KR101497061B1 - Composition for cleaning the oral - Google Patents

Abstract

The present invention relates to an oral cleansing composition comprising cellulose or cellulose and a sequestering agent, and the cleansing force can be maintained even without polishing to have an excellent effect of removing plaque.

Description

Composition for cleaning the oral < RTI ID = 0.0 >

The present invention relates to an oral cleansing composition, and more particularly, to an oral cleansing composition having a cleansing power without the polishing of teeth and having a plaque removing effect.

Oral diseases that occur in the oral cavity are caused by plaque and numerous bacteria in the mouth. The plaque is Streptococcus It is a sticky substance made by bacteria living in the mouth, such as mutans , and is a sticky film attached to the surface of teeth and gums. The membrane is composed of a dental plaque membrane in which oral bacteria are trapped in a network of dextran, a glucose polymer. These plaques are also known to be a major cause of cavities, calculus, and gum disease, which are important diseases commonly occurring in teeth and surrounding tissues.

In addition, when the tooth surface is kept for a long time without removing the bacterial membrane, it forms an insoluble salt by combining with the components such as calcium, magnesium and phosphorus in the oral saliva, thereby forming tartar having hardness similar to that of a tooth. As the teeth continue to form, the gingiva and teeth are pinched between the teeth, causing bleeding easily when brushing teeth, and causing inflammation by bacteria in the mouth, resulting in gingivitis and periodontal disease. Inflammatory symptoms of gingivitis include reddened redness, swelling, and bleeding of the gingiva. Gingivitis causes periodontal disease.

The mechanism of formation of calculus is still not completely understood. In the industry, it is understood that it grows as a crystalline substance called hydroxyapatite such as calcium and calcium phosphate, although there is a difference according to various known technologies. It is known that effective removal can fundamentally inhibit the formation of calculus.

In order to remove such a prage, an antibacterial agent that suppresses the growth of bacteria that generates prage, and a method of effectively cleaning the prage by adding an abrasive to the dentifrice composition to improve the cleaning effect are generally used. However, the use of an antimicrobial agent is problematic in that it is difficult to maintain the effect due to an increase in bacterial resistance, and the effect of inhibiting bacteria in the oral cavity is weak, so that it is generally not effective in preventing periodontal disease and periodontal disease, . On the other hand, the cleaning of the teeth by the abrasive improves the removal effect of the prage by increasing the abrasive to increase the cleaning power or by using the abrasive with a high polishing rate. However, as long as toothpaste having a high abrasive force (abrasion force) is used for a long period of time as well as the induction of syringe due to the abrasion action of the tooth, there is a problem of causing cervical erosion.

Korean Patent Registration No. 10-101987 discloses a composition that provides a chemical cleaning of the oral cavity surface using a combination of a surfactant, a chelating agent, and a pH. It is claimed that the oral surface can be gently cleaned by minimizing the abrasive. However, the chelating agent is used in excess to increase the washing power, but the effect is not good because the stimulus is greatly increased in the oral cavity. Korean Patent Laid-Open Publication No. 10-2004-0054317 discloses an oral hygiene composition containing a vegetable abrasive, wherein the composition comprises fibers of cabbage leaves, green tea leaves, lettuce leaves, ginkgo leaves, maple leaves, pine leaves, It is claimed that the use of a vegetable abrasive is excellent in preventing tooth wear, plaque removal and gingivitis. However, when the vegetable abrasive is used singly or in combination, the stability is poor and the cleaning ability is poor, so that the oral cavity can not be cleaned properly, so that the plaque removal is not properly performed and the gingivitis prevention effect is not good.

Therefore, in order to prevent oral diseases, it is required to continue research on oral cleaning compositions having the effect of reducing the side effects such as tooth wear due to toothpaste use, and at the same time increasing the washing power and effectively removing the plaque.

Accordingly, an object of the present invention is to provide an oral cleaning composition capable of effectively removing plaque and reducing side effects of tooth wear.

More specifically, the present invention seeks to provide an oral cleaning composition having a comparative tooth wear value of 4 or less, which is evaluated by using a surface profile method according to British Standard BS 5136, while effectively eliminating prags .

In order to solve the above problems, the present invention provides an oral cleaning composition comprising cellulose.

According to one embodiment of the present invention, the content of the cellulose may be 0.5 to 30% by weight of the total weight of the oral cleaning composition.

According to an embodiment of the present invention, the oral cleaning composition does not substantially contain an abrasive, and the cellulose may be used for removing purges.

Preferably, the comparative tooth wear value of the oral cleaning composition evaluated using the Surface profile method according to British Standard BS 5136 may be 4 or less.

Preferably, the present invention may further comprise a sequestering agent.

According to one embodiment of the present invention, the sequestering agent is selected from the group consisting of sodium phosphate, monosodium phosphate, disodium phosphate, trisodium phosphate, sodium tripolyphosphate, sodium hexametaphosphate, tetrasodium pyrophosphate, Phosphates, and combinations thereof.

According to an embodiment of the present invention, the content of the sequestering agent may be 0.1 to 5% by weight based on the total weight of the oral cleaning composition.

Hereinafter, the present invention will be described in detail. The terms and words used in the present specification and claims should not be construed as limited to ordinary or dictionary terms and the inventor may appropriately define the concept of the term in order to best describe its invention It should be construed as meaning and concept consistent with the technical idea of the present invention. Therefore, the constitution described in the embodiments described herein is merely the most preferred embodiment, and does not represent all of the technical ideas of the present invention, so that various equivalents and variations And the like.

The present invention is an oral cleaning composition comprising cellulose.

Disclosure of the Invention The present invention has been accomplished based on the discovery that the oral cleaning composition containing the cellulose effectively retains the detergency without the wear of the teeth and has a superior plaque removal effect.

At least one or more of the mesh-type celluloses are connected to each other by a hydrogen bond to form a network, and water molecules are contained in at least one of the mesh networks, and the cellulose chains and water are connected by hydrogen bonding to partially absorb water . Through the mesh-type cellulose, the oral cleaning composition containing the mesh-type cellulose exhibits a high washing power without polishing the tooth during toothbrushing, and exhibits excellent effect of removing plaque.

That is, the cellulose according to the present invention excludes cellulose derivatives such as carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose and hydroxypropylmethyl cellulose modified with cellulose, and the cellulose according to the present invention is a cellulose modified with? -Glucose Quot; refers to a straight-chain polymer that is repeatedly linked by 1 to 4 glucosidic bonds. The cellulose is also called a fibrin, which is the main component of the cell wall of the higher plants, is a white, odorless solid and insoluble in water. The cellulose according to the present invention can be obtained by hydrolyzing pulp fibers or decomposing short fibers.

The mesh-type cellulose according to the present invention can exhibit the effect of removing the plaque without polishing the teeth. Or an abrasive agent may be contained to the extent that damage may occur to dentine-exposed teeth due to weak teeth or retraction of the gingiva, or may not contain or affect the polishing. That is, the oral cleaning composition according to the present invention may not substantially contain an abrasive. The above-mentioned abrasive, in particular a silica-based abrasive such as precipitated silica, silica gel, aluminum silicate and zirconium silicate, a second calcium phosphate dihydrate and calcium phosphate, calcium carbonate, aluminum hydroxide, alumina, calcium carbonate, tribasic magnesium, Means not to include sodium metaphosphate, insoluble potassium metaphosphate, titanium oxide, zeolite, aluminum silicate, zirconium silicate, and synthetic resin abrasive means that the weight of the total oral cleaning composition is not more than 1% by weight, preferably not more than 0.5% By weight, preferably not more than 0.1% by weight, more preferably not more than 0.05% by weight, and even more preferably does not contain an abrasive.

In the present invention, the content of the cellulose may be 0.5 to 30% by weight, preferably 2 to 20% by weight, more preferably 3 to 15% by weight, based on the total weight of the oral cleaning composition. If the content of the net-like cellulose is less than 0.5% by weight, the beating and cleaning ability of the oral cleaning composition is not good, and if it exceeds 30% by weight, the releasing property and the stability of the toothpaste are poor.

The oral cleaning composition according to the present invention has a comparative tooth wear value of 4 or less, preferably 0.1 to 4, preferably 0.01 to 4, more preferably 4 or less, of the oral cleaning composition evaluated using the surface profile method according to British Standard BS 5136 3.5, and more preferably 0 to 3.5 or less. The teeth are sufficiently lower in tooth wear than the toothpaste including the conventional abrasive, and it is possible to prevent cirrhosis caused by the abrasion of the teeth and also to prevent cervical erosion.

Surface profile measurement according to the British Standard BS 5136 is as follows.

After the dentin specimens were covered with PVC tape except for the 2 mm area, the experimental area and the artificial saliva were diluted at a ratio of 2: 1. Brushing machine with a force of 250g of brushing at a rate of 90 round trips per minute for a total of 1,000 times. 20 ml of artificial saliva was added to each brush for 200 strokes in consideration of the dilution of the agent due to the incorporation of saliva during brushing. After brushing, the specimens were dried at room temperature and surface cross-sections were measured with a surface profile meter (Mitutoyo SV-3000, Japan) to calculate the cross-sectional area of the dentin specimens worn by brushing. The same experimental procedure was performed using a standard toothpaste (toothbrush according to British standard BS 5136) to obtain the wear area value, and then the comparative tooth wear value of the test toothpaste against standard toothpaste was calculated.

Comparative tooth wear = Wear area of experimental toothpaste / Wear area of standard toothpaste × 100

The oral cleaning composition according to the present invention further comprises a sequestering agent. If the oral cleaning composition further contains a sequestering agent, it can work together with the mesh cellulosic so that the washing power and the purging effect can be further enhanced.

The sequestering agent is a substance that inhibits tartar formation by chelating components such as calcium ions, magnesium ions, and phosphorus ions that have an important influence on dental calculus formation. The metal ion blocking agent may be at least one selected from the group consisting of sodium phosphate, monosodium phosphate, disodium phosphate, trisodium phosphate, sodium tripolyphosphate, sodium hexametaphosphate, tetrasodium pyrophosphate, sodium oxide pyrophosphate and polyphosphate It is preferable to use a phosphate compound.

The content of the sequestering agent is 0.1 to 5% by weight, preferably 0.5 to 3.5% by weight, based on the total weight of the oral cleaning composition. In the case of the content of the metal ion sequestrant, the chelating action may further improve the detergency and the effect of removing the plaque. However, if the content of the sequestering agent exceeds 5 wt%, the feeling of use such as taste of the oral cleaning composition is poor, Which is undesirable.

The composition for oral cavity according to the present invention is not particularly limited and may be in the form of a paste, spray, liquid, or the like, and may be in the form of a toothpaste, a mouthwash, And the like.

The oral cleaning composition of the present invention may further contain, as components, a wetting agent, a pharmaceutical agent, a sweetener, a pH adjuster, an antiseptic, a binder, a fragrance foaming agent and the like, depending on the formulation and purpose of use.

The wetting agent may be used alone or in combination with one or more selected from the group consisting of concentrated glycerin, glycerin, sorbitol aqueous solution, amorphous sorbitol aqueous solution, polyethylene glycols and propylene glycol. The amount of the wetting agent used is 1 to 70% by weight based on the total weight of the oral cleaning composition do.

Also, minor amounts of additives may include sweeteners, pH adjusters, preservatives, colorants or binders, which are commonly used in toothpastes.

The active agent may be selected from the group consisting of sodium fluoride, sodium fluorophosphate, sodium fluoride, tin fluoride, chlorohexidine, allantoin chlorohydroxy aluminate, aminocaproic acid, zinc chloride, pyridoxine hydrochloride, tocopheryl acetate, Or more.

As the sweetening agent, sodium saccharin, xylitol, erythritol, aspartame and the like can be used. As the pH adjusting agent, sodium phosphate, disodium phosphate, citric acid, triethanolamine and the like can be used. Examples of preservative include benzoic acid, methylparaben, propylparaben, sodium benzoate Can be used.

Examples of the binding agent include sodium carboxymethyl cellulose, carbohydrates, carrageenan, xanthan gum and alginates. Anionic and nonionic surfactants such as sodium alkylsulfate, sodium laurylsulfate, sucrose fatty acid esters and sorbitan fatty acid esters These may be used singly or in combination of two or more.

As the flavor, peppermint oil, spearmint oil, menthol and the like may be mixed and used. As other additives, enzymes such as texutaranase may be used.

As foaming agent, a copolymer of sodium lauryl sulfate, an anionic surfactant, polyoxyethylene polyoxypropylene (non-ionic surfactant), polyoxyethylene hydrogenated castor oil, polyoxyethylene sorbitan fatty acid ester and the like can be used .

In addition, the dentifrice and the composition include, in addition to the above components, a remaining amount of water, preferably purified water.

The oral cleaning composition according to the present invention maintains the cleansing power without polishing and has an excellent plaque removing effect, thereby effectively maintaining and improving oral health. In addition, it is constituted as a natural component and is safe for human body, so it can be universally used for maintenance and improvement of oral health regardless of age.

Hereinafter, embodiments of the present invention will be described in detail to facilitate understanding of the present invention. However, the embodiments according to the present invention can be modified into various other forms, and the scope of the present invention should not be construed as being limited to the following embodiments. Embodiments of the invention are provided to more fully describe the present invention to those skilled in the art.

Example

Dentifrice compositions (Examples 1 to 8) according to the present invention and comparative dentifrice compositions (Comparative Examples 1 to 4) for comparison with each other were prepared with the ratios shown in Table 1 below.

These dentifrice compositions are prepared by dispersing a small amount of powdery components such as sodium carboxymethyl cellulose, saccharin, preservatives and the like in an amorphous sorbitol solution which is a wetting component, diluting with purified water, and then primary mixing in a mixer, then adding cellulose, did. Finally, a dentifrice composition was prepared by adding a foam stabilizer, a stabilizer, a perfume, and the like, followed by tertiary mixing.

Examples 1 to 6 are dentifrice compositions containing cellulose and a sequestering agent, and Examples 7 and 8 are dentifrice compositions containing cellulose without a sequestering agent. Further, Comparative Examples 1 and 2 are dentifrice compositions containing a metal ion sequestering agent without cellulose, and Comparative Examples 3 and 4 are dentifrice compositions containing precipitated silica as an abrasive agent without a cellulose and a metal ion sequestrant.

Name
(unit %) Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Example 7 Example 8 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Precipitated silica 10 20 Concentrated glycerin (98%) 30.0 30.0 30.0 30.0 30.0 30.0 30.0 30.0 30.0 30.0 30.0 30.0 Sorbitol aqueous solution (70%) 30.0 30.0 30.0 30.0 30.0 30.0 30.0 30.0 30.0 30.0 30.0 30.0 Sodium lauryl sulfate 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Carboxymethylcellulose sodium 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 Xanthan gum 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 Sodium fluoride 0.22 0.22 0.22 0.22 0.22 0.22 0.22 0.22 0.22 0.22 0.22 0.22 Spices 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Sodium saccharin 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Citric acid, TEA Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Tetrasodium pyrophosphate 0.5 3.5 0.5 3.5 0.5 3.5 Sodium-thiocyanate pyrophosphate 0.5 3.5 Cellulose 5 5 10 10 5 5 10 10 Purified water To 100 To 100 To 100 To 100 To 100 To 100 To 100 To 100 To 100 To 100 To 100 To 100

Tooth compositions were prepared to perform the experimental examples according to the present invention using the ingredients according to Table 1 below.

Experimental Example 1 - Evaluation of detergency

The dentifrice compositions of Examples 1 to 8 and Comparative Examples 1 to 4 were used to evaluate the detergency against teeth. The measurement of detergency was carried out by using a colorimeter (Minolta CR-321 Japan) after preparing an artificially colored hydroxyapatite specimen (HAP specimen) by applying cleaning power (PCR: Pellicle cleaning ratio) The initial brightness values were measured and the specimens were distributed to all experimental groups so that there was no statistically significant difference among the experimental groups. After brushing the specimen slurry with 25g of the experimental cutter and 40ml of the artificial saliva for 1 hour (about 5,400 times) at a speed of 90g / min at a rate of 250g per minute, the specimen was dried, Were compared and analyzed.

Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Example 7 Example 8 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Cleaning power
Change value
(? L value) 7.2 8.9 8.5 10.2 6.8 7.5 4.8 5.9 2.2 3.1 8.2 9.8

From the results of Table 2, it was confirmed that the cleaning power evaluation results of Examples 1 to 8 are superior to the cleaning power evaluation results of Comparative Examples 1 and 2. The cleaning effect of Comparative Examples 3 and 4 is considered to be a cleaning effect by an abrasive.

Experimental Example 2 - Effect of removing plaque

Clinical trials on the effect of removing the plaque using the dentifrice compositions of Examples 1 to 8 and Comparative Examples 1 to 4 in Table 1 were conducted.

1) Subjects to be tested

Subjects were divided into 10 groups according to their gender, 30 to 50 years of age. The subjects were divided into groups of 120 subjects. The subjects were divided into 60 groups. Clinical experiments on the dental plaque effect of toothpastes (Examples 1 to 8) and comparative toothpastes (Comparative Examples 1 to 4) according to the present invention were carried out as follows.

2) Experimental method

After examining the subjects, the oral examination was explained. The subjects were randomly divided into 60 subjects in each of the examples and the comparative examples. The correct toothbrushing method was trained, and oral examination was performed to measure the Quigley-Hein Index modified by Turesky do. Scaling was performed on all teeth in the experimental group, and oral examination was performed after using the control toothpaste for 14 days. At this time, the plaque index was set as an initial value. The dentifrice and the comparative toothpaste were divided into the subjects and the toothbrushing was performed in the same manner as usual 3 times a day for 3 months, and oral examination was performed for 1 month and 3 months to score the plaque index. The test results were compared with the initial values of the experimental group and the scores after 1 month and 3 months of use, and the statistical significance was tested by t-test.

Experimental toothpaste group Early 1 month 3 months Example 1 3.34 0.34 3.23 ± 0.19 2.88 ± 0.22 Example 2 3.42 0.45 3.21 ± 0.37 2.55 + 0.11 Example 3 3.25 + 0.13 3.28 ± 0.29 2.35 0.35 Example 4 3.25 + 0.49 3.02 ± 0.15 2.17 ± 0.29 Example 5 3.67 ± 0.31 3.34 0.41 3.01 ± 0.24 Example 6 3.44 ± 0.54 3.15 + 0.22 2.89 ± 0.17 Example 7 3.47 ± 0.23 3.41 ± 0.32 3.05 + 0.25 Example 8 3.28 ± 0.10 3.22 ± 0.34 2.82 ± 0.19 Comparative Example 1 3.45 ± 0.32 3.42 ± 0.19 3.38 0.32 Comparative Example 2 3.23 + - 0.38 3.20 ± 0.14 3.11 ± 0.24 Comparative Example 3 3.33 + - 0.41 3.24 ± 0.25 3.05 ± 0.28 Comparative Example 4 3.31 + - 0.34 3.12 ± 0.31 2.91 ± 0.21

From the results of Table 3, it can be seen that the cleaning power of Examples 1 to 8 showed a high plaque removal effect, that Comparative Examples 1 and 2 had a low plaque removal effect, and Comparative Examples 3 and 4 had an effect of polishing with an abrasive Respectively.

Experimental Example 3 - Comparative tooth wear evaluation

The comparative tooth wear was measured using the surface profile method (British standard BS 5136). This method of evaluating tooth wear is a method recognized worldwide, and an experimental method is as follows. After the dentin specimens were covered with PVC tape except for the 2 mm area, the experimental area and the artificial saliva were diluted at a ratio of 2: 1. And a total of 1,000 brushing operations at a rate of 90 reciprocations per minute using a brushing machine with a force of 250 g per minute. 20 ml of artificial saliva was added to each brush for 200 strokes in consideration of the dilution of the agent due to the incorporation of saliva during brushing. After brushing, the specimens were dried at room temperature and surface cross-sections were measured with a surface profile meter (Mitutoyo SV-3000, Japan) to calculate the cross-sectional area of the dentin specimens worn by brushing. The same experimental procedure was performed using a standard toothpaste (toothbrush according to British standard BS 5136) to obtain the wear area value, and then the comparative tooth wear value of the test toothpaste against standard toothpaste was calculated.

Comparative tooth wear = Wear area of experimental toothpaste / Wear area of standard toothpaste × 100

Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Example 7 Example 8 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative tooth wear 0.3 1.5 2.1 2.9 2.1 3.3 0.4 0.8 0.2 1.1 57.2 78.7

From the results of Table 4, the comparative tooth wear values of Examples 1 to 8 and Comparative Examples 1 and 2 were 4 or less, and Comparative Examples 3 and 4 showed values of 57.2 and 78.7, respectively.

According to the above three experiments, the dentifrice composition containing a metal ion sequestering agent together with cellulose or cellulose according to the present invention maintains the cleaning power even with a small amount of polishing (little tooth wear) It is believed that it is effective to maintain and improve oral health effectively.

Claims (7)

[0030]
A mouthwash composition comprising cellulose for removing plaque,
Wherein the content of the cellulose is 0.5 to 30% by weight based on the total weight of the oral cleaning composition,
Wherein the value of the comparative tooth wear of the oral cleaning composition evaluated using the surface profile method according to the British Standard BS 5136 is 4 or less. delete delete delete The method according to claim 1,
Wherein the oral cleaning composition further comprises a sequestering agent. 6. The method of claim 5,
Wherein the metal ion sequestering agent is at least one selected from the group consisting of sodium phosphate, monosodium phosphate, disodium phosphate, trisodium phosphate, sodium tripolyphosphate, sodium hexametaphosphate, tetrasodium pyrophosphate, sodium acid pyrophosphate and polyphosphate Cleaning composition. 6. The method of claim 5,
Wherein the amount of the sequestering agent is 0.1 to 5% by weight of the total weight of the oral cleaning composition.