WO2003000215A1 - Tooth-paste composition having anti-plaque properties - Google Patents

Tooth-paste composition having anti-plaque properties Download PDF

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Publication number
WO2003000215A1
WO2003000215A1 PCT/IT2002/000407 IT0200407W WO03000215A1 WO 2003000215 A1 WO2003000215 A1 WO 2003000215A1 IT 0200407 W IT0200407 W IT 0200407W WO 03000215 A1 WO03000215 A1 WO 03000215A1
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WO
WIPO (PCT)
Prior art keywords
tooth
paste
plaque
composition according
components
Prior art date
Application number
PCT/IT2002/000407
Other languages
French (fr)
Inventor
Gian Maria Amatori
Mario Pastorio
Original Assignee
Herbariorum Medicaminum Officina Alta Badiae S.N.C.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Herbariorum Medicaminum Officina Alta Badiae S.N.C. filed Critical Herbariorum Medicaminum Officina Alta Badiae S.N.C.
Publication of WO2003000215A1 publication Critical patent/WO2003000215A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/42—Colour properties
    • A61K2800/43—Pigments; Dyes

Definitions

  • the present invention refers to compositions useful as tooth-pastes capable of removing dental plaque.
  • Tooth pastes now available on the market, commonly comprise, beside deionised water: a) an abrasive agent to remove the protein film formed on the tooth surface, without any damaging of the tooth enamel.
  • abrasive agents the following can be mentioned: dihydrate calcium phosphate, calcium carbonate, hydrated alumina and silica: b) a preferably anionic surfactant agent to help the frothing and making more pleasant the use of tooth-paste.
  • said surfactant agents lauryl sulphate, lauryl sarcosinate or sodium glutamate are the more commonly used; c) gelating compounds restraining the tooth paste contained water from separating in order to insure long time tooth paste softness.
  • Such products consist generally of glycerol, sorbitol, propylen glycol; d) products capable of maintaining the abrasive agent within the suspension.
  • Some example of the above products are: cellulose derivatives as hydroxymethylcellulose, carboxymethylcellulose, cellulose ethers as well as pyrogenic silica, carrageenans.
  • tooth pastes i.e. aromas, sweetening agents, colours, preservatives, anticorrosion agents when use is made of metal containers.
  • commercial tooth pastes further contain one or more of the following additives: whitening agents, as peroxides or persalts, anticaries agent as fluorine derivatives as well as one or more anti-plaque agents, consisting of anti-microbial anti-bacterial agents. Therefore commercial tooth-pastes carry out a teeth and oral cavity aesthetic and hygienic conservation action due to the presence of antibacterial and anti-microbial ingredients, but they do not provide any information as to the status and the presence of the plaque on the teeth surface, on the gingivas or other zones of the oral cavity.
  • Commercially available are products capable to reveal the presence of the plaque on the tooth surface and other parts of the oral cavity. The plaque detection is based on the change of colour of said detectors when they come in contact with the tooth- plaque.
  • plaque detecting methods comprise the use of radiations which cause a fluorescence of the zones where the plaque does exists. Such a products and methods are carried out before or after tooth brushing, therefore it is not possible to know whether the tooth brushing goes in the direction of the complete plaque removal. In fact no information is available as to the zones wherein plaque is present in a higher concentration and where concentrate the tooth brush action, unless after the teeth brushing is over. It would highly desirable to avail of a tooth paste that while maintaining the properties of the teeth paste comprising the present available components does not exhibit the inconveniences due to the information failure as to the existence and status of the plaque during the usual tooth cleaning treatment.
  • a tooth paste composition that comprises, beside the known components listed above, also a plaque detecting component, indicating the plaque existence, by an intense colour assumed by the tooth paste suspension in the oral cavity.
  • a plaque detecting component indicating the plaque existence
  • the colour indicating the plaque existence become less intense until its disappearance that means that the entire plaque has been attacked and removed by subsequent brushing treatments.
  • the presence of the plaque detecting compound allows to predefine the teeth brushing duration and intensity depending upon the plaque presence and its concentration in the oral cavity.
  • composition useful for the preparation of a new class of tooth paste or collutory capable of detecting the presence of plaque in the oral cavity, during the tooth brushing containing one or more plaque detecting agent, together with all components necessary to accomplishing a good detergent and curative activity on the teeth and furthermore allows to monitory plaque disappearance and removal degree as the teeth brushing proceeds.
  • compositions having the form of a paste of solid materials containing a small amount of water comprising: a) an abrasive agent to remove the protein film formed on the tooth surface, without any damaging of the tooth enamel; b) a preferably anionic surfactant agent to help the frothing and making more pleasant the use of tooth-paste; c) gelating compounds restraining the tooth paste contained water from separating in order to insure a long time tooth paste softness; d) products capable of maintaining the abrasive agent within the suspension; e) one or more of the following additives: whitening agents, as peroxides or persalts, anti-caries agents i.e.
  • fluorine derivatives f) one or more anti-plaque agents, consisting of anti-microbial anti-bacterial ingredients; g) a component capable to detect the presence of plaque by means of an intense colour shown by the tooth-paste suspension present in the oral cavity in the course of teeth brushing operation.
  • dihydrate calcium phosphate dihydrate calcium phosphate, calcium carbonate, hydrated alumina and silica.
  • lauryl sulphate lauryl sarcosinate or sodium glutamate are the more commonly used.
  • the materials useful as group c) components are generally glycerol, sorbitol, propylen glycol.
  • Some example of compounds of group d) are: cellulose derivatives as hydroxymethylcellulose, carboxymethylcellulose, cellulose ethers as well as pyrogenic silica, carrageenans.
  • the tooth-pastes presently available on the market comprise one or more of the following additives: whitening agents as peroxides or persalts, anti-caries agents as fluorine derivatives as well as one or more anti plaque agents generally comprising anti-bacterial or anti-microbial compounds.
  • plaque detector agent use can be made of any known compound which is able to assume or to make assume to the tooth-paste dispersion when used for teeth brushing an colour whose intensity depends on the existing plaque amount.
  • some tooth pastes composition have been prepared which fall within the scope of the present invention containing both Triclosan as anti-plaque agent and erythrosine as plaque detector.
  • Tooth paste composition was as follows: Silica 20%
  • Triclosan Antibacterial and Antiplaque agent
  • Plaque detecting agent (erythrosine or its derivatives) 3%
  • the tooth paste prepared according to the above composition was distributed to volunteers accostumed to a different use of the tooth paste, First of all, the above persons were provided with an anti-plaque containing toothpaste, but without any plaque detector agent and said volunteers were requested to keep brushing their tooth until, according to their opinion, the plaque was totally removed. Another volunteer group were requested to continue the tooth-brush action until an observed plaque disappearance.
  • test on volunteers B, D, F and the relevant composition fall within the scope of the invention, while the results of volunteers A, C, E, testing tooth-pastes without any plaque detector are provided as comparison testes.
  • compositions according to the invention are able to remove dental plaque by a selective and appropriate action on the zones of the oral cavity, whereas volunteers who did not receive the plaque detector require a longer time to remove the plaque and , in some case the removal is not complete.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cosmetics (AREA)

Abstract

Tooth-paste composition having the form of a paste of solid materials containing a small amount of water comprising : a) an abrasive agent to remove the protein film formed on the tooth surface, without any damaging of the tooth enamel. b) a preferably anionic surfactant agent to help the frothing and making more pleasant the use of tooth-paste ; c) gelating compounds restraining the tooth paste contained water from separating in order to insure a long time tooth paste softness. d) products capable of maintaining the abrasive agent within the suspension. e) one or more of the following additives : whitening agents, as peroxides or persalts, anti-caries agents i.e. fluorine derivatives ; f) one or more anti-plaque agents, consisting of anti-microbial anti-bacterial ingredients characterized in that it comprises one or more components capable to detect he presence of plaque by means of an intense colour shown by the tooth-paste suspension present in the oral cavity in the course of teeth brushing operation.

Description

Title:
"TOOTH-PASTE COMPOSITION HAVING ANTI-PLAQUE PROPERTIES"
The present invention refers to compositions useful as tooth-pastes capable of removing dental plaque.
Tooth pastes, now available on the market, commonly comprise, beside deionised water: a) an abrasive agent to remove the protein film formed on the tooth surface, without any damaging of the tooth enamel. Among the abrasive agents the following can be mentioned: dihydrate calcium phosphate, calcium carbonate, hydrated alumina and silica: b) a preferably anionic surfactant agent to help the frothing and making more pleasant the use of tooth-paste. Among said surfactant agents, lauryl sulphate, lauryl sarcosinate or sodium glutamate are the more commonly used; c) gelating compounds restraining the tooth paste contained water from separating in order to insure long time tooth paste softness. Such products consist generally of glycerol, sorbitol, propylen glycol; d) products capable of maintaining the abrasive agent within the suspension. Some example of the above products are: cellulose derivatives as hydroxymethylcellulose, carboxymethylcellulose, cellulose ethers as well as pyrogenic silica, carrageenans.
Other products are generally present in tooth pastes i.e. aromas, sweetening agents, colours, preservatives, anticorrosion agents when use is made of metal containers. Actually commercial tooth pastes further contain one or more of the following additives: whitening agents, as peroxides or persalts, anticaries agent as fluorine derivatives as well as one or more anti-plaque agents, consisting of anti-microbial anti-bacterial agents. Therefore commercial tooth-pastes carry out a teeth and oral cavity aesthetic and hygienic conservation action due to the presence of antibacterial and anti-microbial ingredients, but they do not provide any information as to the status and the presence of the plaque on the teeth surface, on the gingivas or other zones of the oral cavity. Commercially available are products capable to reveal the presence of the plaque on the tooth surface and other parts of the oral cavity. The plaque detection is based on the change of colour of said detectors when they come in contact with the tooth- plaque.
Other plaque detecting methods comprise the use of radiations which cause a fluorescence of the zones where the plaque does exists. Such a products and methods are carried out before or after tooth brushing, therefore it is not possible to know whether the tooth brushing goes in the direction of the complete plaque removal. In fact no information is available as to the zones wherein plaque is present in a higher concentration and where concentrate the tooth brush action, unless after the teeth brushing is over. It would highly desirable to avail of a tooth paste that while maintaining the properties of the teeth paste comprising the present available components does not exhibit the inconveniences due to the information failure as to the existence and status of the plaque during the usual tooth cleaning treatment. It has now been found that it is possible to overcome the above mentioned inconveniences by using a tooth paste composition that comprises, beside the known components listed above, also a plaque detecting component, indicating the plaque existence, by an intense colour assumed by the tooth paste suspension in the oral cavity. As the tooth paste treatment proceeds, the colour indicating the plaque existence become less intense until its disappearance that means that the entire plaque has been attacked and removed by subsequent brushing treatments. The presence of the plaque detecting compound allows to predefine the teeth brushing duration and intensity depending upon the plaque presence and its concentration in the oral cavity. It is therefore an object of the present invention a composition useful for the preparation of a new class of tooth paste or collutory capable of detecting the presence of plaque in the oral cavity, during the tooth brushing containing one or more plaque detecting agent, together with all components necessary to accomplishing a good detergent and curative activity on the teeth and furthermore allows to monitory plaque disappearance and removal degree as the teeth brushing proceeds. The scope of the present invention is reached by means of a composition having the form of a paste of solid materials containing a small amount of water comprising: a) an abrasive agent to remove the protein film formed on the tooth surface, without any damaging of the tooth enamel; b) a preferably anionic surfactant agent to help the frothing and making more pleasant the use of tooth-paste; c) gelating compounds restraining the tooth paste contained water from separating in order to insure a long time tooth paste softness; d) products capable of maintaining the abrasive agent within the suspension; e) one or more of the following additives: whitening agents, as peroxides or persalts, anti-caries agents i.e. fluorine derivatives; f) one or more anti-plaque agents, consisting of anti-microbial anti-bacterial ingredients; g) a component capable to detect the presence of plaque by means of an intense colour shown by the tooth-paste suspension present in the oral cavity in the course of teeth brushing operation.
Among the products useful as components of group a) the following can be mentioned: dihydrate calcium phosphate, calcium carbonate, hydrated alumina and silica.
Among the products useful as surfactant agents of group b) , lauryl sulphate, lauryl sarcosinate or sodium glutamate are the more commonly used.
The materials useful as group c) components, are generally glycerol, sorbitol, propylen glycol.
Some example of compounds of group d) are: cellulose derivatives as hydroxymethylcellulose, carboxymethylcellulose, cellulose ethers as well as pyrogenic silica, carrageenans.
As abovesaid the tooth-pastes presently available on the market comprise one or more of the following additives: whitening agents as peroxides or persalts, anti-caries agents as fluorine derivatives as well as one or more anti plaque agents generally comprising anti-bacterial or anti-microbial compounds. As plaque detector agent use can be made of any known compound which is able to assume or to make assume to the tooth-paste dispersion when used for teeth brushing an colour whose intensity depends on the existing plaque amount. In order to better understand the advantages of the present invention some tooth pastes composition have been prepared which fall within the scope of the present invention containing both Triclosan as anti-plaque agent and erythrosine as plaque detector.
Tooth paste composition was as follows: Silica 20%
SLS or alternative anionic as lauril sarcosinate or sodium glutamate 2% Glycerol or sorbitol 30%
Hydroxymethyl cellulose or Xantam Gum derivatives or Carbomer 1%
Parabene mixture as preservative systems 0,3%
Triclosan (Antibacterial and Antiplaque agent) 0,2%
Sodium fluoride or Sodium monofluorosulphate 1% Demineralised water 42,5%
Plaque detecting agent (erythrosine or its derivatives) 3%
The tooth paste prepared according to the above composition was distributed to volunteers accostumed to a different use of the tooth paste, First of all, the above persons were provided with an anti-plaque containing toothpaste, but without any plaque detector agent and said volunteers were requested to keep brushing their tooth until, according to their opinion, the plaque was totally removed. Another volunteer group were requested to continue the tooth-brush action until an observed plaque disappearance.
In both cases the tooth-brushing time was recorded. The result are reported in the following table:
Volunteers Anti-plaque agent Plaque-detector Time necessary for plaque removal
Triclosan %weight erythrosine %weight estimated effective min min
A 0,2 10
B 0,2 C 0,2 0 11
D 0,2
E 0,2 10
F 0,2 6,5
The test on volunteers B, D, F and the relevant composition fall within the scope of the invention, while the results of volunteers A, C, E, testing tooth-pastes without any plaque detector are provided as comparison testes.
It appears that volunteers using compositions according to the invention are able to remove dental plaque by a selective and appropriate action on the zones of the oral cavity, whereas volunteers who did not receive the plaque detector require a longer time to remove the plaque and , in some case the removal is not complete.

Claims

1) Tooth-past composition having the form of a paste of solid materials containing a small amount of water comprising: a) an abrasive agent to remove the protein film formed on the tooth surface, without any damaging of the tooth enamel. b) a preferably anionic surfactant agent to help the frothing and making more pleasant the use of tooth-paste; c) gelating compounds restraining the tooth paste contained water from separating in order to insure a long time tooth paste softness. d) products capable of maintaining the abrasive agent within the suspension. e) one or more of the following additives: whitening agents, as peroxides or persalts, anti-caries agents i.e. fluorine derivatives; f) one or more anti-plaque agents, consisting of anti-microbial anti-bacterial ingredients characterized in that it comprises one or more components capable to detect the presence of plaque by means of an intense colour shown by the tooth-paste suspension present in the oral cavity in the course of teeth brushing operation.
2) Tooth-past composition according to claim 1 characterised in that the products employed as plaque detecting agent are selected among erythrosine and its derivatives. 3) Tooth-past composition according to claim 1 characterised in that the products employed as components of group a) are: dihydrate calcium phosphate, calcium carbonate, hydrated alumina and silica.
4) Tooth-past composition according to claim 1 characterised in that the products employed as components of group b) are lauryl sulphate, lauryl sarcosinate or sodium glutamate. 5) Tooth-past composition according to claim 1 characterised in that the products employed as components of group c) are glycedrol, sorbitol, propylen glycol.
6) Tooth-past composition according to claim 1 characterised in that the products employed as components of group d) consist of cellulose derivatives as hydroxymethylcellulose, carboxymethylcellulose, cellulose ethers as well as pyrogenic silica, carrageenans.
7) Tooth-past composition according to claim 1 characterised in that the products employed as components of group e) are: whitening agents as peroxides or persalts, anti-caries agents as fluorine derivatives 8) Tooth-past composition according to claim 1 characterised in that the products employed as components of group f) consist of anti-microbial and anti-bacterial ingredients.
9) Use of the toothpaste composition according to one or more of the preceding claims for the preparation of toothpaste enabling the control of the plaque removal during the tooth-brushing operation.
PCT/IT2002/000407 2001-06-21 2002-06-20 Tooth-paste composition having anti-plaque properties WO2003000215A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2001MI001315A ITMI20011315A1 (en) 2001-06-21 2001-06-21 COMPOSITION FOR ANTI-PLATE TOOTHPASTE PASTE WITH PLATE DETECTOR
ITMI2001A001315 2001-06-21

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WO2003000215A1 true WO2003000215A1 (en) 2003-01-03

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Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1844758A1 (en) 2006-03-27 2007-10-17 Nestec S.A. Cosmetic use of whey protein micelles
WO2013074080A1 (en) * 2011-11-15 2013-05-23 Colgate-Palmolive Company Oral care gel dispenser systems
WO2013074079A1 (en) * 2011-11-15 2013-05-23 Colgate-Palmolive Company Oral care gels
US8632822B2 (en) 2008-11-07 2014-01-21 Klox Technologies Inc. Combination of an oxidant and a photoactivator for the healing of wounds
US8685466B2 (en) 2009-07-17 2014-04-01 Klox Technologies Inc. Combination of an oxidant, a photosensitizer and a wound healing agent for oral disinfection and treatment of oral disease
US8986719B2 (en) 2005-11-09 2015-03-24 Klox Technologies Inc. Teeth whitening compositions and methods
US9345648B2 (en) 2006-11-09 2016-05-24 Klox Technologies Inc. Photoactivatable oxygen-evolving compositions and methods for teeth whitening
US9655829B2 (en) 2012-09-14 2017-05-23 Valeant Pharmaceuticals International, Inc. Compositions and methods for teeth whitening
US10130706B2 (en) 2013-03-14 2018-11-20 Klox Technologies Inc. Biophotonic materials and uses thereof
US10207029B2 (en) 2014-04-01 2019-02-19 Klox Technologies Inc. Tissue filler compositions and methods of use
US10213373B2 (en) 2012-04-20 2019-02-26 Klox Technologies, Inc. Chromophore combinations for biophotonic uses
US10881736B2 (en) 2013-07-03 2021-01-05 Klox Technologies Inc. Biophotonic compositions comprising a chromophore and a gelling agent for treating wounds
US11116841B2 (en) 2012-04-20 2021-09-14 Klox Technologies Inc. Biophotonic compositions, kits and methods
US11421349B2 (en) 2014-10-31 2022-08-23 Klox Technologies Inc. Photoactivatable fibers and fabric media

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2463613A1 (en) * 1979-08-20 1981-02-27 Thorel Jean Noel NEW COMPOSITIONS FOR THE REVELATION OF THE DENTAL PLATE
DE2935450A1 (en) * 1979-09-01 1981-03-19 Hermann Dr.Med.Dent. 4044 Kaarst Gertenbach Tooth cleansing compsn. contg. dye - pref. encapsulated in gelatin to indicate presence of tooth deposit e.g. plaque
US4459277A (en) * 1980-10-07 1984-07-10 Kosti Carl M Plaque disclosing dentifrice compositions with solid microcapsules of dye
EP0161899A2 (en) * 1984-05-09 1985-11-21 Unilever Plc Dentifrice compositions

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2463613A1 (en) * 1979-08-20 1981-02-27 Thorel Jean Noel NEW COMPOSITIONS FOR THE REVELATION OF THE DENTAL PLATE
DE2935450A1 (en) * 1979-09-01 1981-03-19 Hermann Dr.Med.Dent. 4044 Kaarst Gertenbach Tooth cleansing compsn. contg. dye - pref. encapsulated in gelatin to indicate presence of tooth deposit e.g. plaque
US4459277A (en) * 1980-10-07 1984-07-10 Kosti Carl M Plaque disclosing dentifrice compositions with solid microcapsules of dye
EP0161899A2 (en) * 1984-05-09 1985-11-21 Unilever Plc Dentifrice compositions

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US8986719B2 (en) 2005-11-09 2015-03-24 Klox Technologies Inc. Teeth whitening compositions and methods
US9387158B2 (en) 2006-03-27 2016-07-12 Nestec S.A. Cosmetic use of whey protein micelles
EP1844758A1 (en) 2006-03-27 2007-10-17 Nestec S.A. Cosmetic use of whey protein micelles
US9345648B2 (en) 2006-11-09 2016-05-24 Klox Technologies Inc. Photoactivatable oxygen-evolving compositions and methods for teeth whitening
US8637086B2 (en) 2008-11-07 2014-01-28 Klox Technologies Inc. Method for acne treatment using an oxidative-photoactivated composition
US8658219B2 (en) 2008-11-07 2014-02-25 Klox Technologies Inc. Oxidatitive photoactivated skin rejeuvenation composition comprising hyaluronic acid, glucosamine, or allantoin
US10758744B2 (en) 2008-11-07 2020-09-01 Klox Technologies Inc. Combination of an oxidant and a photoactivator for the wounds
US8911791B2 (en) 2008-11-07 2014-12-16 Klox Technologies Inc. Method for acne treatment using an oxidative-photoactivated composition
US8974833B2 (en) 2008-11-07 2015-03-10 Klox Technologies Inc. Combination of an oxidant and a photoactivator for the healing of wounds
US10149985B2 (en) 2008-11-07 2018-12-11 Klox Technologies Inc. Methods and compositions for treating rosacea
US8632822B2 (en) 2008-11-07 2014-01-21 Klox Technologies Inc. Combination of an oxidant and a photoactivator for the healing of wounds
US8986745B2 (en) 2008-11-07 2015-03-24 Klox Technologies Inc. Oxidatitive photoactivated skin rejeuvenation composition comprising hyaluronic acid, glucosamine, or allantoin
US11020609B2 (en) 2008-11-07 2021-06-01 Klox Technologies Inc. Methods and compositions for treatment of pigmented lesions
US9375446B2 (en) 2008-11-07 2016-06-28 Klox Technologies Inc. Oxidatitive photoactivated skin rejeuvenation composition comprising hyaluronic acid, glucosamine, or allantoin
US11691025B2 (en) 2008-11-07 2023-07-04 Klox Technologies Inc. Methods and compositions for reversing or mitigating skin aging
US10485986B2 (en) 2008-11-07 2019-11-26 Klox Technologies Inc. Methods and compositions for treatment of pigmented lesions
US10384072B2 (en) 2008-11-07 2019-08-20 Klox Technologies Inc. Combination of an oxidant and a photoactivator for the healing of wounds
US8986746B2 (en) 2009-07-17 2015-03-24 Klox Technologies Inc. Combination of an oxidant, a photosensitizer and a wound healing agent for oral disinfection and treatment of oral disease
US10322179B2 (en) 2009-07-17 2019-06-18 Klox Technologies Inc. Combination of an oxidant, a photosensitizer and a wound healing agent for oral disinfection and treatment of oral disease
US11141482B2 (en) 2009-07-17 2021-10-12 Klox Technologies Inc. Combination of an oxidant, a photosensitizer and a wound healing agent for oral disinfection and treatment of oral disease
US8685466B2 (en) 2009-07-17 2014-04-01 Klox Technologies Inc. Combination of an oxidant, a photosensitizer and a wound healing agent for oral disinfection and treatment of oral disease
US10471147B2 (en) 2009-07-17 2019-11-12 Klox Technologies Inc. Combination of an oxidant, a photosensitizer and a wound healing agent for oral disinfection and treatment of oral disease
US9603929B2 (en) 2009-07-17 2017-03-28 Klox Technologies Inc. Combination of an oxidant, a photosensitizer and a wound healing agent for oral disinfecton and treatment of oral disease
RU2591821C2 (en) * 2011-11-15 2016-07-20 Колгейт-Палмолив Компани Gels for oral care
WO2013074079A1 (en) * 2011-11-15 2013-05-23 Colgate-Palmolive Company Oral care gels
WO2013074080A1 (en) * 2011-11-15 2013-05-23 Colgate-Palmolive Company Oral care gel dispenser systems
US10278796B2 (en) 2011-11-15 2019-05-07 Colgate-Palmolive Company Oral care gel dispenser systems
US9775788B2 (en) 2011-11-15 2017-10-03 Colgate-Palmolive Company Oral care gels
US10213373B2 (en) 2012-04-20 2019-02-26 Klox Technologies, Inc. Chromophore combinations for biophotonic uses
US11116841B2 (en) 2012-04-20 2021-09-14 Klox Technologies Inc. Biophotonic compositions, kits and methods
US11331257B2 (en) 2012-04-20 2022-05-17 Klox Technologies Inc. Biophotonic compositions and methods for providing biophotonic treatment
US10376455B2 (en) 2012-04-20 2019-08-13 Klox Technologies Inc. Biophotonic compositions and methods for providing biophotonic treatment
US11723854B2 (en) 2012-04-20 2023-08-15 Fle International S.R.L. Biophotonic compositions and methods for providing biophotonic treatment
US9655829B2 (en) 2012-09-14 2017-05-23 Valeant Pharmaceuticals International, Inc. Compositions and methods for teeth whitening
US10130706B2 (en) 2013-03-14 2018-11-20 Klox Technologies Inc. Biophotonic materials and uses thereof
US11324823B2 (en) 2013-03-14 2022-05-10 Klox Technologies Inc. Biophotonic materials and uses thereof
US10881736B2 (en) 2013-07-03 2021-01-05 Klox Technologies Inc. Biophotonic compositions comprising a chromophore and a gelling agent for treating wounds
US10207029B2 (en) 2014-04-01 2019-02-19 Klox Technologies Inc. Tissue filler compositions and methods of use
US10772990B2 (en) 2014-04-01 2020-09-15 Klox Technologies Inc. Tissue filler compositions and methods of use
US11421349B2 (en) 2014-10-31 2022-08-23 Klox Technologies Inc. Photoactivatable fibers and fabric media

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ITMI20011315A1 (en) 2002-12-21

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