CN1545409A - 二苯乙烯类化合物在制备用于治疗和预防糖尿病或与逆转录病毒有关疾病的药物中用途 - Google Patents

二苯乙烯类化合物在制备用于治疗和预防糖尿病或与逆转录病毒有关疾病的药物中用途 Download PDF

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Publication number
CN1545409A
CN1545409A CNA028163818A CN02816381A CN1545409A CN 1545409 A CN1545409 A CN 1545409A CN A028163818 A CNA028163818 A CN A028163818A CN 02816381 A CN02816381 A CN 02816381A CN 1545409 A CN1545409 A CN 1545409A
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retrovirus
treating
diseases associated
preventing diabetes
stilbene compounds
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CN1237961C (zh
Inventor
李军林
吴祖泽
袁丽珍
李强
唐仲雄
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Wuhan Guanggu Humanwell Biological Pharmaceutical Co Ltd
Institute of Radiation Medicine of CAMMS
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Beijing Lu Yin Li Hua Pharmaceutical Science Technology Development Co ltd
Institute of Radiation Medicine of CAMMS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/01—Hydrocarbons
    • A61K31/015—Hydrocarbons carbocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • AIDS & HIV (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

本发明涉及二苯乙烯类化合物或其药用盐的新用途，尤其是在制备用于治疗或预防糖尿病或与逆转录病毒有关疾病的药物中用途。

Description

PCT国内申请，说明书已公开。

Claims (1)

  1. PCT国内申请，权利要求书已公开。
CNB028163818A 2001-07-26 2002-07-26 二苯乙烯类化合物在制备用于治疗和预防糖尿病或与逆转录病毒有关疾病的药物中用途 Expired - Fee Related CN1237961C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN01120597A CN1398838A (zh) 2001-07-26 2001-07-26 二苯乙烯类化合物制备以及它们在治疗和预防糖尿病中的应用
CN01120597.0 2001-07-26

Publications (2)

Publication Number Publication Date
CN1545409A true CN1545409A (zh) 2004-11-10
CN1237961C CN1237961C (zh) 2006-01-25

Family

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Family Applications (2)

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CN01120597A Pending CN1398838A (zh) 2001-07-26 2001-07-26 二苯乙烯类化合物制备以及它们在治疗和预防糖尿病中的应用
CNB028163818A Expired - Fee Related CN1237961C (zh) 2001-07-26 2002-07-26 二苯乙烯类化合物在制备用于治疗和预防糖尿病或与逆转录病毒有关疾病的药物中用途

Family Applications Before (1)

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CN01120597A Pending CN1398838A (zh) 2001-07-26 2001-07-26 二苯乙烯类化合物制备以及它们在治疗和预防糖尿病中的应用

Country Status (5)

Country Link
US (1) US7384920B2 (zh)
EP (1) EP1421933B1 (zh)
JP (1) JP4397688B2 (zh)
CN (2) CN1398838A (zh)
WO (1) WO2003009838A1 (zh)

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CA2548671C (en) 2003-12-29 2015-02-24 President And Fellows Of Harvard College Compositions for treating or preventing obesity and insulin resistance disorders
US8017634B2 (en) 2003-12-29 2011-09-13 President And Fellows Of Harvard College Compositions for treating obesity and insulin resistance disorders
JP2008503479A (ja) * 2004-06-16 2008-02-07 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ Ｂａｘ媒介性アポトーシスを調節する方法及び組成物
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WO2006004722A2 (en) * 2004-06-30 2006-01-12 Biomol Research Laboratories, Inc. Compositions and methods for selectively activating human sirtuins
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WO2006138418A2 (en) * 2005-06-14 2006-12-28 President And Fellows Of Harvard College Improvement of cognitive performance with sirtuin activators
US8367669B2 (en) * 2005-06-15 2013-02-05 Vanderbilt University Inhibitors of hemeprotein-catalyzed lipid peroxidation
US9133212B1 (en) 2005-06-15 2015-09-15 Vanderbilt University Inhibitors of hemeprotein-catalyzed lipid peroxidation
US20070149466A1 (en) * 2005-07-07 2007-06-28 Michael Milburn Methods and related compositions for treating or preventing obesity, insulin resistance disorders, and mitochondrial-associated disorders
JP2007126390A (ja) * 2005-11-02 2007-05-24 Mercian Corp 血糖値低下剤
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JP5224648B2 (ja) * 2006-02-21 2013-07-03 丸善製薬株式会社 抗皮膚炎症剤、美白剤及び抗皮膚老化剤
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CN101781173B (zh) * 2009-01-21 2014-03-26 北京三有利科技发展有限公司 二苯乙烯类化合物及其在制备用于治疗和预防前列腺肥大有关疾病的药物中的用途
US20100273203A1 (en) * 2009-04-23 2010-10-28 Board Of Trustees Of The University Of Arkansas Methods and compositions for detecting metabolites
US8883218B2 (en) 2010-03-26 2014-11-11 The Board Of Trustees Of The University Of Arkansas Anti-cancer nanoparticle compositions and methods of use
CN102058678B (zh) * 2010-12-10 2013-01-23 西藏金哈达药业有限公司 一种治疗脂肪肝的药物或保健食品组合物
US9095598B2 (en) * 2010-12-28 2015-08-04 The Board Of Trustees Of The University Of Arkansas Stilbenoid derivatives and their uses
US9044491B2 (en) * 2010-12-28 2015-06-02 The Board Of Trustees Of The University Of Arkansas Method for improving blood flow using stilbenoid derivatives
CN102887925B (zh) * 2011-07-21 2015-08-12 中国科学院兰州化学物理研究所 从河套大黄中提取土大黄苷的方法
CN103156827A (zh) * 2011-12-09 2013-06-19 天津市国际生物医药联合研究院 二苯乙烯类化合物在治疗和预防艾滋病中的用途
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Also Published As

Publication number Publication date
US7384920B2 (en) 2008-06-10
CN1398838A (zh) 2003-02-26
EP1421933B1 (en) 2013-03-27
JP4397688B2 (ja) 2010-01-13
CN1237961C (zh) 2006-01-25
JP2004537561A (ja) 2004-12-16
EP1421933A4 (en) 2007-09-05
EP1421933A1 (en) 2004-05-26
WO2003009838A1 (fr) 2003-02-06
US20050020511A1 (en) 2005-01-27

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Owner name: OPTICS VALLEY HUMANWELL BIOPHARMACEUTICAL CO., LTD

Free format text: FORMER OWNER: BEIJING LUYIN LIHUA PHARMACEUTICAL TECHNOLOGY DEVELOPMENT CO., LTD.

Effective date: 20120829

C41 Transfer of patent application or patent right or utility model
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Effective date of registration: 20120829

Address after: No. 27 Taiping Road, Beijing

Patentee after: Institute of Radiation Medicine of Academy of Military Medical Sciences of Chinese People's Liberation Army

Patentee after: WUHAN GUANGGU HUMANWELL BIOLOGICAL PHARMACEUTICAL CO., LTD.

Address before: No. 27 Taiping Road, Beijing

Patentee before: Institute of Radiation Medicine of Academy of Military Medical Sciences of Chinese People's Liberation Army

Patentee before: Beijing Luyin Lihua Pharmaceutical Technology Development Co., Ltd.

CF01 Termination of patent right due to non-payment of annual fee
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Granted publication date: 20060125

Termination date: 20170726