WO2000059519A2

WO2000059519A2 - Active agent and combination of active agents for human beings and animals

Info

Publication number: WO2000059519A2
Application number: PCT/DE2000/000929
Authority: WO
Inventors: Carl-Heinz Kapitz; Gerhard Knapp
Original assignee: Kapitz Carl Heinz; Gerhard Knapp
Priority date: 1999-03-31
Filing date: 2000-03-29
Publication date: 2000-10-12
Also published as: AU4742600A; EP1180940A2; WO2000059519A3

Abstract

Disclosed is an active agent for human beings and animals. Said active agent is based on colostrum of human beings, sheep and/or goats. The invention also relates to a combination of active agents, whereby said combination consists of colostrum and/or colostrum extracts in the solid, liquid, pasty or microcapsulated form. The combination also consists of minerals and mineral salts, especially obtained from the Dead Sea, plant components and/or plant extracts in the solid, liquid or pasty form. The active agents are used as cosmetics, medicaments, especially for the prophylaxis and therapy of skin diseases, as an aid in infections, for strengthening the immune system, as food, as food supplements and in the pharmaceutical field or as an additive in food, cosmetics, medicaments, food supplements or drinks.

Description

Active ingredient and combination of active ingredients for humans and animals

Description:

The invention relates to an active ingredient and in particular an active ingredient combination for humans and animals, based on colostral milk products and / or colostral milk extracts.

Colostral milk or colostrum, also known as first or first milk, is a secretion of the female mammary glands, usually yellowish due to carotenes, which is often formed during pregnancy, but especially in the first days after birth. Colostrum differs from mature breast milk primarily in its higher protein and vitamin content, especially vitamins A and C, with approximately the same carbohydrate and slightly reduced fat content. Colostrum also has leukocytes loaded with fat drops, the colostrum bodies or colostral bodies. The colostrum, which is rich in immunoglobulins, is the first food of the newborn that is important for the first days of life after birth.

Health and well-being in humans and animals depend in particular on the food or nutrients ingested and also on how the body processes these substances. These substances can be divided into three different groups of active ingredients. The first shows the substances and active ingredients that are contained in animal products. The second is Mineral group or that of the metal salts with their respective active ingredient content. The third can be assigned to the general plant area. A large number of active ingredients that are contained in the plants are known here.

So far, all three drug groups have been processed and used alone.

Colostrum of bovine origin has only been available on the market for a few years. It has been possible to gently filter out the valuable ingredients from the colostral milk. The dairy cows produce more colostral milk than the calf needs. Part of the colostral milk is fed to the calves and the other part is brought to the market in a filtered state. Colostral milk extracts are commercially available in the form of granules or as drinkable extracts.

The well-known Dead Sea salt products have only recently become known, although bathing in the Dead Sea was already known to the Romans as particularly healing. Today it will

Salt extracted from the Dead Sea, cleaned and can also be used as a salt bath at home, for example. Dead Sea salt minerals are also used as raw materials for external use in Kos etika.

Plant components and / or plant extracts have been known for thousands of years and are used in all areas of health.

Although the operation of the three above

Active ingredient groups in the individual application are very diverse and still unexplored in many areas, the effectiveness of the three active ingredient groups mentioned above could be demonstrated for internal and external use, especially for the entire skin area.

In general it can be said that the diseases in the skin area increase drastically. If organs or general the metabolism shows problems, the skin is often affected as a reaction. An attempt is then made to remedy skin problems by external use of, for example, cosmetics, with which symptoms but not the causes of the problems are dealt with.

It has long been known that in all three

Active ingredient groups contain active ingredients that can have a positive effect on cell metabolism in particular. This has effects in the case of defects in the immune system as well as allergic reactions, skin diseases of various types, neurodermatitis or psoriasis. Furthermore, there are cell regeneration active substances and medicinal substances for the treatment of wounds, sunburn, acne, in the tooth area, skin injuries, all kinds of skin infections, pimples, herpes etc.

According to the invention, an active ingredient is now made available which is based on colostral milk products and / or

Colostral milk extracts of humans, based on sheep and / or goat. Used alone or in the combination of active ingredients explained below, for example as a dietary supplement, food, cosmetic, pharmaceutical and / or as a medicament and as an additive used in cosmetics, beverages, pharmaceuticals, food, nutritional supplements and in the pharmaceutical field, the active ingredient can be used externally and / or are used internally in humans and animals. It has these colostral milk products and / or

Human, sheep and / or goat colostrum extracts are significantly different from those of bovine origin and can be used effectively.

In particular, it has proven to be useful

To use colostral milk products and _{/ or} colostral milk extracts from humans, sheep and / or goats in an amount of 0.1 to 60 parts of a hundred, for example

Carrier mass ad 100 parts goat colostrum 0.1-60 parts plant extracts 0.1-17 parts testes extracts 0.1-2 parts

Likewise, in parts between 0.1-60 of a hundred, colostral milk products and / or colostral milk extracts from humans, sheep and / or goats are used as food and nutritional supplements according to the invention. These include in particular refreshment and energy drinks and bars with fiber-containing nutrients and fiber. A tablet, powder or capsule form is preferred as a food supplement.

Examples:

Recipe of a capsule as a recipe for a dietary supplement: Fruit juice:

Plant extracts 30% fruit juice concentrate 25%

Vitamin C 5% Vitamin C 5%

Vitamin E 2% Vitamin E 5% ß-carotenes 15% colostrum (goat) 35%

Colostrum (goat) 22% magnesium salts 5%

Magnesium salts 4% Sodium salts 2%

Sodium salts 4% auxiliary 12%

Excipients ad 100 Aqua ad 100

Formulation of a formulation of an aqueous solution: Cream formulation:

Aqua ad 100 Aqua ad 100

Cetrimonium Chloride 0.08% Butyrum Caprae

Panthenol 0.6b% (colostrum) 12.0%

Hydrolized Wheat Aloe Barbadensis 6.0% Protein 2.16% Calendula Officinalis 0.6

Propylene Glycol 1.05% Urtica Dioica 0.6%

Betula Alba 0.60% Spirulina Pacifica 6.0%

Urtica Dioica 0.60% Magnesium Chloride 3.5%

Hedera Helix 0.60% magnesium sulfate 3.5%

Magnesium Chloride 3.50% Sodium Chloride 3.5%

Sodiu Chloride 3.00% Caprylic / Capric

Butyrum Caprae Triglyceride 15.4%

(Colostrum) 3.50% KOH (10%) 0.4%

Perfume 0.20% Citric Acid 0.6%

Methyl parabens 0.20% methyl dibromo

Propylparabens 0.20% Glutaronitrile 0.5%

Magnesium sulfates 2.85% panthenol 0.2%

Allantoin 0.1%

Formula for a formula for pet food: Lotion:

Aqua ad 100 meat concentrates 55 sorbitol 2.55% colostrum 35 carbomer 0.02% magnesium salts 5 citrus dulcis 0.30% plant extracts 5

Acrylates / C 10 - C 30 alkyl

Acrylates Crosspolymer 0.26 Glyceryl Stearate Ceteareth-20, Ceteareth-12 Cetearyl Alcohol

Cetyl Palmitate 2.95 Butyrum Caprae

(Colostrum) 6.30

Urtica Dioica 0.60

Hedera Helix 0.60

Calendula Officinalis 0.60

Magnesium chloride 3.50

Magnesium sulfates 3, 50

Sodium chloride 3.50

Aloe barbadensis 0.30

Methyl parabens 0.30 Propyl parabens 0.30%

Perfume 0.02%

The present invention further relates to a combination of active substances for human and veterinary use, comprising colostral milk products and / or colostral milk extracts, also of bovine and / or equine origin, in solid, liquid or pasty form or also microencapsulated, in particular enclosed in liposomes; further comprising minerals and / or mineral salts, in particular obtained from the Dead Sea, and further comprising plant components and / or plant extracts, likewise in solid, liquid or pasty form or also microencapsulated, in particular used as a cosmetic, as a medicament, for prophylaxis and therapy Skin irritation of all kinds, as a food, as a food supplement or as a drink, also used as an additive for cosmetics, for medicines, food, food supplements and for beverages.

In particular with the mixture of colostral milk products and / or colostral milk extracts as animal products, of minerals and / or mineral salts as earth active substance substances, particularly because of the high mineral content, preferably obtained from the Dead Sea, and of plant constituents and / or plant extracts with the diverse plant active substances is an inventive one Combination of life-sustaining and healing ingredients have been found.

The invention is further explained using an example of use:

The basic components colostrum, minerals, in particular Dead Sea salt, and tea tree oil as a plant extract have so far been used individually in the skin area for skin irritation of all kinds. Depending on the form of application, the active ingredients contained in colostral milk can be taken internally as an extract or as Ointment to be applied externally. The mineral active ingredients used in various skin diseases, especially psoriasis and neurodermatitis, are supplied to humans through a full salt bath through the skin. Not least because of this, sufferers of it travel to the Dead Sea to bathe. The tea tree oil, already known as a universal agent, can be used according to experimental studies and clinical studies for burns, mouth and gum infections, cuts and thrush infections. It is also known that colostrum ointment is an excellent remedy for burns and has the reddish spots healed within a very short time.

These components of colostrum, Dead Sea salt and tea tree oil, which have hitherto been used individually against burns and skin damage of all kinds, can be put together according to the invention in the form of a single ointment which consists of minerals with 1% Dead Sea salt, colostrum powder and tea tree oil.

In the combination of active substances according to the invention from these three active substance groups, there is an interaction of the groups which, when suitably coordinated with one another, trigger a synergy effect and thus produce an increased healing effect both when taken orally and when used externally, in comparison to one

Single administration.

From DE 296 23 125.8 and DE 196 19 990 it is known to filter out the active ingredients after decaseinizing the colostral milk from cattle and to make them accessible to humans and animals.

The filtered out colostrum extract or colostrum powder is, apart from small deviations in the substance content, fixed in its composition per liter.

Analysis of colostrum extract of bovine origin

Energy content 80.0 kj / 100 g pH 6.16 Osmolarity 418 mθsm / kg

Total protein 7.25 g / 100 ml

Dry substance 8.36 g / 100 ml

Ash 0.68 g / 100ml

Lactose 0.2 g / 100ml

Glucose 1.23 g / 100 ml

Carbohydrates 3.8 g / 100 ml

Fat <0.03 g / 100 ml

VITAMINS

Vitamin A <150 μg / 100 ml

Thiamine (Vit.Bl) 69.6 μg / 100 ml

Riboflavin (Vit. B2) 268.2 μg / 100 ml pyrodoxine (Vit. B6) 17.88 μg / 100 ml

Cobala in (Vit.B12) 0.062 μg / 100 ml

Folic acid 4.9 μg / 100 l

Vitamin C 270 μg / 100 ml

Cholecalciferol (D3) 0.28 μg / 100 ml tocopherol (Vit. E) 30 μg / 100 ml

Ubiquinone 5.4 μg / 100ml

MINERALS

Sodium (Na) 1344.7 mg / l potassium (K) 1883, 5 mg / 1 calcium (Ca) 417.42 mg / l magnesium (Mg) 163.72 mg / l iron (Fe) 0.29 mg / 1 copper (Cu ) 0.06 mg / 1 zinc (Zn) 0.06 mg / 1 chromium (Cr) 0.01 mg / 1 phosphorus (P-) 498 ^ 0 mg / 1 selenium (Se) 0.003 mg / NATURAL GROWTH FACTORS

IGF-1 280 μg / 1

IGF-2 190 µg / 1

FREE AMINO ACIDS

Alanine 7.92 mg / 1

Arginine 6.72 mg / 1

Aspartic acid 3.19 mg / 1 ß-alanine <0.32 mg / 1 ß-aminoisobutyric acid 1.24 mg / 1

Citrulline 1.26 mg / 1

Cystine <0.32 mg / 1

Glutamine 8.77 mg / 1

Glutamic acid 44.4 mg / 1

Glycine 5.82 mg / 1

Histidine 1.68 mg / 1

Isoleucine 5.82 mg / 1

Leucine 11.33 mg / 1

Lysine 9.59 mg / 1

Methionine 1.2 mg / 1

Omithin 0.64 mg / 1

Phenylalanine 5.94 mg / 1

Phosphorethanolamine 32.84 mg / 1

Phosphorus serine 10.87 mg / l

Proline 8.84 mg / 1

Serine 6.05 mg / 1

Taurine 138.0 mg / 1

Threonine 3.73 mg / 1

Tryptophan 7.32 mg / 1

Tyrosine 3.91 mg / 1

Valine 13.36 mg / 1

IMMUNOGLOBULINE IgG 60 g / i IgA 6 g / i IgM 12 g / i

ORGANIC MOLECULES

Creatinine 44.7 mg / 1

Creatine 165.1 mg / 1

Due to the variety of its ingredients, the mode of action of the colostrum has only been partially researched. So far, it has been found that the growth factors have a positive influence on the cell metabolism and increase the body's immune system.

The immunoglobulins (antibodies) support the immune system in preventing and warding off infections and are significantly anti-inflammatory.

The amino acids are vital protein building blocks for cellulose change and cell regeneration.

All active ingredients are water soluble.

Colostrum has special healing properties with regard to skin therapy as a protective substance against bacteria, germs and fungi and leads to a strengthening of the skin tissue.

Minerals, especially Dead Sea salt, are already present in small amounts in colostral milk, but are not the main focus of colostrum in terms of their importance. In the case of a mixture of colostrum and especially Dead Sea salt, the Dead Sea salt also has its therapeutic effect due to the exceptionally high mine drop content. As with colostrum, the analysis of, for example, Dead Sea salt is fixed down to small deviations per kg.

Analysis of the Dead Sea salt

CATIONS

Sodium (Na) 74300 mg / kg

Potassium (K) 162000 mg / kg

Ammonium 310 mg / kg

Magnesium 102000 mg / kg

Calcium 1760 mg / kg

Strontium 175 mg / kg

Manganese 6.8 mg / kg

Iron 45 mg / kg

ANIONS

Fluoride 35 mg / kg

Chloride 557000 mg / kg

Bromide 5100 mg / kg

Iodide 14 mg / kg

Sulfate 460 mg / kg

Hydrogenphi Dsphat 34 mg / kg

Hydrogen carbonate 770 mg / kg

Carbonate 2430 mg / kg

Total 906 440 mg / kg

undissociated substances meta-silica 3450 mg / kg

Dissolved solid components 909890 mg / kg Residual moisture

Metal salts, in particular obtained from the Dead Sea, are mostly used externally in humans or animals, for example as bath salts, as shampoos, etc. due to their mineral components.

Dead Sea salt is particularly valuable for the skin area because it is rich in magnesium and potassium. Magnesium is known as an antiallergen, an important building block for the structural elements of the skin and the enzymes that control the metabolism of the skin. Potassium is an important moisture regulator for the skin. Iodine has a disinfectant and healing effect. Chlorine and sodium are electrolytes dissolved in water and play an important role in

Regulation of the body system on enzymes. External applications are for dandruff, acne, eczema, psoriasis and neurodermatitis as well as other skin diseases and skin irritations. It has been proven that secondary effects from higher exposure

Salt concentrations on the skin increases the production of free amino acids. In the foreground of the reactions of the skin metabolism, however, is the activation of proteolytic degradation processes of high-molecular protein compounds. The resulting breakdown products are

Peptides with hormone-like effects, so that ultimately the ions penetrating the skin can act on the interior of the organism, e.g. on the vascular system, the smooth muscles, on the digestive system and on the autonomic system.

The third active ingredient component, plant components and plant extracts, also allows countless variation options for the new one due to the large number of plants with their diverse active ingredients in the phyto area

Active ingredient combination. In particular, because in many cases not only the extract of a plant, but extracts from different plants, in different heights Concentrations, can be used.

Since the mixture of colostrum extracts and minerals from the Dead Sea salt is preferably used in the skin area, plants, plant constituents and / or plant extracts and their properties which are suitable for the active compound combination according to the invention are listed below, but not exclusively, primarily and secondarily skin-active substances.

Aloe Vera strengthens the skin's self-healing,

Apricot powder removes dead skin cells,

Arnica promotes wound healing,

Avocado oil is soothing and soothing, eucalyptus, geranium, myrrh are antiseptic and antibacterial,

Ginseng is vitalizing

Honey and almond oil are relaxing and nourishing,

Jojoba oil is moisturizing and nourishing, chamomile and lavender are anti-inflammatory,

Clove oil is soothing,

Peppermint oil is cooling and refreshing,

Sunflower oil contains many vitamins A, D, B and E and has a nourishing effect, tea tree oil is draining and has an antibacterial effect.

Only the most important modes of action are given in this list. Most extracts have a variety of ingredients that can have further effects.

Colostrum usually has the greatest effect when ingested and its effects are not so long-lasting when used externally. On the other hand, the effect of the Dead Sea salt is particularly good for health when used externally. With direct

Applying the Dead Sea salt to the skin of the person loosens the keratinized and scaly areas. The minerals can penetrate the upper layers of the skin, which makes the skin lastingly stimulated, more receptive and more permeable. This also has the consequence that the otherwise difficult absorption of the fine materials

Colostral milk products and / or colostral milk extracts, if these are to be absorbed through the skin, are facilitated and substantially improved by the inventive combination with Dead Sea salt. An improved absorption of the active ingredients of admixed plant extracts is also achieved in this way.

Another example of such a synergy effect of the active ingredient combination according to the invention is described below.

An allergy to chamomile often reacts allergically. It has now been proven that the mineral magnesium has an anti-allergic effect and counteracts an allergic reaction when used with chamomile. This means that an active ingredient combination of colostrum, Dead Sea salt and chamomile extracts can also be used by a person who is allergic to chamomile. When used externally as an ointment, this combination of active ingredients has a calming and anti-inflammatory effect and facilitates the absorption of important substances into the skin.

It should be noted that especially in the combination and blending of colostral milk extracts and / or products, minerals and / or mineral salts, in particular Dead Sea salt minerals, and herbal extracts and / or plant components, a new complete active ingredient system for the human and veterinary sector is given.

As a natural product, whose unique natural recipe is unlikely to be exactly imitated in laboratories, colostrum has all the vital nonessential and essential amino acids, immunoglobulins and natural growth factors along with vitamins, minerals and lactose and a large number of necessary building materials Fuel substances for the preservation and protection of life.

Minerals and / or mineral salts, in particular Dead Sea salt as a mineral donor that is unique in the world, complement the minerals that do not contain or only to a small extent in colostrum by a further building block for health, which can affect the entire metabolism of humans, in particular through the skin .

Finally, the active ingredient combination according to the invention is supplemented by herbal extracts and extracts, and their various modes of action are also used.

Claims

Claims:

1. Active ingredient for humans and animals, based on colostral milk products and / or colostral milk extracts from humans, sheep and / or goats.

2. Active substance combination for humans and animals, consisting of a mixture of colostral milk products and / or colostral milk extracts, in particular according to claim 1, of minerals and / or mineral salts and of plant components and / or plant extracts.

3. Active ingredient combination according to claim 2, characterized by colostral milk products and / or

Colostrum extracts of bovine and / or equine origin.

4. Active ingredient combination according to one or more of the preceding claims, characterized in that the proportion of colostral milk products and / or

Colostral milk extracts on the active ingredient combination and / or an end product is between 0.1 and 60 parts of a hundred.

5. Active ingredient combination according to one or more of the preceding claims ^ characterized in that the colostral milk products and / or colostral milk extracts in liquid, solid, pasty or in encapsulated form available.

6. Active ingredient combination according to one or more of the preceding claims, characterized in that the colostral milk products and / or colostral milk extracts are encapsulated in liposomes.

7. Active ingredient combination according to one or more of the preceding claims, characterized in that the minerals and / or mineral salts are present in solid, liquid or pasty form.

8. Active ingredient combination according to one or more of the preceding claims, characterized in that the plant components or plant extracts are in solid, liquid or pasty form.

9. Active ingredient combination according to one or more of the preceding claims, characterized by a solid, liquid or pasty form

10. Active ingredient combination according to one or more of the preceding claims, characterized in that the active ingredient combination is used as a medicament, food, dietary supplement or cosmetic.

11. Active ingredient combination according to one or more of the preceding claims, characterized in that the active ingredient combination is used as an additive for pharmaceuticals, foods, food supplements, beverages or cosmetics.

12. Active ingredient combination according to one or more of the preceding claims, characterized in that the active ingredient combination is used as a component for baby food, dietary food, JTinische food or for special food.

3. Active ingredient combination according to one or more of the preceding claims, characterized in that the active ingredient combination as an additive to baked goods, energy-containing bars, granola bars or power bars, spices, milk products, jams, jellies, edible oils, edible fats, teas, coffee and coffee substitutes, honey, ice cream , Salt, mustard or condiments is used.