WO2003014056A1 - Process for producing optically active 2-substituted carboxylic acid - Google Patents
Process for producing optically active 2-substituted carboxylic acid Download PDFInfo
- Publication number
- WO2003014056A1 WO2003014056A1 PCT/JP2002/008098 JP0208098W WO03014056A1 WO 2003014056 A1 WO2003014056 A1 WO 2003014056A1 JP 0208098 W JP0208098 W JP 0208098W WO 03014056 A1 WO03014056 A1 WO 03014056A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- optically active
- acid
- bromocarboxylic
- sulfonyloxycarboxylic
- carboxylic acid
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 150000001732 carboxylic acid derivatives Chemical class 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 5
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000008030 elimination Effects 0.000 abstract 1
- 238000003379 elimination reaction Methods 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229910001509 metal bromide Inorganic materials 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
- C07C303/30—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reactions not involving the formation of esterified sulfo groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
- C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/363—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
- C07C51/43—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
- C07C51/48—Separation; Purification; Stabilisation; Use of additives by liquid-liquid treatment
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
- C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/48—Separation; Purification; Stabilisation; Use of additives
- C07C67/52—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/48—Separation; Purification; Stabilisation; Use of additives
- C07C67/58—Separation; Purification; Stabilisation; Use of additives by liquid-liquid treatment
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Crystallography & Structural Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/486,085 US20050245764A1 (en) | 2001-08-08 | 2002-08-08 | Process for producing optically active 2-substituted carboxylic acid |
EP02755871A EP1422215A4 (en) | 2001-08-08 | 2002-08-08 | PROCESS FOR PRODUCING OPTICALLY ACTIVE 2-SUBSTITUTED CARBOXYLIC ACID |
JP2003519010A JPWO2003014056A1 (ja) | 2001-08-08 | 2002-08-08 | 光学活性2−置換カルボン酸の製造法 |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2001240672 | 2001-08-08 | ||
JP2001-240672 | 2001-08-08 | ||
JP2002-201976 | 2002-07-10 | ||
JP2002201976 | 2002-07-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2003014056A1 true WO2003014056A1 (en) | 2003-02-20 |
Family
ID=26620181
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2002/008098 WO2003014056A1 (en) | 2001-08-08 | 2002-08-08 | Process for producing optically active 2-substituted carboxylic acid |
Country Status (4)
Country | Link |
---|---|
US (1) | US20050245764A1 (ja) |
EP (1) | EP1422215A4 (ja) |
JP (1) | JPWO2003014056A1 (ja) |
WO (1) | WO2003014056A1 (ja) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003066563A1 (fr) * | 2002-02-04 | 2003-08-14 | Kaneka Corporation | Procede d'obtention d'acides 2-halogeno-carboxyliques optiquement actifs |
JP2006206447A (ja) * | 2005-01-25 | 2006-08-10 | Sumitomo Chemical Co Ltd | α−ケトエステル化合物の製造方法 |
JP2008534448A (ja) * | 2005-03-17 | 2008-08-28 | ビーエーエスエフ ソシエタス・ヨーロピア | 光学活性3−フェニルプロピオン酸誘導体を生成する方法、およびその誘導体の後続生成物 |
WO2014157607A1 (ja) * | 2013-03-29 | 2014-10-02 | 興和株式会社 | 2-ヒドロキシカルボン酸又はその誘導体の光学純度向上法 |
JP2014198698A (ja) * | 2013-03-29 | 2014-10-23 | 大阪有機化学工業株式会社 | アダマンチル(メタ)アクリレート系化合物の製造方法 |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT2118123E (pt) | 2007-01-31 | 2016-02-10 | Harvard College | Péptidos de p53 estabilizados e suas utilizações |
WO2008121767A2 (en) | 2007-03-28 | 2008-10-09 | President And Fellows Of Harvard College | Stitched polypeptides |
RU2582678C2 (ru) | 2010-08-13 | 2016-04-27 | Эйлерон Терапьютикс, Инк. | Пептидомиметические макроциклы |
TWI643868B (zh) | 2011-10-18 | 2018-12-11 | 艾利倫治療公司 | 擬肽巨環化合物 |
JP6450191B2 (ja) | 2012-02-15 | 2019-01-09 | エイルロン セラピューティクス,インコーポレイテッド | ペプチドミメティック大環状化合物 |
EP2819688A4 (en) | 2012-02-15 | 2015-10-28 | Aileron Therapeutics Inc | TRIAZOL AND THIOETHER-COUPLED PEPTIDOMIMETIC MACROCYCLES |
WO2014071241A1 (en) | 2012-11-01 | 2014-05-08 | Aileron Therapeutics, Inc. | Disubstituted amino acids and methods of preparation and use thereof |
KR102570210B1 (ko) | 2014-09-24 | 2023-08-23 | 에일러론 테라퓨틱스 인코포레이티드 | 펩티드모방 거대고리 및 이의 제제 |
KR20170058424A (ko) | 2014-09-24 | 2017-05-26 | 에일러론 테라퓨틱스 인코포레이티드 | 펩티드모방 거대고리 및 이의 용도 |
JP2018516844A (ja) | 2015-03-20 | 2018-06-28 | エルロン・セラピューティクス・インコーポレイテッドAileron Therapeutics,Inc. | ペプチド模倣大環状分子およびその使用 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0067698A2 (en) * | 1981-06-15 | 1982-12-22 | Syntex Pharmaceuticals International Limited | Optically active 1-aromatic-group-substituted-1-alkanones and methods for their manufacture |
EP0081993A2 (en) * | 1981-12-11 | 1983-06-22 | Syntex Pharmaceuticals International Limited | Optically active alpha-substituted aryl ketones, their preparation and their use in preparing alpha-arylalkanoic acids |
JPH1014590A (ja) * | 1996-06-28 | 1998-01-20 | Kanegafuchi Chem Ind Co Ltd | 光学活性2−置換−3−フェニルプロピオン酸及びそのエステルの製造方法 |
WO1999042431A1 (en) * | 1998-02-18 | 1999-08-26 | Zambon Group S.P.A. | Process for preparing (r)-2-bromo-3-phenyl-propionic acid |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8623582D0 (en) * | 1986-10-01 | 1986-11-05 | Secr Defence | Mandelic acid derivatives |
US7388098B2 (en) * | 2000-09-29 | 2008-06-17 | Bristol-Myers Squibb Company | Dynamic resolution of isomers and resolved isomers |
KR100451672B1 (ko) * | 2001-06-05 | 2004-10-08 | 한미약품 주식회사 | 결정성 세프디니르 산부가염, 이의 제조방법 및 이를이용한 세프디니르의 제조방법 |
US7009047B2 (en) * | 2002-03-19 | 2006-03-07 | Sanofi-Aventis Deutschland Gmbh | Ethane-1,2-diaminium bis[(2R)-2-bromo-3-phenylpropanoate], processes for its preparation and its use |
-
2002
- 2002-08-08 JP JP2003519010A patent/JPWO2003014056A1/ja active Pending
- 2002-08-08 US US10/486,085 patent/US20050245764A1/en not_active Abandoned
- 2002-08-08 WO PCT/JP2002/008098 patent/WO2003014056A1/ja active Application Filing
- 2002-08-08 EP EP02755871A patent/EP1422215A4/en not_active Withdrawn
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0067698A2 (en) * | 1981-06-15 | 1982-12-22 | Syntex Pharmaceuticals International Limited | Optically active 1-aromatic-group-substituted-1-alkanones and methods for their manufacture |
EP0081993A2 (en) * | 1981-12-11 | 1983-06-22 | Syntex Pharmaceuticals International Limited | Optically active alpha-substituted aryl ketones, their preparation and their use in preparing alpha-arylalkanoic acids |
JPH1014590A (ja) * | 1996-06-28 | 1998-01-20 | Kanegafuchi Chem Ind Co Ltd | 光学活性2−置換−3−フェニルプロピオン酸及びそのエステルの製造方法 |
WO1999042431A1 (en) * | 1998-02-18 | 1999-08-26 | Zambon Group S.P.A. | Process for preparing (r)-2-bromo-3-phenyl-propionic acid |
Non-Patent Citations (5)
Title |
---|
"The Chemical Society of Japan", 30 November 1992, MARUZEN CO. LTD., article "Jikken kagaku koza 22 yuki gosei IV -San.Amino-san.peptide-", pages: 7, XP002960798 * |
DATABASE CASREACT [online] accession no. STN Database accession no. 19:10433 * |
HANESSIAN S.: "Design and reactivity of organic functional groups - 2-pyridylsulfonates as nucleofugal esters", HETEROCYCLES, vol. 28, no. 2, 1989, pages 1115 - 1120, XP002960796 * |
KENYON JOSEPH ET AL.: "Dependence of rotatory power on chemical constitution. XXIV.", J. CHEM. SOC., vol. 127, 1925, pages 399 - 417, XP002960797 * |
See also references of EP1422215A4 * |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003066563A1 (fr) * | 2002-02-04 | 2003-08-14 | Kaneka Corporation | Procede d'obtention d'acides 2-halogeno-carboxyliques optiquement actifs |
JP2006206447A (ja) * | 2005-01-25 | 2006-08-10 | Sumitomo Chemical Co Ltd | α−ケトエステル化合物の製造方法 |
JP2008534448A (ja) * | 2005-03-17 | 2008-08-28 | ビーエーエスエフ ソシエタス・ヨーロピア | 光学活性3−フェニルプロピオン酸誘導体を生成する方法、およびその誘導体の後続生成物 |
JP4763771B2 (ja) * | 2005-03-17 | 2011-08-31 | ビーエーエスエフ ソシエタス・ヨーロピア | 光学活性3−フェニルプロピオン酸誘導体を生成する方法、およびその誘導体の後続生成物 |
WO2014157607A1 (ja) * | 2013-03-29 | 2014-10-02 | 興和株式会社 | 2-ヒドロキシカルボン酸又はその誘導体の光学純度向上法 |
JP2014198698A (ja) * | 2013-03-29 | 2014-10-23 | 大阪有機化学工業株式会社 | アダマンチル(メタ)アクリレート系化合物の製造方法 |
US9682913B2 (en) | 2013-03-29 | 2017-06-20 | Kowa Company, Ltd. | Method for improving optical purity of 2-hydroxycarboxylic acid or derivative thereof |
Also Published As
Publication number | Publication date |
---|---|
JPWO2003014056A1 (ja) | 2004-11-25 |
US20050245764A1 (en) | 2005-11-03 |
EP1422215A4 (en) | 2005-07-06 |
EP1422215A1 (en) | 2004-05-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2003014056A1 (en) | Process for producing optically active 2-substituted carboxylic acid | |
SG151330A1 (en) | Process for production of optically active amine derivatives | |
EA200500264A1 (ru) | Модифицированная реакция пикте-шпенглера и полученные с ее использованием продукты | |
EA200200016A1 (ru) | Способ получения чистого циталопрама | |
EP1253130A3 (en) | Method for producing 3-l-menthoxypropane-1,2-diol | |
RU94042228A (ru) | Способ получения сложных эфиров метакриловой кислоты | |
DE69119234T2 (de) | Verfahren zur herstellung von reiner hydroxyessigsäure | |
EP1559705A4 (en) | PRODUCTION OF HYDROXYBENZOIC ACIDS | |
ES2149931T3 (es) | Procedimiento para la produccion de xilitol. | |
WO2003028665A3 (en) | Methods for the purification of levofloxacin | |
WO2002076934A3 (en) | Purification of 2-nitro-4-methylsulphonylbenzoic acid | |
ES2139908T3 (es) | Procedimiento para la produccion de 1,1,1,2,3,3,3-heptafluoropropano. | |
DK125387D0 (da) | Fremgangsmaade til fremstilling af macrolidforbindelser | |
EP1258470A3 (en) | Process for producing optically active alcohol | |
PL352359A1 (en) | Method of making (nitroxymethylo)phenyl esters, derivatives of salicylic acid | |
BR0012953A (pt) | Processo para a recupepação de ácidos organicos | |
BR9913720A (pt) | Processo de purificação por cristalização ourecristalização de ácidos carboxìlicos | |
EP1460997A4 (en) | METHODS OF PURIFYING LEVOFLOXACIN | |
CY1108469T1 (el) | Διαδικασια για την παρασκευη αλατων με οξεα της γεμιφλοξακινης | |
MY149638A (en) | Method for producing a purified lipase | |
EP1600438A4 (en) | METHODS FOR PRODUCING OPTICALLY ACTIVE COMPOUNDS COMPRISING SUBSTITUENTS IN POSITION 2 | |
NO20032098L (no) | Fremgangsmåte for fremstilling av eddiksyre | |
EP1193253A4 (en) | METHOD FOR THE PRODUCTION OF OPTICALLY ACTIVE AZETIDIN-2-CARBOXYLIC ACIDS | |
WO2003031636A1 (fr) | Procede de production de 3-hydroxy-pentanenitrile optiquement actif | |
CA2482294A1 (en) | Multicolumn selectivity inversion generator for production of ultrapure radionuclides |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW Kind code of ref document: A1 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BY BZ CA CH CN CO CR CU CZ DE DM DZ EC EE ES FI GB GD GE GH HR HU ID IL IN IS JP KE KG KP KR LC LK LR LS LT LU LV MA MD MG MN MW MX MZ NO NZ OM PH PL PT RU SD SE SG SI SK SL TJ TM TN TR TZ UA UG US UZ VC VN YU ZA ZM |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LU MC NL PT SE SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG Kind code of ref document: A1 Designated state(s): GH GM KE LS MW MZ SD SL SZ UG ZM ZW AM AZ BY KG KZ RU TJ TM AT BE BG CH CY CZ DK EE ES FI FR GB GR IE IT LU MC PT SE SK TR BF BJ CF CG CI GA GN GQ GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
WWE | Wipo information: entry into national phase |
Ref document number: 2003519010 Country of ref document: JP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2002755871 Country of ref document: EP |
|
WWP | Wipo information: published in national office |
Ref document number: 2002755871 Country of ref document: EP |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
WWE | Wipo information: entry into national phase |
Ref document number: 10486085 Country of ref document: US |