KR20040059030A - Whitening toothpaste composition - Google Patents

Abstract

PURPOSE: Provided is a dentifrice composition for tooth whitening which is safe to the human body, has stability against secular aging and blockades iron and potassium which are causes of tooth discoloration. CONSTITUTION: A dentifrice composition is characterized by containing 0.1-4.0 wt.% of water soluble pyrophosphate, and 0.1-5.0 wt.% of ultra metaphosphate as a tooth whitening agent. It further contains one of polishing agent, humectant, agonist, binding agent, foaming agent, perfumery, colorings, preservative, acidity controller and the like.

Description

Whitening Toothpaste Composition {WHITENING TOOTHPASTE COMPOSITION}

The present invention relates to a whitening toothpaste composition, and more particularly, safe to the human body, excellent in time stability, and at the same time iron, calcium, etc., which cause tooth discoloration by chelating action of the cationic metal cation. It relates to a whitening toothpaste composition excellent by blocking the tooth whitening effect.

In general, tooth discoloration may be classified into exogenous discoloration and endogenous discoloration. Exogenous tooth discoloration is caused by food deposits, nicotine and tar components of tobacco, coffee, tea, etc. deposited on the tooth surface, or soft deposits on the tooth surface by dye components. Endogenous tooth discoloration is caused by tooth nerve damage, tetracycline It is caused by the overdose of antibiotics or aging phenomenon.

Whitening toothpaste has been commercialized and used for a long time in order to prevent whitening and discoloration of teeth discolored by various causes. Tooth whitening techniques that have been commercialized to date include the most conventional method by a strong grinding degree and a method of corroding the tooth surface by adjusting the pH of the product to a strong acidity.

The method by the strong grinding degree is to expect the whitening effect by simply polishing the surface of the tooth physically to smooth the surface, but in the area where the tooth and the gum are connected with the thinnest enamel area due to excessive wear of the tooth for a long time use First, there is a problem that wear may occur and cause cervical wear. In addition, the method of corroding the tooth surface by adjusting the pH of the product to strong acidity is that the tooth damage caused by the corrosion of the tooth surface not only increases the rate of tooth decay by decreasing the hardness of the tooth, but also causes irritable teeth. There is this.

Therefore, it is thought that it is difficult to expect the actual whitening effect by the technology that only smoothes the tooth surface. Such action is expected to be effective for the coloring material due to the exogenous mentioned above, but for the coloring by the endogenous pigmentation in the tooth surface. The effect is considered to be very weak. Therefore, the use of peroxide is essential to have a whitening effect on the coloration due to endogenous, but it is difficult to stabilize the peroxide in toothpaste for a long time, and the safety issue for the human body when excessive use is controversial.

In addition, when the peroxide is used in the toothpaste composition, not only the compatibility with the general components used in the toothpaste is not good, the peroxide itself is very unstable, there is a problem that the concentration of active oxygen rapidly decreases over time.

Accordingly, Korean Patent Publication No. 103,344, US Pat. No. 4,687,663, and US Pat. No. 5,020,694 disclose methods for improving the time stability of peroxide by separating and packaging the peroxide using a double container system. In addition, US Pat. No. 5,122,365 uses three separate packaging to corrode the tooth surface by acid in the first step, bleaching by peroxide in the second step, and teeth with abrasive and titanium oxide in the third step. A method of smoothing the surface is disclosed. However, this method has a problem on the human safety in the first and second stages, there is a problem that the cumbersome use and the packaging cost of the manufacturer increases.

On the other hand, as another method for enhancing the tooth whitening effect US Patent No. 4,986,981 discloses a method for promoting tooth whitening by using a papain (vegetable proteolytic enzyme) without the use of peroxide, which is the enzyme itself Toothpaste is not good time stability of the toothpaste, the effect is also very weak.

Another technique applied to the whitening toothpaste is a method of inhibiting the generation of the causative agent by blocking the polyvalent metal cations (cations such as Ca and Fe), which are the causes of tooth discoloration, using phosphates including sodium pyrophosphate. . However, the whitening toothpaste using conventional phosphates has a problem that it is difficult to expect the actual whitening effect.

Therefore, there is a need for a study on a whitening toothpaste composition which is safe for the human body and is excellent in light-temporal stability, and at the same time, can significantly improve the tooth whitening effect.

In order to solve the problems of the prior art as described above, the present invention is safe for the human body, excellent in aging stability, and at the same time iron, calcium, etc., which cause tooth discoloration by chelating action of the cation metal cation. The object of the present invention is to provide a whitening toothpaste composition having excellent tooth whitening effect.

In order to achieve the above object, the present invention provides a whitening toothpaste composition comprising 0.1 to 4.0% by weight of water-soluble pyrophosphate, and 0.1 to 5.0% by weight of ultra metaphosphate as a whitening agent.

Hereinafter, the present invention will be described in detail.

The inventors of the present invention have been researching a new whitening system that is safe for human body, has excellent seizure stability, and can significantly improve the tooth whitening effect, and has produced a whitening toothpaste using water-soluble pyrophosphate and ultra metaphosphate as the whitening agent. As a result, the chelating action of the cation metal cation blocks the iron and calcium, which cause tooth discoloration, thereby significantly improving the tooth whitening effect, and is safe for the human body and excellent in aging stability. Based on this, the present invention has been completed.

The whitening toothpaste composition of the present invention is characterized in that it comprises 0.1 to 4.0% by weight of water-soluble pyrophosphate, and 0.1 to 5.0% by weight of ultra metaphosphate as a whitening agent.

The water-soluble pyrophosphate used in the present invention acts to block the iron, calcium, and the like, which cause tooth discoloration by chelating action of the metal cation, thereby increasing the tooth whitening effect.

The water-soluble pyrophosphate is sodium pyrophosphate (Na ₄ P ₂ O ₇ , tetrasodium pyrophosphate), potassium pyrophosphate (K ₄ P ₂ O ₇ , tetrapotasium pyrophosphate), or acidic sodium pyrophosphate (Na ₂ H ₂ P ₂ O ₇ , acidic sodium pyrophosphate).

The water-soluble pyrophosphate is preferably contained in 0.1 to 4.0% by weight in the whitening toothpaste composition. When the content is less than 0.1% by weight, the tooth whitening synergistic effect is insignificant, and when the content exceeds 4.0% by weight, there is a problem in that the tooth whitening effect is insignificant.

In addition, the ultra metaphosphate used in the present invention is preferably a water-soluble alkali metal metaphosphate (sodium ultra metaphosphate) having a mesh-like molecular structure with a strong blocking power of the metal cation. In particular, the ultra metaphosphate is preferably an ultra metaphosphate sodium salt.

Condensation phosphates are generally distinguished by the ratio of P ₂ O ₅ : M ₂ O, where M is an alkali metal. When the ratio of P ₂ O ₅ : M ₂ O is less than 1, it is classified into ultraphosphate, polyphosphate when greater than 1, and metaphosphate which is neutral when near. That is, the ultra meta phosphate of the present invention is a water-soluble alkali metal condensate phosphate having an ultra-thin mesh-like molecular structure of P ₂ O ₅ : M ₂ O ratio of less than 1, and conventional meta-phosphate, pyrophosphate, It has a stronger metal cation containment effect than water-soluble condensed phosphates such as polyphosphate.

The ultra metaphosphate is preferably contained in 0.1 to 5.0% by weight in the whitening toothpaste composition. If the content is less than 0.1% by weight, the tooth whitening synergistic effect is insignificant, if it exceeds 5.0% by weight there is a problem that the tooth whitening effect according to the amount used is insignificant.

The whitening toothpaste composition according to the present invention comprising the above components is generally very compatible with the components used in the toothpaste, so that the final product formulation is prepared in a conventional ointment (paste form) in one package ( Tube, etc.) and can be usefully used.

The whitening toothpaste composition of the present invention may be used in combination with an appropriate amount of abrasives, wetting agents, medicinal agents (fluorides, enzymes, etc.), binders, foaming agents, sweeteners, flavorings, pigments, preservatives, acidity regulators, brighteners and the like commonly used in toothpaste compositions. Can be.

The abrasive used in the present invention may be precipitated silica, silica gel, zirconium silicate, calcium monohydrogen phosphate, calcium dihydrogen phosphate, hydrous alumina, hard calcium carbonate, heavy calcium carbonate, calcium pyrophosphate, insoluble methacrylate, aluminum silicate, or the like. Can be used.

The abrasive is preferably included in 5 to 50% by weight in the whitening toothpaste composition. In addition, in order to avoid tooth abrasion due to excessive polishing, the final product was shown to have a value of 30 to 100. The particle size also varies depending on the type of abrasive, but an average particle diameter of 20 μm or less was used. In general, the polishing value starts at 0 and represents a relative polishing degree with a standard toothpaste of 100. In general, most products have a value of 200 or less.

The humectant used in the present invention is a base ingredient essential for making an ointment formulation, which prevents the toothpaste from drying and solidifying when exposed to the air and provides shine to the surface of the toothpaste. Serves to give.

The wetting agent may be concentrated glycerin (98%), glycerin (85%), sorbitol aqueous solution (70%), amorphous sorbitol aqueous solution (70%), xylitol, polyethylene glycol, or propylene glycol. The humectant is preferably included in 20 to 70% by weight in the whitening toothpaste composition.

The drug used in the present invention may be a fluoride or an enzyme.

The fluoride acts to prevent tooth decay, and examples thereof include sodium phosphate fluoride, sodium fluoride, amine fluoride, and tin fluoride. The fluoride is preferably included up to 1,500 ppm in the whitening toothpaste composition.

The enzyme is used for bactericidal oral inhibition and removal of cationic surfactants and plaques. In order to prevent periodontal disease, the enzyme may be a water-soluble salt such as sodium chloride and sodium hydrogen carbonate having high osmotic pressure, aminocaproic acid, allantoin, and derivatives of allantoin, or vitamins having a hemostatic action.

The binder used in the present invention serves to prevent the powder component and the solid component from being separated from each other. Any binder may be used as long as it is a water-soluble polymer, preferably, carboxymethylcellulose sodium synthesized from cellulose of wood, carrageenan extracted from seaweed, or xanthan gum obtained from metabolism of microorganisms.

The foaming agent used in the present invention enhances the feeling of use of the product and helps the cleaning action, and quickly disperses and penetrates the other active ingredients, and reduces the interfacial tension to act to easily remove foreign substances in the oral cavity.

The foaming agent is preferably an anionic surfactant, sodium lauryl sulfate, and co-polymer of polyoxyethylene polyoxypropylene (poloxamer), polyoxyethylene hardened castor oil, or polyoxyethylene depending on the characteristics of the formulation Nonionic surfactants, such as a sorbitan fatty acid ester, can be used.

The fragrances, sweeteners, pigments and the like serves to improve the feel of the toothpaste composition.

The fragrance is preferably used edible, for example, peppermint oil, spearmint oil, sage, eucalyptol, methyl salicylate, or fruit extract. In addition, it is preferable to use sodium saccharin as the sweetener, and food coloring is preferably used as the dye.

The whitening toothpaste composition of the present invention comprising the above components is safe for the human body and is excellent in aging stability, and at the same time, iron, calcium, etc., which cause tooth discoloration by chelating action of metal cations. Blocking has the advantage of excellent tooth whitening effect.

Hereinafter, preferred examples are provided to help understanding of the present invention, but the following examples are merely to illustrate the present invention, and the scope of the present invention is not limited to the following examples.

EXAMPLE

Example 1

55% by weight of an aqueous solution of sorbitol (70%) as a wetting agent, 0.6% by weight of sodium carboxymethylcellulose, 0.5% by weight of carrageenan as a binder, and 1.0% by weight of fragrance as an additive and 0.1% by weight of saccharin were dispersed and mixed. 18% by weight of precipitated silica as abrasive, 2.0% by weight of silica gel, and 0.1% by weight of pyrophosphate (P ₂ O ₇ ) as a whitening agent, 0.1% by weight of ultra sodium phosphate, 0.76% by weight of sodium fluoride as fluoride, 0.11% of sodium fluoride After the weight% was added, the mixture was stirred for about 30 minutes. 2.2 wt% of sodium lauryl sulfate as a foaming agent was added thereto, and stirred for 20 minutes in a vacuum state to prepare a whitening toothpaste composition.

Examples 2-5, and Comparative Examples 1-3

A whitening toothpaste composition was prepared in the same manner as in Example 1, except that Example 1 was used as a component and a composition ratio as shown in Table 1 below. The unit in Table 1 below is weight percent.

division Example Comparative example One 2 3 4 5 One 2 3 abrasive Precipitated silica 18 15.0 - - 5.0 20.0 5.0 20.0 Potassium Dihydrogen Phosphate - - 38.0 - - - - - Hydrous alumina - - 8.0 - - - - - Hard calcium carbonate - - - - 25.0 - 25.0 - Calcium Pyrophosphate - - - 30.0 - - - - Silica gel 2.0 3.0 - 5.0 - - - - Humectant Concentrated glycerin (98%) - 45.0 20.0 - - 20.0 45.0 - Sorbitol aqueous solution (70%) 55.0 - 10.0 38.0 20.0 20.0 - 30.0 Xylitol - 1.0 - - 3.0 - - 3.0 Foam Sodium Lauryl Sulfate 2.2 2.2 2.2 2.2 2.2 2.2 2.2 2.2 Poloxamer - - - 1.0 2.0 - - 2.0 Binder Carboxymethylcellulose Sodium 0.6 1.0 0.9 0.5 - 0.9 1.0 - Carrageenan 0.5 - - 0.5 0.8 - - 0.8 Whitening agent Pyrophosphate 0.1 1.0 2.0 4.0 6.0 - 4.0 3.0 Ultra Sodium Metaphosphate 0.1 1.0 3.0 5.0 7.0 4.0 - - Hydrogen peroxide (30%) - - - - - 1.0 - 2.5 Fluoride Sodium Fluoride 0.76 0.38 0.76 - 0.76 0.76 0.76 0.76 Sodium fluoride 0.11 0.11 - 0.22 - - - - additive Spices 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Saccharin 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 Purified water Up to 100% by weight

Experimental Example 1. Whitening effect test using shading teeth

Tobacco, coffee, tea, sugar, and calcium are mixed into a gel, which is then transferred to the bottom container of a motorized device for rotation, and epoxy samples from 20 to 30 healthy people After the specimen was prepared by fixing with resin to have an exposed area of 2 mm (width) x 2 mm (length), it was attached to a rotating plate and operated for 3 days to force attachment.

At this time, an incandescent lamp was installed at the center of the rotating plate to dry the stain attached to the specimen to promote the adhesion of the stain. Remove the stained specimen on the last day and measure the whiteness (a) using a color difference meter (SZ, Nippon Denshoku), fix the specimen on a specially designed abrasive force meter to allow reciprocating motion, It was fixed so that it could rub against the specimen. At this time, put the whitening toothpaste composition prepared in Examples 1 to 5, and Comparative Examples 1 to 3 to the end of the bristles, respectively, and operated for 30 minutes to allow 90 reciprocations per minute, and then take out the specimen. After measuring the whiteness (b) of the specimen again using a color difference meter, the degree of increase of whiteness (ΔL, ba) is shown in Table 2 below.

division Example Comparative example One 2 3 4 5 One 2 3 Whiteness increase degree (△ L) 16.6 31.9 52.7 72.5 73.7 21.0 18.9 22.8

Through Table 2, it was confirmed that the toothpaste composition of Examples 1 to 5 simultaneously containing a water-soluble pyrophosphate and ultra metaphosphate according to the present invention is excellent in whiteness increase, that is, the whitening effect compared to Comparative Examples 1 to 3 Could.

Experimental Example 2. Measurement of whitening effect through clinical trial

Sixty people with relatively yellowish teeth were selected to measure the color tone of the incisor plane before the experiment using a Trubyte Bioform colorimeter in a room with a constant lighting device. Each group was divided into 6 groups of 10 persons to be almost identical, and the whitening toothpaste compositions prepared in Examples 1 to 5 and Comparative Examples 1 to 3 were used to brush their teeth for 3 months as usual.

In order to confirm the increase of the brightness of teeth, 10 kinds of sensory identifications were selected from 24 kinds of standard standards of TrueBit Bioform Colorimeter, and each was evaluated from 1 to 10 points in order of increasing brightness. The score was added. Before using the experimental toothpaste, the tooth brightness value of each group was evaluated to the first digit after the decimal point based on the above criteria, and after evaluating the brightness value after brushing for 3 months, the increase rate of the average brightness value compared to the brightness value before the experiment was calculated. It is shown in Table 3 below.

division Example Comparative example One 2 3 4 5 One 2 3 Average brightness before experiment 4.3 4.3 4.4 4.4 4.3 4.4 4.3 4.4 Average brightness after 3 months of use 5.1 6.7 7.9 8.6 8.6 5.3 5.2 5.9 Brightness growth rate (%) 18.6 55.8 79.5 95.5 100 20.5 20.9 34.1

Through the Table 3, according to the present invention, the toothpaste composition of Examples 1 to 5 simultaneously containing the water-soluble pyrophosphate and ultra metaphosphate was significantly improved compared to the general whitening toothpaste composition of Comparative Examples 1 to 3, This shows that the whitening effect is excellent.

The whitening toothpaste composition according to the present invention is safe for the human body and has excellent seizure stability, and also has excellent tooth whitening effect by blocking iron and calcium, which cause tooth discoloration, by chelating action of metal cations. It works.

Claims (6)

A whitening toothpaste composition comprising: 0.1 to 4.0% by weight of water-soluble pyrophosphate, and 0.1 to 5.0% by weight of ultra metaphosphate as a whitening agent. The method of claim 1, The water-soluble pyrophosphate is sodium pyrophosphate (Na ₄ P ₂ O ₇ , tetrasodium pyrophosphate), potassium pyrophosphate (K ₄ P ₂ O ₇ , tetrapotasium pyrophosphate), and acidic sodium pyrophosphate (Na ₂ H ₂ P ₂ O ₇ , acidic sodium pyrophosphate) at least one selected from the group consisting of whitening toothpaste composition. The method of claim 1, Whitening toothpaste composition wherein the ultra metaphosphate is ultra metaphosphate sodium salt having a network molecular structure. The method of claim 1, The whitening toothpaste composition comprising at least one component selected from the group consisting of an abrasive, a humectant, a medicament, a binder, a foaming agent, a sweetener, a flavoring agent, a pigment, a preservative, an acidity regulator, and a brightener. The method of claim 4, wherein The abrasive is one kind from the group consisting of precipitated silica, silica gel, zirconium silicate, calcium monohydrogen phosphate, calcium monohydrogen phosphate, hydrous alumina, hard calcium carbonate, heavy calcium carbonate, calcium pyrophosphate, insoluble methacrylate, and aluminum silicate. Whitening toothpaste composition selected above. The method of claim 4, wherein A whitening toothpaste composition wherein the fluoride is selected from the group consisting of sodium fluoride phosphate, sodium fluoride, amine fluoride, and tin fluoride.