JPS604117A - Oral cavity composition - Google Patents

Abstract

PURPOSE:An oral cavity composition capable of preventing securely stein attaching itself to the teeth, containing a compound selected from tartronic acid, glyceric acid, hydroxy-n-butyric acid, etc. CONSTITUTION:The titled composition containing 0.001-30wt%, preferably 0.01-10wt% compound selected from tartronic acid, glyceric acid, hydroxy-n- butyric acid, dihydroxymalonic acid and their salts based on the total amounts of the composition. It and proper components for conventional use are processed into dentifrice such as toothpaste, wetting paste, etc., mouthwash, troche, chewing gum, paste for oral cavity, gum-massging cream, refreshing agent in the mouth, etc.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to an oral composition that can effectively prevent stain adhesion.

Conventionally, active ingredients for preventing stains from adhering to teeth or removing stains include organic peroxides (Belgium Patent No. 81.8735, US Pat. No. 3,988,433), esters having one or more aromatic rings ( Special Public Service April 3, 1972
No. 869), specific metal chelating agents (JP-A-51-13
9639), a combination of polyphosphoric acid and a polyvalent metal cation (Japanese Patent Application Laid-Open No. 108029/1982), and fine granules of polyphosphate (Japanese Patent Application Laid-open No. 80429/1989) are known. Practical evaluation of ingredients is not always fixed.

Natural stains on the teeth (stin>i), which occur as a result of normal food and drink contact with the teeth, and iron is thought to be the primary cause; The adhesion of Stain is not desirable, therefore, it is important that oral compositions such as toothpastes have an excellent ability to prevent Stain from adhering.

The present inventors conducted intensive research on active ingredients that can reliably prevent stains from wearing, using an evaluation method that is closer to actual stains, and found that tartronic acid, glyceric acid, hydroxy-1)-butyric acid, and It has been discovered that dihydroxymalonic acid and salts thereof have an extremely excellent ability to inhibit the adhesion of stain, and that oral compositions containing these compounds as active ingredients can reliably prevent the adhesion of stain. , the present invention was accomplished.

Therefore, the present invention provides an oral composition containing one or more compounds selected from tartronic acid, glycerin α, hydroxy-11-acetic acid, dihydroxymalonic acid, and salts thereof, The oral composition of the present invention has an excellent stain adhesion prevention effect.

The present invention will be explained in more detail below.

Oral compositions according to the present invention include toothpastes, moisturized toothpastes, liquid toothpastes and other toothpastes, 7 mouthwashes, troches, chewing gum, oral pasta, gum massage creams, liquid mouth fresheners, and solid mouthwashes. Those prepared and applied as refreshing agents, etc., containing one or more compounds selected from thallic acid, glyceric acid, hydroxy-11-acetic acid, dihydroxymalonic acid, and salts thereof. By blending these compounds, it is possible to reliably prevent the stain from adhering.

Here, tartronic acid, glyceric acid, hydroxy-n
- Salts of acetic acid and dihydroxymalonic acid include alkali metal salts such as 1-lium salts.゛t, Tal 1 ~ Ronic acid, Glyceric acid, Hydroxy-
The blend m of the compound selected from n-acetic acid, dihydroxymalonic acid, and salts thereof is 0.0% of the entire oral composition.
001 to 30% (weight%, same below), especially 0.01 to 30%
Preferably it is 10%.

As other components of the present invention, appropriate components commonly used may be blended depending on the type of the composition, purpose of use, etc.

For example, in the case of toothpaste, dibasic calcium phosphate
Hydrates and anhydrides, monocalcium phosphate, tertiary calcium phosphate, calcium carbonate, calcium birophosphate,
Titanium oxide, alumina, hydrated alumina, silica gel, colloidal silica, anhydrous alkali metal silicate complex, aluminum silicate, insoluble sodium to lithium metaphosphate, insoluble potassium metaphosphate, tribasic magnesium phosphate, magnesium carbonate, sulfuric acid One or more of calcium, polymethyl methacrylate, bentonite, zirconium silicate, synthetic resin, etc. should be blended (the amount usually ranges from 10% to
99% and 10% to 75% in the case of toothpaste).

In the case of a composition for use in paste form such as toothpaste, a binder such as carragnan, sodium carboxymethyl, methyl cellulose, hydroxyethyl cellulose, sodium carboxymethyl hydroxyethyl lulose, etc. may be used as a binder. Cellulose derivatives, alkali metal alginates such as sodium alginate,
Gums such as alginate propylene glycol ester, xanthan gum, tragacanth gum, Kara A7 gum, gum arabic, synthetic binders such as polyvinyl alcohol, sodium polyacrylate, carboxyvinyl polymer, polyvinylpyrrolidone, and silica gel.

One or more inorganic binders such as aluminum licage gel, gum, laponite, etc. may be blended (Blend ① Usually 0.5 to 5%).

Furthermore, toothpaste and other oral compositions! In the 1Iil production, one or more of sorbitol, glycerin, ethylene glycol, propylene glycol, 1,3-butylene glycol, polyethylene glycol, polypropylene glycol, xylit, multi-l-, luffit, etc. may be blended as a thickening agent. (Mixture m usually 10~
70%). In addition, water-soluble salts of higher alkyl sulfates whose alkyl groups have carbon atoms of 8 to 18, such as sodium lauryl sulfate and sodium myristyl sulfate, and water-soluble salts such as hydrogenated coconut oil fatty acid monoglycium chloride monosulfate, etc. Higher fatty acid monoglyceride monosulfate, alkylaryl sulfonate such as dodecylbenzenesulfonate, higher alkyl sulfonate, higher fatty acid ester of 1,2-dihydroxypropanesulfonate,
anionic activators such as substantially saturated higher aliphatic acylamides of lower aliphatic aminocarboxylic acid compounds such as the sodium, potassium or ethanolamine salts of N-lauroyl, N-myristoyl or N-balmitoyl sarcosine, sucrose; Sucrose fatty acid esters in which the fatty acid group has 12 to 18 carbon atoms such as mono- and dilaurate, lactose fatty acid esters, lactitol fatty acid esters, maltitol fatty acid esters, stearic acid monoglyceride,
Polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan monostearate, polyoxyethylene (10, 20, 40, 60, 80° 100 mol), hydrogenated castor oil, polymer of ethylene oxide and propylene oxide, and polyA-oxyethylene One or more types of nonionic surfactants such as condensation products of polyethylene oxide such as polyoxypropylene monolauryl ester and fatty acids, fatty alcohols, polyhydric alcohols, and polypropylene oxide, and amphoteric surfactants such as betaine type and amino acid type. surfactant (compounding amount usually 0~7
%, preferably 0.5 to 5%).

The oral composition of the present invention further includes saccharin sodium, stevioside, and neohesve! Sweeteners such as dildihyde O chalcone, glycyrrhizin, perillartin, thaumatin, asparatyl phenylalanine methyl ester, p-methoxycinnamic aldehyde, sucrose, lactose, fructose, sodium ichlamate (0 to 1%, preferably 0.01%) ~0.5%), and if necessary, p-hydroxyethylbenzoic acid, 1]-hydroxyethylbenzoic acid, 0-hydroxypropylbenzoic acid, p-hydroxybutylbenzoic acid 1:, Rest? ll'Asu1 Helium, preservatives such as lower fat-articulated monogrilerite, fragrances such as wintergreen oil, spearmint oil, peppergin oil, satsafras oil, clove, eucalyptus oil, gelatin, peptone, arginine hydrochloride, Brighteners such as albumin, casein, titanium dioxide, silicone, pigments, and other ingredients can be blended. For example, in the case of toothpaste, the above-mentioned desired ingredients can be mixed with an appropriate amount of water. .

In addition, when producing other oral compositions, they can be produced according to conventional methods using appropriate ingredients commonly used in 77S.

Furthermore, in the present invention, allantoins, epsilon aminocaproic acid, tranexamic acid, dextranase,
amylase, protease, mutanase, lysozyme,
Enzymes such as bacteriolytic enzyme, Litetsuenzyme, monofluor [
Alkali metal monofluorophosphates such as sodium monophosphate and potassium monofluorophosphate, fluorides such as sodium fluoride, ammonium fluoride, and stannous fluoride, chlorhexidine salts, dihydrocholesterol,
Glycyrrhetinic salts, glycyrrhetinic acid, chryserophosphate, chlorophyll, riclobebutide, water-soluble (
One or more active ingredients such as polyphosphoric acid compounds, vitamins, tartar inhibitors, antibacterial agents, and plaque inhibitors may be blended.

Next, the effects of the present invention will be specifically illustrated by experimental examples.

[Experiment example]

Using the compounds shown in Table 1 as active ingredients, the ability to inhibit stain adhesion was evaluated by the following method. The results are also listed in Table 1.

A natural tooth made of I11 (protruding tooth) was cut into 6 m square pieces and embedded in resin with the enamel side facing up. Polish the enamel surface to a level that does not expose dentin to create a smooth surface and use it as a sample for human rosdin attachment.

To preserve it, soak it in artificial saliva and store it in a refrigerator.

Rostin's Stop Evaluation Method: Brush the sample under water with a toothbrush to remove contaminants adhering to the sample surface. Then, press paper against the sample to remove water, measure the L value with a color difference meter, and set this value as Ll. Next, the sample is immersed in a 0.5% by weight aqueous solution of the active ingredient for 1 minute, washed with water, then immersed in the following iron tannin solution for 5 minutes, and washed with water. After repeating the immersion in this active ingredient solution and tannin iron solution 5 times,
Measure L11 with a color difference meter, and define this as L2. Said L
The adhesion prevention ability of STEIN is evaluated from the difference between + and L2 (Δ1f=L+ 12 ) (the smaller the Δ, the higher the STEIN adhesion prevention ability).

KU22 LZ Oni jH 0.17% aqueous solution of iron acetate and 0.1m of iron tannin
Mix the same amount of m% aqueous solution and immediately immerse the lean pull. Through this operation, the enamel surface of the sample becomes colored red-black.

Examples are shown below in Table 1-0 [Example 1] Toothpaste Amorphous silicon dioxide 30.0% Propylene glycol 2.0% Glycerin 30.0% Sorbitol 20.0% Sodium lauryl sulfate 2, 0% Carboxymethyl cellulose sodium flavor 1.0
% 1-lium saccharinate 0.1% dJ-glycerin tlI! t' 2.0% Preservative Slight hanging wood Remaining amount Total 100.0% [Example 2] Toothpaste Calcium hydrogen phosphate dihydrate 43.0% Colloidal silica 2.0% Propylene glycol 2.0 % Glycerin 10.0% Sorbitol 10.0% Sodium lauryl sulfate 1.5% Sodium carboxymethyl cellulose 0.7% Carrageenan 0.3% Flavoring 1.0% Sodium saccharinate 0.1% Sodium tal]heronate 1. 0% Preservative Trace amount of water Balance total ioo. o% [Example 3] Mouthrinse ethanol 20.0% Sodium monofluorophosphate 0.05% Fragrance 1.0% Sodium monofluorophosphate 0.1% Chlorhexidine 0.01% Lauryl jetanolamide 0.3 % Tartronic acid 0.5% Water Balance total 100.0% [Example 4] Liquid toothpaste Total 100.0% [Example 5] Contains ethanol 15% Glycerin 10% Fragrance 0.2% Saccharin n Thorium sec 0.05% Sodium fluoride 0.5% Cibide [1ximalonic acid 0.5% Sodium monofluorophosphate 0.1% Water Balance total 100.0% (Example 6) Mouthwash ethanol 20.0 % Sodium phosphate 0.05% Flavor 1.0% Chlorhexidine 0.01% Laurylgetanolamide 0.3% Hydroxy-
1) - Butyric acid 2.0% Water Foreign applicant: Lion Co., Ltd. agent Patent attorney: Takashi Kojima

Claims (1)

[Claims] 1. An oral composition comprising a compound selected from tartronic acid, glyceric acid, hydroxy-n-butyric acid, dihydroxymalonic acid, and salts thereof.