WO2001036670A3 - Diagnose-kit, verfahren und mikroarray zur bestimmung der menschlichen entgiftungsfähigkeit - Google Patents

Diagnose-kit, verfahren und mikroarray zur bestimmung der menschlichen entgiftungsfähigkeit Download PDF

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Publication number
WO2001036670A3
WO2001036670A3 PCT/EP2000/010478 EP0010478W WO0136670A3 WO 2001036670 A3 WO2001036670 A3 WO 2001036670A3 EP 0010478 W EP0010478 W EP 0010478W WO 0136670 A3 WO0136670 A3 WO 0136670A3
Authority
WO
WIPO (PCT)
Prior art keywords
microarray
diagnosis kit
determining human
detoxification capacity
human detoxification
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2000/010478
Other languages
English (en)
French (fr)
Other versions
WO2001036670A2 (de
Inventor
Stefanie Waschuetza
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alere Diagnostics GmbH
Original Assignee
Adnagen GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adnagen GmbH filed Critical Adnagen GmbH
Priority to JP2001538548A priority Critical patent/JP2003517147A/ja
Priority to CA002388563A priority patent/CA2388563A1/en
Priority to EP00969543A priority patent/EP1230386A2/de
Priority to AU79223/00A priority patent/AU7922300A/en
Publication of WO2001036670A2 publication Critical patent/WO2001036670A2/de
Publication of WO2001036670A3 publication Critical patent/WO2001036670A3/de
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/142—Toxicological screening, e.g. expression profiles which identify toxicity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

Abstract

Die Erfindung betrifft ein Diagnose-Kit, einen Mikroarray sowie ein Verfahren für die Bestimmung der menschlichen Entgiftungsfähigkeit. Das Diagnose-Kit enthält mindestens ein Paar Oligonukleotide (Reverseprimer, Forwardprimer), wobei die beiden Oligonukleotide eines Paares als Primer zur Amplifikation mittels Polymerasekettenreaktion jeweils eines der beiden komplementären Stränge eines gesuchten DNS-Abschnittes geignet sind und wobei der gesuchte DNS-Abschnitt zumindest für einen Teil eines Enzyms des tierischen Entgiftungsstoffwechsels kodiert.
PCT/EP2000/010478 1999-11-16 2000-10-25 Diagnose-kit, verfahren und mikroarray zur bestimmung der menschlichen entgiftungsfähigkeit Ceased WO2001036670A2 (de)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2001538548A JP2003517147A (ja) 1999-11-16 2000-10-25 ヒトの解毒能力を検定するための診断キット、方法およびマイクロアレイ
CA002388563A CA2388563A1 (en) 1999-11-16 2000-10-25 Diagnosis kit, method and microarray for determining human detoxification capacity
EP00969543A EP1230386A2 (de) 1999-11-16 2000-10-25 Diagnose-kit, verfahren und mikroarray zur bestimmung der menschlichen entgiftungsfähigkeit
AU79223/00A AU7922300A (en) 1999-11-16 2000-10-25 Diagnosis kit, method and microarray for determining human detoxification capacity

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19955024.7 1999-11-16
DE19955024A DE19955024C2 (de) 1999-11-16 1999-11-16 Diagnose-Kit

Publications (2)

Publication Number Publication Date
WO2001036670A2 WO2001036670A2 (de) 2001-05-25
WO2001036670A3 true WO2001036670A3 (de) 2001-12-06

Family

ID=7929173

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/010478 Ceased WO2001036670A2 (de) 1999-11-16 2000-10-25 Diagnose-kit, verfahren und mikroarray zur bestimmung der menschlichen entgiftungsfähigkeit

Country Status (6)

Country Link
EP (1) EP1230386A2 (de)
JP (1) JP2003517147A (de)
AU (1) AU7922300A (de)
CA (1) CA2388563A1 (de)
DE (1) DE19955024C2 (de)
WO (1) WO2001036670A2 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10219373A1 (de) * 2002-04-30 2004-02-19 Adnagen Ag Verfahren und Diagnosekit zur molekularen Diagnostik pharmakologisch relevanter Gene
DE10246339A1 (de) * 2002-10-04 2004-04-15 Adnagen Ag Verfahren zur Vorhersage der Wahrscheinlichkeit an einer Chemikalien-induzierten Krankheit zu erkranken
EP3385393A1 (de) * 2017-04-05 2018-10-10 Eckart Schnakenberg In-vitro-verfahren zur diagnose des risikos einer person zur ausbildung eines aerotoxischen syndroms und kit zur durchführung des verfahrens
CN107475397A (zh) * 2017-09-06 2017-12-15 江苏省疾病预防控制中心 一种检测易感职业性噪声聋基因的方法及其试剂盒

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19738908A1 (de) * 1997-09-05 1999-03-11 Stefanie Dr Waschuetza Verfahren zur Bestimmung individueller genetischer Einflüsse für Schadstoffeinwirkungen und/oder Planung eines Therapiekonzeptes für neurodermitis- und/oder asthmagefährdete oder -erkrankte Personen
US5919627A (en) * 1997-10-29 1999-07-06 Incyte Pharmaceuticals, Inc. Microsomal glutathione-S-transferase
GB2339200A (en) * 1998-06-06 2000-01-19 Genostic Pharma Ltd Genomic profiling of disease susceptibility

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19738908A1 (de) * 1997-09-05 1999-03-11 Stefanie Dr Waschuetza Verfahren zur Bestimmung individueller genetischer Einflüsse für Schadstoffeinwirkungen und/oder Planung eines Therapiekonzeptes für neurodermitis- und/oder asthmagefährdete oder -erkrankte Personen
US5919627A (en) * 1997-10-29 1999-07-06 Incyte Pharmaceuticals, Inc. Microsomal glutathione-S-transferase
GB2339200A (en) * 1998-06-06 2000-01-19 Genostic Pharma Ltd Genomic profiling of disease susceptibility

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ABDEL-RAHMAN SHERIF Z ET AL: "A multiplex PCR procedure for polymorphic analysis of GSTM1 and GSTT1 genes in population studies.", CANCER LETTERS, vol. 107, no. 2, 1996, pages 229 - 233, XP000934095, ISSN: 0304-3835 *
PEMBLE SALLY ET AL: "Human glutathione S-transferase theta (GSTT1): cDNA cloning and the characterization of a genetic polymorphism.", BIOCHEMICAL JOURNAL, vol. 300, no. 1, 1994, pages 271 - 276, XP000934185, ISSN: 0264-6021 *
SHI MICHAEL M ET AL: "High-throughput genotyping method for glutathione S-transferase T1 and M1 gene deletions using TaqMan(R) probes.", RESEARCH COMMUNICATIONS IN MOLECULAR PATHOLOGY AND PHARMACOLOGY, vol. 103, no. 1, January 1999 (1999-01-01), pages 3 - 15, XP000934086, ISSN: 1078-0297 *

Also Published As

Publication number Publication date
DE19955024C2 (de) 2003-01-16
DE19955024A1 (de) 2001-06-13
AU7922300A (en) 2001-05-30
WO2001036670A2 (de) 2001-05-25
CA2388563A1 (en) 2001-05-25
JP2003517147A (ja) 2003-05-20
EP1230386A2 (de) 2002-08-14

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