KR900005069B1 - Tooth paste compositions - Google Patents

Abstract

A tooth paste compsn. comprises, 0.1-2 wt.% of fluoride cpd.; 0.01- 2.0 wt.% of trinexamic acid; 0.05-5.0 wt.% of alantoin chloro hydroxy aluminum; 0.05-5.0 wt.% of tochopherol acetate; and other conventional ingradients. The compsn. may be used to prevent gingival diseases.

Description

Toothpaste composition for promoting oral hygiene

The present invention relates to a toothpaste composition for promoting oral hygiene. More specifically, fluorine compounds, antiplasmin agents, allantoin derivatives and vitamin esters are used to prevent tooth decay and periodontal disease, and to relieve symptoms of periodontal disease. Oral hygiene improves tooth cleaning power and stability of the drug by using hydrous alumina. It relates to a toothpaste composition for promotion.

Tooth decay is caused by the three elements of tooth, weak tooth, food containing sugar, oral bacteria, and oral hygiene can be obtained by reinforcing the three elements.

In other words, fluorine use, preventive filling, remineralization of the tooth to strengthen the hemorrhoids (resistance), non-fermented sugar use, artificial sweetener use, calcium and phosphorus fortified foods to suppress sugar intake, immune antibodies, Examples of such methods include disinfecting or suppressing oral bacteria or plaque generated by bacteria using a fungicide or enzyme.

In addition, the cause of periodontal disease is usually the case of neglecting the maintenance of oral hygiene, such as brushing teeth, metal ions such as calcium, magnesium, etc. formed on the bacterial surface of the gingival bacterial membranes are adsorbed and gradually solidified to form a poorly soluble salt It forms a dental plaque almost like teeth, and the dental plaque continues to dig up the interface between the gums and teeth, causing bleeding easily when brushing teeth and inflammation caused by bacteria in the oral cavity, causing various periodontal diseases such as gingivitis, periodontitis, and alveolar. Causes untreated.

Conventional toothpaste used a fluorine compound for the prevention of tooth decay, and in the specification of British Patent No. 2,122,491A for the prevention of periodontal disease, the use of amino capronic acid, such as an anti-plasmin agent, disclosed in the specification of Japanese Patent No. 86-15531A An antiplasmin agent, a vitamin derivative, an allantoin derivative, and licorice acid were used alone or in combination. In the specification of US Patent No. 3,514,513, an allantoin derivative was used, and in Japanese Patent Nos. 71-10437 and 76-41445, the vitamin derivative was used. Although it was disclosed that all of them are difficult to expect the effect of preventing tooth decay and periodontal disease, and the stability of the pharmacological agents used by them is poor due to the severe decrease in the effect over time, has a disadvantage of poor tooth cleaning power.

The present inventors have extensively researched and examined in order to improve the above disadvantages, and as a result of adding an appropriate amount of fluorine compound, trinexamic acid, allantoinchlorohydroxyaluminum and tocopherol acetate to the existing toothpaste composition, caries, prevent periodontal disease and alleviate symptoms It was found that the effect is excellent, the tooth cleaning power and the stability over time of the medicinal agent is improved and completed the present invention.

That is, the present invention is 0.1-2% by weight of a fluorine compound alone or a mixture, 0.01-2% by weight of trinexamic acid [trans-4- (aminomethyl) -cyclohexanecarboxylic acid] having excellent geothermal effect, and a convergent and anti-inflammatory effect agent. 0.05-5% by weight of allantoinchlorohydroxyaluminum, 0.05-5% by weight of tocopherol acetate, a peripheral blood flow improving and tissue anti-aging agent, and 1-30 weight of precipitated silica known to those skilled in the art. It is a toothpaste composition for promoting oral hygiene, characterized in that it contains 10-0.5% by weight of hydrous alumina having a%, calcium monohydrogen phosphate 60-10% by weight, and an average particle diameter of 1.0-12 micrometers.

Generally, abrasives used in toothpaste compositions include calcium monohydrogen phosphate, precipitated silica, silica gel, calcium carbonate, hydrous alumina, insoluble sodium metaphosphate, calcium pyrophosphate, zirconium silicate, and the like. 20-70% by weight of the mixture is used, preferably 20-50% by weight of calcium monohydrogen phosphate, precipitated silica, hydrous alumina alone or a mixture of two or more thereof.

Conventional moisturizers are used to maintain the dentifrice composition and prevent drying.

As the moisturizer, glycerin, sorbitol solution (70% aqueous solution), amorphous sorbitol solution, propylene glycol, etc. may be used, but preferably 20-70% by weight of glycerin and amorphous sorbitol solution alone or by mixing two or more kinds thereof. use.

The binder serves to bind the solid component and the liquid component in the toothpaste composition without separation, and synthetic polymer materials such as carrageenan, xanthan gum, carboxy methyl cellulose sodium, and carboxy vinyl polymer are usually used. It is preferable to mix the composition to 0.5 to 2.0% by weight. Examples of sweeteners include saccharin sodium, aspartame, stevioside, and licorice. In view of sugar content, quality of sweetness, and economics, saccharin sodium, aspartame, and licorice acid are 0.05 or a mixture of two or more. -0.5% by weight of the composition. Preservatives may be used to prepare for the antimicrobial contamination expected in the manufacture and use of dentifrice compositions, and it is preferred to add 0.05-0.25% by weight of paraoxybenzoic acid esters, benzoic acid, sodium benzoate, etc., which are commonly accepted as additives in medicines and foods. . Foaming agent helps the cleaning action of the abrasive, accelerate the dispersion and penetration of the drug, and reduces the interfacial tension has the effect of easily falling foreign substances in the oral cavity.

Examples of the foaming agent include sodium alkyl sulfates such as sodium lauryl sulfate and sodium lauroyl salkosylate, which are anionic surfactants, and polyoxyethylene glycol sorbitan-fatty acid esters, sorbitan fatty acid esters, and secondary nonionic surfactants Polyoxyethylene hardened castor oil, polyoxyethylene polyoxy propylene copolymer, etc. are used.

The amount of foaming agent used is preferably made up of 0.5-5% by weight of anionic and nonionic surfactants alone or in combination of two or more thereof.

PH adjusters may be used for the purpose of matching the liquidity of the dentifrice composition to neutral or desired liquidity. As the pH adjuster, phosphoric acid, sodium phosphate, citric acid, sodium citrate, sodium succinate, sodium stannate, etc. are usually used, and suitable ones are 0.01-1.0 wt% of phosphoric acid, sodium phosphate, citric acid, sodium citrate alone or a mixture of two or more thereof. Use%.

The use of fragrance is essential to conceal the unpleasant taste caused by the abrasives and foaming agents in the toothpaste composition and to give a refreshing and refreshing feeling when brushing teeth. The main flavors are peppermint oil, spearmint oil, mantle and carbon (Carvone), and depending on the purpose of the toothpaste, you may use a mixture of gepyaldehyde, methyl salicylate, lemon oil, eugenol and eucalyptol. The amount used is 0.5-1.5 wt%.

Example 1-3

Toothpaste composition of the present invention was prepared using the ingredients shown in Table 1 as a main component.

Comparative Example 1-5

Next, the toothpaste composition was prepared using the ingredients shown in Table 1 as main components.

TABLE 1

Experimental Example 1

[Efficacy and Effect Clinical Trial of Toothpaste of the Invention (Examples 1-3)]

The results of clinical trials using the toothpaste of the present invention are as follows. (Korean Journal of Oral Health Vol 12, No.1.1988)

1) subjects; The subjects were 240 S professional college students aged 19-20 years.

2) Toothpaste to be tested: Toothpaste (traditional toothpaste) containing a combination of tranexamic acid, allantoinchlorohydroxyaluminum, tocopherol acetate and sodium monofluorophosphate (toothpaste of the present invention) and a toothpaste (control toothpaste) not containing these substances were compared.

3) Experimental Method: The test subjects were divided into 120 experimental groups (the present invention used toothpaste group) and 120 control groups. Recorded. In addition, all subjects were given a medium-strength bristle toothbrush and brushed with the toothpaste. After 20 and 40 days, the periodontal tissues were examined and compared with the results.

4) Experiment result

Treatment rate of gingivitis (%) is as follows.

5) Consideration

The gingivitis prevention and alleviating effect of the toothpaste of the present invention containing four medicinal agents was significantly better than the common toothpaste (control toothpaste) after 20 days and 40 days after the start of the experiment.

Experimental Example 2

[Comparison Experiment and Effect of Periodontal Disease Prevention of Toothpaste (Examples 1, 2) and Comparative Toothpaste (Comparative Example 5)]

The toothpaste and the control toothpaste of the present invention were brushed three times daily (for 3 minutes each) for 20 days and the color change of the gum was measured to compare and maintain the health condition and improvement effect of the gums. For color change, ∑-80 color difference meter was used.

Normally, healthy gums have a higher brightness index, higher redness, and lower yellowness.

That is, a bright red color will appear.

The results of this experiment were compared with each other.

As a result of the experiment, the brightness index was increased by 4.2, 4.7, 4.0 and 4.4 on average in toothpaste compared to the comparative example, the redness increased by 5.0, 6.0, 4.8 and 3.6 on average and the increase in yellowness was 0.3, 1.0, 0.4 As a result, the toothpaste was shown to have a bright red color, which is a healthy color, resulting in excellent periodontal disease prevention and treatment. That is, the composition of Example 1 is a fluorine compound and trinexamic acid when the main component of the mono-fluorine system, trinexamic acid, tocopherol acetate, allantoin chlorohydroxy aluminum, which is not a binary fluorine providing system, is blended with a known toothpaste composition. Toothpaste composition (Comparative Example 1), Toothpaste composition containing fluorine compound and allantoin chlorohydroxy aluminum (Comparative Example 2), Toothpaste composition containing allantoin chlorohydroxy aluminum (Comparative Example 4), Trinexamic acid, Allantoin And when comparing the toothpaste composition containing tocopherol (Comparative Example 5), as shown in the table shows that the toothpaste composition of the present invention is superior to the composition of the comparative example, excellent periodontal disease prevention and treatment effect.

[Experiment 3]

[Comparison Test of Cleaning Power of Invention Toothpaste (Examples 1-3) and Comparative Examples 1,2,3,5]

1) Preparation for experiment

Two packs of cigarettes (40 packs) were extracted using acetone as a solvent in a soxhlet apparatus, tar was extracted, distilled under reduced pressure, acetone was removed, and glaze was applied on one side of the thin tile (3 × 3cm) to make a thin layer. After drying, it is dried at 60 ℃, soaked in water for 2-3 days, taken out, dried at 140 ℃ for 24 hours, and used for testing.

2) operation

The tile is fixed to an abrasive tester equipped with a toothbrush, and a solution containing 20 g of toothpaste and 20 g of glycerin is mixed, and after reciprocating brushing with a load of 250 g 1500 times, it is taken out and carefully wiped with water and dried. The toothbrush used was a toothbrush of medium strength bristles.

3) Evaluation method

A transparent grid paper (2 × 2 mm scale) was placed on the finished tile, and the tar removed area was measured to compare the toothpaste cleaning example of the example and the toothpaste cleaning power of the comparative example.

4) Experiment result

5) Discussion: As a result of the comparative test of the cleaning power, the polishing power was similar except for Example 2, but the cleaning power of Example 1 was the best and there was almost no difference between the formulations of the comparative example. In view of the above results, it can be seen that the cleaning power increases when an appropriate amount of hydrous alumina is added to the example formulation.

Experimental Example 4

[Stability Comparison Test of Drug]

1. Comparative test of residual effective fluorine content over time of Example 1 and Comparative Examples 1 and 2

The toothpaste of Example 1 and Comparative Examples 1 and 2 were stored at room temperature and 50 ° C. in a thermostat, and the contents of effective fluorine over time were tested by potentiometric titration using Orion ion meta (Orion Ionmeter Model 701A). same.

[Test result]

Example 1 In the case of toothpaste, when a small amount of hydrous alumina and precipitated silica were added, the effective fluorine remaining amount over time was much better than that of Comparative Examples 1 and 2, which are the same abrasive formulations.

2. Stability comparison test of allantoinchlorohydroxyaluminum (allantoin in the comparative example) and tocopherol acetate (tocopherol in the comparative example) over time of Example 1 and Comparative Example 5.

The two toothpastes were stored at room temperature and 50 ° C., and the results of the analysis of the change in the residual amount over time by high performance liquid chromatography were as follows.

[Test result]

Example 1 contains allantoinchlorohydroxyaluminum and tocopherol acetate

The drug stability test of Example 1 and Comparative Example 5 showed that the composition of Example 1 in which allantoinchlorohydroxyaluminum and tocopherol acetate were combined was excellent.

In other words, the use of allantoin chlorohydroxy aluminum and tocopherol acetate was found to be more stable than the use of allantoin and tocopherol.

As described above, the composition of the present invention comprises a fluorine compound (regardless of the choice of mono- or binary fluorine systems), allantoin chlorohydroxy aluminum, tocopherol acetate, and trinexamic acid in combination with a known toothpaste composition. As a result, it exhibits not only the effect of preventing tooth decay, but also the effect of preventing and treating periodontal disease and gingivitis as well as the stability over time.

Claims (1)

Toothpaste composition containing a fluorine-containing compound, 0.01-2.0% by weight of trinexamic acid, 0.05-5.0% by weight of allantoinchlorohydroxy aluminum, 0.05-5.0% by weight of tocopherol acetate for improving oral hygiene Toothpaste Composition.