ITMI20011315A1 - COMPOSITION FOR ANTI-PLATE TOOTHPASTE PASTE WITH PLATE DETECTOR - Google Patents
COMPOSITION FOR ANTI-PLATE TOOTHPASTE PASTE WITH PLATE DETECTOR Download PDFInfo
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- ITMI20011315A1 ITMI20011315A1 IT2001MI001315A ITMI20011315A ITMI20011315A1 IT MI20011315 A1 ITMI20011315 A1 IT MI20011315A1 IT 2001MI001315 A IT2001MI001315 A IT 2001MI001315A IT MI20011315 A ITMI20011315 A IT MI20011315A IT MI20011315 A1 ITMI20011315 A1 IT MI20011315A1
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- Prior art keywords
- plaque
- toothpaste
- composition according
- group
- toothpaste composition
- Prior art date
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- 239000000606 toothpaste Substances 0.000 title claims description 39
- 229940034610 toothpaste Drugs 0.000 title claims description 31
- 239000000203 mixture Substances 0.000 title claims description 24
- 239000006072 paste Substances 0.000 title claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 14
- 230000002882 anti-plaque Effects 0.000 claims description 10
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 9
- 210000000214 mouth Anatomy 0.000 claims description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 8
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 8
- 230000000844 anti-bacterial effect Effects 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 6
- 239000003082 abrasive agent Substances 0.000 claims description 6
- 150000001875 compounds Chemical class 0.000 claims description 6
- 239000000725 suspension Substances 0.000 claims description 6
- 230000000845 anti-microbial effect Effects 0.000 claims description 5
- 239000007844 bleaching agent Substances 0.000 claims description 5
- 238000004140 cleaning Methods 0.000 claims description 5
- 125000001153 fluoro group Chemical class F* 0.000 claims description 5
- 150000002978 peroxides Chemical class 0.000 claims description 5
- TXNJAVCZNMSELK-UHFFFAOYSA-N CCCCCCCCCCCCOC(=O)CNC Chemical compound CCCCCCCCCCCCOC(=O)CNC TXNJAVCZNMSELK-UHFFFAOYSA-N 0.000 claims description 4
- 239000000654 additive Substances 0.000 claims description 4
- 125000000129 anionic group Chemical group 0.000 claims description 4
- 239000004075 cariostatic agent Substances 0.000 claims description 4
- PXEDJBXQKAGXNJ-QTNFYWBSSA-L disodium L-glutamate Chemical compound [Na+].[Na+].[O-]C(=O)[C@@H](N)CCC([O-])=O PXEDJBXQKAGXNJ-QTNFYWBSSA-L 0.000 claims description 4
- 235000011187 glycerol Nutrition 0.000 claims description 4
- 229920003063 hydroxymethyl cellulose Polymers 0.000 claims description 4
- 229940031574 hydroxymethyl cellulose Drugs 0.000 claims description 4
- 239000004615 ingredient Substances 0.000 claims description 4
- 229940071204 lauryl sarcosinate Drugs 0.000 claims description 4
- 235000013923 monosodium glutamate Nutrition 0.000 claims description 4
- 229940073490 sodium glutamate Drugs 0.000 claims description 4
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 3
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 3
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 3
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims description 3
- 230000015572 biosynthetic process Effects 0.000 claims description 3
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 3
- XAAHAAMILDNBPS-UHFFFAOYSA-L calcium hydrogenphosphate dihydrate Chemical compound O.O.[Ca+2].OP([O-])([O-])=O XAAHAAMILDNBPS-UHFFFAOYSA-L 0.000 claims description 3
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 3
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 3
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 3
- 229920001525 carrageenan Polymers 0.000 claims description 3
- 235000010418 carrageenan Nutrition 0.000 claims description 3
- 239000001913 cellulose Substances 0.000 claims description 3
- 229920002678 cellulose Polymers 0.000 claims description 3
- 210000003298 dental enamel Anatomy 0.000 claims description 3
- MOTZDAYCYVMXPC-UHFFFAOYSA-N dodecyl hydrogen sulfate Chemical compound CCCCCCCCCCCCOS(O)(=O)=O MOTZDAYCYVMXPC-UHFFFAOYSA-N 0.000 claims description 3
- 229940043264 dodecyl sulfate Drugs 0.000 claims description 3
- IINNWAYUJNWZRM-UHFFFAOYSA-L erythrosin B Chemical compound [Na+].[Na+].[O-]C(=O)C1=CC=CC=C1C1=C2C=C(I)C(=O)C(I)=C2OC2=C(I)C([O-])=C(I)C=C21 IINNWAYUJNWZRM-UHFFFAOYSA-L 0.000 claims description 3
- 239000004174 erythrosine Substances 0.000 claims description 3
- 229940011411 erythrosine Drugs 0.000 claims description 3
- 235000012732 erythrosine Nutrition 0.000 claims description 3
- 150000002170 ethers Chemical class 0.000 claims description 3
- 239000006260 foam Substances 0.000 claims description 3
- 229910021485 fumed silica Inorganic materials 0.000 claims description 3
- 102000004169 proteins and genes Human genes 0.000 claims description 3
- 108090000623 proteins and genes Proteins 0.000 claims description 3
- 239000000377 silicon dioxide Substances 0.000 claims description 3
- 239000000600 sorbitol Substances 0.000 claims description 3
- 239000004094 surface-active agent Substances 0.000 claims description 3
- 238000004040 coloring Methods 0.000 claims description 2
- 239000011343 solid material Substances 0.000 claims description 2
- 230000000675 anti-caries Effects 0.000 claims 1
- 230000008030 elimination Effects 0.000 description 3
- 238000003379 elimination reaction Methods 0.000 description 3
- 208000002064 Dental Plaque Diseases 0.000 description 2
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 2
- 230000001680 brushing effect Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 2
- 229960003500 triclosan Drugs 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 229960001631 carbomer Drugs 0.000 description 1
- 239000012459 cleaning agent Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000002324 mouth wash Substances 0.000 description 1
- 229940051866 mouthwash Drugs 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000005201 scrubbing Methods 0.000 description 1
- 239000011775 sodium fluoride Substances 0.000 description 1
- 235000013024 sodium fluoride Nutrition 0.000 description 1
- XCXLEIPEAAEYTF-UHFFFAOYSA-M sodium fluorosulfate Chemical compound [Na+].[O-]S(F)(=O)=O XCXLEIPEAAEYTF-UHFFFAOYSA-M 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/42—Colour properties
- A61K2800/43—Pigments; Dyes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
Description
Descrizione dell'invenzione avente per titolo: "COMPOSIZIONE PER PASTA DENTIFRICIA CON CARATTERISTICHE ANTIPLACCA" Description of the invention entitled: "COMPOSITION FOR TOOTHPASTE PASTE WITH ANTI-PLAQUE CHARACTERISTICS"
La presente invenzione si riferisce a composizioni utilizzabili come paste dentifricie capaci di rimuovere la placca. The present invention relates to compositions usable as toothpastes capable of removing plaque.
Le paste dentifricie, comunemente disponibili sul mercato, contengono generalmente, oltre all'acqua demineralizzata: Toothpastes, commonly available on the market, generally contain, in addition to demineralized water:
a) un agente abrasivo per rimuovere la pellicola proteica che si forma sui denti, senza intaccare lo smalto. Fra i prodotti che si possono citare per questo scopo vi sono: il fosfato di calcio diidrato, il carbonato di calcio, l'allumina idrata e la silice; b) un agente tensioattivo preferibilmente anionico che favorisce la formazione di schiuma e rende più piacevole l'uso del dentifricio, i più comunemente utilizzati sono il laurilsolfato, il lauril sarcosinato o glutammato di sodio; a) an abrasive agent to remove the protein film that forms on the teeth, without damaging the enamel. Among the products that can be mentioned for this purpose are: calcium phosphate dihydrate, calcium carbonate, hydrated alumina and silica; b) a surfactant, preferably anionic, which favors the formation of foam and makes the use of toothpaste more pleasant, the most commonly used are lauryl sulfate, lauryl sarcosinate or sodium glutamate;
c) composti gelificanti che trattengono l'acqua contenuta nel dentifricio e ne assicurano la morbidezza nel tempo. Questi prodotti sono in genere costituiti da glicerina, sorbitolo, glicol propilenico; c) gelling compounds that retain the water contained in the toothpaste and ensure its softness over time. These products are generally made up of glycerin, sorbitol, propylene glycol;
d) agenti che permettono di mantenere l'agente abrasivo in sospensione nella miscela. Esempi di questi composti sono: derivati della cellulosa, quali idrossimetilcellulosa, carbossimetilcellulosa, eteri cellulosici nonché silice pirogenica, carragenani. d) agents which allow to keep the abrasive agent in suspension in the mixture. Examples of these compounds are: cellulose derivatives, such as hydroxymethylcellulose, carboxymethylcellulose, cellulosic ethers as well as fumed silica, carrageenans.
Altri prodotti sono generalmente presenti nelle paste dentifricie, quali aromi, dolcificanti, coloranti, conservanti, agenti anticorrosione quando si usino contenitori metallici. Other products are generally present in toothpastes, such as flavors, sweeteners, dyes, preservatives, anticorrosion agents when using metal containers.
Attualmente i dentifrici commerciali contengono, inoltre, uno o più dei seguenti additivi: agenti sbiancanti, quali perossidi o persali, agenti anticarie quali i derivati del fluoro, nonché uno o più agenti antiplacca, costituiti in genere da ingredienti antimicrobici o antibatterici. Currently, commercial toothpastes also contain one or more of the following additives: whitening agents, such as peroxides or persals, anticaries agents such as fluorine derivatives, as well as one or more anti-plaque agents, generally consisting of antimicrobial or antibacterial ingredients.
Pertanto i dentifrici commercialmente disponibili sul mercato, svolgono una azione di conservazione estetica ed igienica della dentatura e del cavo orale dovuta alla presenza di agenti antibatterici ed antimicrobici, ma non danno informazioni circa lo stato e l'esistenza della placca sulla superficie dei denti e sulle gengive e/o in altre zone del cavo orale. Therefore, the toothpastes commercially available on the market perform an aesthetic and hygienic preservation action of the teeth and oral cavity due to the presence of antibacterial and antimicrobial agents, but do not give information about the state and existence of plaque on the surface of the teeth and on the gums and / or other areas of the oral cavity.
Esistono in commercio prodotti per rivelare l'esistenza della placca presente sulla superficie dei denti e in altre zone del cavo orale che si basano sul cambiamento di colore di detti indicatori quando entrano in contatto con la placca dentale. There are commercially available products to reveal the existence of plaque present on the surface of the teeth and in other areas of the oral cavity which are based on the change in color of said indicators when they come into contact with dental plaque.
Altri metodi per rilevare la placca consistono nell'impiego radiazioni che provocano la fluorescenza delle zone dove è presente la placca. Questi prodotti o sistemi per la rilevazione della placca possono essere utilizzati prima e o dopo il lavaggio dei denti con lo spazzolino e, pertanto, non si può avere la sicurezza che il lavaggio dei denti stia conducendo alla eliminazione completa della placca. Non si hanno, infatti, informazioni circa le zone nelle quali la placca si annida in quantità maggiore e dove concentrare l'azione dello spazzolino se non a posteriori dopo che il lavaggio è terminato. Other methods to detect plaque consist in the use of radiations that cause fluorescence of the areas where the plaque is present. These plaque detection products or systems can be used before and after brushing your teeth and therefore you cannot be sure that tooth brushing is leading to the complete elimination of plaque. In fact, there is no information about the areas in which the plaque lurks in greater quantities and where to concentrate the action of the toothbrush if not a posteriori after the washing is finished.
Sarebbe quindi altamente desiderabile disporre di un dentifricio che, pur mantenendo le prestazioni dei dentifrici costituiti da componenti attualmente disponibili, non mostrasse gli inconvenienti dovuti alla mancanza di informazioni sull'esistenza o meno della placca durante il normale trattamento di pulizia dei denti. It would therefore be highly desirable to have a toothpaste which, while maintaining the performance of toothpastes made up of currently available components, does not show the drawbacks due to the lack of information on whether or not plaque exists during normal tooth cleaning treatment.
E' stato ora trovato che è possibile ovviare agli inconvenienti lamentati sopra utilizzando una composizione dentifricia che contiene, oltre ai componenti usuali elencati sopra, anche un componente rivelatore di placca che indica cioè l'esistenza o meno della placca con il colore intenso assunto dalla sospensione di pasta dentifricia presente nel cavo orale. Con il procedere del trattamento con la pasta dentifricia, la colorazione che indica la presenza della placca perde di intensità fino alla sua scomparsa quando tutta la placca è stata aggredita e eliminata con successivi lavaggi. La presenza del materiale rilevatore di placca permette di programmare la durata e l'intensità del lavaggio in dipendenza dell'esistenza o meno della placca e della sua concentrazione nel cavo orale. It has now been found that it is possible to overcome the drawbacks mentioned above by using a toothpaste composition which contains, in addition to the usual components listed above, also a plaque-detecting component which indicates the existence or not of the plaque with the intense color assumed by the suspension. of toothpaste present in the oral cavity. As the treatment with the toothpaste proceeds, the color that indicates the presence of the plaque loses intensity until it disappears when all the plaque has been attacked and eliminated with subsequent washes. The presence of the plaque detector material allows to program the duration and intensity of the washing depending on the existence or not of the plaque and its concentration in the oral cavity.
E' pertanto uno scopo della presente invenzione una composizione utile come pasta dentifricia o come collutorio per il cavo orale che contenga uno o più agenti rivelatori di placca oltre a tutti i componenti che sono necessari per esplicare una buona funzione detergente e curativa dei denti e del cavo orale ed inoltre permetta di monitorare la scomparsa o il grado di eliminazione della placca con il procedere del lavaggio dei denti. Therefore, an object of the present invention is a composition useful as a toothpaste or as a mouthwash for the oral cavity which contains one or more plaque detectors as well as all the components that are necessary to perform a good cleaning and healing function of the teeth and the oral cavity and also allows to monitor the disappearance or the degree of elimination of plaque as the teeth are brushed.
Lo scopo della presente invenzione si raggiunge con una composizione che si presenta sotto forma di una pasta di materiali solidi contenente una modesta quantità di acqua comprendente: The object of the present invention is achieved with a composition which is presented in the form of a paste of solid materials containing a modest quantity of water comprising:
a) un agente abrasivo per rimuovere la pellicola proteica che si forma sui denti, senza intaccare lo smalto; a) an abrasive agent to remove the protein film that forms on the teeth, without damaging the enamel;
b) un agente tensioattivo, preferibilmente anionico, che favorisca la formazione di schiuma e renda più piacevole l'uso del dentifricio; b) a surfactant, preferably anionic, which favors the formation of foam and makes the use of the toothpaste more pleasant;
c) composti gelificanti che trattengono l'acqua contenuta nel dentifricio e ne assicurano la morbidezza nel tempo; c) gelling compounds that retain the water contained in the toothpaste and ensure its softness over time;
d) agenti che permettono di mantenere l'agente abrasivo in sospensione nella miscela; d) agents which allow to keep the abrasive agent in suspension in the mixture;
e)uno o più dei seguenti additivi: agenti sbiancanti, quali perossidi o persali, agenti anticarie quali i derivati del fluoro, f)uno o più agenti antiplacca, costituiti in genere da ingredienti antimicrobici o antibatterici; e) one or more of the following additives: bleaching agents, such as peroxides or persals, anticaries agents such as fluorine derivatives, f) one or more anti-plaque agents, generally consisting of antimicrobial or antibacterial ingredients;
g)componente per rivelazione della placca mediante colorazione intensa impartita alla sospensione di pasta dentifricia presente nel cavo orale durante l'operazione di pulitura dei denti. g) component for detecting plaque by means of intense coloring imparted to the toothpaste suspension present in the oral cavity during the teeth cleaning operation.
Fra i prodotti che possono essere impiegati come componenti del gruppo a) vi sono: il fosfato di calcio diidrato, il carbonato di calcio, l'allumina idrata e la silice. Among the products that can be used as components of group a) there are: calcium phosphate dihydrate, calcium carbonate, hydrated alumina and silica.
I prodotti più comunemente utilizzati come componenti del gruppo b) sono il laurilsolfato, il lauril sarcosinato o il glutammato di sodio. The products most commonly used as components of group b) are lauryl sulfate, lauryl sarcosinate or sodium glutamate.
I materiali utilizzabili del gruppo c) sono in genere costituiti da glicerina, sorbitolo, glicol propilenico; Esempi di composti utilizzabili nel gruppo d) sono i derivati della cellulosa, quali idrossimetilcellulosa, carbossimetilcellulosa, eteri cellulosici, oppure silice pirogenica, carragenani. The usable materials of group c) generally consist of glycerin, sorbitol, propylene glycol; Examples of compounds usable in group d) are cellulose derivatives, such as hydroxymethylcellulose, carboxymethylcellulose, cellulosic ethers, or fumed silica, carrageenans.
Come accennato sopra i dentifrici commerciali attuali contengono, inoltre, uno o più dei seguenti additivi: agenti sbiancanti, quali perossidi o persali, agenti anticarie quali i derivati del fluoro, nonché uno o più agenti antiplacca, costituiti in genere da composti antimicrobici o antibatterici. As mentioned above, current commercial toothpastes also contain one or more of the following additives: whitening agents, such as peroxides or persals, anticaries agents such as fluorine derivatives, as well as one or more anti-plaque agents, generally consisting of antimicrobial or antibacterial compounds.
Come agente rivelatore di placca può essere utilizzato qualunque agente noto che possa assumere e/o far assumere alla pasta dentifricia utilizzata come agente di lavaggio per i denti, una colorazione la cui intensità sia funzione della quantità di placca esistente. Any known agent that can take and / or cause the toothpaste used as a cleaning agent for the teeth to be used as a plaque-detecting agent, a color whose intensity is a function of the amount of existing plaque.
Per poter maglio comprendere i vantaggi della presente invenzione abbiamo preparato alcune composizioni dentifricie comprese nell'ambito della presente invenzione e contenenti sia il Triclosan come agente anti-placca e eritrosina come rivelatore della placca. La composizione della pasta dentifricia era la seguente : In order to understand the advantages of the present invention we have prepared some toothpaste compositions included in the scope of the present invention and containing both Triclosan as an anti-plaque agent and erythrosine as a plaque detector. The composition of the toothpaste was as follows:
Silici 20% SLS o alternativi anionici quali lauril sarcosinato o Glutammato sodico 2% Glicerina o sorbirolo 30% Idrossimetil cellulosa o derivati dallo Xantan Gum 0 Carbomer 1% Miscele di parabeni come sistemi conservanti 0,3% Triclosan (antibatterico e antiplacca) 0,2% Fluoruro sodico o monofluorosolfato sodico 1% Acqua demineralizzata 42,5% Agente rivelatore antiplacca eritrosina o derivati In una percentuale del 3%. Silicas 20% SLS or anionic alternatives such as lauryl sarcosinate or sodium glutamate 2% Glycerin or sorbirol 30% Hydroxymethyl cellulose or derivatives from Xantan Gum 0 Carbomer 1% Mixtures of parabens as preservative systems 0.3% Triclosan (antibacterial and anti-plaque) 0.2 % Sodium fluoride or sodium monofluorosulfate 1% Demineralized water 42.5% Anti-plaque detecting agent erythrosine or derivatives In a percentage of 3%.
La pasta dentifricia così preparata è stata distribuita a volontari abituati in modo diverso all'uso dello spazzolino con pasta dentifricia. Inizialmente veniva fornito un dentifricio contenente un agente antiplacca, ma privo del rivelatore di placca e si richiedeva a questi volontari di continuare il lavaggio finche, secondo la loro opinione la placca fosse scomparsa. A un altro gruppo di volontari è stato richiesto di protrarre l'azione dello spazzolino da denti fino a scomparsa osservata della placca. The toothpaste thus prepared was distributed to volunteers accustomed in a different way to the use of the toothbrush with toothpaste. A toothpaste containing an anti-plaque agent was initially provided, but without the plaque detector, and these volunteers were required to continue scrubbing until, in their opinion, the plaque was gone. Another group of volunteers was asked to continue the action of the toothbrush until the plaque disappeared.
In ambedue i casi veniva registrato il tempo dì trattamento . In both cases the treatment time was recorded.
I risultati sono riportati nella tabella che segue: The results are shown in the table below:
VOLONTARI Anti-placca rivelat. VOLUNTEERS Anti-plaque revealed.
(tipo e % peso) (type and% weight)
Tempo per l'eliminazione della placca stimato effettivo triclosaneritros min min Time for plaque elimination estimated effective triclosaneritros min min
Le prove dei volontari B, D, F e le relative composizioni sono comprese nell'ambito dell'invenzione, mentre le prove con i volontari A, C, E che sperimentano composizioni dentifricie senza l'aggiunta di rivelatore di placca, sono fornite a titolo comparativo. The tests of the volunteers B, D, F and the relative compositions are included in the scope of the invention, while the tests with the volunteers A, C, E who experiment with toothpaste compositions without the addition of a plaque detector, are provided by way of comparative.
Si vede che i volontari che utilizzano le composizioni secondo l'invenzione riescono ad eliminare la placca dentaria operando in modo selettivo e mirato sulle zone dove si annida la placca, mentre i volontari ai quali non à stato fornito il rivelatore di placca richiedono un tempo più lungo per eliminare la placca e, in alcuni casi l'asportazione non è completa. It can be seen that the volunteers who use the compositions according to the invention are able to eliminate dental plaque by operating in a selective and targeted manner on the areas where the plaque lurks, while the volunteers who have not been provided with the plaque detector require a longer time. long to remove plaque and, in some cases, the removal is not complete.
Claims (9)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2001MI001315A ITMI20011315A1 (en) | 2001-06-21 | 2001-06-21 | COMPOSITION FOR ANTI-PLATE TOOTHPASTE PASTE WITH PLATE DETECTOR |
| PCT/IT2002/000407 WO2003000215A1 (en) | 2001-06-21 | 2002-06-20 | Tooth-paste composition having anti-plaque properties |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2001MI001315A ITMI20011315A1 (en) | 2001-06-21 | 2001-06-21 | COMPOSITION FOR ANTI-PLATE TOOTHPASTE PASTE WITH PLATE DETECTOR |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ITMI20011315A0 ITMI20011315A0 (en) | 2001-06-21 |
| ITMI20011315A1 true ITMI20011315A1 (en) | 2002-12-21 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT2001MI001315A ITMI20011315A1 (en) | 2001-06-21 | 2001-06-21 | COMPOSITION FOR ANTI-PLATE TOOTHPASTE PASTE WITH PLATE DETECTOR |
Country Status (2)
| Country | Link |
|---|---|
| IT (1) | ITMI20011315A1 (en) |
| WO (1) | WO2003000215A1 (en) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5366553B2 (en) | 2005-11-09 | 2013-12-11 | クロックス テクノロジーズ インコーポレイテッド | Teeth whitening composition and method |
| DE602006015164D1 (en) | 2006-03-27 | 2010-08-12 | Nestec Sa | Cosmetic use of whey protein micelles |
| US20100266989A1 (en) | 2006-11-09 | 2010-10-21 | Klox Technologies Inc. | Teeth whitening compositions and methods |
| EA029534B1 (en) | 2008-11-07 | 2018-04-30 | Клокс Текнолоджиз Инк. | Combination of an oxidant and a photoactivator for the healing of wounds |
| SG177635A1 (en) | 2009-07-17 | 2012-03-29 | Klox Technologies Inc | Combination of an oxidant, a photosensitizer and a wound healing agent for oral disinfection and treatment of oral disease |
| EP2780085B1 (en) | 2011-11-15 | 2017-06-14 | Colgate-Palmolive Company | Oral care gels |
| WO2013074080A1 (en) * | 2011-11-15 | 2013-05-23 | Colgate-Palmolive Company | Oral care gel dispenser systems |
| US20130281913A1 (en) | 2012-04-20 | 2013-10-24 | Klox Technologies Inc. | Biophotonic compositions and methods for providing biophotonic treatment |
| US11116841B2 (en) | 2012-04-20 | 2021-09-14 | Klox Technologies Inc. | Biophotonic compositions, kits and methods |
| MX351267B (en) | 2012-09-14 | 2017-10-06 | Valeant Pharmaceuticals Int Inc | Compositions and methods for teeth whitening. |
| US20140276354A1 (en) | 2013-03-14 | 2014-09-18 | Klox Technologies Inc. | Biophotonic materials and uses thereof |
| JP6932304B2 (en) | 2013-07-03 | 2021-09-08 | 広東科洛克生物医薬集団有限公司 | A bio-light composition for treating wounds, including a chromophore and a gelling agent |
| JP2017509433A (en) | 2014-04-01 | 2017-04-06 | クロックス テクノロジーズ インコーポレイテッドＫｌｏｘ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｉｎｃ． | Tissue filler composition and method of use |
| MX2017005673A (en) | 2014-10-31 | 2017-08-02 | Klox Tech Inc | Photoactivatable fibers and fabric media. |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2463613A1 (en) * | 1979-08-20 | 1981-02-27 | Thorel Jean Noel | NEW COMPOSITIONS FOR THE REVELATION OF THE DENTAL PLATE |
| DE2935450A1 (en) * | 1979-09-01 | 1981-03-19 | Hermann Dr.Med.Dent. 4044 Kaarst Gertenbach | Tooth cleansing compsn. contg. dye - pref. encapsulated in gelatin to indicate presence of tooth deposit e.g. plaque |
| US4459277A (en) * | 1980-10-07 | 1984-07-10 | Kosti Carl M | Plaque disclosing dentifrice compositions with solid microcapsules of dye |
| GB8411841D0 (en) * | 1984-05-09 | 1984-06-13 | Unilever Plc | Oral compositions |
-
2001
- 2001-06-21 IT IT2001MI001315A patent/ITMI20011315A1/en unknown
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2002
- 2002-06-20 WO PCT/IT2002/000407 patent/WO2003000215A1/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ITMI20011315A0 (en) | 2001-06-21 |
| WO2003000215A1 (en) | 2003-01-03 |
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