WO2003011241A1 - Utilization of creatinine and/or creatinine derivatives in cosmetic and dermatological preparations - Google Patents

Utilization of creatinine and/or creatinine derivatives in cosmetic and dermatological preparations

Info

Publication number
WO2003011241A1
WO2003011241A1 PCT/EP2002/008124 EP0208124W WO03011241A1 WO 2003011241 A1 WO2003011241 A1 WO 2003011241A1 EP 0208124 W EP0208124 W EP 0208124W WO 03011241 A1 WO03011241 A1 WO 03011241A1
Authority
WO
Grant status
Application
Patent type
Prior art keywords
skin
invention
example
acid
preparations
Prior art date
Application number
PCT/EP2002/008124
Other languages
German (de)
French (fr)
Other versions
WO2003011241A8 (en )
Inventor
Helga Biergiesser
Thomas Blatt
Inge Kruse
Melanie Schmidt
Uwe SCHÖNROCK
Franz STÄB
Original Assignee
Beiersdorf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/30Cosmetics or similar toilet preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toilet preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/30Cosmetics or similar toilet preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toilet preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/43Guanidines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/30Cosmetics or similar toilet preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toilet preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494Cosmetics or similar toilet preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4946Imidazoles or their condensed derivatives, e.g. benzimidazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
    • A61Q17/00Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/007Preparations for dry skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/008Preparations for oily skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/02Preparations for care of the skin for chemically bleaching or whitening the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
    • A61Q5/00Preparations for care of the hair
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
    • A61Q5/00Preparations for care of the hair
    • A61Q5/006Antidandruff preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
    • A61Q5/00Preparations for care of the hair
    • A61Q5/008Preparations for oily hair
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
    • A61Q7/00Preparations for affecting hair growth

Abstract

The invention relates to cosmetic or dermatological preparations containing a combination of active ingredients consisting of creatinine and creatine.

Description

Beiersdorf Aktiengesellschaft Hamburg

description

USE OF CREATININE AND / OR IN KREATININDERIVATEN cosmetic or dermatological preparations

The present invention relates to the use of combinations of creatinine and / or Kreatininderivaten with creatine and / or its derivatives in cosmetic or dermatological preparations for the treatment and prophylaxis of the symptoms of UV and or ozone-induced skin damage and inflammatory and degenerative skin conditions.

Cosmetic skin care is to be understood in the first place is that the natural function of the skin as a barrier against environmental influences strengthened (for example, dirt, chemicals, microorganisms) and against the loss of endogenous substances (eg water, natural fats, electrolytes).

If this function is impaired, increased resorption of toxic or allergenic substances or attack by microorganisms, leading to toxic or allergic skin reactions.

Another aim of skin care is to compensate for the fat and water loss from the skin caused by daily washing. This is particularly important if the natural regeneration ability is inadequate. Furthermore, skin care products against environmental influences, in particular against sun and wind, and delay skin aging.

Chronological skin aging is caused eg by endogenous, genetically determined factors. In the epidermis and Der is a result of aging, for example, the following structural damage and functional disorders, which can also fall under the term "senile xerosis": a) dryness, roughness and formation of dryness wrinkles, b) itching and c) reduced re-oiling after by sebaceous glands (eg To wash).

External factors, such as UV light and chemical noxae, can have a cumulative effect and, for example, accelerate the endogenous aging processes or supplement. In the epidermis and dermis, in particular by exogenous factors such as the following structural damage and functional disorders in the skin that go beyond the extent and quality of the damage during chronological aging:

d) visible vascular dilations (telangiectasia, cuperosis); e) flaccidity and formation of wrinkles; f) local hyperpigmentation, hypopigmentation and abnormal pigmentation (for example senile keratosis) and g) increased susceptibility to mechanical stress (for example cracking).

The present invention particularly relates to products for the care of aged skin in a natural way, as well as for the treatment of damage caused by photo-aging, and in particular the phenomena listed under a) to g).

Products for the care of aged skin are known per se. They contain, for example, retinoids (vitamin A acid and / or derivatives thereof) or vitamin A and / or its derivatives. Their effect on structural damage is, however, limited. Daüber, there are considerable difficulties in stabilizing the active ingredients sufficiently against oxidative decomposition of product development. The use of vitamin A acid-containing products, moreover, often causes severe erythematous skin irritations. Retinoids are therefore only be used in low concentrations.

Specifically, the present invention relates to cosmetic compositions having an effective protection against harmful oxidation processes in the skin, but also for the protection of cosmetic preparations themselves or for the protection of the components of cosmetic preparations against harmful oxidation processes.

The damaging effect of the ultraviolet part of solar radiation on the skin is generally known. While rays having a wavelength of less than 290 nm (the so-called UVC range) are absorbed by the ozone layer in the earth's atmosphere, rays in the range between 290 nm and 320 nm, the so-called UVB range, cause erythema, simple sunburn or even more or less severe burns.

As a maximum erythema of sunlight the relatively narrow range around 308 nm.

For protection against UVB radiation, numerous compounds are known, which are derivatives of 3-benzylidenecamphor, of 4-aminobenzoic acid, of cinnamic acid, of salicylic acid, of benzophenone and also of 2-phenylbenzimidazole.

For the range between about 320 nm and about 400 nm, the UVA region, it is important to have available filter substances, since its rays can cause reactions in cases of sensitive skin. It has been proven that UVA radiation leads to damage of the elastic and collagen fibers of the connective tissue, which causes the skin to prematurely, and that it is regarded as the cause of numerous phototoxic and photoallergic reactions. The harmful effect of UVB radiation can be enhanced by UVA radiation.

Thus certain derivatives of dibenzoylmethane are used for protection against the radiation of the UVA region used, the photostability (Int. J. Cosm. Science 10, 53 (1988)), is not given sufficiently.

However, UV radiation can also lead to photochemical reactions, in which case the photochemical reaction products in the skin metabolism.

Are predominantly Such photochemical reaction products free-radical compounds, for example hydroxy. Undefined free-radical photoproducts which form in the skin itself can also display uncontrolled secondary reactions because of their high reactivity. However, singlet oxygen, a non-excited state of the oxygen molecule, may occur under UV irradiation, as can short-lived epoxides and many others. Singlet oxygen, for example, (radical ground state) is distinguished from the normal triplet oxygen by increased reactivity. However, excited, reactive (radical) exist triplet states of the oxygen molecule.

Furthermore UV radiation is ionizing radiation. There is therefore the risk that ionic species are formed during UV exposure, which are then able to intervene in the biochemical processes in turn oxidatively.

To prevent these reactions, the cosmetic or dermatological formulations, additional antioxidants and / or radical scavengers can be incorporated.

It has already been proposed to use vitamin E, a substance with known antioxidative tive action, in light protection formulations, although here too the effect achieved falls far short of expectations.

The object of the invention was therefore also to provide cosmetic, dermatological and pharmaceutical active ingredients and preparations, and sunscreen formulations dermatoses for the prophylaxis and treatment of photosensitive skin, in particular photo-, preferably PLD.

Other names for polymorphous light dermatosis are PLD, PLE, Majorca- acne and a variety of other names as described in the literature (eg A. Voelckel et al, Zentralblatt Skin and Venereal Diseases (1989) 156, p.2) are given.

Antioxidants are mainly used as protective agents against the deterioration of preparations containing them. Nevertheless, it is known that undesired oxidation processes may occur in human and animal skin. Such processes play an essential role in skin aging.

In the essay "Skin Diseases Associated with Oxidative Injury" in "Oxidative stress in Dermatology", pp 323 et seq (Marcel Dekker Inc., New York, Basel, Hong Kong, Publisher:. Jürgen Fuchs, Frankfurt, and Lester Packer, Berkeley / California), are oxidative skin damage and its more obvious causes. Also for the reason of preventing such reactions, cosmetic or dermatological formulations antioxidants and / or radical scavengers can be additionally incorporated.

A number of antioxidants and free radical scavengers are known. So a substance with known antioxidant activity is already in the US Patents 4,144,325 and 4,248,861 and numerous other documents have been proposed, vitamin E use in sunscreen formulations, although here too the effect achieved falls far short of expectations.

It was therefore an object of the present invention is to find ways of avoiding the disadvantages of the prior art. In particular, the effect of repairing the damage associated with endogenous, chronological and exogenous skin aging and the prophylaxis should permanently be sustainable and without the risk of side effects.

To overcome these shortcomings, an object of the present invention.

It has surprisingly been found that the use of creatinine and / or Kreatininderivaten with creatine and / or its derivatives in cosmetic or dermatological preparations for the treatment and prophylaxis of the symptoms of UV and or ozone-induced skin damage and inflammatory and degenerative skin conditions the disadvantages overcomes the prior art and at the same time the content of creatinine increases the stability of creatine in cosmetic or dermatological preparations.

Creatinine (from the Greek .: τo κpεotς = "meat") is characterized by the following structure

and is produced in the body by non-enzymatic conversion of creatine phosphate in accordance with and is excreted through the kidneys. The amount of creatinine excretion is proportional to the muscle mass and approximately constant for each individual. Creatinine is found in meat extract and Fleischbrühwürfeln.

Creatine (also from the Greek .: τo pεας = "the meat") is characterized by the following structure:

It is found in muscle juice of vertebrates 0.05 to 0.4%, in small amounts in the brain and blood. As a monohydrate, it is a colorless, crystalline powder. In aqueous solution, creatinine is formed. In the organism, it is formed by Transamidi- discrimination of L-arginine to glycine to guanidinoacetic acid and their subsequent metal thylierung by means of S-adenosylmethionine (by guanidinoacetate methyltransferase). Keeping creatine for an appetite-enhancing ingredient of beef and meat extract. Creatine supplement to food enhances physical performance.

Preferably cosmetic or dermatological preparations according to the invention, an active ingredient combination of 0.001 to 50 wt .-%, particularly preferably 0.01 to 15 wt .-%, most preferably from 0.1 to 8 wt .-% of creatine and / or creatine derivative with from 0.001 to 50 wt .-%, particularly preferably 0.01 to 15 wt .-%, most preferably from 0.1 to 8 wt .-% of creatinine and / or Kreatininderivaten, based on the total composition of the preparations. It is of advantage that the weight ratio of creatinine to creatine from the range from 50: to select 2: 1 to 1: 50, preferably from 10: 1 to 1: 10, more preferably from 2: 1 to. 1

Preferred derivative is creatine phosphate, which has the following structure: and which is common in fresh muscle and there as energy-storing phosphate (Phosphagen) plays an important role. In working muscle creatine phosphate is adenosine 5'-diphosphate under the influence of the enzyme creatine kinase, adenosine-5'-triphosphate (ATP) and creatine; in resting muscle the reverse reaction takes place.

But creatine sulfate, creatine acetate, creatine and esterified at the carboxyl group with mono- or polyfunctional alcohols lead to advantageous embodiments of the invention.

Although the JP2000 / 247866 describes skin cosmetics containing creatine and / or creatinine, which can be used as a cream or milky lotion, wherein the preparations in question excellent skin-care properties are attributed. However, this document could not pave the way to the present invention.

Further, the WO00 / 33787 describes the use of creatinine as an effective ingredient of deodorants. This essay could not pave the way to the present invention.

Furthermore, EP-A 565 010 describes hair growth and hair dye containing Kreatininphosphat. This essay could not pave the way to the present invention.

Finally, in US-A 4,590,067 and EP-A-178 602, the use of creatine or creatinine for producing preparations described having anti-inflammatory activity. Also, these documents were not pave the way to the present invention.

When applying the combination of active ingredients or used in the invention cosmetic or topical dermatological preparations with an effective content of inventive active ingredient combination, in a surprising manner is an effective treatment, but also a prophylaxis of deficient, sensitive or hypoactive skin states or deficient, sensitive or hypoactive states of the skin appendages of phenomena premature aging of the skin (eg wrinkles, age spots, tele angiectasias) and / or the skin appendages, environmentally-induced (smoking, smog, reactive oxygen species, free radicals) and, in particular light-induced negative changes in the skin and skin appendages, light-induced skin damage of pigmentation disorders, itching, dry skin conditions and horny layer barrier disturbances, hair loss and for improved hair growth of inflammatory skin conditions and atopic eczema, seborrheic eczema, polymorphic light, psoriasis, vitiligo possible. The active compound combination according to the invention or cosmetic or topical dermatological preparations with an effective content of the invention

but the active ingredient combination is also used in a surprising way to calm sensitive or irritated skin to stimulate collagen, hyaluronic acid and elastin for stimulation of intracellular DNA synthesis, in particular in cases of deficient or hypoactive skin states. to increase cell renewal and regeneration of the skin to enhance the skin's own protective and repair mechanisms (for example for dysfunctional enzymes, DNA, lipids, proteins) for pre- and post-treatment with topical application of laser and abrasive z. Example, to reduce skin wrinkles and scars serve to counteract the resulting skin irritations and to promote the regeneration processes in the damaged skin.

It is according to the invention in particular extremely advantageous to use the active substance combination or used in the invention, cosmetic or topical dermatological preparations with an effective content of active ingredient combination used in the invention for cosmetic or dermatological treatment or prophylaxis of undesirable skin conditions.

According to formulations containing combinations of active substances according to the invention, customary antioxidants can be used.

the antioxidants are selected from the group consisting of amino acids (for example glycine, histidine, tyrosine, tryptophan) and their derivatives advantageous, imidazoles (eg Uro caninsäure) and derivatives thereof, peptides such as D, L-carnosine, D-carnosine, L- carnosine and derivatives thereof (for example anserine), carotenoids, carotenes (for example α-carotene, beta-carotene, lycopene) and derivatives thereof, lipoic acid and derivatives thereof (for example dihydrolipoic acid), Au rothioglucose, propylthiouracil and other thiols (for example thioredoxin, glutathione , cysteine, cystine, cystamine and their glycosyl, N-acetyl, methyl, ethyl, propyl, amyl, butyl and lauryl, palmitoyl, oleyl, γ-linoleyl, cholesteryl and glyceryl esters) and salts thereof, dilauryl thiodipropionate, distearyl thiodipropionate, thiodipropionic acid and derivatives thereof (esters, ethers, peptides, lipids, nucleotides, nucleosides and salts) as well as sulfoxides oximinverbindungen (eg Buthioninsulfoximine, homocysteine ​​sulfoximine, fone Buthioninsul-, penta-, hexa-, Heptathioninsulfoximin) in very low tolerated dosages (for example pmol to .mu.mol / kg), also (metal) chelating agents (for example α-hydroxy fatty acids, palmitic acid, phytic acid, lactoferrin), α-hydroxy acids (for example citric acid, lactic acid, malic acid), humic acid, bile acid, bile extracts , bilirubin, biliverdin, EDTA, EGTA and derivatives thereof, unsaturated fatty acids and their derivatives (eg, γ-linolenic acid, lithium nolsäure, oleic acid), folic acid and derivatives thereof, alanine diacetic acid, flavonoids, polyvinyl lyphenole, catechins, vitamin C and derivatives ( for example ascorbyl palmitate, Mg ascorbyl bylphosphat, ascorbyl acetate), tocopherols and derivatives (for example vitamin e acetate), and coniferyl benzoate of benzoin, rutinic acid and derivatives thereof, ferulic acid and derivatives thereof, butylhydroxytoluene, butylhydroxyanisole, Nordihydroguajakharzsäure, NOR dihydroguajaretsäure, trihydroxybutyrophenone , uric acid and derivatives thereof, mannose and derivatives thereof, zinc and derivatives thereof (for example ZnO, ZnS0) selenium and derivatives thereof (for example selenium this said active ingredients methionine), stilbenes and derivatives thereof (for example stilbene oxide, trans-stilbene oxide) and the derivatives suitable according to the invention (salts, esters, ethers, sugars, nucleotides, nucleosides, peptides and lipids).

The amount of antioxidants (one or more compounds) in the preparations is preferably 0.001 to 30 wt .-%, particularly preferably 0.05 to 20 wt .-%, in particular 1 - 10 wt .-%, based on the total weight the preparation.

The prophylaxis or the cosmetic or dermatological treatment with the inventively used active compound combinations or with the cosmetic or topical dermatological preparations with an effective content of inventively used active ingredient combination is carried out in the usual manner, namely such that the active ingredient or used in the invention cosmetic or topical dermatological preparations with an effective content of active ingredient used according to the invention to the affected skin.

Advantageously, the combination of active ingredients used in the invention can be incorporated into customary cosmetic and dermatological preparations, which can be in various forms. Thus they can, for example, a solution, an emulsion of the water-in-oil (W / O) or oil-in-water type (O / W) type or a multiple E- mulsionen, for example of the type water-in-oil -in-water represent (W / O / W) or oil-in-water-in-oil (O / W / O), a hydraulic or lipodispersion, a gel, a solid stick or also an aerosol.

Emulsions of the invention in the context of the present invention, eg in the form of a cream, a lotion, a cosmetic milk are advantageous and comprise, for example, fats, oils, waxes and / or other fatty substances, as well as water and one or more emulsifiers, as are typically for a formulation of this type can be used.

It is also possible and advantageous for the purposes of the present invention to incorporate the active ingredient combination used in the invention in aqueous systems or surfactant for cleansing the skin and hair.

It is of course known to the skilled man that demanding cosmetic compositions are mostly inconceivable without the customary auxiliaries and additives. Among them are, for example, builders, fillers, perfume, dyes, emulsifiers, sektenrepellentien additional active ingredients such as vitamins or proteins, light protection agents, stabilizers, domestic, alcohol, water, salts, antimicrobial, proteolytic or keratolytic active substances into one, etc., mutatis mutandis, corresponding requirements to the formulation of medicinal preparations.

Medicinal topical compositions within the meaning of the present invention comprise one or more medicaments in an effective concentration. For simplicity, for a clear distinction between cosmetic and medicinal use and corresponding products to the legal provisions of the Federal Republic of Germany (eg Cosmetics Directive, Foods and Drugs Act).

It is likewise advantageous to give the drug combination used in the invention as additive to preparations that already contain other active ingredients for other purposes.

Accordingly, cosmetic or topical dermatological compositions may be in the sense of the present invention, depending on their structure, for example, as skin protection cream, cleansing milk, sunscreen lotion, nutrient cream, day or night cream, etc. It is optionally possible and advantageous to the compositions of the invention as a base for pharmaceutical formulations use.

are low optionally also those cosmetic and dermatological preparations which are in the form of a sunscreen. These preferably additionally contain, besides the active ingredient combination according to the invention at least one UVA filter substance and / or at least one UVB filter substance and / or at least one inorganic pigment.

It is also advantageous for the purposes of the present invention to provide cosmetic and dermatological preparations whose main purpose is not protection against sunlight, but which nevertheless have a content of UV protection substances. For example, incorporated into day creams usually UV-A and UV-B filter substances. Advantageously, the preparations according to the invention may contain substances which absorb UV radiation in the UVB range, the total amount of filter substances, for example, 0.1 wt .-% to 30 wt .-%, preferably 0.5 to 10 wt .-%, particularly 1 to 6 wt .-%, based on the total weight of the preparations.

The UVB filters can be oil-soluble or water soluble. Oil-soluble substances are to be mentioned:

3-benzylidenecamphor and derivatives thereof, for example 3- (4-methylbenzylidene) camphor,

4-aminobenzoic acid derivatives, preferably 4- (dimethylamino) benzoic acid (2-ethylhexyl) ester, 4- (dimethylamino) benzoesäureamylester;

Esters of cinnamic acid, preferably 4-methoxycinnamic acid (2-ethylhexyl) ester, 4-meth- oxyzimtsäureisopentylester;

Esters of salicylic acid, preferably salicylic acid (2-ethylhexyl) ester, salicylic acid

(4-isopropylbenzyl) homomenthyl salicylate;

Derivatives of benzophenone, preferably 2-hydroxy-4-methoxybenzophenone, 2-

Hydroxy-4-methoxy-4'-methylbenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone;

Esters of benzalmalonic acid, preferably 4-methoxybenzalmalonate (2-ethyl hexyl) ester;

2,4,6-Thanilino- (p-carbo-2'-ethyl-1 '-hexyloxy) -1, 3,5-triazine.

Water-soluble substances are beneficial:

2-phenylbenzimidazole-5-sulfonic acid and its salts, for example sodium, potassium or

Triethanolammonium salts,

Sulphonic acid derivatives of benzophenones, preferably 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid and its salts;

Sulphonic acid derivatives of 3-benzylidenecamphor, eg 4- (2-oxo-3-bornylidenemethyl) benzenesulfonic acid, 2-methyl-5- (2-oxo-3-bornylidenemethyl) sulfonic acid and their salts.

The list can be used according to the invention of the UVB filters mentioned, of course intended to be limiting.

The invention also provides the combination of an inventive UVA-FIL ters with a UVB filter or a cosmetic or dermatological preparation according to the invention, which also comprises a UVB filter.

It may also be advantageous to use UVA filters inventive preparations, which are usually present in cosmetic and / or dermatological preparations. Such filter substances are preferably derivatives of dibenzoylmethane, in particular 1- (4'-tert-butylphenyl) -3- (4'-methoxyphenyl) - propan-1, 3-dione and by 1-phenyl-3- ( 4'-isopropylphenyl) propane-1, 3-dione. Preparations which contain these combinations are also subject matter of the invention. It can use the same amounts used of UVA filter substances which were given for UVB filter substances.

Cosmetic and / or dermatological preparations within the meaning of the present invention can also contain inorganic pigments which are customarily used in cosmetics for protecting the skin against UV rays. These are oxides of titanium, zinc, iron, zirconium, silicon, manganese, aluminum, cerium and mixtures thereof, and modifications in which the oxides are the active agents. Particular preference is given to pigments based on titanium dioxide. It can be used the amounts mentioned for the above combinations.

The cosmetic and dermatological preparations of the invention can contain cosmetic active compounds, auxiliaries and / or additives such as are customarily used in such preparations, for example, antioxidants, preservatives, bactericides, perfumes, substances for preventing foaming, dyestuffs, pigments, the coloring effect have, thickeners, surface-active substances, emulsifiers, emollients, moisturizing and / or humectant substances, fats, oils, waxes or other customary constituents of a cosmetic or dermatological formulation such as alcohols, polyols, polymers, foam stabilizers,-electrolytes electron, organic solvents or silicone derivatives.

If the cosmetic or dermatological preparation within the meaning of the present invention is a solution or emulsion or dispersion can be used as solvents: water or aqueous solutions oils, but such as triglycerides of capric or caprylic acid, preferably castor oil;

Fats, waxes and other natural and synthetic fatty substances, preferably esters of fatty acids with alcohols of low carbon number, for example with isopropanol, product pylenglykol or glycerol, or esters of fatty alcohols with alkanoic acids of low C number or with fatty acids;

Alcohols, diols or polyols of low carbon number, and ethers thereof, preferably monoethyl ethanol, isopropanol, propylene glycol, glycerol, ethylene glycol, ethylene glycol or monobutyl ether, propylene glycol monomethyl, monoethyl or - monobutyl ether, diethylene glycol monomethyl or monoethyl ether and analogous products ,

In particular, mixtures of the abovementioned solvents are used. Of alcoholic solvents, water can be a further constituent.

The oil phase of the emulsions, oleogels or hydrodispersions or lipodispersions for the purposes of the present invention is advantageously chosen from the group of esters of saturated and / or unsaturated, branched and / or unbranched Alkancar- acids having a chain length of 3 to 30 C atoms and saturated and / or unsaturated, branched and / or unbranched alcohols having a chain length of 3 to 30 carbon atoms, from the group of esters of aromatic carboxylic acids and saturated and / or unsaturated, branched and / or unbranched alcohols having a chain length of 3 to 30 carbon atoms. Such Esteröle can then advantageously be selected from the group consisting of isopropyl myristate, isopropyl palmitate, isopropyl stearate, isopropyl oleate, n-butyl stearate, n-hexyl laurate, n-decyl oleate, isooctyl stearate, Isononylstearat, nonylisononanoat iso-, 2-ethylhexyl palmitate, 2-ethylhexyl laurate, 2- hexyldecyl stearate, 2-octyl tyldodecylpalmitat, oleyl oleate, oleyl erucate, erucyl oleate, erucyl erucate and synthetic, semi-synthetic and natural mixtures of such esters such as jojoba oil.

Further, the oil phase can advantageously be chosen from the group of branched and unbranched hydrocarbons and waxes, silicone oils, dialkyl ethers, the group of saturated or unsaturated, branched or unbranched alcohols, and fatty acid triglycerides, namely the triglycerol esters of saturated and / or unsaturated saturated, branched and / or unbranched alkanecarboxylic acids having a chain length of 8 to 24, in particular 12-18 C-atoms. The fatty acid triglycerides can, for example, advantageously be chosen from the group of synthetic, semisynthetic and natural oils, such as olive oil, sunflower oil, soybean oil, peanut oil, rapeseed oil, almond oil, palm oil, coconut oil, palm kernel oil and the like.

Any mixtures of such oil and wax components are used advantageously for the purposes of the present invention. It may also be advantageous to use waxes, for example cetyl palmitate, as the sole lipid component of the oil phase.

The oil phase is selected from the group 2-ethylhexyl, Octyldo- decanol, isotridecyl isononanoate, isoeicosane, 2-ethylhexyl cocoate advantageous, C 12-15 alkyl benzoate, caprylic-capric acid triglyceride, dicaprylyl ether.

Particularly advantageous mixtures of C 12-15 -alkyl benzoate and 2-Ethylhexylisostea- are rat, mixtures of C 12-15 -alkyl benzoate and isotridecyl isononanoate and mixtures of C 12th 15 -alkyl benzoate, 2-ethylhexyl isostearate and isotridecyl isononanoate.

Of the hydrocarbons, paraffin oil, squalane and squalene may advantageously be used for the purposes of the present invention.

Advantageously, the oil phase may also have a content of cyclic or linear silicone oils or consist entirely of such oils, although it is preferable is to use senkomponenten an additional content of other oil phase components apart from the silicone oil or the silicone oils.

Is advantageously cyclomethicone (octamethylcyclotetrasiloxane) were used as according to the invention to be used silicone oil. However, other silicone oils can also be used advantageously for the purposes of the present invention, for example hexamethylcyclotrisiloxane, polydimethylsiloxane, poly (methylphenylsiloxane).

Also particularly advantageous are mixtures of cyclomethicone and isotridecyl isononanoate and of cyclomethicone and 2-ethylhexyl. The aqueous phase of the preparations according to the invention optionally advantageously comprises alcohols, diols or polyols of low carbon number, and ethers thereof, preferably ethanol, isopropanol, propylene glycol, glycerol, ethylene glycol, ethylene glycol monoethyl or monobutyl ether, propylene glycol monomethyl, monoethyl or monobutyl ether, di - ethylene glycol monomethyl or monoethyl ether and analogous products, furthermore alcohols having a low carbon number, for example ethanol, isopropanol, 1, 2-propanediol, glycerol, and especially one or more thickeners, one or more thickeners which can advantageously be chosen from the group silicon dioxide, aluminum silicates, polysaccharides and derivatives thereof, for example hyaluronic acid, xanthan gum, hydroxypropylmethylcellulose, particularly advantageously from the group of polyacrylates, preferably a polyacrylate from the group of Carbopols, for example Carbopol grades 980, 981, 1382, 2984, 5984, each individually or in combination ,

Gels used in the invention usually comprise alcohols of low carbon number, for example ethanol, isopropanol, 1, 2-propanediol, glycerin, and water or an abovementioned oil in the presence of a thickening agent, the case of oily-alcoholic gels is preferably silicon dioxide or an aluminum silicate in aqueous -alkoholischen or alcoholic gels is preferably a polyacrylate.

Solid sticks contain, for example, natural or synthetic waxes, fatty alcohols or fatty acid ester.

Customary bases which are suitable for use as cosmetic sticks for the purposes of the present invention are liquid oils (for example, paraffin oils, castor oil, iso- propyl myristate), semisolid constituents (for example petroleum jelly, lanolin), solid constituents (for example, beeswax, ceresine and microcrystalline waxes and ozokerite), and high-melting waxes (for example carnauba wax, candelilla wax)

Suitable propellants for sprayed from aerosol containers cosmetic and / or dermatological preparations within the meaning of the present invention the customary known easily volatile, liquefied propellants, for example hydrocarbons (propane, butane, isobutane) are suitable, which can be used alone or in admixture with each other. Compressed air can also be used advantageously. Of course, the expert knows that there are non-toxic propellants, which would in principle be suitable for realizing the present invention in the form of aerosol preparations, but which should be avoided because of their unacceptable effect on the environment or other accompanying However, in particular fluorocarbons and chlorofluorocarbon ( CFC).

Cosmetic preparations according to the present invention may also be present as gels, in addition to an effective content of the active ingredient according to the invention and solvents customarily used, preferably water, also organic thickeners, such as gum arabic, xanthan gum, sodium alginate, cellulose derivatives, preferably methylcellulose, hydroxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, or inorganic thickeners, such. B. aluminum silicates such as bentonites, or a mixture of polyethylene glycol and polyethylene glycol stearate or distearate. in the gel is ckungsmittel the Verdi- example in an amount between 0.1 and 30 wt .-%, preferably between 0.5 and 15 wt .-%, of.

The following examples illustrate the present invention.

1. PIT - emulsions

Claims

claims:
1. Cosmetic or dermatological preparations with a content of an active compound combination of creatinine and / or its derivatives with creatine and / or its derivatives.
2. Use of compositions according to claim 1 for the prophylaxis and / or treatment of inflammatory skin conditions and / or to protect the skin at sensitively determined and dry skin (such. As atopic eczema, seborrheic eczema, polymorphic light eruption, psoriasis, vitiligo, wound healing disorders, pruritus , sensitive or irritated skin, light-induced skin damage and UV-induced immunosuppression, changes in desquamation, changes in the normal fibroblast and Keratinozytenproliferation.Veränderungen the normal fibroblast and keratinocyte deficient sensitive or hypoactive skin conditions or deficient sensitive or hypoactive states of skin appendages and reducing skin thickness).
3. Use of compositions according to claim 1 for the treatment and prophylaxis of the symptoms of intrinsic and / or extrinsic skin aging and for the treatment and prophylaxis of the harmful effects of ultraviolet radiation on the skin (such as, for example, degenerative phenomena of the skin (such as age spots, wrinkles , telangiectasia, skin slackness, loss of elasticity, and loss of the epidermal and dermal cell layers, the components of the connective tissue, rete pegs and capillaries), so-called skin luster and fatigue (sagging skin and / or skin fatigue), increased activation of proteolytic enzymes in the skin such. B . metalloproteinases, disorders of normal collagen, hyaluronic acid, elastin and glycosaminoglycan homeostasis and regeneration of the normal skin, changes in the normal fibroblast and Keratinozytenproliferation.Veränderungen the normal fibroblast and keratinocyte, deficiency of intracellular D NS synthesis (in particular, in cases of deficient or hypoactive skin states), environmental (caused by smoking, smog, reactive oxygen species, free radicals and the like caused) negative changes in the skin and / or the integuments).
4. Use of compositions according to claim 1 for the treatment and / or prevention of pigmentation disorders.
5. Use of compositions according to claim 1 for increasing the Ceramidbio- synthesis (such as changes in the ceramide, lipid and energy metabolism of healthy skin).
6. Use of preparations according to Claim 1 for strengthening the barrier function of the skin (such as, for example, horny layer barrier disturbances, changes in the normal pidperoxidationen Ü, changes in transepidermal water loss and the normal moisture content of the skin).
7. Use of compositions according to claim 1 for the treatment and / or prophylaxis of disorders of normal skin pH value and the Osmolytbalance.
8. Use of compositions according to claim 1 for the treatment and / or prophylaxis of deviations from the normal cell-cell communication in the skin (for example, intercellular communications over mediators and / or mechanical / physiological compounds).
9. Use of compositions according to claim 1 for the treatment and / or prophylaxis of functional disorders of the skin appendages (for example, hair loss, improved hair growth, seborrhoeic symptoms, oily skin, oily hair, comedones as well as dandruff).
10. Preparations according to Claim 1 and use of claim 2 to 9, characterized in that the content of creatinine and / or derivatives thereof from 0.001 to 50 wt .-%, preferably 0.1 to 10 wt .-% and the content of creatine and derivatives thereof from 0.001 to 50 wt .-%, preferably 0.1 to 10 wt .-%, based on the total weight of the preparations.
PCT/EP2002/008124 2001-07-25 2002-07-22 Utilization of creatinine and/or creatinine derivatives in cosmetic and dermatological preparations WO2003011241A8 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DE2001136076 DE10136076A1 (en) 2001-07-25 2001-07-25 Cosmetic or dermatological preparations containing creatinine or its derivative, useful e.g. for combating skin aging symptoms or treating inflammatory conditions such as eczema or psoriasis
DE10136076.2 2001-07-25

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP20020760258 EP1414401A1 (en) 2001-07-25 2002-07-22 Utilization of creatinine and/or creatinine derivatives in cosmetic and dermatological preparations
JP2003516473A JP2004538299A (en) 2001-07-25 2002-07-22 Use used creatinine and / or creatinine derivatives cosmetic and Dispensing dermatological
US10767962 US20040241197A1 (en) 2001-07-25 2004-01-26 Cosmetic or dermatological preparations including creatinine or a derivative thereof and creatine or a derivative thereof and methods of applying the preparations to the skin

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10767962 Continuation US20040241197A1 (en) 2001-07-25 2004-01-26 Cosmetic or dermatological preparations including creatinine or a derivative thereof and creatine or a derivative thereof and methods of applying the preparations to the skin

Publications (2)

Publication Number Publication Date
WO2003011241A1 true true WO2003011241A1 (en) 2003-02-13
WO2003011241A8 true WO2003011241A8 (en) 2003-03-20

Family

ID=7692944

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/008124 WO2003011241A8 (en) 2001-07-25 2002-07-22 Utilization of creatinine and/or creatinine derivatives in cosmetic and dermatological preparations

Country Status (4)

Country Link
EP (1) EP1414401A1 (en)
JP (1) JP2004538299A (en)
DE (1) DE10136076A1 (en)
WO (1) WO2003011241A8 (en)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004064801A1 (en) * 2003-01-17 2004-08-05 Beiersdorf Ag Cosmetic or dermatological preparations containing creatine, creatinine and/or the derivatives thereof combined with soya bean extracts
WO2004089326A1 (en) * 2003-04-10 2004-10-21 Beiersdorf Ag Cosmetic or dermatological preparations containing a combination of creatinine, creatine and bioquinones
EP1535604A1 (en) * 2003-11-26 2005-06-01 Beiersdorf AG Combination of creatine and/or creatinine, phenoxyethanol and eventually glycerine
EP1535603A1 (en) * 2003-11-26 2005-06-01 Beiersdorf AG Cosmetic or dermatological preparation containing creatin and/or creatinin and concentrations of electrolytes of at least 50 mmol/l
DE10355715A1 (en) * 2003-11-26 2005-06-16 Beiersdorf Ag Active compound combinations creatine and / or creatine derivatives and / or creatinine and / or Kreatininderivaten and an effective amount of retinoids, especially retinol and retinyl palmitate, and formulations comprising such active compound combinations comprising
WO2009002913A1 (en) * 2007-06-22 2008-12-31 Avicena Group, Inc. Use of creatine compounds to treat dermatitis
WO2009046819A2 (en) * 2007-10-01 2009-04-16 Beiersdorf Ag Method for reducing signs of ageing on skin
EP2123252A1 (en) * 2003-02-28 2009-11-25 E-L Management Corp. Method for increasing hair growth
EP1535605B1 (en) * 2003-11-26 2014-05-14 Beiersdorf AG Cosmetic preparations containing creatine, creatinine and/or the derivatives thereof combined with an organic thickener.

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10355717A1 (en) * 2003-11-26 2005-06-23 Beiersdorf Ag Cosmetic or dermatological formulation for treatment and prophylaxis of e.g. ultraviolet and ozone-damaged, inflamed and dry skin, has aqueous phase containing creatine, creatinine and/or derivative in given ratio to water activity
DE102004008440A1 (en) * 2004-02-19 2005-09-22 Stockhausen Gmbh Cosmetic and / or dermatological agent for increasing the endogenous lipid content of the skin

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63263060A (en) * 1987-04-21 1988-10-31 Ajinomoto Co Inc Method for imparting food with taste of dried sardine soup
US5968544A (en) * 1996-05-31 1999-10-19 The Howard Foundation Compositions containing creatine
DE19841385A1 (en) * 1998-09-10 2000-03-16 Sueddeutsche Kalkstickstoff Use of creatine and/or creatine derivatives as moisturizers in cosmetic compositions
JP2000247866A (en) * 1998-12-28 2000-09-12 Lion Corp Skin agent for external use
WO2000059519A2 (en) * 1999-03-31 2000-10-12 Kapitz Carl Heinz Active agent and combination of active agents for human beings and animals
DE19963628A1 (en) * 1999-12-29 2001-07-12 Knapp Gerhard Synergistic active agent combination of colostrum product, minerals and herbal component, useful as or in medicaments, foodstuffs, food supplements or cosmetics, e.g. for skin treatment
WO2002069740A1 (en) * 2001-03-02 2002-09-12 The Howard Foundation Compositions containing creatine and creatinine
WO2002076408A2 (en) * 2001-03-24 2002-10-03 Wella Aktiengesellschaft Use of creatine, creatinine and/or derivatives thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4590067A (en) * 1984-10-18 1986-05-20 Peritain, Ltd. Treatment for periodontal disease
US4647453A (en) * 1984-10-18 1987-03-03 Peritain, Ltd. Treatment for tissue degenerative inflammatory disease
US5091171B2 (en) * 1986-12-23 1997-07-15 Tristrata Inc Amphoteric compositions and polymeric forms of alpha hydroxyacids and their therapeutic use
EP0565010A1 (en) * 1992-04-10 1993-10-13 Antonio Rizzo Hair dye and hair growth composition
FR2786690A1 (en) * 1998-12-08 2000-06-09 Oreal Cosmetic composition DEODORANTE

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63263060A (en) * 1987-04-21 1988-10-31 Ajinomoto Co Inc Method for imparting food with taste of dried sardine soup
US5968544A (en) * 1996-05-31 1999-10-19 The Howard Foundation Compositions containing creatine
DE19841385A1 (en) * 1998-09-10 2000-03-16 Sueddeutsche Kalkstickstoff Use of creatine and/or creatine derivatives as moisturizers in cosmetic compositions
JP2000247866A (en) * 1998-12-28 2000-09-12 Lion Corp Skin agent for external use
WO2000059519A2 (en) * 1999-03-31 2000-10-12 Kapitz Carl Heinz Active agent and combination of active agents for human beings and animals
DE19963628A1 (en) * 1999-12-29 2001-07-12 Knapp Gerhard Synergistic active agent combination of colostrum product, minerals and herbal component, useful as or in medicaments, foodstuffs, food supplements or cosmetics, e.g. for skin treatment
WO2002069740A1 (en) * 2001-03-02 2002-09-12 The Howard Foundation Compositions containing creatine and creatinine
WO2002076408A2 (en) * 2001-03-24 2002-10-03 Wella Aktiengesellschaft Use of creatine, creatinine and/or derivatives thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BURKE D G ET AL: "Analysis of creatine and creatinine in urine by capillary electrophoresis", JOURNAL OF CHROMATOGRAPHY B: BIOMEDICAL APPLICATIONS, ELSEVIER SCIENCE PUBLISHERS, NL, vol. 732, no. 2, 24 September 1999 (1999-09-24), pages 479 - 485, XP004181090, ISSN: 0378-4347 *
PATENT ABSTRACTS OF JAPAN vol. 013, no. 069 (C - 569) 16 February 1989 (1989-02-16) *
PATENT ABSTRACTS OF JAPAN vol. 2000, no. 12 3 January 2001 (2001-01-03) *

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004064801A1 (en) * 2003-01-17 2004-08-05 Beiersdorf Ag Cosmetic or dermatological preparations containing creatine, creatinine and/or the derivatives thereof combined with soya bean extracts
EP2123252A1 (en) * 2003-02-28 2009-11-25 E-L Management Corp. Method for increasing hair growth
WO2004089326A1 (en) * 2003-04-10 2004-10-21 Beiersdorf Ag Cosmetic or dermatological preparations containing a combination of creatinine, creatine and bioquinones
EP1535603A1 (en) * 2003-11-26 2005-06-01 Beiersdorf AG Cosmetic or dermatological preparation containing creatin and/or creatinin and concentrations of electrolytes of at least 50 mmol/l
DE10355715A1 (en) * 2003-11-26 2005-06-16 Beiersdorf Ag Active compound combinations creatine and / or creatine derivatives and / or creatinine and / or Kreatininderivaten and an effective amount of retinoids, especially retinol and retinyl palmitate, and formulations comprising such active compound combinations comprising
EP1535604A1 (en) * 2003-11-26 2005-06-01 Beiersdorf AG Combination of creatine and/or creatinine, phenoxyethanol and eventually glycerine
EP1535605B1 (en) * 2003-11-26 2014-05-14 Beiersdorf AG Cosmetic preparations containing creatine, creatinine and/or the derivatives thereof combined with an organic thickener.
EP2796136A1 (en) * 2003-11-26 2014-10-29 Beiersdorf AG Cosmetic preparations containing creatine and/or creatine derivatives and organic thickeners
WO2009002913A1 (en) * 2007-06-22 2008-12-31 Avicena Group, Inc. Use of creatine compounds to treat dermatitis
WO2009046819A2 (en) * 2007-10-01 2009-04-16 Beiersdorf Ag Method for reducing signs of ageing on skin
WO2009046819A3 (en) * 2007-10-01 2009-08-06 Beiersdorf Ag Method for reducing signs of ageing on skin

Also Published As

Publication number Publication date Type
DE10136076A1 (en) 2003-02-13 application
EP1414401A1 (en) 2004-05-06 application
WO2003011241A8 (en) 2003-03-20 application
JP2004538299A (en) 2004-12-24 application

Similar Documents

Publication Publication Date Title
US5952391A (en) Use of flavones and flavonoids against the UV-induced decomposition of dibenzoylmethane and its derivatives
US20080286217A1 (en) Sunscreen compositions and methods
US6355230B2 (en) Cosmetic and dermatological light protection formulations with a content of benzotriazole derivatives and alkyl naphthalates
US6121243A (en) Treatment of skin with a formulation comprising alpha-glucosyl rutin and one or more cinnamic acid derivatives
US20020013481A1 (en) Use of flavones flavanones and flavonoids for protecting ascorbic acid and/or ascorbyl compounds from oxidation
US20070092469A1 (en) Topically applied Glucosamine Sulfate and all its related, precursor, and derivative compounds significantly increases the skin's natural produciton of hyaluronic acid for the rejuvenation of healthier younger-looking skin; while PhosphatidylCholine is required to replace its deficiency caused by topical Dimethylaminoethanol (DMAE)
US20040220137A1 (en) Cosmetic and dermatological preparations containing osmolytes for the treatment of and active prevention of dry skin and of other negative alterations in the physiological homeostasis of healthy skin
WO2007135196A2 (en) Stable soluble salts of phenylbenzimidazole sulfonic acid at phs at or below 7.0
US20040258717A1 (en) Cosmetic and dermatological preparations containing creatine for treating and actively preventing dry skin and other negative alterations of the physiological homeostasis of the healthy-skin
US5710177A (en) Synergistic combinations of active substance for the cosmetic or dermatological care of the skin, hair & nails
US5804167A (en) Emulsifier-free, finely disperse cosmetic or dermatological formulations of the water-in-oil type
DE4341001A1 (en) Topical formulations having a content of L-arginine
US20050158259A1 (en) Cosmetic or dermatological preparation comprising a combination of a dye and an anti-inflammatory active ingredient
JPH08175960A (en) Wrinkle-preventing cosmetic
WO1994004129A2 (en) Cosmetic and dermatological sunscreen compositions containing thiols and/or thiol derivates
US6436414B1 (en) Active ingredient combinations or adducts of biotin and/or biotin derivatives and cyclodextrins and use of such active ingredient combinations in cosmetic preparations
US20050031572A1 (en) Cosmetic or dermatological preparations including hops or hop-malt extracts and methods of using same for the prophylaxis and treatment of skin symptoms
WO1995015147A1 (en) Use of l-arginine, l-ornithine or l-citrulline and topical preparations with these substances
WO2002087517A2 (en) Use of isoflavonoids in cosmetic or dermatological preparations for the prophylaxis or treatment of sensitive skin
DE19806947A1 (en) Combination of (acyl) carnitine and (hydro)quinone for use in skin care, effective e.g. against light-induced damage and inflammation
US20060018869A1 (en) Cosmetic or dermatological preparation with a content of creatine, creatinine or derivatives thereof in combination with soybean germ extract
US20040029969A1 (en) Use of creatine or creatine derivatives in cosmetic or dematological preparations
WO1998036730A2 (en) Compositions for treating acne rosacea
US20040197282A1 (en) Method and preparation containing idebenone for protecting human skin
DE19540749A1 (en) Cosmetic preparations with an effective content of Glycosylglyceriden

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): JP

Kind code of ref document: A1

Designated state(s): JP US

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FR GB GR IE IT LU MC NL PT SE SK TR

Kind code of ref document: A1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LU MC NL PT SE SK TR

CR1 Correction of entry in section i

Free format text: PAT. BUL. 07/2003 UNDER "PUBLISHED" DELETE "WITH AMENDED CLAIMS"

CFP Corrected version of a pamphlet front page
121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2002760258

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2003516473

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 10767962

Country of ref document: US

WWP Wipo information: published in national office

Ref document number: 2002760258

Country of ref document: EP