide (Reverseprimer, Forwardprimer), wobei die beiden Oligonukleotide des Paares als Primer zur Amplifikation mittels Polymerasekettenreaktion jeweils eines der beiden komplementären Stränge eines DNS-Abschnittes des menschlichen RhD-Gens geeignet sind.
PCT/EP2001/003301 2000-04-20 2001-03-23 Verfahren, diagnose-kit und mikroarray zur bestimmung des rhesus-faktors WO2001081621A2 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001242507A AU2001242507A1 (en) 2000-04-20 2001-03-23 Method, diagnostic kit and microarray for determining the rhesus factor

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE10019553 2000-04-20
DE10019553.9 2000-04-20
DE10049363.7 2000-10-05
DE10049363A DE10049363A1 (de) 2000-04-20 2000-10-05 Verfahren, Diagnose-Kit und Mikroarray zur Bestimmung des Rhesusfaktors

Publications (2)

Publication Number Publication Date
WO2001081621A2 WO2001081621A2 (de) 2001-11-01
WO2001081621A3 true WO2001081621A3 (de) 2002-11-07

Family

ID=26005393

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/003301 WO2001081621A2 (de) 2000-04-20 2001-03-23 Verfahren, diagnose-kit und mikroarray zur bestimmung des rhesus-faktors

Country Status (2)

Country Link
AU (1) AU2001242507A1 (de)
WO (1) WO2001081621A2 (de)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8895298B2 (en) 2002-09-27 2014-11-25 The General Hospital Corporation Microfluidic device for cell separation and uses thereof
US8921102B2 (en) 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US9174222B2 (en) 2005-04-05 2015-11-03 The General Hospital Corporation Devices and method for enrichment and alteration of cells and other particles

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2581240A1 (en) * 2004-09-22 2006-03-30 University Of The West Of England, Bristol Rhd and abo genotyping by multiplex pcr
EA201201627A1 (ru) * 2012-12-03 2014-06-30 Общество С Ограниченной Ответственностью "Тестген" Набор олигонуклеотидных праймеров и зондов, а также способ для определения резус-фактора эмбриона или плода по фетальной днк из крови резус-отрицательной беременной женщины

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5723293A (en) * 1995-11-06 1998-03-03 The New York Blood Center, Inc. Diagnostic method and kit for determining Rh blood group genotype
WO1999037763A2 (en) * 1998-01-23 1999-07-29 Drk Blutspendedienst Baden-Wuerttemberg Ggmbh Novel nucleic acid molecules correlated with the rhesus weak d phenotype
WO2001032702A2 (en) * 1999-11-02 2001-05-10 Drk Blutspendedienst Baden-Wuerttemberg Ggmbh Molecular structure of rhd negative locus

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5723293A (en) * 1995-11-06 1998-03-03 The New York Blood Center, Inc. Diagnostic method and kit for determining Rh blood group genotype
WO1999037763A2 (en) * 1998-01-23 1999-07-29 Drk Blutspendedienst Baden-Wuerttemberg Ggmbh Novel nucleic acid molecules correlated with the rhesus weak d phenotype
WO2001032702A2 (en) * 1999-11-02 2001-05-10 Drk Blutspendedienst Baden-Wuerttemberg Ggmbh Molecular structure of rhd negative locus

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MAASKANT-VAN WIJK P A ET AL: "Genotyping of RHD by multiplex polymerase chain reaction analysis of six RHD-specific exons.", TRANSFUSION (BETHESDA), vol. 38, no. 11-12, November 1998 (1998-11-01), pages 1015 - 1021, XP008005129, ISSN: 0041-1132 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8895298B2 (en) 2002-09-27 2014-11-25 The General Hospital Corporation Microfluidic device for cell separation and uses thereof
US8986966B2 (en) 2002-09-27 2015-03-24 The General Hospital Corporation Microfluidic device for cell separation and uses thereof
US9174222B2 (en) 2005-04-05 2015-11-03 The General Hospital Corporation Devices and method for enrichment and alteration of cells and other particles
US8921102B2 (en) 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles

Also Published As

Publication number Publication date
AU2001242507A1 (en) 2001-11-07
WO2001081621A2 (de) 2001-11-01

Similar Documents

Publication Publication Date Title
WO2007004057A3 (en) Chromosome conformation capture-on-chip (4c) assay
JP2003524416A5 (de)
WO2002068685A3 (en) Diagnostic test for the detection of chromosomal abnormalities in a fetus
WO1997018334A3 (en) Nucleic acid probes complementary to human papillomavirus nucleic acid and related methods and kits
WO2006050499A3 (en) Single step detection assay
AU2003268397A1 (en) Improved compositions and methods for cdna synthesis
WO2005082042A3 (en) Therapeutic methods employing nitric oxide precursors
EP2149614A8 (de) Primer zum Nachweis von Mycobacterium tuberculosis
EP2204457A3 (de) Standardisiertes und optimiertes quantitatives Reverse-Transkriptase Echtzeit-Polymerasekettenreaktionsverfahren zum Nachweis von minimalen Resterkrankungen bei Leukämie
WO1996006949A3 (en) Nucleic acid hybridization assay probes targeted to mycoplasma pneumoniae nucleic acid
WO2004094668A3 (en) Oligonucleotide pairs for multiplexed binding assays
WO1996021042A3 (en) Primers for the pcr amplification of metastatic sequences
WO2006081623A8 (en) Double-stranded oligonucleotides and uses therefor
WO2001081621A3 (de) Verfahren, diagnose-kit und mikroarray zur bestimmung des rhesus-faktors
WO2006076010A3 (en) Methods and compositions to detect bacteria using multiplex pcr
CN101886131B (zh) 用两性离子化合物提高核酸杂交特异性的方法
EP1178119A3 (de) Auf PCR beruhender Multiplextest zur Bestimmung des Haplotyps
WO2002006523A3 (en) Method for detecting pre-disposition to hepatotoxicity
WO2005056839A3 (de) Primer und sonden zum nachweis genitaler hpv-genotypen
SI1565573T1 (sl) Sonde nukleinske kisline in primerji širokega območja iz regij v topoizomeraznih genih ter postopki, pri katerih jih uporabljamo
WO2001071026A3 (de) Kit, verfahren und mikroarray zur bestimmung des geschlechtes eines menschlichen fötus
WO2001036670A3 (de) Diagnose-kit, verfahren und mikroarray zur bestimmung der menschlichen entgiftungsfähigkeit
JP2006520587A5 (de)
EP1323835A3 (de) Methode zur Bestimmung einer Biospezies in einer Testprobe und dafür verwendeter Testsatz
EP0872561A3 (de) Neisseria gonorrhoae spezifische Oligonukleotide

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

Ref country code: DE

Ref legal event code: 8642

WA Withdrawal of international application