EP1178788A4 - Novel diphenylethylene compounds - Google Patents
Novel diphenylethylene compoundsInfo
- Publication number
- EP1178788A4 EP1178788A4 EP99924332A EP99924332A EP1178788A4 EP 1178788 A4 EP1178788 A4 EP 1178788A4 EP 99924332 A EP99924332 A EP 99924332A EP 99924332 A EP99924332 A EP 99924332A EP 1178788 A4 EP1178788 A4 EP 1178788A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- diphenylethylene compounds
- novel
- novel diphenylethylene
- compounds
- diphenylethylene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C15/00—Cyclic hydrocarbons containing only six-membered aromatic rings as cyclic parts
- C07C15/40—Cyclic hydrocarbons containing only six-membered aromatic rings as cyclic parts substituted by unsaturated carbon radicals
- C07C15/50—Cyclic hydrocarbons containing only six-membered aromatic rings as cyclic parts substituted by unsaturated carbon radicals polycyclic non-condensed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
- A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
- A61K31/09—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon having two or more such linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/12—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings
- C07C39/15—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings with all hydroxy groups on non-condensed rings, e.g. phenylphenol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/215—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring having unsaturation outside the six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
- C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
- C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US1999/011001 WO2000069430A1 (en) | 1999-05-18 | 1999-05-18 | Novel diphenylethylene compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1178788A1 EP1178788A1 (en) | 2002-02-13 |
EP1178788A4 true EP1178788A4 (en) | 2005-08-10 |
Family
ID=22272785
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP99924332A Withdrawn EP1178788A4 (en) | 1999-05-18 | 1999-05-18 | Novel diphenylethylene compounds |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP1178788A4 (en) |
JP (1) | JP2002544227A (en) |
KR (1) | KR100598638B1 (en) |
CN (1) | CN1194674C (en) |
AU (1) | AU778767C (en) |
CA (1) | CA2373603A1 (en) |
HK (1) | HK1046642B (en) |
MX (1) | MXPA01011760A (en) |
WO (1) | WO2000069430A1 (en) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7323496B2 (en) | 1999-11-08 | 2008-01-29 | Theracos, Inc. | Compounds for treatment of inflammation, diabetes and related disorders |
NZ520829A (en) * | 2000-02-04 | 2004-12-24 | Calyx Therapeutics Inc | Diphenylethylene compounds for treating diabetes and related conditions |
US6410596B1 (en) * | 2000-08-16 | 2002-06-25 | Insmed Incorporated | Compositions containing hypoglycemically active stillbenoids |
US6552085B2 (en) * | 2000-08-16 | 2003-04-22 | Insmed Incorporated | Compositions containing hypoglycemically active stilbenoids |
US7384920B2 (en) * | 2001-07-26 | 2008-06-10 | Institute Of Radiation Medicine, Academy Of Military Medical Sciences, Pla | Use of stilbene compounds in the manufacture of medicament for the prevention and treatment of diabetes or retrovirus-associated diseases |
JP4781580B2 (en) * | 2001-09-26 | 2011-09-28 | 日本メナード化粧品株式会社 | Collagenase inhibitor |
US8017634B2 (en) | 2003-12-29 | 2011-09-13 | President And Fellows Of Harvard College | Compositions for treating obesity and insulin resistance disorders |
AU2004312072B2 (en) | 2003-12-29 | 2011-06-23 | President And Fellows Of Harvard College | Compositions for treating or preventing obesity and insulin resistance disorders |
CN1723884A (en) * | 2004-07-21 | 2006-01-25 | 中国人民解放军军事医学科学院放射医学研究所 | Cis-1, the diphenyl ethylene derivatives that 2-replaces are used to prepare the purposes of the medicine of treatment or prevent diabetes |
WO2006138418A2 (en) | 2005-06-14 | 2006-12-28 | President And Fellows Of Harvard College | Improvement of cognitive performance with sirtuin activators |
CN100384801C (en) * | 2006-06-23 | 2008-04-30 | 中国科学院广州化学研究所 | (E)-3,5-dimethox-4'-hydroxy diphenyl ethylene synthesis method |
FR2904311B1 (en) | 2006-07-28 | 2013-01-11 | Clariant Specialty Fine Chem F | NEW PROCESS FOR THE SYNTHESIS OF (E) STILBENIC DERIVATIVES PERM TO OBTAIN RESVERATROL AND PICEATANNOL |
FR2921921B1 (en) | 2007-10-03 | 2011-08-19 | Clariant Specialty Fine Chem F | PROCESS FOR THE SYNTHESIS OF POLYHYDROXYSTILBENIC COMPOUNDS |
CN107324976B (en) * | 2017-07-28 | 2020-06-16 | 安徽理工大学 | Method for preparing (E) - β -alkyl styrene compound |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999056737A1 (en) * | 1998-05-05 | 1999-11-11 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Arylhydrocarbon receptor ligand antagonists |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5314693A (en) * | 1992-02-07 | 1994-05-24 | Kioritz Corporation | Pest control chemicals against pine wood nematodes |
US5430062A (en) * | 1992-05-21 | 1995-07-04 | Research Corporation Technologies, Inc. | Stilbene derivatives as anticancer agents |
US5770620A (en) * | 1995-06-19 | 1998-06-23 | Ontogen Corporation | Aryl acrylic acid derivatives useful as protein tyrosine phosphatase inhibitors |
US5827898A (en) * | 1996-10-07 | 1998-10-27 | Shaman Pharmaceuticals, Inc. | Use of bisphenolic compounds to treat type II diabetes |
-
1999
- 1999-05-18 WO PCT/US1999/011001 patent/WO2000069430A1/en active IP Right Grant
- 1999-05-18 JP JP2000617889A patent/JP2002544227A/en active Pending
- 1999-05-18 CA CA002373603A patent/CA2373603A1/en not_active Abandoned
- 1999-05-18 MX MXPA01011760A patent/MXPA01011760A/en not_active IP Right Cessation
- 1999-05-18 KR KR1020017014590A patent/KR100598638B1/en not_active IP Right Cessation
- 1999-05-18 AU AU40857/99A patent/AU778767C/en not_active Ceased
- 1999-05-18 CN CNB998166448A patent/CN1194674C/en not_active Expired - Fee Related
- 1999-05-18 EP EP99924332A patent/EP1178788A4/en not_active Withdrawn
-
2002
- 2002-11-14 HK HK02108244.5A patent/HK1046642B/en not_active IP Right Cessation
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999056737A1 (en) * | 1998-05-05 | 1999-11-11 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Arylhydrocarbon receptor ligand antagonists |
Non-Patent Citations (4)
Title |
---|
JANG DAE-SIG ET AL: "Inhibitory effects of resveratrol analogs on unopsonized zymosan-induced oxygen radical production", BIOCHEMICAL PHARMACOLOGY, vol. 57, no. 6, 15 March 1999 (1999-03-15), pages 705 - 712, XP002322563, ISSN: 0006-2952 * |
MANICKAM M ET AL: "ANTIHYPERGLYCEMIC ACTIVITY OF PHENOLICS FROM PTEROCARPUS MARSUPIUM", JOURNAL OF NATURAL PRODUCTS, XX, XX, vol. 6, no. 60, 23 June 1997 (1997-06-23), pages 609 - 610, XP001066243, ISSN: 0163-3864 * |
RYU S Y ET AL: "Antitumor activity of some phenolic components in plants", ARCHIVES OF PHARMACAL RESEARCH, NATL. FISHERIES UNIVERSITY, PUSAN, KR, vol. 17, no. 1, January 1994 (1994-01-01), pages 42 - 44, XP002968965, ISSN: 0253-6269 * |
See also references of WO0069430A1 * |
Also Published As
Publication number | Publication date |
---|---|
HK1046642B (en) | 2005-11-25 |
MXPA01011760A (en) | 2003-09-04 |
AU778767B2 (en) | 2004-12-23 |
AU4085799A (en) | 2000-12-05 |
HK1046642A1 (en) | 2003-01-24 |
WO2000069430A1 (en) | 2000-11-23 |
CA2373603A1 (en) | 2000-11-23 |
CN1194674C (en) | 2005-03-30 |
JP2002544227A (en) | 2002-12-24 |
EP1178788A1 (en) | 2002-02-13 |
KR100598638B1 (en) | 2006-07-07 |
AU778767C (en) | 2006-09-07 |
CN1354659A (en) | 2002-06-19 |
KR20020012220A (en) | 2002-02-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20011208 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: 7C 07C 39/215 B Ipc: 7C 07C 39/06 B Ipc: 7C 07C 43/215 B Ipc: 7C 07C 43/205 B Ipc: 7C 07C 59/48 B Ipc: 7A 61P 3/10 B Ipc: 7A 61K 31/05 B Ipc: 7A 61K 31/09 B Ipc: 7A 61K 31/192 A |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20050627 |
|
17Q | First examination report despatched |
Effective date: 20070813 |
|
RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: THERACOS, INC. |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN |
|
18W | Application withdrawn |
Effective date: 20100222 |