KR0180119B1 - Stable peroxide dentifrice composition - Google Patents

Abstract

The present invention relates to a dentifrice composition in which the time stability of the peroxide and the state stability of the dentifrice are greatly improved by using the ultra-phosphate to stabilize the peroxide in the dentifrice composition while using the peroxide as the whitening agent.

Description

Stable Peroxide-Containing Toothpaste Composition

The present invention relates to a whitening toothpaste composition of aesthetic function with improved stability over time. More specifically, the present invention relates to a toothpaste composition for whitening, characterized in that the addition of ultra-condensation phosphate for stabilizing the peroxide in the toothpaste composition using a peroxide as a whitening agent.

Ultra-type condensed phosphate is a water-soluble alkali metal condensed phosphate with a network-like molecular structure. The molar ratio of metal oxide (M ₂ O) and phosphorus pentoxide (P ₂ O ₅ ) used as the classification scale of phosphate is 1 or less. The chemical formula is as follows.

(XM ₂ O) P ₂ O ₅

0 <X <1

Wherein M is sodium (Na) or potassium (K).

In general, phosphates are classified by the molar ratio of M ₂ O and P ₂ O ₅ , and in the case of ortho phosphate (M ₃ PO ₄ ), the molar ratio (M ₂ O / P ₂ O ₅ ) becomes 3 and the metal ion In the case of pyrophosphate (M ₄ P ₂ O ₇ ), which is frequently used for the purpose of containment and stabilization of peroxides, the molar ratio is 2. In addition, the degree of condensation increases the poly or metaphosphate (poly or metaphosphate) in the molar ratio of 1 to 2 can be seen.

However, ultra-condensed phosphate is more condensed than poly or metaphosphate, and the molar ratio of M ₂ O and P ₂ O ₅ is less than 1, and its structure is known to have a three-dimensional network structure.

Prior to describing the present invention, a prior art of a whitening toothpaste that whitens discoloration factors and discolored teeth will be described.

Generally, tooth discoloration factors can be classified into exogenous discoloration and endogenous discoloration. Exogenous tooth discoloration may be caused by food deposits, nicotine, coffee, tea, etc. deposited on the tooth surface, or tartar or soft deposits on the tooth surface stained with pigments. Overdose of cyclin antibiotics or aging can be cited as the cause.

Toothpaste for whitening has been commercialized and used for a long time in order to suppress or prevent tooth discoloration caused by various causes, but its effect is to simply polish the tooth surface by physically polishing the tooth surface by containing the abrasive with high abrasive force in the toothpaste. By smoothing the whitening effect was to be expected. However, the whitening toothpaste having such a function has a problem that the effect does not meet expectations and may cause irritable teeth or cervical abrasion due to excessive wear of the tooth over a long period of use.

Therefore, in order to achieve the intended purpose without side effects such as abrasion of teeth, the whitening effect by the chemical action was conceived, and the peroxide is used here. The whitening effect by the peroxide is excellent enough to visually confirm the effect even after a short period of use and has the advantage that it can be widely applied to tooth discoloration caused by various factors.

As such, it is well known that the peroxide enhances the whitening effect of the teeth. However, the peroxide does not have good usability between the raw material for toothpaste and the peroxide, which causes rapid decomposition of the peroxide after production, gas generation or phase separation in the product. In case of long-term storage of toothpaste, there was a problem in stabilizing peroxide in toothpaste, which made it difficult to commercialize.

In order to improve such a problem, a method which has been used so far is classified into a raw material having good compatibility and a raw material having poor usability, and a method of mixing and brushing the tooth by filling it in a suitable container.

For this reason, U.S. Patent Nos. 4,687,663 and 5,020,694 describe a method of simultaneously extruding two components when used by separately filling peroxide and toothpaste components in a dispensing twin container, and U.S. Patent No. 5,122,365. In order to enhance the effect of use and to improve the stability of the peroxide over time, commercialization in three separate packages is described. These three forms are intended to be used as a first step to widen the surface of teeth by acid, to widen the surface area, two steps of bleaching reaction by peroxide, and three steps to smooth tooth surface with titanium oxide. However, it has been pointed out that such a product has a problem of increased packaging cost and complicated use when used separately.

On the other hand, US Patent No. 4,986,981 used a papain (phytoenzyme) instead of peroxide as another approach to the tooth whitening effect, but it was determined that the actual whitening effect is very weak.

As another approach, U.S. Patent No. 4,891,211 attempted to stabilize peroxides in toothpaste using sodium bicarbonate, polyethylene glycol and nonionic surfactants, but ultimately the peroxides were not stabilized and the phase separation at room temperature was extremely severe. The value as a commodity was much damaged.

In such a situation, the present inventors, while performing a number of studies and tests to improve the above-mentioned problems of the prior art, by using condensed phosphate to stabilize the peroxide in the toothpaste composition using the peroxide as a whitening agent, the time-lapse stability of the peroxide And it has been found that the state stability of the toothpaste can be improved to complete the present invention.

The present invention relates to a toothpaste composition for whitening, characterized in that in the dentifrice composition using a peroxide as a whitening agent, the ultracondensation phosphate is contained to stabilize the peroxide in the toothpaste.

Ultra-based condensed phosphate used in the present invention is a molar ratio of metal oxide (M ₂ O: M = sodium or potassium) and phosphorus pentoxide (P ₂ O ₅ ) is less than 1 and has a three-dimensional network structure.

The amount of the ultra-condensed phosphate is slightly different depending on the type of abrasive component of the toothpaste, but it is preferable to use 0.01 to 10% by weight.

However, in toothpaste using silica or silicate as an abrasive, only 0.01 to 5% by weight was used to stabilize peroxides.

If the amount of ultra-low phosphate stabilizer is less than 0.01% by weight, the stabilization effect of the peroxide is not only weak, but the state of the toothpaste is extremely poor due to the decomposition of the peroxide in the product.

In addition, excessive use of ultra-phosphate in toothpaste not only increases the raw material cost of the product, but also lowers the product value because of poor taste.

As the peroxide, one or two or more selected from calcium peroxide, urea peroxide, sodium carbonate and hydrogen peroxide solution are used in the range of 0.1 to 5% by weight as hydrogen peroxide relative to the entire toothpaste composition. If the peroxide is used at a concentration of less than 0.1% by weight, the whitening effect is insignificant and the original function of the toothpaste product cannot be exerted, and when it is used in excess of 5% by weight, it may cause side effects such as irritable teeth or irritation due to prolonged use. Can be.

In addition, the toothpaste composition of the present invention may further contain an abrasive, a humectant, a foaming agent, a binder, a medicament, a fragrance and a sweetener.

The abrasive component used in the toothpaste composition is one or two or more selected from precipitated silica, silica gel, dihydrate or anhydride of calcium dihydrogen phosphate, calcium carbonate, hydrous alumina, zirconium silicate, insoluble sodium metaphosphate and calcium pyrophosphate. It is preferable to use 5 to 50% by weight, and the particle size also varies slightly depending on the type of abrasive, but it is preferable to use 20 micrometer (μm) or less.

Wetting agent prevents toothpaste from solidifying when exposed to air and acts as a body of toothpaste with abrasives. Sorbitol, amorphous sorbitol (about 70%), glycerin, polyethylene glycol, propylene glycol, xylitol, etc. One or two or more selected from these are used.

In addition, the toothpaste composition can be used according to the purpose of the appropriate medicament, and as the medicament may be mentioned caries preventive agent and periodontal disease preventive agent. Among them, a fluorine compound is typically used as a caries preventive agent, and specifically, sodium fluoride, sodium monofluorophosphate, and amine fluoride may be used, and 0.1 to 3% by weight of one or more selected from these may be used. have. In addition, a small amount of cationic surfactant may be added for sterilization of oral cavity bacteria, and enzymes may be used to suppress and remove plaque. As a treatment for periodontal disease, it is a high osmotic action that disinfects and disinfects. Sodium chloride and hemostatic anti-plasmin agent that suppresses edema and bleeding are allanetoin derivatives with tranexamic acid, aminocaronic acid and anti-astringent. Vitamins and the like can be used.

The use of water-soluble polymers such as sodium carboxymethyl cellulose, carrageenan, xanthan gum and the like is essential for the general toothpaste composition, which prevents separation between the solid abrasive and the liquid wetting agent and adjusts the viscosity of the product. Play a role.

The foaming agent helps cleansing, and quickly disperses and penetrates the medicinal agent and reduces interfacial tension so that foreign substances in the oral cavity easily come off.

As the foaming agent, anionic surfactants such as sodium lauryl sulfate, sodium lauroyl sulfate, sodium alkyl sulfate, and the like are used. Secondly, nonionic surfactants such as polyoxyethylene, polyoxypropylene copolymer, polyoxyethylene hydrogenated castor oil, and poly Oxyethylene sorbitan fatty acid esters, sugar fatty acid esters and the like are used. The amount of foaming agent is preferably 0.5 to 5.0% by weight of one or two or more selected from anionic and nonionic surfactants.

In addition, the toothpaste composition according to the present invention may use a flavoring agent and sweetener to improve the feeling. As the fragrance used for this purpose, mention may be made of peppermint, spearmint, wintergreen, sage, eucalyptol oil, methyl salicylate and other fruit extracts. The lactose, aspartame, sodium saccharin, etc. may be used, and preferably, saccharin sodium is used in an amount of 0.05 to 1% by weight.

Toothpaste composition according to the present invention prepared in the configuration as described above was found to be much better than the existing toothpaste composition stability of the peroxide contained in the toothpaste, stability of the toothpaste composition over time and whitening effect (Table 2, 3, 4 and 5).

Hereinafter, the present invention will be described in more detail based on the following Examples and Comparative Examples. However, this is only to help the understanding of the present invention, and the scope of the present invention in any way is not limited thereto.

[Examples 1 to 5 and Comparative Examples 1 to 4]

Toothpaste compositions according to the present invention (Examples 1 to 5) and conventional toothpaste compositions (Comparative Examples 1 to 4) for comparison thereto were prepared in a ratio as shown in Table 1 below.

Referring to the manufacturing method of the toothpaste composition, first disperse the ultra-based condensate phosphate as a stabilizer in the wetting agent, and then added to the abrasive and other ingredients (sweetening agent, preservatives and agonist, etc.) and stirred uniformly. A foaming agent, a fragrance and a peroxide were added thereto, and the mixture was stirred thoroughly while maintaining a vacuum state.

Example 1 Evaluation of Time-lapse Stability of Peroxides in Toothpaste Compositions

The toothpaste compositions of Examples 1 to 5 and Comparative Examples 1 to 4 were stored at room temperature and 40 ° C., respectively, to quantify the peroxide content in the composition at regular intervals.

As a quantification, a known redox quantitative method using potassium permanganate solution was used, and the experimental results indicating the residual amount according to time after seeing the initial peroxide input amount as 100 are shown in Tables 2 and 3 below.

As can be seen from the results of Tables 2 and 3, compared to the toothpaste composition of the comparative example, the toothpaste composition according to the present invention was found to be excellent in stability over time at both room temperature and 40 ℃.

Experimental Example 2 Evaluation of Stability of Toothpaste Compositions with Time.

The toothpaste compositions of Examples 1 to 5 and Comparative Examples 1 to 4 were stored at room temperature and 40 ° C., respectively, to evaluate the state stability of the toothpaste composition according to the following criteria.

* Evaluation standard

◎ very good (almost same as after the tissue)

(Circle) the surface of toothpaste becomes rough (good)

△: relatively poor (phase separation phenomenon, gas amount generation, discoloration phenomenon, etc.)

X: Poor (severe phase separation, gas generation and discoloration)

As shown in Table 4, the toothpaste composition of the Example was superior to the stability status over time than the toothpaste composition of the comparative example.

Experimental Example 3: Evaluation of Whitening Effect of Toothpaste Composition

After preparing the toothpaste compositions of Examples and Comparative Examples and left for 3 months at room temperature, the whitening effect was evaluated by the following two methods.

1) Evaluation experiment on human teeth

The stain removal effect of the toothpaste composition of Examples 1-5 and Comparative Examples 1-4 was evaluated by the following method. Tobacco, coffee, tea, sugar and calcium are mixed into a gel, which is then transferred to the bottom container of a motorized device for rotation, and tooth specimens extracted from healthy people in their 20s to 30s are epoxy resins. After fixing the specimen to make the exposed area horizontal x vertical = 2mm x 2mm, it was attached to a rotating plate and operated for 3 days to force stains. At this time, incandescent lamps were installed in the center of the rotating plate to dry the stains attached to the specimens, thereby promoting adhesion of the stains. Remove the stained specimen on the last day and measure the whiteness using a color difference meter (Model: SZ, Nippon Denshoku), fix the specimen on a specially designed abrasive force meter to allow reciprocating motion, and then fix the soft bristles on the axis of motion. To rub against the specimen. At this time, each of the Example and Comparative Example composition at the end of the bristles 0.5g equally put and operated for 30 minutes to reciprocate 180 times per minute, and then take out the specimen again using a colorimeter to improve the degree of whiteness of the specimen After the measurement was calculated in percentage, the results are shown in Table 5 below.

2) Evaluation experiment using cotton cloth

The whiteness of the cotton cloth deposited in red wine was measured using a colorimeter as described in 1) above. Thereafter, 50 ml of distilled water was added to a 100 ml beaker, and 5 g of the dentifrice compositions according to Examples 1 to 5 and Comparative Examples 1 to 4 were added. The cotton cloth was spaced apart from the bottom of the beaker by a constant height, and then the degree of improvement of the stain was evaluated by percentage by measuring the whiteness of the cotton cloth, and the results are shown in Table 5 below.

As can be seen from Table 5, the toothpaste composition according to the present invention was evaluated to have a better whitening effect (whiteness increasing effect) on human teeth and cotton cloth than the toothpaste composition of the comparative example.

Claims (6)

A toothpaste composition for whitening, comprising: an ultra-condensed phosphate for stabilizing the peroxide in a dentifrice composition using a peroxide. The dentifrice composition according to claim 1, wherein the molar ratio of the metal oxide (M ₂ O; M: sodium or potassium) and the phosphorus pentoxide (P ₂ O ₅ ) exhibits a value of 1 or less. The dentifrice composition of Claim 2 containing 0.01-10 weight% of ultra type condensation phosphates with respect to the whole dentifrice composition. The toothpaste composition according to claim 1, wherein the peroxide is one or two selected from urea peroxide, sodium carbonate, calcium peroxide and hydrogen peroxide. The dentifrice composition of Claim 4 containing 0.1-5 weight% of peroxides with respect to the whole dentifrice composition. The toothpaste composition of claim 1, further comprising an abrasive, a humectant, a foaming agent, a binder, a medicament, a fragrance, and a sweetener.