WO2003001215A2 - Ventilblock für eine anordnung von kolbenpipetten - Google Patents
Ventilblock für eine anordnung von kolbenpipetten Download PDFInfo
- Publication number
- WO2003001215A2 WO2003001215A2 PCT/CH2002/000306 CH0200306W WO03001215A2 WO 2003001215 A2 WO2003001215 A2 WO 2003001215A2 CH 0200306 W CH0200306 W CH 0200306W WO 03001215 A2 WO03001215 A2 WO 03001215A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- valve block
- plates
- plate
- channels
- openings
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/0241—Drop counters; Drop formers
- B01L3/0265—Drop counters; Drop formers using valves to interrupt or meter fluid flow, e.g. using solenoids or metering valves
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K99/0001—Microvalves
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K99/0001—Microvalves
- F16K99/0003—Constructional types of microvalves; Details of the cutting-off member
- F16K99/0011—Gate valves or sliding valves
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00783—Laminate assemblies, i.e. the reactor comprising a stack of plates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00851—Additional features
- B01J2219/00871—Modular assembly
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00891—Feeding or evacuation
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K2099/0073—Fabrication methods specifically adapted for microvalves
- F16K2099/0076—Fabrication methods specifically adapted for microvalves using electrical discharge machining [EDM], milling or drilling
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K2099/0073—Fabrication methods specifically adapted for microvalves
- F16K2099/008—Multi-layer fabrications
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K2099/0082—Microvalves adapted for a particular use
- F16K2099/0084—Chemistry or biology, e.g. "lab-on-a-chip" technology
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00178—Special arrangements of analysers
- G01N2035/00237—Handling microquantities of analyte, e.g. microvalves, capillary networks
- G01N2035/00247—Microvalves
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1065—Multiple transfer devices
- G01N35/1074—Multiple transfer devices arranged in a two-dimensional array
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T137/00—Fluid handling
- Y10T137/8593—Systems
- Y10T137/86493—Multi-way valve unit
- Y10T137/86879—Reciprocating valve unit
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T137/00—Fluid handling
- Y10T137/8593—Systems
- Y10T137/87249—Multiple inlet with multiple outlet
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T137/00—Fluid handling
- Y10T137/8593—Systems
- Y10T137/87917—Flow path with serial valves and/or closures
Definitions
- the invention is in the field of microanalysis and relates to a valve block according to the preamble of the independent claim.
- the valve block can be used, for example, in a metering device, with which a large number of small quantities of liquid can be handled in parallel, with which, for example, small quantities of liquids can be simultaneously metered into a plurality of cavities on a test plate or can also be removed from the cavities.
- Such a metering device is described in the patent EP-0363450 (or US-5193403, Bürgisser). It has a plurality of piston pipettes or similar dosing means which are equipped for the dosed suction or ejection of liquid through a distal end. Furthermore, the device has a valve plate, one surface of which is directed against the distal ends of the piston pipettes and is pressed against them, for example, by means of spring force.
- the valve plate has a pattern of through openings which is adapted to the arrangement of the piston pipettes in such a way that a distal end of the pipette can be aligned with a through opening.
- hollow metering tips advantageously adjoin the mouths of the through openings.
- the valve plate has two channel systems, each of which has a main connection and a plurality of orifices connected to the main connection by channels at the end facing the distal pipette ends. th side of the valve plate.
- the mouths of each channel system in turn form a pattern that is adapted to the pipette arrangement.
- one of the duct systems is connected to a liquid source via the main connection and the other to a drain.
- the distal ends of the piston pipettes are optionally connected to the through openings or to the orifices of one or the other of the channel systems, which enables a multitude of metering functions.
- the dosing device briefly described above is simple and robust and can be operated at satisfactory speeds.
- orifices must be provided for each channel system on the surface of the valve plate directed against the piston pipettes and must be accommodated within a grid determined by the through openings, the number of possible channel systems for a given grid of the through openings is limited.
- the same limitation also applies to the valve plate for manufacturing reasons, because the valve plate is • essentially made from one piece.
- valve block for a metering device, as briefly described above, the valve block should be easy to manufacture regardless of the number of channel systems, the valve block should also be easy to implement with a small pitch and the grid dimension in this valve block should in no way limit the possible number of channel systems.
- the valve block according to the invention is modularly composed of plates.
- the valve block has a connection plate and a plurality of preferably identical channel plates, each of which represents one of the channel systems.
- the plates are arranged in a stack adjacent to one another and are displaceable to a limited extent.
- the connection plate is directed against the distal ends of an arrangement of piston pipettes or other dosing means and has a plurality of through openings aligned with these distal ends.
- the channel plates also have through openings, the through openings of the connection plate and the channel plates being able to be aligned with one another, that is to say all are arranged in the same grid.
- each channel plate has a channel system that is open at least to one plate side, which is matched to the grid of the through openings, but is laterally displaced relative to this.
- the duct system advantageously has at least one main connection on the narrow side of the plate.
- each channel plate is displaceable in relation to each other and relative to the connection plate in the plate stack in such a way that each channel plate can have essentially two positions: a first position in which its through openings face the outgoing openings of the connection plate are aligned, and a second position in which their channel system is aligned with the through openings of the connection plate.
- connection plate and the channel plates of the valve block according to the invention consist of a material whose surfaces (if appropriate processed accordingly) can seal against one another on the one hand and can still be moved against one another in a sealing manner. Furthermore, the material should of course not be attacked by the liquids used. It is known from valve technology, ⁇ in particular from the widespread single-lever mixers, that ceramic materials are advantageously used for such applications.
- valve block according to the invention is described in more detail with reference to the following figures. Show:
- FIGS. 1 to 3 an exemplary embodiment of the valve block according to the invention in section with different positions of channel plates;
- FIG. 4 shows a top view of the connection plate of an exemplary embodiment of the valve block according to the invention
- Figure 5 is a plan view of a channel plate of the same embodiment of the valve block according to the invention
- FIG. 6 shows a detail of the channels of the channel plate according to FIG. 5.
- FIG. 1 shows a very schematic and incomplete section through a metering device as described at the beginning.
- the metering device shows a valve block 1 according to the invention, an arrangement of metering means (e.g. piston pipettes 2) arranged on one side of the valve block and an arrangement of metering tips 3 arranged on the opposite side of the valve block.
- the valve block has a connecting plate 10 and a first, second and third (outermost) channel plate 11, 12 and 13 adjoining the connecting plate 10, the plates being held together in a stack by means of suitable means (not shown) in such a way that the connection plate 10 forms one end face of the stack and the outermost channel plate 13 the other.
- connection plate 10 and the channel plates 11, 12 and 13 have the same through-openings 14, which are advantageously arranged in a regular pattern, which pattern is adapted to the arrangement of the piston pipettes.
- these through openings form first orifices 15 and second orifices 16 to which, with suitable means, the piston pipettes 2 or other suitable dosing means or the dosing tips or other suitable connecting means are connected.
- the channel plates have a channel system 20. This is designed such that there are all openings of an opening arranged in the same pattern with at least one main connection connects, but it is laterally shifted from the pattern of the through openings. If the through openings are arranged, for example, in straight rows, the channels of the channel system run parallel to these rows and at a constant distance therefrom. Furthermore, collecting channels are advantageously provided outside the pattern of openings and connect the channels to the at least one main connection.
- Figure 1 shows such channels 21 arranged between rows of through openings in section.
- a not visible, parallel to the section plane collecting channel 22 is indicated by broken lines.
- a main connection 23 is indicated in the same way.
- the channels 21 are arranged, for example, centrally between the rows of through openings 14, so that a lateral displacement of two adjacent plates by half the grid size means switching between the position with aligned through openings and a position with channels aligned with through openings.
- the channel systems 20 of the channel plates 11, 12 and 13 according to FIG. 1 have a depth that is smaller than the plate thickness (trough-shaped channels).
- the channels are closed off on one side in the stack of plates by an adjacent plate. It is also possible to give the channels a depth that is the same as the plate thickness (slot-shaped channels). Such slot-like channels are closed on both sides in the stack of plates by adjacent plates.
- a further connection plate is to be arranged on the end face of the valve block opposite the connection plate 10.
- the plates which together form the valve block according to the invention preferably consist of a ceramic material, for example of aluminum oxide. As shown in Figure 1, it is advantageous to design the channel plates 11, 12 and 13 all the same, which keeps the price of the valve block low. If the channels are trough-shaped, it is obviously also possible to use a channel plate as the connection plate, the channels of this plate then having no functional meaning.
- valve block is held, for example, between two holding plates, for example made of steel, perforated accordingly for the first and second orifices, the two plates being pressed lightly against one another.
- appropriate servomotors are to be installed on two sides of the plate stack. When actuated appropriately, they act on one of the channel plates.
- FIG. 1 the metering device is shown in a state in which the piston pipettes are connected to the metering tips via the aligned, continuous openings of all plates.
- FIG. 2 which only shows the valve block 1
- the piston pipettes are connected to the channel system of the third channel plate 13 via the through openings 14 in the connecting plate 10 and the first two channel plates 11 and 12.
- FIG. 3 which also only shows the valve block 1, the piston pipettes are connected to the channel system of the first channel plate 11 via the through openings 14 of the connection plate 10.
- FIGS. 1, 2 and 3 show that for a changeover of the valve block 1 from a state in which the first and second orifices 15 and 16 are each connected to one another in a state in which the first orifices 15 are connected are connected to a selected duct system, a displacement of the corresponding duct plate by half a grid dimension is sufficient (FIG. 2: third duct plate 13, FIG. 3: first duct plate 11).
- FIG. 4 shows a top view of an exemplary embodiment of a connecting plate 10.
- the through openings 14 or first openings 15 are arranged in rows with a distance d.
- the pattern of the through openings corresponds, for example, to the cavity pattern of standardized microtest plates (with 96, 384 or 1536 cavities).
- FIG. 5 shows a channel plate 11 which can be used together with the connection plate 10 of FIG. 4 in a valve block according to the invention.
- the channel plate 11 has channels 21 which run centrally between the rows of through openings, ie have a distance d / 2 from them.
- the channels 21 open into common channels 22, which run outside the pattern of through openings and which in turn open into the main connection 23.
- FIG. 6 shows in a three-dimensional detail the channels 21 of the channel plate 11 according to FIG. 5.
- These channels 21 run centrally between the rows of through openings 14 and are trough-shaped, as is also shown in FIGS. 1 to 3.
- the channels 21 are advantageously designed in such a way that their cross section increases towards the mouth into a collecting channel 22. This is realized, for example, as can be seen from FIG. 6, by increasing the depth of the trough-shaped channels.
Abstract
Description
Claims
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02732306A EP1399745A2 (de) | 2001-06-26 | 2002-06-10 | Ventilblock für eine anordnung von kolbenpipetten |
AU2002304953A AU2002304953A1 (en) | 2001-06-26 | 2002-06-10 | Valve block for an arrangement of piston pipettes |
US10/481,803 US7073531B2 (en) | 2001-06-26 | 2002-06-10 | Valve block |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH1171/01 | 2001-06-26 | ||
CH11712001 | 2001-06-26 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2003001215A2 true WO2003001215A2 (de) | 2003-01-03 |
WO2003001215A3 WO2003001215A3 (de) | 2003-06-26 |
Family
ID=4561256
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/CH2002/000306 WO2003001215A2 (de) | 2001-06-26 | 2002-06-10 | Ventilblock für eine anordnung von kolbenpipetten |
Country Status (4)
Country | Link |
---|---|
US (1) | US7073531B2 (de) |
EP (1) | EP1399745A2 (de) |
AU (1) | AU2002304953A1 (de) |
WO (1) | WO2003001215A2 (de) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109074062B (zh) * | 2016-02-24 | 2023-02-17 | 琳娜·莱文 | 机械驱动的排序歧管 |
US11035480B2 (en) | 2016-02-24 | 2021-06-15 | Leanna Levine and Aline, Inc. | Mechanically driven sequencing manifold |
KR20230170665A (ko) * | 2021-04-12 | 2023-12-19 | 옥테인 바이오테크 인코포레이티드 | 자동화된 세포 공학 시스템에서 사용하기 위한 조합 유체 스위치 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5137698A (en) * | 1988-04-22 | 1992-08-11 | Europaisches Laboratorium fur Molekularbiologic (EMBL) | Apparatus for carrying out chemical reaction sequences |
US5538694A (en) * | 1992-03-02 | 1996-07-23 | Deutsches Krebsforschungszentrum Stiftung Des Oeffentlichen Rechts | Device for simultaneously or sequentially carrying out chemical reactions |
WO1998057738A1 (de) * | 1997-06-16 | 1998-12-23 | Chemspeed Ltd. | Vorrichtung zur parallelen durchführung einer vielzahl von chemischen, biochemischen oder physikalischen verfahren |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2904070A (en) * | 1955-06-06 | 1959-09-15 | Ibm | Multi-port selector |
US2857082A (en) * | 1957-04-19 | 1958-10-21 | Nat Equip Corp | Pump construction for candy depositing machines |
FR1586152A (de) * | 1968-07-26 | 1970-02-13 |
-
2002
- 2002-06-10 EP EP02732306A patent/EP1399745A2/de not_active Withdrawn
- 2002-06-10 US US10/481,803 patent/US7073531B2/en not_active Expired - Fee Related
- 2002-06-10 WO PCT/CH2002/000306 patent/WO2003001215A2/de not_active Application Discontinuation
- 2002-06-10 AU AU2002304953A patent/AU2002304953A1/en not_active Abandoned
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5137698A (en) * | 1988-04-22 | 1992-08-11 | Europaisches Laboratorium fur Molekularbiologic (EMBL) | Apparatus for carrying out chemical reaction sequences |
US5538694A (en) * | 1992-03-02 | 1996-07-23 | Deutsches Krebsforschungszentrum Stiftung Des Oeffentlichen Rechts | Device for simultaneously or sequentially carrying out chemical reactions |
WO1998057738A1 (de) * | 1997-06-16 | 1998-12-23 | Chemspeed Ltd. | Vorrichtung zur parallelen durchführung einer vielzahl von chemischen, biochemischen oder physikalischen verfahren |
Also Published As
Publication number | Publication date |
---|---|
US20040112441A1 (en) | 2004-06-17 |
US7073531B2 (en) | 2006-07-11 |
EP1399745A2 (de) | 2004-03-24 |
AU2002304953A1 (en) | 2003-01-08 |
WO2003001215A3 (de) | 2003-06-26 |
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