WO2003009838A1 - Utilisation de composes de stilbene dans la preparation de medicaments pour le traitement ou la prevention du diabete et des maladies associees au retrovirus - Google Patents

Utilisation de composes de stilbene dans la preparation de medicaments pour le traitement ou la prevention du diabete et des maladies associees au retrovirus Download PDF

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Publication number
WO2003009838A1
WO2003009838A1 PCT/CN2002/000522 CN0200522W WO03009838A1 WO 2003009838 A1 WO2003009838 A1 WO 2003009838A1 CN 0200522 W CN0200522 W CN 0200522W WO 03009838 A1 WO03009838 A1 WO 03009838A1
Authority
WO
WIPO (PCT)
Prior art keywords
retrovirus
treating
diseases associated
preventing diabetes
stilbene compounds
Prior art date
Application number
PCT/CN2002/000522
Other languages
English (en)
French (fr)
Inventor
Junlin Li
Zuze Wu
Lizhen Yuan
Qiang Li
Zhongxiong Tang
Original Assignee
Institute Of Radiation Medicine, Academy Of Military Medical Sciences, Pla
Beijing Luyin Lihua Pharmaceutical Science And Technology Development Company Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US10/484,821 priority Critical patent/US7384920B2/en
Application filed by Institute Of Radiation Medicine, Academy Of Military Medical Sciences, Pla, Beijing Luyin Lihua Pharmaceutical Science And Technology Development Company Ltd filed Critical Institute Of Radiation Medicine, Academy Of Military Medical Sciences, Pla
Priority to JP2003515231A priority patent/JP4397688B2/ja
Priority to EP02754147A priority patent/EP1421933B1/en
Publication of WO2003009838A1 publication Critical patent/WO2003009838A1/zh

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/01—Hydrocarbons
    • A61K31/015—Hydrocarbons carbocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • AIDS & HIV (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
PCT/CN2002/000522 2001-07-26 2002-07-26 Utilisation de composes de stilbene dans la preparation de medicaments pour le traitement ou la prevention du diabete et des maladies associees au retrovirus WO2003009838A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US10/484,821 US7384920B2 (en) 2001-07-26 2001-07-26 Use of stilbene compounds in the manufacture of medicament for the prevention and treatment of diabetes or retrovirus-associated diseases
JP2003515231A JP4397688B2 (ja) 2001-07-26 2002-07-26 糖尿病またはレトロウイルス関連疾患の予防および治療用医薬の製造におけるスチルベン化合物の使用
EP02754147A EP1421933B1 (en) 2001-07-26 2002-07-26 Use of stilbene compounds in preparing medicaments for treating or preventing diabetes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN01120597A CN1398838A (zh) 2001-07-26 2001-07-26 二苯乙烯类化合物制备以及它们在治疗和预防糖尿病中的应用
CN01120597.0 2001-07-26

Publications (1)

Publication Number Publication Date
WO2003009838A1 true WO2003009838A1 (fr) 2003-02-06

Family

ID=4664262

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2002/000522 WO2003009838A1 (fr) 2001-07-26 2002-07-26 Utilisation de composes de stilbene dans la preparation de medicaments pour le traitement ou la prevention du diabete et des maladies associees au retrovirus

Country Status (5)

Country Link
US (1) US7384920B2 (zh)
EP (1) EP1421933B1 (zh)
JP (1) JP4397688B2 (zh)
CN (2) CN1398838A (zh)
WO (1) WO2003009838A1 (zh)

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WO2006001278A1 (ja) * 2004-06-28 2006-01-05 Kao Corporation Ａｍｐｋ活性化剤
JP2006273834A (ja) * 2004-06-28 2006-10-12 Kao Corp Ａｍｐｋ活性化剤
JP2007527418A (ja) * 2003-12-29 2007-09-27 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 肥満及びインシュリン耐性障害を治療又は防止するための組成物
US8017634B2 (en) 2003-12-29 2011-09-13 President And Fellows Of Harvard College Compositions for treating obesity and insulin resistance disorders
US8039513B2 (en) 2004-07-21 2011-10-18 Institute Of Radiation Medicine, Academy Of Military Medical Sciences, Pla Cis-1,2-substituted stilbene derivatives and their use in preparation of drugs for treatment and/or prevention of diabetes
US8575115B2 (en) * 2005-12-13 2013-11-05 Shenzhen Neptunus Pharmaceutical Holdings Co., Ltd. Crystalline form I of 3,4′5-trihydroxy-stilbene-3-β-D glucoside

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US7977049B2 (en) 2002-08-09 2011-07-12 President And Fellows Of Harvard College Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms
US20050096256A1 (en) * 2003-07-01 2005-05-05 President And Fellows Of Harvard College Compositions for manipulating the lifespan and stress response of cells and organisms
US20060025337A1 (en) * 2003-07-01 2006-02-02 President And Fellows Of Harvard College Sirtuin related therapeutics and diagnostics for neurodegenerative diseases
WO2006007411A2 (en) * 2004-06-16 2006-01-19 President And Fellows Of Harvard College Methods and compositions for modulating bax-mediated apoptosis
US20060014705A1 (en) * 2004-06-30 2006-01-19 Howitz Konrad T Compositions and methods for selectively activating human sirtuins
WO2006138418A2 (en) * 2005-06-14 2006-12-28 President And Fellows Of Harvard College Improvement of cognitive performance with sirtuin activators
US9133212B1 (en) * 2005-06-15 2015-09-15 Vanderbilt University Inhibitors of hemeprotein-catalyzed lipid peroxidation
US8367669B2 (en) * 2005-06-15 2013-02-05 Vanderbilt University Inhibitors of hemeprotein-catalyzed lipid peroxidation
US20070149466A1 (en) * 2005-07-07 2007-06-28 Michael Milburn Methods and related compositions for treating or preventing obesity, insulin resistance disorders, and mitochondrial-associated disorders
JP2007126390A (ja) * 2005-11-02 2007-05-24 Mercian Corp 血糖値低下剤
CN1331841C (zh) * 2006-01-26 2007-08-15 南京大学 一类白藜芦醇的衍生物及其制法和用途
JP5224648B2 (ja) * 2006-02-21 2013-07-03 丸善製薬株式会社 抗皮膚炎症剤、美白剤及び抗皮膚老化剤
US20080021885A1 (en) * 2006-07-24 2008-01-24 Chacha Search, Inc. System for substantially immediate payment for search related tasks
JPWO2008136173A1 (ja) * 2007-04-20 2010-07-29 国立大学法人お茶の水女子大学 スチルベン誘導体を有効成分とする脂肪細胞分化抑制剤
CN101781173B (zh) * 2009-01-21 2014-03-26 北京三有利科技发展有限公司 二苯乙烯类化合物及其在制备用于治疗和预防前列腺肥大有关疾病的药物中的用途
US20100273203A1 (en) * 2009-04-23 2010-10-28 Board Of Trustees Of The University Of Arkansas Methods and compositions for detecting metabolites
US8883218B2 (en) 2010-03-26 2014-11-11 The Board Of Trustees Of The University Of Arkansas Anti-cancer nanoparticle compositions and methods of use
CN102058678B (zh) * 2010-12-10 2013-01-23 西藏金哈达药业有限公司 一种治疗脂肪肝的药物或保健食品组合物
US9044491B2 (en) * 2010-12-28 2015-06-02 The Board Of Trustees Of The University Of Arkansas Method for improving blood flow using stilbenoid derivatives
US9095598B2 (en) * 2010-12-28 2015-08-04 The Board Of Trustees Of The University Of Arkansas Stilbenoid derivatives and their uses
CN102887925B (zh) * 2011-07-21 2015-08-12 中国科学院兰州化学物理研究所 从河套大黄中提取土大黄苷的方法
CN103156827A (zh) * 2011-12-09 2013-06-19 天津市国际生物医药联合研究院 二苯乙烯类化合物在治疗和预防艾滋病中的用途
CN102512507A (zh) * 2012-01-12 2012-06-27 西藏金哈达药业有限公司 藏边大黄提取物在制备防治糖尿病药物中的应用
CN103012513A (zh) * 2013-01-09 2013-04-03 昆明翔昊科技有限公司 一种甲羟茋苷晶体其制备方法及其应用
US20160346226A1 (en) * 2015-04-08 2016-12-01 Arkansas State University Therapeutic Applications Of Prenylated Stilbenoids Against Rotavirus Infections
EP3111780B1 (en) * 2015-07-03 2019-12-18 Analyticon Discovery GmbH Natural stilbenes as sweeteners or sweetener enhancer
CN107875161A (zh) * 2017-12-15 2018-04-06 中国科学院西北高原生物研究所 土大黄苷在制备与胰岛素抵抗相关疾病中的用途
CN113101295A (zh) * 2020-03-20 2021-07-13 上海疆云医疗健康科技有限公司 二苯乙烯类似物在治疗糖尿病肾脏疾病中的用途

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Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007527418A (ja) * 2003-12-29 2007-09-27 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 肥満及びインシュリン耐性障害を治療又は防止するための組成物
US8017634B2 (en) 2003-12-29 2011-09-13 President And Fellows Of Harvard College Compositions for treating obesity and insulin resistance disorders
US8242171B2 (en) 2003-12-29 2012-08-14 President And Fellows Of Harvard College Method for reducing the weight of a subject or inhibiting weight gain in a subject
US8846724B2 (en) 2003-12-29 2014-09-30 President And Fellows Of Harvard College Compositions for treating obesity and insulin resistance disorders
US9597347B2 (en) 2003-12-29 2017-03-21 President And Fellows Of Harvard College Compositions for treating obesity and insulin resistance disorders
WO2006001278A1 (ja) * 2004-06-28 2006-01-05 Kao Corporation Ａｍｐｋ活性化剤
JP2006273834A (ja) * 2004-06-28 2006-10-12 Kao Corp Ａｍｐｋ活性化剤
US8039513B2 (en) 2004-07-21 2011-10-18 Institute Of Radiation Medicine, Academy Of Military Medical Sciences, Pla Cis-1,2-substituted stilbene derivatives and their use in preparation of drugs for treatment and/or prevention of diabetes
US8575115B2 (en) * 2005-12-13 2013-11-05 Shenzhen Neptunus Pharmaceutical Holdings Co., Ltd. Crystalline form I of 3,4′5-trihydroxy-stilbene-3-β-D glucoside

Also Published As

Publication number Publication date
US7384920B2 (en) 2008-06-10
CN1237961C (zh) 2006-01-25
US20050020511A1 (en) 2005-01-27
CN1545409A (zh) 2004-11-10
EP1421933A1 (en) 2004-05-26
EP1421933A4 (en) 2007-09-05
JP4397688B2 (ja) 2010-01-13
EP1421933B1 (en) 2013-03-27
CN1398838A (zh) 2003-02-26
JP2004537561A (ja) 2004-12-16

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