KR19990027730A - Stable Whitening Toothpaste Composition - Google Patents

Abstract

The present invention relates to a whitening toothpaste composition having a safe and aesthetic function to the human body. More specifically, the present invention relates to a stable and effective whitening toothpaste composition containing two or more water-soluble pyrophosphates, hydroxyapatite and fluorine in a toothpaste composition having a whitening effect.

Description

Stable Whitening Toothpaste Composition

The present invention relates to a whitening toothpaste composition having a safe and aesthetic function to the human body. More specifically, the present invention relates to a stable and effective whitening toothpaste composition containing two or more water-soluble pyrophosphates, hydroxyapatite and fluorine in a toothpaste composition having a whitening effect.

In general, tooth discoloration factors can be classified into exogenous discoloration and endogenous discoloration. Exogenous tooth discoloration may be caused by food deposits, nicotine and tar components of tobacco or coffee, tea, etc. deposited on the surface of the tooth, or soft deposits on the tooth surface by pigmentation. Endogenous tooth discoloration is caused by tooth loss. Or overdose of tetracycline antibiotics or aging.

Whitening toothpaste has been commercialized and used for a long time in order to suppress or prevent tooth discoloration caused by various causes. Looking at the teeth whitening technology commercialized to date, the most classic method is a method of strong polishing and the corrosion of the tooth surface by adjusting the pH of the product to a strong acidity.

However, the method by the strong grinding degree simply polishes the surface of the tooth and smoothes the surface to expect a whitening effect.However, in long-term use, the enamel area is the thinnest area where the tooth and gum are connected due to excessive wear of the tooth itself. It is obvious that abrasion can occur first and cause cervical wear. The method of corroding the tooth surface by adjusting the pH of the product to strong acidity also presupposes that the surface of the tooth is corroded. Thus, the damage of the tooth caused by this corrosion decreases the hardness of the tooth, which increases the speed of tooth decay and causes irritable teeth. There is a problem that can be done.

Recently, commercially available technologies are used to fill a rough tooth surface with hydroxyapatite or titanium dioxide to smooth the tooth surface or to bleach using a peroxide-based material.

However, it is difficult to expect the actual whitening effect with only the smoothing of the tooth surface, and the bleaching effect due to the peroxide is expected to be effective. It is considered inappropriate to use it. In particular, generator oxygen generated from peroxides has been controversial as a causative agent for carcinogenicity and cellular aging in the past. Therefore, care should be taken when using toothpaste. I think it will be necessary. Due to such a problem of human stability, most countries prohibit the use of peroxide in toothpaste (Japan) or limit the amount used in small amounts (Europe, USA).

In addition, when the peroxide is used in toothpaste, not only the compatibility with general ingredients used in the toothpaste is not good and the peroxide itself is very unstable, so the concentration of active oxygen decreases rapidly over time. In order to stabilize peroxides, US Pat. Nos. 4,687,663 and 5,020,694, etc., use a double container system to separate and package the peroxides, while US Pat. No. 5,122,365 uses three separate packages to provide acid in the first step. In the second stage, the treatment of tooth surface corrosion, the peroxide bleaching treatment and the third stage insisted on smoothing the tooth surface with titanium oxide, but in the first and second stages, the safety of the human body was not considered. And commercialized on this principle It is expected that the trouble of use and the increase of the packaging cost of the manufacturer are problems.

On the other hand, US Patent No. 4,968,981 attempts to whiten teeth using papain, a plant proteolytic enzyme, without peroxide as another approach to the teeth whitening effect. The effect was also evaluated to be very weak.

Therefore, the inventors of the present invention do not have excessive wear and corrosion of the teeth, do not use peroxide, have excellent aging stability, and study the prescription of a whitening toothpaste that is safe for the human body. Toothpaste compositions containing apatite at the same time have been developed to complete the present invention. In addition, the formulation and packaging form of the final product to provide a toothpaste composition contained in the tube of the conventional ointment (paste).

Accordingly, an object of the present invention is to provide a whitening toothpaste composition containing two or more water-soluble pyrophosphates and simultaneously containing fluoride and hydroxyapatite.

The whitening toothpaste composition of this invention contains 2 or more types of water-soluble pyrophosphates, and contains fluoride and hydroxyapatite simultaneously.

The whitening toothpaste composition of the present invention is used by mixing two or more kinds of water-soluble phosphate sodium pyrophosphate, potassium pyrophosphate and acidic pyrophosphate 1-6% by weight, 0.5-10% by weight of hydroxyapatite and sodium fluoride, fluoride Safe whitening toothpaste having a value of 40 to 100 as measured by British Standard Method using 0.05 to 0.15% by weight of fluorine using at least one of sodium, amine fluoride and tin fluoride To provide a composition.

Although there is no standard standard for toothpaste polishing, the comparative analysis of the commercially available toothpaste is classified as low polishing of less than 50, medium polishing of 50-100 or less, and high polishing of 100 or more. Long-term brushing with high-polishing toothpaste is very likely to cause cervical abrasion as mentioned above. The degree of polishing of the toothpaste may be determined by the type and amount of the abrasive among the components of the toothpaste.

Therefore, the type and the amount of abrasive used in the present invention are precipitated silica, silica gel, zirconium silicate, calcium dihydrogen phosphate, calcium dihydrogen phosphate, hydrous alumina, hard calcium carbonate, heavy calcium carbonate, calcium pyrophosphate, insoluble metaphosphate, And 5 to 50% by weight of at least one of the aluminum silicates to give a value of 50 to 100 of the degree of polishing of the final product, the particle size also varies depending on the type of abrasive, but it is preferable to use an average particle diameter of 20 micro or less Do.

The use of humectants in toothpaste is an essential base ingredient in the preparation of ointment formulations, which prevents the toothpaste from drying out when exposed to the air, gives the surface of the toothpaste a gloss, and also provides a sweetening effect when brushing teeth. . In the present invention, concentrated glycerin (98%), glycerin (85%), sorbitol aqueous solution (70%), amorphous sorbitol aqueous solution (70%), xyitol, polyethylene glycol, and propylene glycol using at least one 20 to 70 Use by weight.

In addition, in conventional toothpaste compositions, suitable medicinal ingredients may be used according to the purpose of use, but sodium pyrophosphate, potassium pyrophosphate, sodium pyrophosphate, hydroxyapatite, sodium phosphate, sodium fluoride, amine fluoride and fluoride used in the present invention. In addition to the whitening effect of tin and other combinations, fluoride-containing ingredients prevent tooth decay, hydroxyapatite is sensitive to teeth, and sodium pyrophosphate, potassium pyrophosphate and sodium pyrophosphate are effective ingredients in inhibiting tartar formation. It is a well known ingredient. In addition to the above components, enzymes may be used together for the purpose of suppressing and removing cationic surfactants or plaques for the purpose of sterilizing oral bacteria. In addition, in order to prevent periodontal disease, water-soluble salts such as sodium chloride or sodium bicarbonate having high osmotic pressure, aminocapronic acid, allantoin and allantoin derivatives having hemostatic action, and various vitamins may be used simultaneously.

In particular, the hydroxyapatite used in the present invention has been known to be effective for hypersensitive teeth by filling the crown of dentin exposed from damaged teeth in the past, but these techniques have recently been applied as a whitening effect. In other words, hydroxyapatite is the main component of the bones and teeth of the human body, and especially in the enamel layer, which is the outer surface of the tooth, hydroxyapatite accounts for about 97%. Therefore, when the fine powder of hydroxyapatite is used, the tooth surface can be whitened by filling the tooth surface by adsorption action on the damaged and rough tooth surface. However, this effect is not simply because the use of hydroxyapatite in the toothpaste composition, even if diarrhea whitening effect will be extremely weak.

Therefore, the present inventors mixed two or more kinds of water-soluble phosphate sodium pyrophosphate, potassium pyrophosphate and acidic pyrophosphate through numerous prescription tests and evaluation tests in order to optimize the effect of hydroxyapatite and maximize the whitening effect. Whitening effect on teeth when used together with 0.05 to 0.15% by weight of fluoride using 0.5 to 10% by weight of hydroxyapatite and one or more of sodium phosphate, sodium fluoride, amine fluoride and tin fluoride Is remarkable.

On the other hand, the use of the binder in the toothpaste is a role that prevents the separation of the solid powder and the liquid component is essential in the ointment toothpaste, and any kind of water-soluble polymer can be used. Commonly used components include sodium carboxymethylcellulose synthesized from cellulose of wood, carrageenan extracted from seaweed, xanthan gum obtained from metabolism of microorganisms, and the like.

The use of foaming agent enhances the feeling of use of the product, helps cleansing action, speeds up dispersal and penetration of other active ingredients, and decreases interfacial tension, thereby making it easy to remove foreign substances in the oral cavity. As the foaming agent, sodium lauryl sulfate, an anionic surfactant, is mainly used, and a copolymer of a polyoxyethylene polyoxypropylene (poloxamer), a polyoxyethylene-cured castor oil, poly Oxyethylene sorbitan fatty acid ester etc. are used.

In addition, in order to improve the feeling of use of the toothpaste composition according to the present invention can be used flavors, sweeteners and pigments, etc. The fragrance used for this purpose is necessary to use edible edible flavors, peppermint oil, spearmint oil, Sage, eucalyptol, methyl salicylate and fruit extract can be used. Sodium saccharin is the most commonly used sweetener, and food coloring is mainly used.

Comparative test evaluation of the effect of the composition of the present invention composed of the above components and the existing commercially available whitening toothpaste in various aspects was found to be much superior to the toothpaste composition according to the present invention (Table 2, 3, Therefore, it was confirmed that the inventors achieved the intended effect.

Hereinafter, the present invention will be described in more detail based on the following Examples and Comparative Examples. However, this is only to help the understanding of the present invention, but the scope of the present invention in any sense is not limited thereto.

Examples 1-5 and Comparative Examples 1-3

Toothpaste compositions according to the present invention (Examples 1 to 5) and conventional toothpaste compositions (Comparative Examples 1 to 3) for comparison thereto were prepared at the composition ratio as shown in Table 1 below.

The manufacturing method is as follows.

1) The binder and other additives were previously dispersed in the humectant, and the abrasive and the whitening agent were added, followed by stirring for about 30 minutes.

2) Finally, the foaming agent was added and stirred for 20 minutes in a vacuum to obtain a final product.

division Ingredient Name Example Comparative example One 2 3 4 5 One 2 3 abrasive Precipitated silica 15.0 - 10.0 - - 15.0 - - Calcium dihydrogen phosphate - 35.0 - - - - - 40.0 Hydrous alumina - 5.0 - 25.0 - - 25.0 - Hard calcium carbonate - - 30.0 10.0 - - 10.0 - Calcium Pyrophosphate - - - 5.0 - - 5.0 - Silica gel 3.0 - - - 10.0 3.0 - - Humectant Concentrated glycerin (98%) 50.0 - 20.0 - 2.0 50.0 - 35.0 Sorbitol aqueous solution (70%) - 35.0 - 33.0 68.0 - 33.0 - Zyritol - - 5.0 1.0 - - 1.0 - Foam Sodium Lauryl Sulfate 2.0 1.5 1.5 2.0 1.5 2.0 2.0 1.5 Poloxamer - - 0.5 - - - - - Binder Carboxymethyl Cellulose Sodium 0.8 - 0.8 0.8 0.4 0.8 0.8 - Carrageenan - 0.7 - - 0.2 - - 1.0 Whitening Agents and Drugs Sodium pyrophosphate 0.5 0.5 - 1.5 3.0 - 1.5 - Potassium pyrophosphate 0.5 0.5 2.5 1.5 - - 1.5 2.0 Sodium Pyrophosphate - 1.5 1.0 2.0 2.5 - 2.0 - Hydroxyapatite 10.0 7.5 5.0 3.0 0.5 10.0 - 5.0 Sodium Fluoride 1.1 - 0.76 - 0.38 1.1 - - Sodium fluoride - 0.12 0.11 - 0.05 - 0.23 - Amine fluoride - - - 1.31 - - - - Tin fluoride - - - - 0.1 - - - Hydrogen peroxide (30%) - - - - - - 5.0 - Titanium dioxide - - - - - - 1.0 - Papain - - - - - - - 1.0 Sodium bicarbonate - - - - - - 5.0 - additive Spices 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Saccharin 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 Purified water 16.0 11.58 21.73 12.79 10.27 17.0 5.87 13.4

Experimental Example 1: Evaluation of the whitening effect of the toothpaste composition

1) Evaluation test of whitening effect using human teeth

The stain removal effect of the toothpaste composition of Examples 1-5 and Comparative Examples 1-3 was evaluated by the following method. Tobacco, coffee, tea, sugar and calcium are mixed into gel and transferred to the bottom container of a motorized device for rotation, and tooth specimens extracted from healthy people in their 20s to 30s are epoxy resins. After the specimens were manufactured to have an exposed area of width × length = 2 mm × 2 mm by fixing to, the plates were attached to a rotating plate and operated for 3 days to force attachment.

At this time, an incandescent lamp was installed at the center of the rotating plate to dry the stains attached to the specimens, thereby promoting the adhesion of the stains. On the last day, remove the stained specimen and measure the whiteness using a colorimeter (model: SZ, manufactured by Nippon Denshoku). To rub against the specimen. At this time, put the composition of each Example and Comparative Example at the end of the bristles 0.5g in the same operation for 30 minutes to reciprocate 180 times per minute, and then take out the specimen again using a colorimeter to improve the degree of whiteness of the specimen After the measurement, the percentage is calculated and the results are shown in Table 2 below.

division Example 1 Example 2 Example 3 Example 4 Example 5 Comparative Example 1 Comparative Example 2 Comparative Example 3 Whiteness Improvement Rate (%) 89.3 84.5 86.3 90.2 87.4 65.4 71.0 63.9

As can be seen from Table 2, the toothpaste composition according to the present invention was evaluated to have a better whitening effect (the effect of increasing whiteness) than the composition of the comparative example.

2) Whitening effect test through clinical trial

In order to see the more obvious whitening effect of the toothpaste composition according to the present invention, the whitening effect of the toothpaste compositions of Examples 1 and 3 and Comparative Examples 1 and 2 was directly evaluated for two months.

Select 40 people who had relatively strong teeth, and measure the color tone of the incisor plane before starting the experiment using a Trubyte Bioform colorimeter in a room with a constant lighting device. Each grouping toothpaste composition was divided into 4 groups (10 people each), and the toothbrushing was performed as usual.

In order to confirm the increase of the brightness of teeth, 10 kinds of easy-to-identify identifications were selected from 24 standard standards of brightness of the Tourbite Bioform colorimeter, and from 1 to 10 points in order of increasing brightness for each Evaluation score was added.

Before using the experimental toothpaste, the tooth brightness value of each group was evaluated to the first digit below the decimal point based on the above criteria, and after increasing the brightness value after the brushing for 2 months, the increase rate of the average brightness value was calculated.

division Example 1 Example 3 Comparative Example 1 Comparative Example 2 Average brightness value (before experiment) 3.5 4.1 3.3 4.2 Average brightness value (after 2 months use) 7.7 7.5 4.5 5.8 % Increase in brightness 120.0 82.9 36.6 38.0

As can be seen from the results, the toothpaste composition according to the present invention when evaluated clinically was evaluated to have a better whitening effect (increase effect of brightness) than the composition of Comparative Example.

Experimental Example 2: Evaluation of Polishing of Toothpaste Composition

As described above, when the polishing degree of the toothpaste composition is too high, the slight whitening effect may be slightly increased. However, the composition according to the present invention and the comparative example are both high in the standard according to the present invention. When measured by the test method, it was adjusted to have a medium degree of polishing value to correct the whitening effect by the polishing degree and compared with the results of the whitening test. The results are shown in Table 4 below.

division Example Comparative example One 2 3 4 5 One 2 3 Polishing degree 65.3 46.7 72.4 90.9 53.2 65.5 90.1 48.8 Whiteness Improvement (%) Experimental Example 1,1) 89.3 84.5 86.3 90.2 87.4 65.4 71.0 63.9 Brightness increase rate (%) Experimental examples 1,2) 120.0 - 82.9 - - 36.6 38.0 -

Among the above results, when the whiteness improvement rate and the polishing degree were compared, the polishing degree from Examples 1,2,4,5 and Comparative Examples 1,2,3 showed some relation to the whitening effect, but the effect was not only very small but also implemented. When comparing Examples 3 and 5, the opposite result can be seen.

When comparing Example 1 and Comparative Example 1 or when comparing Example 2 and Comparative Example 3, the whitening effect by the degree of polishing was the same, it was found that the toothpaste composition according to the present invention is excellent in the whitening effect.

In the brightness increase rate test conducted by the clinical test, it can be seen that the polishing degree does not affect the whitening effect, and the toothpaste composition according to the present invention was found to have an excellent whitening effect.

Experimental Example 3: Comparative evaluation of the stability of the toothpaste composition

The toothpaste compositions of Examples 1 to 5 and Comparative Examples 1 to 3 were stored at room temperature and 40 ° C. to evaluate the state stability of the toothpaste composition at regular intervals according to the following criteria. The results are shown in Table 5 below.

"Evaluation standard"

◎ Very good: smooth surface, no phase separation, normal toothpaste

○ relatively good: only slightly rough surface or slightly poor tube entrance

▽ relatively poor: phase separation and slight discoloration

× Very poor: severe phase separation and gas generation or hardening

Time lapse Example Comparative example One 2 3 4 5 One 2 3 1 month Room temperature ◎ ◎ ◎ ◎ ◎ ◎ ○ ◎ 40 degrees ◎ ◎ ◎ ◎ ◎ ◎ ▽ ○ 3 months Room temperature ◎ ◎ ◎ ◎ ◎ ◎ ▽ ○ 40 degrees ◎ ◎ ◎ ◎ ◎ ○ × × 6 months Room temperature ◎ ◎ ◎ ◎ ◎ ○ × ▽ 40 degrees ○ ○ ○ ▽ ○ ▽ × × 12 months Room temperature ○ ◎ ◎ ◎ ◎ ▽ × ▽ 40 degrees ▽ ▽ ▽ ▽ ▽ × × ×

As shown in the above results, the toothpaste composition according to the present invention is superior to the existing toothpaste composition, in particular, the toothpaste composition containing peroxide or enzyme as a whitening agent, and thus it is considered to be advantageous in terms of product value. Appeared.

The toothpaste composition according to the present invention through the above experimental example is a whitening toothpaste composition that is excellent in whitening effect, excellent aging stability, and there is no excessive wear and corrosion of teeth and no peroxide.

Claims (3)

A whitening toothpaste composition comprising two or more water-soluble pyrophosphates and containing fluoride and hydroxyapatite at the same time, wherein the content of hydroxyapatite is 0.5 to 10% by weight relative to the entire toothpaste composition. The dentifrice composition of claim 1 wherein the water-soluble pyrophosphate is selected from two or more of sodium pyrophosphate, potassium pyrophosphate, and acidic pyrophosphate, the content of which is 1 to 6% by weight based on the entire toothpaste composition. The dentifrice composition according to claim 1, wherein the fluoride is at least one selected from sodium phosphate, sodium fluoride, amine fluoride, and tin fluoride, and the content is 0.05 to 0.15% by weight as fluorine relative to the entire dentifrice composition.