EP1178788A1 - Novel diphenylethylene compounds - Google Patents
Novel diphenylethylene compoundsInfo
- Publication number
- EP1178788A1 EP1178788A1 EP99924332A EP99924332A EP1178788A1 EP 1178788 A1 EP1178788 A1 EP 1178788A1 EP 99924332 A EP99924332 A EP 99924332A EP 99924332 A EP99924332 A EP 99924332A EP 1178788 A1 EP1178788 A1 EP 1178788A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- compound
- hydrogen
- ome
- composition according
- diabetes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C15/00—Cyclic hydrocarbons containing only six-membered aromatic rings as cyclic parts
- C07C15/40—Cyclic hydrocarbons containing only six-membered aromatic rings as cyclic parts substituted by unsaturated carbon radicals
- C07C15/50—Cyclic hydrocarbons containing only six-membered aromatic rings as cyclic parts substituted by unsaturated carbon radicals polycyclic non-condensed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
- A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
- A61K31/09—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon having two or more such linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/12—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings
- C07C39/15—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings with all hydroxy groups on non-condensed rings, e.g. phenylphenol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/215—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring having unsaturation outside the six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
- C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
- C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
Definitions
- the field of the invention is novel diphenylethylene compounds and their use for treatment of diabetes.
- Extracts of the leaves, flowers, and gum of the tree Pterocarpus marsupium Roxb. (Leguminosae) , also known as the Indian Kino Tree, have been used traditionally for the treatment of diarrhea, toothaches, fever and urinary and skin infections. Extracts of the bark have been long regarded as useful for the therapy of diabetes.
- Type I Insulin dependent
- Type II non-insulin dependent
- Type I is an autonomic immune disease in which the responsible autoantigen is still unknown. Patients of Type I need to take insulin intravenously to survive.
- Type II diabetes the more common form of the disease, is a metabolic disorder resulting from the body's inability to make a sufficient amount of insulin or to properly use the insulin that is produced within the body. Insulin secretion and insulin resistance are considered the major defects, however, the precise genetic factors involved in the mechanism remain unknown.
- Patients with diabetes usually have one or more of the following defects: less production of insulin by the pancreas; over secretion of glucose by the liver; impairment of glucose uptake by the skeletal muscle; defects in glucose transporters; desensitation of insulin receptors; and defects in the metabolic breakdown of polysaccharides.
- defects in the intravenous application of insulin there are four classes of oral hypoglycemic agents in use.
- a novel class of styrenes is also provided of the formula II
- compositions of compounds of the formula I or II are provided for treatment of diabetes comprising of therapeutically effective amount of the compound in a physiologically acceptable carrier.
- a method of treating diabetes comprising step of orally administering to a subject suffering from a diabetic condition a therapeutically effective amount of a compound of formula I or II.
- FIG. 1 shows the effect of administration of the compound in Example 1 on blood glucose level in STZ induced diabetic rats.
- FIG. 2 shows the effect of the compound in Example 1 on glucose tolerance in hyperinsulinemic and insulin resistant Zucker rats.
- FIG. 3 shows the effect of the compound in Example 1 on plasma triglyceride levels in Zucker rats.
- FIG. 4 shows the effect of the compound in Example 1 on glucose tolerance in Zucker rats.
- FIGS. 5A, 5B and 5C show, respectively, results of a lethal effect study on Swiss Webster mice by administration of dosages of 16.7, 167, and 333 mg/kg/BW on day zero.
- Diphenylethylene of the formula I and styrenes of formula II are provided by synthetic methods generally known in the art. Particularly, preferred are compounds of formula I in which R 2 and R 3 are methoxy. A particularly preferred species is a compound in which R 2 and R 3 are methoxy and R is C0 2 Z, and R_ is OH.
- the cations for Z are typically sodium, lithium, potassium, or any other physiologically acceptable cation which may be introduced orally to a subject.
- Particularly preferred styrenes of the formula II are those in which R 6 and R 7 are methoxy and R 8 is hydrogen.
- Another preferred class of the formula II includes compounds wherein R 6 and R 7 are hydrogen and R 8 is hydroxy.
- the compounds of the formula I and II are made by methods known in the art. In general, for the compounds of formula I, appropriate benzaldehyde and phenylacetic acid starting materials are condensed, then decarboxylated, if required.
- the compounds according to the present invention may be combined with a physiologically acceptable vehicle in pharmaceutical composition.
- a physiologically acceptable vehicle in pharmaceutical composition.
- the particularly preferred form of composition is an orally administrated capsule or solution in which the compound is delivered in water, saline, a phosphate buffer, or lyophilized powder in a form of tablets or capsules which also includes various fillers and binders.
- the effective dosages of the compound in a composition will be selected by those of ordinary skill in the art and may empirically be determined.
- the compounds of the present invention are useful for the treatment of diseases such as diabetes characterized by the presence of elevated blood glucose levels, that is, hyperglycemic disorders such as diabetes melitus, including both Type I and II diabetes as well as other hyperglycemic related disorders such as obesity, increased cholesterol, kidney related disorders, and the like.
- treatment it is meant that the compound is administered at least to reduce the blood glucose level in the patient suffering from the hyperglycemic disorder.
- the compound is administered in an amount sufficient to reduce blood glucose level to an acceptable range, wherein an acceptable range means ⁇ 10%, usually ⁇ 8% and usually ⁇ 5% of the normal average blood glucose level for the subject.
- an acceptable range means ⁇ 10%, usually ⁇ 8% and usually ⁇ 5% of the normal average blood glucose level for the subject.
- an acceptable range means ⁇ 10%, usually ⁇ 8% and usually ⁇ 5% of the normal average blood glucose level for the subject.
- a variety of subjects may be treated with the compounds to reduce blood glucose levels, such as livestock, valuable or rare animals, pets, as well as humans.
- the compounds may be administered to the subject suffering from the hyperglycemic disorder using a convenient administration technique, including intravenous, intradermal, intramuscular subcutaneous oral and the like. However, the oral route of administration is particularly preferred.
- the dosage delivered to the host will necessarily depend upon the route by which the compound is delivered,
- the organic extract was further extracted with IN NaOH, then the NaOH extract was washed with water, the aqueous layer was acidified with concentrated HCl and washed with water to obtain the crude product. Crude product was recrystallized from ethanol/water to yield the acid I .
- EXAMPLE 3 Referring to FIG. 1, the streptozotocin (STZ) - induced diabetic rats were produced by injecting STZ (40 mg/kg/BW) intravenously. The blood glucose levels were measured 72 hrs. after the injection. Experiments were conducted with rats showing fasting blood glucose levels more than 200 mg/dl . The compound in example 1 was administered at a dose of 20 mg/kg/BW orally to test rats. Simultaneously, a control group received vehicle PBS (phosphate buffered saline) . Soon after administration, glucose tolerance tests were conducted by administering glucose (2g/kg/BW) and blood glucose levels were monitored at different time points. The results are shown in FIG. 1.
- STZ streptozotocin
- EXAMPLE 4 glucose tolerance was measured in Zucker (fa/fa) rats. Hyperinsulinemic and insulin resistant Zucker rats were randomized into two groups designated as a test group and a control group to check the effect of compound in Example 1 on glucose tolerance and insulin levels. Six of the test group rats were given dosages of the compound of Example 1 (20 mg/kg/BW/oral) once per day for period of three days . The control group was gavaged with an equal volume of PBS. An oral glucose (2 g/kg/BW) tolerance test was conducted on overnight-fasted rats soon after administration of test materials on day-3. Referring to FIG. 2, it shows that the compound of Example 1 improves glucose tolerance in insulin resistant obese Zucker rats.
- EXAMPLE 5 Referring to FIG. 3, twelve insulin resistant hyperinsulinemic obese Zucker (fa/fa) rats were randomized into two groups designated as a test group and a control group. Six of the test group rats received the compound of Example 1 (20 mg/kg/BW) at zero hour. The control group received an equal volume PBS. Plasma triglyceride levels were monitored for a period of 24 hours on fed state. The results are shown in FIG. 3. The compound from Example 1 lowers plasma triglyceride levels in obese insulin resistant hyperinsulinemic and triglyceridemic Zucker rats.
- EXAMPLE 6 Referring to FIG. 4, twelve obese hyperinsulinemic and insulin resistant Zucker (fa/fa) rats were randomized into groups designated as the test group and control group. Six of the test group were kept on the compound of Example 1 (20 mg/kg/BW/oral) once per day for a period of thirteen days . The control group was gavaged with an equal volume of PBS. Basal plasma insulin levels were monitored intermittently every three or four days during the course of the thirteen day study. The results in FIG. 4 show that the compound has an effect on lowering plasma insulin levels in this animal model.
- EXAMPLE 7 Nine healthy male Swiss Webster mice were divided into three study groups of three.
- the first study group (FIG. 5A) received the compound of Example 1 at a dose of 16.7 mg/kg/BW
- the second study group (FIG. 5B) received a dose of 167 mg/kg/BW
- the third study group (FIG. 5C) received a dose of 333 mg/kg/BW on day zero of the study.
- the mice were kept on regular food and water during the entire study period. During the study, the mice were under close observation and their behavior, gross physiology and mortality/survival were monitored.
- FIGS. 5A, 5B and 5C show that the survival rate in these mice in the course of the study period was 100%.
Abstract
Description
Claims
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US1999/011001 WO2000069430A1 (en) | 1999-05-18 | 1999-05-18 | Novel diphenylethylene compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1178788A1 true EP1178788A1 (en) | 2002-02-13 |
EP1178788A4 EP1178788A4 (en) | 2005-08-10 |
Family
ID=22272785
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP99924332A Withdrawn EP1178788A4 (en) | 1999-05-18 | 1999-05-18 | Novel diphenylethylene compounds |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP1178788A4 (en) |
JP (1) | JP2002544227A (en) |
KR (1) | KR100598638B1 (en) |
CN (1) | CN1194674C (en) |
AU (1) | AU778767C (en) |
CA (1) | CA2373603A1 (en) |
HK (1) | HK1046642B (en) |
MX (1) | MXPA01011760A (en) |
WO (1) | WO2000069430A1 (en) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7323496B2 (en) | 1999-11-08 | 2008-01-29 | Theracos, Inc. | Compounds for treatment of inflammation, diabetes and related disorders |
JP2003521500A (en) * | 2000-02-04 | 2003-07-15 | カリックス セラピューティックス インコーポレイテッド | New diphenylethylene compounds |
US6552085B2 (en) | 2000-08-16 | 2003-04-22 | Insmed Incorporated | Compositions containing hypoglycemically active stilbenoids |
US6410596B1 (en) * | 2000-08-16 | 2002-06-25 | Insmed Incorporated | Compositions containing hypoglycemically active stillbenoids |
US7384920B2 (en) | 2001-07-26 | 2008-06-10 | Institute Of Radiation Medicine, Academy Of Military Medical Sciences, Pla | Use of stilbene compounds in the manufacture of medicament for the prevention and treatment of diabetes or retrovirus-associated diseases |
JP4781580B2 (en) * | 2001-09-26 | 2011-09-28 | 日本メナード化粧品株式会社 | Collagenase inhibitor |
JP2007527418A (en) | 2003-12-29 | 2007-09-27 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | Composition for treating or preventing obesity and insulin resistance disorders |
US8017634B2 (en) | 2003-12-29 | 2011-09-13 | President And Fellows Of Harvard College | Compositions for treating obesity and insulin resistance disorders |
CN1723884A (en) * | 2004-07-21 | 2006-01-25 | 中国人民解放军军事医学科学院放射医学研究所 | Cis-1, the diphenyl ethylene derivatives that 2-replaces are used to prepare the purposes of the medicine of treatment or prevent diabetes |
WO2006138418A2 (en) | 2005-06-14 | 2006-12-28 | President And Fellows Of Harvard College | Improvement of cognitive performance with sirtuin activators |
CN100384801C (en) * | 2006-06-23 | 2008-04-30 | 中国科学院广州化学研究所 | (E)-3,5-dimethox-4'-hydroxy diphenyl ethylene synthesis method |
FR2904311B1 (en) | 2006-07-28 | 2013-01-11 | Clariant Specialty Fine Chem F | NEW PROCESS FOR THE SYNTHESIS OF (E) STILBENIC DERIVATIVES PERM TO OBTAIN RESVERATROL AND PICEATANNOL |
FR2921921B1 (en) | 2007-10-03 | 2011-08-19 | Clariant Specialty Fine Chem F | PROCESS FOR THE SYNTHESIS OF POLYHYDROXYSTILBENIC COMPOUNDS |
CN107324976B (en) * | 2017-07-28 | 2020-06-16 | 安徽理工大学 | Method for preparing (E) - β -alkyl styrene compound |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999056737A1 (en) * | 1998-05-05 | 1999-11-11 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Arylhydrocarbon receptor ligand antagonists |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5314693A (en) * | 1992-02-07 | 1994-05-24 | Kioritz Corporation | Pest control chemicals against pine wood nematodes |
US5430062A (en) * | 1992-05-21 | 1995-07-04 | Research Corporation Technologies, Inc. | Stilbene derivatives as anticancer agents |
US5770620A (en) * | 1995-06-19 | 1998-06-23 | Ontogen Corporation | Aryl acrylic acid derivatives useful as protein tyrosine phosphatase inhibitors |
US5827898A (en) * | 1996-10-07 | 1998-10-27 | Shaman Pharmaceuticals, Inc. | Use of bisphenolic compounds to treat type II diabetes |
-
1999
- 1999-05-18 WO PCT/US1999/011001 patent/WO2000069430A1/en active IP Right Grant
- 1999-05-18 KR KR1020017014590A patent/KR100598638B1/en not_active IP Right Cessation
- 1999-05-18 MX MXPA01011760A patent/MXPA01011760A/en not_active IP Right Cessation
- 1999-05-18 CN CNB998166448A patent/CN1194674C/en not_active Expired - Fee Related
- 1999-05-18 AU AU40857/99A patent/AU778767C/en not_active Ceased
- 1999-05-18 CA CA002373603A patent/CA2373603A1/en not_active Abandoned
- 1999-05-18 EP EP99924332A patent/EP1178788A4/en not_active Withdrawn
- 1999-05-18 JP JP2000617889A patent/JP2002544227A/en active Pending
-
2002
- 2002-11-14 HK HK02108244.5A patent/HK1046642B/en not_active IP Right Cessation
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999056737A1 (en) * | 1998-05-05 | 1999-11-11 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Arylhydrocarbon receptor ligand antagonists |
Non-Patent Citations (4)
Title |
---|
JANG DAE-SIG ET AL: "Inhibitory effects of resveratrol analogs on unopsonized zymosan-induced oxygen radical production" BIOCHEMICAL PHARMACOLOGY, vol. 57, no. 6, 15 March 1999 (1999-03-15), pages 705-712, XP002322563 ISSN: 0006-2952 * |
MANICKAM M ET AL: "ANTIHYPERGLYCEMIC ACTIVITY OF PHENOLICS FROM PTEROCARPUS MARSUPIUM" JOURNAL OF NATURAL PRODUCTS, XX, XX, vol. 6, no. 60, 23 June 1997 (1997-06-23), pages 609-610, XP001066243 ISSN: 0163-3864 * |
RYU S Y ET AL: "Antitumor activity of some phenolic components in plants" ARCHIVES OF PHARMACAL RESEARCH, NATL. FISHERIES UNIVERSITY, PUSAN, KR, vol. 17, no. 1, January 1994 (1994-01), pages 42-44, XP002968965 ISSN: 0253-6269 * |
See also references of WO0069430A1 * |
Also Published As
Publication number | Publication date |
---|---|
EP1178788A4 (en) | 2005-08-10 |
CN1354659A (en) | 2002-06-19 |
CN1194674C (en) | 2005-03-30 |
AU4085799A (en) | 2000-12-05 |
CA2373603A1 (en) | 2000-11-23 |
HK1046642A1 (en) | 2003-01-24 |
JP2002544227A (en) | 2002-12-24 |
WO2000069430A1 (en) | 2000-11-23 |
HK1046642B (en) | 2005-11-25 |
KR100598638B1 (en) | 2006-07-07 |
KR20020012220A (en) | 2002-02-15 |
AU778767B2 (en) | 2004-12-23 |
AU778767C (en) | 2006-09-07 |
MXPA01011760A (en) | 2003-09-04 |
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Legal Events
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PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
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RIC1 | Information provided on ipc code assigned before grant |
Ipc: 7C 07C 39/215 B Ipc: 7C 07C 39/06 B Ipc: 7C 07C 43/215 B Ipc: 7C 07C 43/205 B Ipc: 7C 07C 59/48 B Ipc: 7A 61P 3/10 B Ipc: 7A 61K 31/05 B Ipc: 7A 61K 31/09 B Ipc: 7A 61K 31/192 A |
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A4 | Supplementary search report drawn up and despatched |
Effective date: 20050627 |
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17Q | First examination report despatched |
Effective date: 20070813 |
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RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: THERACOS, INC. |
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Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN |
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18W | Application withdrawn |
Effective date: 20100222 |