JPH0449523B2 - - Google Patents
Info
- Publication number
- JPH0449523B2 JPH0449523B2 JP58113354A JP11335483A JPH0449523B2 JP H0449523 B2 JPH0449523 B2 JP H0449523B2 JP 58113354 A JP58113354 A JP 58113354A JP 11335483 A JP11335483 A JP 11335483A JP H0449523 B2 JPH0449523 B2 JP H0449523B2
- Authority
- JP
- Japan
- Prior art keywords
- acid
- sodium
- salts
- water
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000203 mixture Substances 0.000 claims description 14
- 150000001875 compounds Chemical class 0.000 claims description 8
- 150000003839 salts Chemical class 0.000 claims description 8
- RBNPOMFGQQGHHO-UHFFFAOYSA-N -2,3-Dihydroxypropanoic acid Natural products OCC(O)C(O)=O RBNPOMFGQQGHHO-UHFFFAOYSA-N 0.000 claims description 7
- AFENDNXGAFYKQO-UHFFFAOYSA-N 2-hydroxybutyric acid Chemical compound CCC(O)C(O)=O AFENDNXGAFYKQO-UHFFFAOYSA-N 0.000 claims description 7
- RBNPOMFGQQGHHO-UWTATZPHSA-N D-glyceric acid Chemical compound OC[C@@H](O)C(O)=O RBNPOMFGQQGHHO-UWTATZPHSA-N 0.000 claims description 6
- 210000000214 mouth Anatomy 0.000 claims 1
- -1 alkali metal salts Chemical class 0.000 description 12
- 239000000606 toothpaste Substances 0.000 description 10
- 235000014113 dietary fatty acids Nutrition 0.000 description 9
- 239000000194 fatty acid Substances 0.000 description 9
- 229930195729 fatty acid Natural products 0.000 description 9
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 8
- 239000004480 active ingredient Substances 0.000 description 8
- DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- 239000002253 acid Substances 0.000 description 5
- 229940034610 toothpaste Drugs 0.000 description 5
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- 150000004665 fatty acids Chemical class 0.000 description 4
- 229910052742 iron Inorganic materials 0.000 description 4
- 230000002265 prevention Effects 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 3
- 229910052783 alkali metal Inorganic materials 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- 239000011230 binding agent Substances 0.000 description 3
- 238000013329 compounding Methods 0.000 description 3
- 210000003298 dental enamel Anatomy 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 239000000741 silica gel Substances 0.000 description 3
- 229910002027 silica gel Inorganic materials 0.000 description 3
- 239000001648 tannin Substances 0.000 description 3
- 235000018553 tannin Nutrition 0.000 description 3
- 229920001864 tannin Polymers 0.000 description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical class C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
- WINXNKPZLFISPD-UHFFFAOYSA-M Saccharin sodium Chemical compound [Na+].C1=CC=C2C(=O)[N-]S(=O)(=O)C2=C1 WINXNKPZLFISPD-UHFFFAOYSA-M 0.000 description 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 2
- 235000010443 alginic acid Nutrition 0.000 description 2
- 229920000615 alginic acid Polymers 0.000 description 2
- 150000001340 alkali metals Chemical class 0.000 description 2
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 2
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 239000003205 fragrance Substances 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 229960003451 lactitol Drugs 0.000 description 2
- 239000008101 lactose Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000002324 mouth wash Substances 0.000 description 2
- 229920001451 polypropylene glycol Polymers 0.000 description 2
- 229910052700 potassium Inorganic materials 0.000 description 2
- 239000011591 potassium Substances 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 2
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 2
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 2
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 2
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 2
- 239000000600 sorbitol Substances 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 description 1
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 1
- MPDGHEJMBKOTSU-WFJWTYAKSA-N (2s,4as,6as,6br,10s,12as)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid Chemical class C12C(=O)C=C3C4C[C@@](C)(C(O)=O)CC[C@]4(C)CC[C@@]3(C)[C@]1(C)CCC1[C@]2(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-WFJWTYAKSA-N 0.000 description 1
- QYIXCDOBOSTCEI-QCYZZNICSA-N (5alpha)-cholestan-3beta-ol Chemical compound C([C@@H]1CC2)[C@@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@H](C)CCCC(C)C)[C@@]2(C)CC1 QYIXCDOBOSTCEI-QCYZZNICSA-N 0.000 description 1
- JLPAMKUIIFHLBH-UHFFFAOYSA-N 1,2-dihydroxypropane-1-sulfonic acid Chemical compound CC(O)C(O)S(O)(=O)=O JLPAMKUIIFHLBH-UHFFFAOYSA-N 0.000 description 1
- 229940058015 1,3-butylene glycol Drugs 0.000 description 1
- BTWNEJOURYOHME-UHFFFAOYSA-N 1,3-thiazol-2-ylhydrazine Chemical compound NNC1=NC=CS1 BTWNEJOURYOHME-UHFFFAOYSA-N 0.000 description 1
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- LFJJOPDNPVFCNZ-UHFFFAOYSA-N 2-[hexadecanoyl(methyl)amino]acetic acid Chemical compound CCCCCCCCCCCCCCCC(=O)N(C)CC(O)=O LFJJOPDNPVFCNZ-UHFFFAOYSA-N 0.000 description 1
- NGOZDSMNMIRDFP-UHFFFAOYSA-N 2-[methyl(tetradecanoyl)amino]acetic acid Chemical group CCCCCCCCCCCCCC(=O)N(C)CC(O)=O NGOZDSMNMIRDFP-UHFFFAOYSA-N 0.000 description 1
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 description 1
- AXCXHFKZHDEKTP-NSCUHMNNSA-N 4-methoxycinnamaldehyde Chemical compound COC1=CC=C(\C=C\C=O)C=C1 AXCXHFKZHDEKTP-NSCUHMNNSA-N 0.000 description 1
- DDFHBQSCUXNBSA-UHFFFAOYSA-N 5-(5-carboxythiophen-2-yl)thiophene-2-carboxylic acid Chemical compound S1C(C(=O)O)=CC=C1C1=CC=C(C(O)=O)S1 DDFHBQSCUXNBSA-UHFFFAOYSA-N 0.000 description 1
- SLXKOJJOQWFEFD-UHFFFAOYSA-N 6-aminohexanoic acid Chemical compound NCCCCCC(O)=O SLXKOJJOQWFEFD-UHFFFAOYSA-N 0.000 description 1
- 244000215068 Acacia senegal Species 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 239000004382 Amylase Substances 0.000 description 1
- 102000013142 Amylases Human genes 0.000 description 1
- 108010065511 Amylases Proteins 0.000 description 1
- 239000000120 Artificial Saliva Substances 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- UDIPTWFVPPPURJ-UHFFFAOYSA-M Cyclamate Chemical compound [Na+].[O-]S(=O)(=O)NC1CCCCC1 UDIPTWFVPPPURJ-UHFFFAOYSA-M 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 208000006558 Dental Calculus Diseases 0.000 description 1
- 108010001682 Dextranase Proteins 0.000 description 1
- 101000925662 Enterobacteria phage PRD1 Endolysin Proteins 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- MPDGHEJMBKOTSU-UHFFFAOYSA-N Glycyrrhetinsaeure Natural products C12C(=O)C=C3C4CC(C)(C(O)=O)CCC4(C)CCC3(C)C1(C)CCC1C2(C)CCC(O)C1(C)C MPDGHEJMBKOTSU-UHFFFAOYSA-N 0.000 description 1
- 239000004378 Glycyrrhizin Substances 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- 229920000569 Gum karaya Polymers 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 description 1
- 108010014251 Muramidase Proteins 0.000 description 1
- 102000016943 Muramidase Human genes 0.000 description 1
- AOMUHOFOVNGZAN-UHFFFAOYSA-N N,N-bis(2-hydroxyethyl)dodecanamide Chemical compound CCCCCCCCCCCC(=O)N(CCO)CCO AOMUHOFOVNGZAN-UHFFFAOYSA-N 0.000 description 1
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 239000001888 Peptone Substances 0.000 description 1
- 108010080698 Peptones Proteins 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 229920000388 Polyphosphate Polymers 0.000 description 1
- 229920001213 Polysorbate 20 Polymers 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 description 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 241000934878 Sterculia Species 0.000 description 1
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 description 1
- 229920001615 Tragacanth Polymers 0.000 description 1
- YKTSYUJCYHOUJP-UHFFFAOYSA-N [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] Chemical compound [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] YKTSYUJCYHOUJP-UHFFFAOYSA-N 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 229910052910 alkali metal silicate Inorganic materials 0.000 description 1
- 150000008055 alkyl aryl sulfonates Chemical class 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 150000008051 alkyl sulfates Chemical class 0.000 description 1
- 229940045714 alkyl sulfonate alkylating agent Drugs 0.000 description 1
- 150000008052 alkyl sulfonates Chemical class 0.000 description 1
- QYIXCDOBOSTCEI-UHFFFAOYSA-N alpha-cholestanol Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(C)CCCC(C)C)C1(C)CC2 QYIXCDOBOSTCEI-UHFFFAOYSA-N 0.000 description 1
- AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 229940024606 amino acid Drugs 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 229960002684 aminocaproic acid Drugs 0.000 description 1
- 229910021486 amorphous silicon dioxide Inorganic materials 0.000 description 1
- 239000002280 amphoteric surfactant Substances 0.000 description 1
- 235000019418 amylase Nutrition 0.000 description 1
- 150000008064 anhydrides Chemical class 0.000 description 1
- 239000003945 anionic surfactant Substances 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229960003589 arginine hydrochloride Drugs 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 239000000305 astragalus gummifer gum Substances 0.000 description 1
- 239000000440 bentonite Substances 0.000 description 1
- 229910000278 bentonite Inorganic materials 0.000 description 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
- VBICKXHEKHSIBG-UHFFFAOYSA-N beta-monoglyceryl stearate Natural products CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 1
- 229960003237 betaine Drugs 0.000 description 1
- 239000007844 bleaching agent Substances 0.000 description 1
- 235000019437 butane-1,3-diol Nutrition 0.000 description 1
- YYRMJZQKEFZXMX-UHFFFAOYSA-L calcium bis(dihydrogenphosphate) Chemical compound [Ca+2].OP(O)([O-])=O.OP(O)([O-])=O YYRMJZQKEFZXMX-UHFFFAOYSA-L 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 235000010216 calcium carbonate Nutrition 0.000 description 1
- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 description 1
- XAAHAAMILDNBPS-UHFFFAOYSA-L calcium hydrogenphosphate dihydrate Chemical compound O.O.[Ca+2].OP([O-])([O-])=O XAAHAAMILDNBPS-UHFFFAOYSA-L 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 229940043256 calcium pyrophosphate Drugs 0.000 description 1
- 229920003090 carboxymethyl hydroxyethyl cellulose Polymers 0.000 description 1
- 235000010418 carrageenan Nutrition 0.000 description 1
- 239000000679 carrageenan Substances 0.000 description 1
- 229920001525 carrageenan Polymers 0.000 description 1
- 229940113118 carrageenan Drugs 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- 229940112822 chewing gum Drugs 0.000 description 1
- 235000015218 chewing gum Nutrition 0.000 description 1
- 229960003260 chlorhexidine Drugs 0.000 description 1
- 229930002875 chlorophyll Natural products 0.000 description 1
- 235000019804 chlorophyll Nutrition 0.000 description 1
- ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical compound C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 description 1
- 239000010634 clove oil Substances 0.000 description 1
- 235000019864 coconut oil Nutrition 0.000 description 1
- 239000003240 coconut oil Substances 0.000 description 1
- 239000008119 colloidal silica Substances 0.000 description 1
- 239000007859 condensation product Substances 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 239000000625 cyclamic acid and its Na and Ca salt Substances 0.000 description 1
- 239000000551 dentifrice Substances 0.000 description 1
- 210000004268 dentin Anatomy 0.000 description 1
- 235000019821 dicalcium diphosphate Nutrition 0.000 description 1
- QGGZBXOADPVUPN-UHFFFAOYSA-N dihydrochalcone Chemical compound C=1C=CC=CC=1C(=O)CCC1=CC=CC=C1 QGGZBXOADPVUPN-UHFFFAOYSA-N 0.000 description 1
- PXLWOFBAEVGBOA-UHFFFAOYSA-N dihydrochalcone Natural products OC1C(O)C(O)C(CO)OC1C1=C(O)C=CC(C(=O)CC(O)C=2C=CC(O)=CC=2)=C1O PXLWOFBAEVGBOA-UHFFFAOYSA-N 0.000 description 1
- FXNRKXSSLJKNGH-UHFFFAOYSA-L dipotassium;fluoro-dioxido-oxo-$l^{5}-phosphane Chemical compound [K+].[K+].[O-]P([O-])(F)=O FXNRKXSSLJKNGH-UHFFFAOYSA-L 0.000 description 1
- GVGUFUZHNYFZLC-UHFFFAOYSA-N dodecyl benzenesulfonate;sodium Chemical compound [Na].CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 GVGUFUZHNYFZLC-UHFFFAOYSA-N 0.000 description 1
- 229960003720 enoxolone Drugs 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 150000002169 ethanolamines Chemical class 0.000 description 1
- 239000010642 eucalyptus oil Substances 0.000 description 1
- 229940044949 eucalyptus oil Drugs 0.000 description 1
- 108010000165 exo-1,3-alpha-glucanase Proteins 0.000 description 1
- 125000005313 fatty acid group Chemical group 0.000 description 1
- 150000002191 fatty alcohols Chemical class 0.000 description 1
- 150000002222 fluorine compounds Chemical class 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 description 1
- 229960004949 glycyrrhizic acid Drugs 0.000 description 1
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 description 1
- 235000019410 glycyrrhizin Nutrition 0.000 description 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- PVFSDGKDKFSOTB-UHFFFAOYSA-K iron(3+);triacetate Chemical compound [Fe+3].CC([O-])=O.CC([O-])=O.CC([O-])=O PVFSDGKDKFSOTB-UHFFFAOYSA-K 0.000 description 1
- 235000010494 karaya gum Nutrition 0.000 description 1
- 239000000231 karaya gum Substances 0.000 description 1
- 229940039371 karaya gum Drugs 0.000 description 1
- 239000000832 lactitol Substances 0.000 description 1
- VQHSOMBJVWLPSR-JVCRWLNRSA-N lactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-JVCRWLNRSA-N 0.000 description 1
- 235000010448 lactitol Nutrition 0.000 description 1
- 229940094522 laponite Drugs 0.000 description 1
- XCOBTUNSZUJCDH-UHFFFAOYSA-B lithium magnesium sodium silicate Chemical compound [Li+].[Li+].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[Na+].[Na+].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3 XCOBTUNSZUJCDH-UHFFFAOYSA-B 0.000 description 1
- 239000004325 lysozyme Substances 0.000 description 1
- 229960000274 lysozyme Drugs 0.000 description 1
- 235000010335 lysozyme Nutrition 0.000 description 1
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
- 239000001095 magnesium carbonate Substances 0.000 description 1
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 1
- GVALZJMUIHGIMD-UHFFFAOYSA-H magnesium phosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GVALZJMUIHGIMD-UHFFFAOYSA-H 0.000 description 1
- 229910000400 magnesium phosphate tribasic Inorganic materials 0.000 description 1
- 239000000845 maltitol Substances 0.000 description 1
- 235000010449 maltitol Nutrition 0.000 description 1
- 229940035436 maltitol Drugs 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000001525 mentha piperita l. herb oil Substances 0.000 description 1
- 239000001683 mentha spicata herb oil Substances 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 150000004702 methyl esters Chemical class 0.000 description 1
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 235000019691 monocalcium phosphate Nutrition 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 150000001451 organic peroxides Chemical class 0.000 description 1
- AXCXHFKZHDEKTP-UHFFFAOYSA-N para-methoxycinnamaldehyde Natural products COC1=CC=C(C=CC=O)C=C1 AXCXHFKZHDEKTP-UHFFFAOYSA-N 0.000 description 1
- 235000015927 pasta Nutrition 0.000 description 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
- 235000019477 peppermint oil Nutrition 0.000 description 1
- 235000019319 peptone Nutrition 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-N phosphoric acid Substances OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000004926 polymethyl methacrylate Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 description 1
- 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 description 1
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 1
- 239000001205 polyphosphate Substances 0.000 description 1
- 235000011176 polyphosphates Nutrition 0.000 description 1
- 229920000137 polyphosphoric acid Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 229940085605 saccharin sodium Drugs 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- AWUCVROLDVIAJX-GSVOUGTGSA-N sn-glycerol 3-phosphate Chemical compound OC[C@@H](O)COP(O)(O)=O AWUCVROLDVIAJX-GSVOUGTGSA-N 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 235000015424 sodium Nutrition 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 229960001462 sodium cyclamate Drugs 0.000 description 1
- 229940080264 sodium dodecylbenzenesulfonate Drugs 0.000 description 1
- 239000011775 sodium fluoride Substances 0.000 description 1
- 235000013024 sodium fluoride Nutrition 0.000 description 1
- KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical group [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 description 1
- AQMNWCRSESPIJM-UHFFFAOYSA-M sodium metaphosphate Chemical compound [Na+].[O-]P(=O)=O AQMNWCRSESPIJM-UHFFFAOYSA-M 0.000 description 1
- 229960004711 sodium monofluorophosphate Drugs 0.000 description 1
- 229950005425 sodium myristyl sulfate Drugs 0.000 description 1
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- UPUIQOIQVMNQAP-UHFFFAOYSA-M sodium;tetradecyl sulfate Chemical compound [Na+].CCCCCCCCCCCCCCOS([O-])(=O)=O UPUIQOIQVMNQAP-UHFFFAOYSA-M 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 235000019721 spearmint oil Nutrition 0.000 description 1
- ANOBYBYXJXCGBS-UHFFFAOYSA-L stannous fluoride Chemical compound F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 description 1
- 229960002799 stannous fluoride Drugs 0.000 description 1
- 229940013618 stevioside Drugs 0.000 description 1
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 description 1
- 235000019202 steviosides Nutrition 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 229920003002 synthetic resin Polymers 0.000 description 1
- 239000000057 synthetic resin Substances 0.000 description 1
- 239000000892 thaumatin Substances 0.000 description 1
- 235000010436 thaumatin Nutrition 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical compound NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 description 1
- 229960000401 tranexamic acid Drugs 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000009637 wintergreen oil Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
- GFQYVLUOOAAOGM-UHFFFAOYSA-N zirconium(iv) silicate Chemical compound [Zr+4].[O-][Si]([O-])([O-])[O-] GFQYVLUOOAAOGM-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Emergency Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
Description
本発明はステインの付着を良好に防止し得る口
腔用組成物に関する。
従来、歯牙に対するステインの付着を防止し、
或いはステインを除去するための有効成分として
は、有機ペルオキシド（ベルギー特許818735号、
米国特許3988433号）、１個以上の芳香族環を有す
るエステル（特公昭48−43869号）、特定の金属キ
レート剤（特開昭51−139639号）、ポリリン酸と
多価金属陽イオンとの組合せ（特開昭52−108029
号）、ポリホスフエートの微細顆粒物（特開昭54
−80429号）などが知られているが、これら有効
成分の実際的な評価は必ずしも定まつていない。
歯牙の自然の汚れ（ステイン）は、通常の飲食
物と歯牙との接触の結果として生ずるもので、鉄
分が第一義的な原因と考えられるものであるが、
このようなステインの歯牙への付着は好ましいも
のではなく、従つて歯磨等の口腔用組成物として
は、ステインの付着阻止能が優れたものであるこ
とが要望される。
本発明者らは、ステインの付着を確実に防止し
得る有効成分につき実際のステインにより近い評
価法を採用して鋭意研究を行なつた結果、グリセ
リン酸及びヒドロキシ−ｎ−酪酸並びにこれらの
塩がステインの付着阻止能に非常に優れ、これら
化合物を有効成分として配合した口腔用組成物が
ステインの付着を確実に防止することができるも
のであることを知見し、本発明をなすに至つた。
従つて、本発明は、グリセリン酸及びヒドロキ
シ−ｎ−酪酸並びにこれらの塩から選ばれる１種
又は２種以上の化合物を含有するステイン付着防
止用口腔用組成物を提供するものであり、本発明
の口腔用組成物は優れたステインの付着防止効果
を有するものである。
以下、本発明につき更に詳しく説明する。
本発明に係る口腔用組成物は、練歯磨、潤製歯
磨、液状歯磨等の歯磨類、マウスウオツシユ、ト
ローチ、チユーインガム、口腔用パスタ、歯肉マ
ツサージクリーム、液状口中清涼剤、固形状口中
清涼剤等として調製、適用されるもので、グリセ
リン酸及びヒドロキシ−ｎ−酪酸並びにこれらの
塩から選ばれる１種又は２種以上の化合物を含有
するものであり、これら化合物の配合によりステ
インの付着を確実に防止し得るものである。
ここで、グリセリン酸、ヒドロキシ−ｎ−酪酸
の塩としてはナトリウム塩等のアルカリ金属塩な
どが挙げられる。
また、グリセリン酸、ヒドロキシ−ｎ−酪酸、
及びこれらの塩から選ばれる化合物の配合量は、
口腔用組成物全体の0.001〜30％（重量％、以下
同じ）、特に0.01〜10％とすることが好ましい。
本発明の他の成分としては、口腔用組成物の種
類、使用目的等に応じて通常使用される適宜な成
分が配合され得る。
例えば、歯磨類の場合には、第２リン酸カルシ
ウム・２水和物及び無水物、第１リン酸カルシウ
ム、第３リン酸カルシウム、炭酸カルシウム、ピ
ロリン酸カルシウム、酸化チタン、アルミナ、水
和アルミナ、シリカゲル、コロイド状シリカ、無
水アルカリ金属ケイ酸塩錯塩、ケイ酸アルミニウ
ム、不溶性メタリン酸ナトリウム、不溶性ムタリ
ン酸カリウム、第３リン酸マグネシウム、炭酸マ
グネシウム、硫酸カルシウム、ポリメタクリル酸
メチル、ベントナイト、ケイ酸ジルコニウム、合
成樹脂等の１種又は２種以上を配合し得る（配合
量通常10％〜99％、練歯磨の場合には10％〜75
％）。
また、練歯磨等のペースト形態の口腔用組成物
の場合には、粘結剤としてカラゲナン、カルボキ
シメチルセルロースナトリウム、メチルセルロー
ス、ヒドロキシエチルセルロース、カルボキシメ
チルヒドロキシエチルセルロースナトリウムなど
のセルロース誘導体、アルギン酸ナトリウムなど
のアルカリ金属アルギネート、アルギン酸プロピ
レングリコールエステル、キサンタンガム、トラ
ガカントガム、カラヤガム、アラビアガムなどの
カム類、ポリビニルアルコール、ポリアクリル酸
ナトリウム、カルボキシビニルポリマー、ポリビ
ニルピロリドなどの合成粘結剤、シリカゲル、ア
ルミニウムシリカゲル、ビーガム、ラポナイトな
どの無機粘結剤等の１種又は２種以上が配合され
得る（配合量通常0.5〜５％）。
更に、歯磨類、その他の口腔用組成物の製造に
おいて、粘稠剤としてソルビツト、グリセリン、
エチレングリコール、プロピレングリコール、
１，３−ブチレングリコール、ポリエチレングリ
コール、ポリプロピレングリコール、キシリツ
ト、マルチツト、ラクチツト等１種又は２種以上
を配合し得る（配合量通常10〜70％）。また、ラ
ウリル硫酸ナトリウム、ミリスチル硫酸ナトリウ
ム等のアルキル基の炭素数が８〜18である高級ア
ルキル硫酸エステルの水溶性塩、水素化ヤシ油脂
肪酸モノグリセリドモノ硫酸ナトリウム等の水溶
性の高級脂肪酸モノグリセリドモノ硫酸塩、ドデ
シルベンゼンスルホン酸ナトリウム等のアルキル
アリールスルホン酸塩、高級アルキルスルホン酸
塩、１，２−ジヒドロキシプロパンスルホン酸塩
の高級脂肪酸エステル、Ｎ−ラウロイル、Ｎ−ミ
リストイル又はＮ−パルミトイルザルコシンのナ
トリウム、カリウム又はエタノールアミン塩等の
低級脂肪族アミノカルボン酸化合物の実質的に飽
和の高級脂肪族アシルアミドなどのアニオン活性
剤、シヨ糖モノ及びジラウレート等の脂肪酸基の
炭素数が12〜18であるシヨ糖脂肪酸エステル、ラ
クトース脂肪酸エステル、ラクチトール脂肪酸エ
ステル、マルチトール脂肪酸エステル、ステアリ
ン酸モノグリセライド、ポリオキシエチレンソル
ビタンモノラウレート、ポリオキシエチレンソル
ビタンモノステアレート、ポリオキシエチレン
（10，20，40，60，80，100モル）硬化ヒマシ油、
エチレンオキサイドとプロピレンオキサイドの重
合物及びポリオキシエチレンポリオキシプロピレ
ンモノラウリルエステル等のポリエチレンオキサ
イドと脂肪酸、脂肪アルコール、多価アルコール
及びポリプロピレンオキサイドとの縮合生成物な
どのノニオン活性剤、ベタイン型、アミノ酸型な
どの両性活性剤といつた１種または２種以上の界
面活性剤（配合量通常０〜７％、好ましくは0.5
〜５％）を配合し得る。
本発明の口腔用組成物には、更にサツカリンナ
トリウム、ステビオサイド、ネオヘスペリジルジ
ヒドロカルコン、グリチルリチン、ペリラルチ
ン、タウマチン、アスパラチルフエニルアラニン
メチルエステル、ｐ−メトキシシンナミツクアル
デヒド、シヨ糖、乳糖、果糖、サイクラミン酸ナ
トリウムなどの甘味剤（０〜１％、好ましくは
0.01〜0.5％）、更に必要よりｐ−ヒドロキシメチ
ルベンゾイツクアシド、ｐ−ヒドロキシエチルベ
ンゾイツクアシド、ｐ−ヒドロキシプロピルベン
ゾイツクアシド、ｐ−ヒドロキシブチルベンゾイ
ツクアシド、安息香酸ナトリウム、低級脂肪酸モ
ノグリセライドなどの防腐剤、ウインターグリー
ン油、スペアミント油、ペパーミント油、サツサ
フラス油、丁字油、ユーカリ油などの香料、ゼラ
チン、ペプトン、アルギニン塩酸塩、アルブミ
ン、カゼイン、二酸化チタンなどの増白剤、シリ
コーン、色素、その他の成分を配合し得、例えば
練歯磨の場合には上記した所望の成分を適量の水
と練合することにより製造し得る。
また、他の口腔用組成物を製造する場合も通常
用いられている適宜な成分を使用し、常法に従つ
て製造することができる。
更に本発明においては、アラントイン類、イプ
シロンアミノカプロン酸、トラネキサム酸、デキ
ストラナーゼ、アミラーゼ、プロテアーゼ、ムタ
ナーゼ、リゾチーム、溶菌酵素、リテツクエンザ
イム等の酵素、モノフルオロリン酸ナトリウム、
モノフルオロリン酸カリウムなどのアルカリ金属
モノフルオロホスフエート、フツ化ナトリウム、
フツ化アンモニウム、フツ化第１錫等のフツ化
物、クロルヘキシジン塩類、ジヒドロコレステロ
ール、グリチルレチン塩類、グリチルレチン酸、
グリセロホスフエート、クロロフイル、カロペプ
タイド、水溶性無機リン酸化合物、ビタミン類、
歯石防止剤、抗菌剤、歯垢阻止剤等の有効成分を
１種又は２種以上配合し得る。
次に、実施例により本発明の効果を具体的に示
す。
（実施例）
第１表に示す化合物を有効成分として用い、下
記方法によりステイン付着阻止能を評価した。結
果を第１表に併記する。
評価用歯牙の調製
牛歯を６mm角に切断し、エナメル面を上にして
樹脂に包埋する。象牙質が出ない程度にエナメル
面を研磨して平滑面をつくり、人工ステイン付着
用サンプルとする。保存は人工唾液中に浸漬し、
冷蔵庫に保存する。
人工ステインの付着阻止能能評価方法
サンプルを水中で歯刷子を用いてブラツシング
し、サンプル表面に付着している汚染物を取り除
く。その後、サンプルに紙を押しあてて水を除
き、色差計でＬ値を測定し、この値をL1とする。
次に、有効成分の0.5重量部水溶液にサンプルを
１分間浸漬し、水洗後下記のタンニン鉄鉄溶液に
５分間浸漬し、水洗する。この有効成分溶液及び
タンニン鉄溶液への浸漬を５回くり返した後、色
差計でＬ値を測定し、これをL2とする。前記L1
とL2との差（ΔL＝L1＝L2）よりステインの付着
阻止能を評価する（ΔLの小さい程、ステインの
付着阻止能が高いものである）。
タンニン鉄溶液
酢酸鉄の0.17重量％水溶液とクンニン酸の0.1
重量％水溶液とを同量混合し、直ちにサンプルを
浸漬する。この操作によりサンプルのエナメル面
が赤黒色に着色してくる。
The present invention relates to an oral composition that can effectively prevent stain adhesion. Traditionally, it prevents stains from adhering to teeth,
Alternatively, as an active ingredient for removing stains, organic peroxides (Belgian Patent No. 818735,
(U.S. Patent No. 3988433), esters having one or more aromatic rings (Japanese Patent Publication No. 48-43869), specific metal chelating agents (Japanese Patent Publication No. 139639-1983), combinations of polyphosphoric acid and polyvalent metal cations. Combination (JP-A-52-108029
No.), fine granules of polyphosphate (Unexamined Japanese Patent Publication No. 1983)
-80429), but the practical evaluation of these active ingredients has not necessarily been determined. Natural stains on teeth occur as a result of contact between normal foods and drinks, and iron is thought to be the primary cause.
Such adhesion of stains to teeth is not desirable, and therefore oral compositions such as toothpastes are required to have excellent ability to prevent stains from adhering. The present inventors conducted intensive research on active ingredients that can reliably prevent stain adhesion by adopting an evaluation method that is closer to actual stains, and found that glyceric acid, hydroxy-n-butyric acid, and their salts The inventors have discovered that oral compositions that have excellent ability to prevent stain adhesion and contain these compounds as active ingredients can reliably prevent stain adhesion, leading to the present invention. Therefore, the present invention provides an oral composition for preventing stain adhesion, which contains one or more compounds selected from glyceric acid, hydroxy-n-butyric acid, and salts thereof. The oral composition has an excellent stain adhesion prevention effect. The present invention will be explained in more detail below. Oral compositions according to the present invention include toothpastes, toothpastes such as moisturized toothpastes, liquid toothpastes, mouthwashes, troches, chewing gum, oral pasta, gum tissue surge cream, liquid mouth fresheners, and solid mouth fresheners. It contains one or more compounds selected from glyceric acid, hydroxy-n-butyric acid, and their salts, and the combination of these compounds ensures the adhesion of stains. This can be prevented. Here, examples of the salts of glyceric acid and hydroxy-n-butyric acid include alkali metal salts such as sodium salts. Also, glyceric acid, hydroxy-n-butyric acid,
and the compounding amount of the compound selected from these salts,
It is preferably 0.001 to 30% (weight %, same hereinafter), particularly 0.01 to 10% of the entire oral composition. As other components of the present invention, appropriate components commonly used may be blended depending on the type of oral composition, purpose of use, etc. For example, in the case of toothpaste, dibasic calcium phosphate dihydrate and anhydride, monobasic calcium phosphate, tribasic calcium phosphate, calcium carbonate, calcium pyrophosphate, titanium oxide, alumina, hydrated alumina, silica gel, colloidal silica, Anhydrous alkali metal silicate complex, aluminum silicate, insoluble sodium metaphosphate, insoluble potassium mutarate, tertiary magnesium phosphate, magnesium carbonate, calcium sulfate, polymethyl methacrylate, bentonite, zirconium silicate, synthetic resin, etc. species or two or more species may be blended (compounding amount usually 10% to 99%, in the case of toothpaste 10% to 75%)
%). In addition, in the case of paste-form oral compositions such as toothpaste, cellulose derivatives such as carrageenan, sodium carboxymethylcellulose, methylcellulose, hydroxyethylcellulose, and sodium carboxymethylhydroxyethylcellulose, and alkali metal alginates such as sodium alginate are used as binders. , alginate propylene glycol ester, xanthan gum, tragacanth gum, karaya gum, gum arabic and other gums, polyvinyl alcohol, sodium polyacrylate, carboxyvinyl polymer, polyvinyl pyrrolid and other synthetic binders, silica gel, aluminum silica gel, vegum, laponite, etc. One or more types of inorganic binders may be blended (the blending amount is usually 0.5 to 5%). Furthermore, in the production of dentifrices and other oral compositions, sorbitol, glycerin,
ethylene glycol, propylene glycol,
One or more of 1,3-butylene glycol, polyethylene glycol, polypropylene glycol, xyrite, maltite, lactite, etc. may be blended (the blending amount is usually 10 to 70%). In addition, water-soluble salts of higher alkyl sulfates whose alkyl group has 8 to 18 carbon atoms, such as sodium lauryl sulfate and sodium myristyl sulfate, and water-soluble higher fatty acid monoglyceride monosulfates, such as hydrogenated coconut oil fatty acid monoglyceride monosulfate, etc. salts, alkylaryl sulfonates such as sodium dodecylbenzenesulfonate, higher alkyl sulfonates, higher fatty acid esters of 1,2-dihydroxypropanesulfonate, sodium N-lauroyl, N-myristoyl or N-palmitoyl sarcosine. , anionic surfactants such as substantially saturated higher aliphatic acylamides of lower aliphatic aminocarboxylic acid compounds such as potassium or ethanolamine salts, and compounds whose fatty acid group has 12 to 18 carbon atoms such as sucrose mono- and dilaurates. Sugar fatty acid ester, lactose fatty acid ester, lactitol fatty acid ester, maltitol fatty acid ester, stearic acid monoglyceride, polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan monostearate, polyoxyethylene (10, 20, 40, 60, 80 , 100 mol) hydrogenated castor oil,
Nonionic active agents such as polymers of ethylene oxide and propylene oxide and condensation products of polyethylene oxide such as polyoxyethylene polyoxypropylene monolauryl ester and fatty acids, fatty alcohols, polyhydric alcohols, and polypropylene oxide, betaine type, amino acid type One or more surfactants such as amphoteric surfactants (compounding amount usually 0 to 7%, preferably 0.5%)
~5%). The oral composition of the present invention further contains saccharin sodium, stevioside, neohesperidyl dihydrochalcone, glycyrrhizin, perillartin, thaumatin, asparatylphenylalanine methyl ester, p-methoxycinnamic aldehyde, sucrose, lactose, fructose. , a sweetening agent such as sodium cyclamate (0-1%, preferably
0.01 to 0.5%), and if necessary, p-hydroxymethyl benzoituku acid, p-hydroxyethyl benzoituku acid, p-hydroxypropyl benzoituku acid, p-hydroxybutyl benzoituku acid, sodium benzoate, lower fatty acid monoglyceride, etc. Preservatives, fragrances such as wintergreen oil, spearmint oil, peppermint oil, satsafras oil, clove oil, eucalyptus oil, whitening agents such as gelatin, peptone, arginine hydrochloride, albumin, casein, titanium dioxide, silicones, pigments, etc. For example, in the case of a toothpaste, it can be produced by mixing the above-mentioned desired components with an appropriate amount of water. Moreover, when producing other oral compositions, they can be produced according to conventional methods using appropriate commonly used ingredients. Furthermore, in the present invention, enzymes such as allantoins, epsilon aminocaproic acid, tranexamic acid, dextranase, amylase, protease, mutanase, lysozyme, lytic enzyme, and litequeenzyme, sodium monofluorophosphate,
Alkali metal monofluorophosphates such as potassium monofluorophosphate, sodium fluoride,
Fluorides such as ammonium fluoride and stannous fluoride, chlorhexidine salts, dihydrocholesterol, glycyrrhetinic salts, glycyrrhetinic acid,
Glycerophosphate, chlorophyll, calopeptide, water-soluble inorganic phosphoric acid compound, vitamins,
One or more active ingredients such as tartar inhibitors, antibacterial agents, and plaque inhibitors may be included. Next, the effects of the present invention will be specifically illustrated by examples. (Example) Using the compounds shown in Table 1 as active ingredients, the stain adhesion inhibiting ability was evaluated by the following method. The results are also listed in Table 1. Preparation of teeth for evaluation Cut a bovine tooth into 6 mm square pieces and embed them in resin with the enamel side facing up. The enamel surface is polished to an extent that no dentin is exposed to create a smooth surface and used as a sample for artificial stain attachment. Preservation is done by immersing in artificial saliva.
Store in the refrigerator. Method for evaluating adhesion prevention ability of artificial stain Brush the sample in water with a toothbrush to remove contaminants adhering to the sample surface. Then, press paper against the sample to remove water, measure the L value with a color difference meter, and define this value as L1 .
Next, the sample is immersed in an aqueous solution of 0.5 parts by weight of the active ingredient for 1 minute, washed with water, and then immersed in the following iron tannin solution for 5 minutes and washed with water. After repeating the immersion in the active ingredient solution and tannin iron solution 5 times, the L value is measured using a color difference meter, and this value is defined as L 2 . Said L 1
The adhesion prevention ability of the stain is evaluated from the difference between and L 2 (ΔL=L 1 =L 2 ) (the smaller ΔL is, the higher the stain adhesion prevention ability). Iron tannin solution 0.17% by weight aqueous solution of iron acetate and 0.1% of cunnic acid
Mix the same amount of wt% aqueous solution and immediately immerse the sample. Through this operation, the enamel surface of the sample becomes colored red-black.
【表】 以下、実施例を示す。 実施例 １ 練歯磨 非晶質二酸化珪素 30.0％ プロピレングリコール 2.0％ グリセリン 30.0％ ソルビトール 20.0％ ラウリル硫酸ナトリウム 2.0％ カルボキシメチルセルロースナトリウム 1.0％ 香料 1.0％ サツカリン酸ナトリウム 0.1％ dl−グリセリン酸 2.0％ 防腐剤 微量水 残 合 計 100.0％ 実施例 ２ 洗口剤 エタノール 20.0％ サツカリン酸ナトリウム 0.05％ 香料 1.0％ クロルヘキシジン 0.01％ ラウリルジエタノールアマイド 0.3％ ヒドロキシ−ｎ−酪酸 2.0％水 残 合 計 100.0％[Table] Examples are shown below. Example 1 Toothpaste Amorphous silicon dioxide 30.0% Propylene glycol 2.0% Glycerin 30.0% Sorbitol 20.0% Sodium lauryl sulfate 2.0% Sodium carboxymethyl cellulose 1.0% Flavoring 1.0% Sodium saccharinate 0.1% DL-glyceric acid 2.0% Preservative Trace amount of water Total remaining 100.0% Example 2 Mouth rinse ethanol 20.0% Sodium saccharinate 0.05% Fragrance 1.0% Chlorhexidine 0.01% Lauryl diethanolamide 0.3% Hydroxy-n-butyric acid 2.0% Water Total remaining 100.0%
Claims (1)
にこれらの塩から選ばれる化合物を含有してなる
ことを特徴とするステイン付着防止用口腔用組成
物。1. An oral cavity composition for preventing stain adhesion, comprising a compound selected from glyceric acid, hydroxy-n-butyric acid, and salts thereof.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11335483A JPS604117A (en) | 1983-06-22 | 1983-06-22 | Oral cavity composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11335483A JPS604117A (en) | 1983-06-22 | 1983-06-22 | Oral cavity composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS604117A JPS604117A (en) | 1985-01-10 |
| JPH0449523B2 true JPH0449523B2 (en) | 1992-08-11 |
Family
ID=14610139
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP11335483A Granted JPS604117A (en) | 1983-06-22 | 1983-06-22 | Oral cavity composition |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS604117A (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4874850A (en) * | 1986-08-07 | 1989-10-17 | Medice Chem.-Pharm. Fabrik Putter Gmbh & Co. | Pharmaceutical preparations |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5459340A (en) * | 1977-10-19 | 1979-05-12 | Sunstar Inc | Tooth polishing composition |
-
1983
- 1983-06-22 JP JP11335483A patent/JPS604117A/en active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5459340A (en) * | 1977-10-19 | 1979-05-12 | Sunstar Inc | Tooth polishing composition |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS604117A (en) | 1985-01-10 |
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