KR101331734B1 - Toothpaste composition - Google Patents

Abstract

(A) at least one linearly water-soluble polyphosphate represented by the general formula M _{n +2} P _n O _{3n +1} (wherein M represents Na or K and n is an integer of 2 or 3); 0.3-1.2 mass%, (B) 0.1-2.0 mass% of the methylvinyl ether maleic anhydride copolymer whose viscosity of 2.0 mass% aqueous solution in 25 degreeC and pH7.0 is 5-1000 mPa * s, and (C) lauryl A dentifrice composition comprising 0.6-2.0 mass% of sulfate, 0.2-1.0 mass% of (D) betaine type amphoteric surfactant, and the compounding ratio of (C) / (D) is 1-4 by mass ratio. This toothpaste composition is hardly qualified for the oral mucosa, is excellent in foaming at the time of use, and excellent in the effect of inhibiting adhesion to tooth surface contamination.

Toothpaste composition

Description

Toothpaste composition {TOOTHPASTE COMPOSITION}

The present invention relates to a dentifrice composition which is hardly qualified for the oral mucosa, is excellent in foaming during use, and is excellent in the effect of inhibiting adhesion to tooth surface contamination.

Various methods have been studied in the past in order to whiten teeth which have been colored with cigarettes or chalcedony. For example, use of highly abrasive abrasives, whitening with peroxides, dissolving and removing of tobacco with polyethylene glycol, removal of iron ions with a chelating agent, and tooth surface by remineralization The smoothing of the is common.

However, the use of a high abrasive abrasive may damage teeth, and polyethylene glycol or the like has insufficient effect of dissolving and removing stubborn stains such as tartar. In addition, the method using peroxide also causes problems such as demineralization of organic matter on the enamel surface and deterioration of acid resistance. Therefore, the present invention is a treatment that only a dentist can use in our country. It is a state.

Conventionally, linear polyphosphate, such as sodium pyrophosphate, is known as a component for preventing tartar and removing contamination of teeth, and is incorporated into a composition for oral cavity (see Patent Documents 1, 2 and 3). In addition, there has been reported a composition for preventing dental plaque comprising a synthetic anionic linear polymer polycarboxylate and lauryl sulfate containing a water-soluble polyphosphate and a methyl vinyl ether maleic anhydride copolymer (patent) References 4, 5, 6, 7, 8, 9, 10, 11). In these proposals, for example, a composition containing 1.5% by mass or more of water-soluble polyphosphate such as sodium pyrophosphate and 1.2% by mass or more of lauryl sulfate is proposed, and there is a problem that strong qualification is generated for the oral mucosa. .

In addition, in patent document 12, the composition which mix | blended 13.6 mass% of methylvinyl ether maleic anhydride copolymers (brand name: Gantoretsu S-97), 0.125 mass% of sodium pyrophosphate, and 0.945 mass% of lauryl sulfate as Example 1 Although this is described, since the compounding concentration of sodium pyrophosphate is low in this composition, the effect of suppressing adhesion to tooth surface contamination cannot be obtained.

In addition, in patent document 10, the composition which mix | blended 15 mass% of methylvinyl ether maleic anhydride copolymers (brand name: Kantoretsu S-97), 0.25 mass% of sodium pyrophosphate, and 0.75 mass% of lauryl sulfate as Example 1 is carried out. Although this is described, the compounding quantity of sodium pyrophosphate and surfactant amount in a composition is small, the foam | bubble at the time of use does not form well, and also the effect of suppressing adhesion to tooth contamination is not acquired.

As described above, in the prior art, toothpaste compositions having excellent adhesion inhibitory effect on tooth surface contamination, being hypoallergenic to the oral mucosa and excellent in foaming at the time of use, and satisfying all of these characteristics, have not been obtained. It is a state and development of the toothpaste composition which overcomes these subjects is desired.

Patent Document 1: Japanese Patent Application Laid-Open No. 9-175966

Patent Document 2: Japanese Patent Application Laid-Open No. 10-182389

Patent Document 3: Japanese Patent Application Laid-Open No. 11-343220

Patent Document 4: Japanese Patent Application Laid-Open No. 2-4708

Patent Document 5: Japanese Patent Application Laid-Open No. 4-270210

Patent Document 6: Japanese Patent Application Laid-Open No. 8-18961

Patent Document 7: Japanese Patent No. 2528492

Patent Document 8: Japanese Patent Laid-Open No. 11-506104

Patent Document 9: Japanese Patent Application Laid-Open No. 2002-316920

Patent Document 10: Japanese Patent Application Laid-Open No. 2002-526394

Patent Document 11: Japanese Patent Application Laid-Open No. 2004-517833

Patent Document 12: Japanese Patent Application Laid-Open No. 2002-500174

The present invention has been made in view of the above circumstances, and it is hypoallergenic to the oral mucosa and provides a toothpaste composition having good foaming in the mouth when brushing and having an excellent anti-adhesion effect against tooth contamination. It is for the purpose.

Means for solving the problem

MEANS TO SOLVE THE PROBLEM As a result of earnestly researching in order to achieve the said objective, in order to suppress adhesion of tooth surface contamination, this inventor carried out (A) linear water-soluble polyphosphate, (B) of 25 mass% aqueous solution in 25 degreeC, pH7.0. (D) Beta to mix methylvinyl ether maleic anhydride copolymer having a viscosity of 5 to 1000 mPa · s and (C) lauryl sulfate, and also to be hypoallergenic to the oral mucosa and to ensure excellent foaming in use. When the doll-positive surfactant is blended so that the blending ratio of (C) / (D) is 1 to 4 by mass ratio, in particular, the water-soluble polyphosphate is more than 1.2% by mass in the combined composition with lauryl sulfate. Since qualification occurs about the oral mucosa, 0.3-1.2 mass% of water-soluble polyphosphate which is (A) component, 0.1-2.0 mass% of methyl vinyl ether maleic anhydride copolymer which is (B) component, and lauryl which is (C) component 0.6-2.0 mass% of sulfates, (D) component By mixing 0.2-1.0 mass% of betaine type amphoteric surfactant and making (C) / (D) the said ratio, it is hypoallergenic with respect to oral mucosa, and the effect of inhibiting adhesion to tooth contamination is synergistically increased, and It was found that excellent foaming can be obtained when wiping, and the present invention has been achieved.

Accordingly, the present invention, (A) the general formula M _{n +2} P _n O _{3n +1} soluble poly straight chain represented by the following (note that the formula, M is Na or K represents an, n is an integer of 2 or 3) 0.1-2.0 mass% of methylvinyl ether maleic anhydride copolymer whose viscosity is 2.0-1000 mass% aqueous solution in 0.3-1.2 mass%, (B) 25 degreeC, pH7.0 in at least 1 sort (s) of phosphate, (C) 0.6-2.0 mass% of lauryl sulfate, 0.2-1.0 mass% of (D) betaine-type amphoteric surfactant, and the compounding ratio of (C) / (D) is 1-4 by mass ratio, It is characterized by the above-mentioned. Toothpaste composition which consists of and the above toothpaste prepared as a cream toothpaste composition by mix | blending 5-50 mass% of abrasives, 10-50 mass% of viscous agents, and 0.1-5 mass% of thickeners. To provide a composition.

Effects of the Invention

The dentifrice composition of the present invention is hypoallergenic with respect to the oral mucosa, can obtain sufficient foaming at the time of use, and can express an effect of inhibiting adhesion to tooth surface contamination.

Hereinafter, the present invention will be described in more detail, the toothpaste composition of the present invention, (A) linear water-soluble polyphosphate, (B) methyl vinyl ether maleic anhydride copolymer, (C) lauryl sulfate and (D) beta It contains a doll amphoteric surfactant.

Component (A) is a water-soluble polyphosphates for use in dentifrice compositions of the present invention represented by the general formula _{M n + 2 P n O 3n} + 1 ( stage, wherein, M represents a Na or K, n is 2 or 3 constant of Is displayed.

Specific examples of the compound include sodium pyrophosphate having a degree of polymerization (n) = 2 (manufactured by Taiping Chemical Industry Co., Ltd.), potassium pyrophosphate (manufactured by Taiping Chemical Industry Co., Ltd.), and n = 3 sodium tripolyphosphate (central glass ( And the like, and tripolyphosphate potassium (manufactured by Taiping Chemical Industry Co., Ltd.). Especially, sodium pyrophosphate is preferable. These polyphosphates are used individually by 1 type or in mixture of 2 or more types.

The compounding quantity of water-soluble polyphosphate is 0.3 to 1.2% (mass% or less) of the whole composition, and 0.5 to 1.0% is especially preferable. If it is less than 0.3%, the adhesion inhibitory effect against tooth contamination is not sufficiently exhibited, and if it exceeds 1.2%, qualification may occur for the oral mucosa in a combination composition with lauryl sulfate.

The methylvinyl ether maleic anhydride copolymer of (B) component used for the toothpaste composition of this invention shows the viscosity of 5-1000 mPa * s at 25 degreeC and the pH of 2.0% aqueous solution at pH7.0. In addition, the 2.0% aqueous solution was dissolved while stirring the methylvinyl ether maleic anhydride copolymer and water at 60 to 70 ° C, and then cooled to 25 ° C, adjusted to pH7.0 using 10N NaOH, and the concentration was Distilled water was added to 2.0%, and the final pH was produced to 7.0. The methylvinyl ether maleic anhydride copolymer is obtained by copolymerizing methyl vinyl ether and maleic anhydride, and the mixing ratio of methyl vinyl ether and maleic anhydride is 25% at 25 ° C. and the viscosity of the 2.0% aqueous solution at pH 7.0 is within the viscosity described above. Ramen is not particularly limited.

Moreover, the viscosity of 2.0% aqueous solution in 25 degreeC and pH7.0 is 5-1000 mPa * s, Preferably it is 5-500 mPa * s. If the viscosity is less than 5 mPa · s, the effect of inhibiting adhesion to contamination is not sufficiently exhibited. If the viscosity is more than 1000 mPa · s, stickiness occurs in the oral cavity when the toothpaste composition is used, and sufficient foaming is not obtained at the time of use. In addition, the viscosity was 2.0% adjusted to 25 degreeC, pH7.0 by 30 rpm of rotation speeds, measuring time 3 minutes using Tokyo-BK type B clay meter (model: BL) and rotor No. 1 or 2. It is the measured value in aqueous solution. In addition, a pH meter (made by Dong-A DKK Co., Ltd., model: HM-30G) and a pH electrode (made by Dong-A DKK Co., Ltd., model: GST-5721C) were used for pH adjustment.

As such a copolymer, Gantretz manufactured by ISP, for example, GANTREZ AN-119 (the viscosity of 2.0% aqueous solution in 25 degreeC, pH7.0 is 10 mPa * s), AN-139 (25 degreeC, pH7.0) The viscosity of the 2.0% aqueous solution at 60 mPa * s), AN-169 (The viscosity of the 2.0% aqueous solution at 25 degreeC, pH7.0 is 450 mPa * s), etc. can be used.

The compounding quantity of the methyl vinyl ether maleic anhydride copolymer is 0.1 to 2.0% of the whole composition, and 0.5 to 1.0% is especially preferable. If the blending amount is less than 0.1%, the effect of inhibiting adhesion to tooth surface contamination is not sufficiently exhibited. If the blending amount is more than 2.0%, foaming at the time of use does not easily occur.

The lauryl sulfate which is (C) component used for this invention is an anionic surfactant whose average alkyl chain length synthesize | combined with higher fatty acid is 12. Specifically, sodium lauryl sulfate, potassium lauryl sulfate, ammonium lauryl sulfate, etc. are mentioned, but sodium lauryl sulfate (Dong Bang Chemical Co., Ltd. product, Cheil Pharm. Co., Ltd.) from the convenience of mix | blending to a toothpaste composition. And the like) are most preferred.

The compounding quantity of lauryl sulfate is 0.6 to 2.0% of the whole composition, Preferably it is 0.8 to 1.5%. If the blending amount is less than 0.6%, the effect of suppressing fouling adhesion is not exerted. Moreover, when it exceeds 2.0%, qualification may arise about an oral mucosa.

Moreover, the toothpaste composition of this invention contains the betaine type amphoteric surfactant which is (D) component as a foaming component. Examples of the betaine amphoteric surfactants include 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, lauryldimethylaminoacetic acid betaine, fatty acid amidepropyl betaine, and the like. A species can be used individually or in combination of 2 or more types.

As an alkyl chain length of the said amphoteric surfactant, since foaming also arises in any case, Preferably it is 8-20 carbon atoms of an alkyl chain, More preferably, it is 10-18. Among them, 2-alkyl-N-carboxymethyl-N-hypoxyethylimidazoliniumbetaine is preferable in terms of foaming and hypoallergenicity. As 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine, 2-palm oil alkyl-N-carboxymethyl-N-hydroxy sold by Lion Co., Ltd. as a brand name Enazol C-4OH is mentioned. Aqueous sodium imidazolinium betaine solution and the like can be used.

The compounding quantity of a betaine type amphoteric surfactant is 0.2-1.0% in terms of pure content, Preferably it is 0.3-0.8% with respect to the whole composition. If the amount is less than 0.2%, foaming at the time of wiping the teeth is insufficient. In addition, if it exceeds 1.0%, the combination composition with the water-soluble polyphosphate and lauryl sulfate will qualify for the oral mucosa. In addition, although a betaine type amphoteric surfactant may be obtained only as a mixture with water etc., the mass at the time of mix | blending in this invention is a pure part of active agent except a solvent etc ..

In addition, in the present invention, the compounding amount of lauryl sulfate to the betaine-type amphoteric surfactant ((C) / It is necessary to make (D)) into the range of 1-4 and preferably 2-3 in mass ratio. If (C) / (D) is less than 1, the adhesion inhibiting effect against contamination is not exhibited, and foaming at the time of use becomes insufficient. If you exceed 4, you may qualify.

Although the toothpaste composition of this invention can be prepared by a conventional method as a cream toothpaste, a liquid toothpaste, a lubricant toothpaste, etc., in addition to the said essential component, the formulation (within the range which does not impair the effect of this invention) Arbitrary components according to 劑型 can be blended. In the case of a cream toothpaste, as an optional ingredient, surfactants other than an abrasive, lauryl sulfate, and a betaine type amphoteric surfactant, a viscous agent, a caking additive, a sweetener, a preservative, a fragrance | flavor, various active ingredients, etc. are mix | blended, and it mixes with water, It can manufacture according to a conventional method.

Examples of the abrasive include dibasic calcium phosphate (dihydrate or anhydride), dibasic calcium phosphate, tricalcium phosphate, calcium pyrophosphate, calcium carbonate, aluminum hydroxide, alumina, magnesium carbonate, tertiary magnesium phosphate, insoluble sodium metaphosphate, insoluble Potassium metaphosphate, titanium oxide, zeolite, silicic anhydride, hydrous silicic acid, titanium silicate, zirconium silicate, synthetic resin-based abrasives, and the like, but silica-based abrasives such as silicic anhydride are preferred in view of the effect. . In the case of the cream toothpaste which is a typical formulation, the compounding quantity of an abrasive | polishing agent may be 5 to 50% of the whole composition. Preferably 10 to 50% is good.

Moreover, as surfactant, it is possible to use 1 type individually or in combination of 2 or more types of nonionic surfactant, in the range which does not impair the effect of this invention. Examples of nonionic surfactants include sucrose fatty acid esters such as sucrose fatty acid esters and maltose fatty acid esters, sugar alcohol fatty acid esters such as maltitol fatty acid esters, and lactolic acid esters, alkylol mydoes, and polyoxyethylene sorbitan monostearates. Polyoxyethylene fatty acid esters such as polyoxyethylene sorbitan fatty acid esters, polyoxyethylene hardened castor oil, fatty acid diethanolamides such as lauryl acid mono or diethanolamide, sorbitan fatty acid esters, polyoxyethylene higher alcohol ethers , Polyoxyethylene polyoxypropylene copolymer, polyoxyethylene polyoxypropylene fatty acid ester, polyglycerol fatty acid ester, pluronic and the like. As for the compounding quantity of a nonionic surfactant, 0.1-2% of the whole composition is suitable. Moreover, in the composition of the present invention, the total amount of the surfactant is preferably in the range of 0.8 to 3%.

As the viscous agent, in addition to at least one or more selected from sorbet, glycerin, propylene glycol, polyethylene glycol, xylitol, maltitol and lactol, 1,3-butylene glycol, polypropylene glycol, ethanol, modified ethanol as appropriate , Sugar alcohol reduced starch saccharose and the like can be used. The compounding quantity is suitably selected according to the form, purpose of use, etc. of the composition for oral cavity of this invention (normally, compounding quantity is 10 to 50% of the whole composition).

Examples of the thickener include carrageenan, sodium carboxymethyl cellulose, methyl cellulose, sodium hydroxyethyl cellulose, sodium alginate, xanthan gum, tracant gum, karaya gum, gum arabic, locust beam gum, polyvinyl alcohol, sodium polyacrylate, and carboxyvinyl polymer. , Polyvinylpyrrolidone, carbopol, silica gel, aluminum silica gel, bee gum, laponite and the like (usually 0.1 to 5% of the total composition).

Examples of sweetening agents include sodium saccharin, stevioside, stevia extract, paramethoxycinnamicaldehyde, neohespyridine dihydrochalcone, perillarutin, glycyrazine, taumatin, aspartylphenylalanine methyl ester, and the like. .

As the fragrance, menthol, anetol, carbon, eugenol, limonene, n-decyl alcohol, citronellol, α-terpineol, citronellyl acetate, cineol, rinnarol, ethylinalol, vanillin, thymol, Spearmint oil, peppermint oil, lemon oil, orange oil, sage oil, rosemary oil, cinnamon oil, pimento oil, cinnamon oil, purple soybean oil, copper green oil, sperm oil (Iii) or eucalyptus oil (usually 0.00001 to 1%).

In the composition of the present invention, in addition to these components, as an active ingredient or an active ingredient, enzymes such as dextranase, amylase, furotenase and mutanase, alkali metal monohulophosphates such as sodium monofluorophosphate and fluoride Anti-inflammatory agents such as fluorides such as sodium and fluorinated tin, trinexamic acid, epsilonaminocaproic acid, aluminium chlorhydroxyalantoin, azulene, glycyrrhizinate, glycyrrhetinic acid, sodium chloride, and vitamins; Disinfectants, such as copper chlorophyll, copper gluconate, cetylpyridium chloride, benzalkonium chloride, triclosan, hinokthiol, and lysozyme, polyphosphates, and tartar preventive agents, such as a zeolite, can also be mix | blended. In addition, the compounding quantity of the said active ingredient or an active ingredient can be made into an effective amount.

The pH of the toothpaste composition of this invention is 6-9 suitably. When pH is less than 6, tooth enamel may be damaged at the time of using toothpaste. Moreover, when pH exceeds 9, the adhesion inhibitory effect to tooth surface contamination may not be exhibited. Moreover, as a pH adjustment type, sodium hydroxide, sodium hydrogen phosphate, etc. are mentioned normally.

The material of the container containing the toothpaste composition of this invention is not specifically limited, Usually, the container used for a toothpaste composition can be used. Specifically, plastic containers such as polyethylene, polypropylene, polyethylene terephthalate, and nylon can be used.

Example

Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not limited to the following Example. In addition, in the following example, all compounding quantities are the mass%.

[Examples 1 to 9 and Comparative Examples 1 to 9]

Toothpaste compositions of the compositions shown in Tables 1 and 2 were prepared by the following production method.

Recipe for toothpaste composition:

(1) The A phase which mixed-dissolved the water component (except a binder, propylene glycol, etc.) in purified water at normal temperature was prepared.

(2) The B phase which disperse | distributed the binder in propylene glycol at normal temperature was prepared.

The B phase was added and mixed in the A phase under stirring, and the C phase was prepared.

(3) In phase C, components other than water-soluble components such as perfumes, abrasives, and surfactants are mixed at room temperature using 1.5 L kneader (manufactured by Ishiyama Corporation), degassed under reduced pressure, and 1.2 kg of toothpaste composition is prepared. Got.

Using the obtained test toothpaste, the tooth surface contamination inhibitory effect, the qualification with respect to the oral mucosa, and the foaming at the time of wiping were evaluated by the following method. In addition, evaluation of the tooth surface contamination adhesion inhibitory effect evaluated the inhibition of tannin iron adhesion which is a typical tooth surface contamination.

Test Method of Tannin Iron Stain Adhesion Inhibition Evaluation:

The surface of the hydroxy avatarite pellets (manufactured by Pentax, 7 mm in diameter x 3.5 mm in thickness) was subjected to sandblasting, and then washed with an ultrasonic cleaner in an aqueous neutral detergent solution. Lab value of pellets before etching tannin iron by using a spectrophotometer (Japan Electro-Color Industry Co., Ltd., Model: SE-2000) after etching (water for 10 minutes), washing the surface with 30% phosphoric acid aqueous solution. Was measured and L value was made into L0. In addition, a toothpaste dispersion prepared by diluting the prepared toothpaste with twice the amount of ion-exchanged water was prepared. To the pellets described above, the procedure of repeated immersion in a toothpaste dispersion → 0.5 mass% albumin aqueous solution → tannin extract → 0.6 mass% ferric citrate (III) ammonium aqueous solution for 1 hour was repeated 50 times, and dried at room temperature for 1 day. After wind, it wash | cleaned with running water, and it dried again by the wind, and produced the colored pellet. The tannin extract was placed in 1200 ml of boiled ion-exchanged water, 50 g of Japanese tea (name: Noson), 5 bags of black tea (Brisk Dibuck) and 12 g of instant coffee (Nescafe), and left overnight. Japanese tea and black tea were produced by filtration. The Lab value of the produced colored pellets was measured and L value was made into L1. In addition, the L value (L2) of the pellets which were treated with ion-exchanged water instead of the toothpaste dispersion was used as a control, and the inhibition of coloring contamination adhesion was calculated by the following equation, and the coloring contamination adhesion inhibition effect was calculated.

Color contamination adhesion inhibition rate (%) = [(L1-L2) / (L0-L2)] × 100

From the obtained stain stain adhesion inhibition, the cigarette removal effect was evaluated according to the following criteria,

Evaluation standard

◎: 60% or more suppression of coloring contamination adhesion

(Circle): 50% or more of coloring stain adhesion inhibition less than 60%

(Triangle | delta): 40% or more of coloring contamination adhesion suppression rate is less than 50%

X: Less than 40% of colored contamination adhesion inhibition

Method of evaluation of eligibility for oral mucosa:

Using 10 subjects sensitive to mucosa qualification, about 1 g of toothpaste composition of each composition shown in Table 1, 2 was taken in a toothbrush, and the grade of the qualification with respect to the oral mucosa when this brush was performed for 3 minutes was "qualified." We make "we feel strong" one point, "we feel qualification" two points, "we rarely feel qualification" three points, "we do not feel qualification" four points, and oral mucosa from the mean of ten people by the following standards The eligibility for was evaluated.

Evaluation standard ;

◎: 3.5 points or more and 4.0 points or less

(Circle): Average score 3.0 points or more and less than 3.5 points

Δ: 2.0 points or more and less than 3.0 points

X: Average point 1.0 or more and less than 2.0 points

How to evaluate foaming when brushing:

Using 10 subjects, about 1 g of toothpaste of each composition shown in Tables 1 and 2 was put in a toothbrush, and foaming when this wiping was performed for 3 minutes was "foam good" and "good foaming". We got answer in four steps of "a little bubble", "a little bubble". In this answer, we make three points of "bubble goodness" three points, "bubble goodness little" two points, "bubble little thing" with one point of "bubble goodness" one point, and from the average point of ten people The feeling of use was evaluated as a standard.

◎: 3.5 points or more and 4.0 points or less

(Circle): Average score 3.0 points or more and less than 3.5 points

Δ: 2.0 points or more and less than 3.0 points

×: 1.0 or more average points and less than 2.0 points

[Table 1]

* 1: The 30% article was used and the value in the table | surface showed the compounding quantity converted into the net fraction.

* 2: The component (D) was purely converted and the ratio of (C) / (D) was calculated using the value.

[Table 2]

* 1: The 30% article was used and the value in the table | surface showed the compounding quantity converted into the net fraction.

* 2: The component (D) was purely converted and the ratio of (C) / (D) was calculated using the value.

Tetrasodium pyrophosphate: manufactured by Taepyung Chemical Co., Ltd.

Sodium tripolyphosphate: Central Glass Co., Ltd.

Methyl vinyl ether maleic anhydride copolymer: manufactured by ISP (trade name: Kantoretsu AN-169)

Sodium lauryl sulfate: Toyo Chemical Co., Ltd.

2-palm oil alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium beta sodium (30% aqueous solution): Lion company make (brand name: enazicol C-4OH)

From Table 1, 2, the toothpaste composition (Examples 1-9) which contains the specific amount of (A)-(D) component of this invention, and whose mass ratio of (C) / (D) is 1-4 is the tooth surface Inhibition of fouling adhesion, qualification for oral mucosa, and foaming when brushing were all good. On the other hand, the toothpaste composition (Comparative Examples 1 to 9) lacking any one of the essential requirements of the present invention is sufficient in any one of the effect of inhibiting tooth surface contamination adhesion, qualification for oral mucosa, and foaming when brushing. The effect was not exerted.

Example 10 Cream Toothpaste

(A) 1.2% sodium pyrophosphate

(B) Kantoretsu AN-169 1.0

(C) sodium lauryl sulfate 1.2

(D) 2- Palm oil alkyl-N-carboxymethyl-N-hydroxyethylimidazoliniumbetaine sodium (* 1) 0.6

Silicic anhydride 25.0

70% Sorbit Liquid 20.0

Propylene Glycol 3.0

Carboxymethyl cellulose sodium 1.4

Saccharin Sodium 0.1

Potassium Glyciric Acid 1.0

Toraneksamsan 0.05

α-alumina anhydride 3.0

Methylparaben 0.05

Benzetonium Chloride 0.25

Spices 1.0

Dihydrogen Phosphate 1.0

water Remainder

Total 100.0%

* 1: The 30% article was used and the compounding quantity converted into pure parts was shown.

(C) / (D) = 2

Tannin iron stain suppression effect: ◎

Qualifications for the oral mucosa: ○

Foaming during use Evaluation: ○

It was confirmed that the above toothpaste composition has an anti-adhesion effect on tannin iron stain, which is a representative tooth surface contamination, is hypoallergenic to the oral mucosa, and foaming during use is high.

Example 11 Cream Toothpaste

(A) disodium pyrophosphate dipotassium 1.0%

(B) Kantoretsu AN-139 1.0

(C) sodium lauryl sulfate 1.2

(D) 2- Palm oil alkyl-N-carboxymethyl-N-hydroxyethylimidazoliniumbetaine sodium (* 1) 0.4

Aluminum Hydroxide 35.0

Titanium Oxide 2.0

85% Glycerin 20.0

Higeshiethyl cellulose sodium 1.4

Propylene Glycol 3.0.

Saccharin Sodium 0.1

Colloidal Silica 3.0

Sodium Fluoride 0.22

Trilosan 0.1

Methylparaben 0.05

Spices 1.0

water Remainder

Total 100.0%

* 1: The 30% article was used and the compounding quantity converted into pure parts was shown.

(C) / (D) = 3

Tannin iron stain suppression effect: ○

Qualifications for the oral mucosa: ◎

Foaming during use Evaluation: ○

It was confirmed that the above toothpaste composition had an anti-adhesion effect on tannin iron stain, which is a representative tooth surface contamination, is hypoallergenic to the oral mucosa, and foaming during use was also high.

Example 12 Cream Toothpaste

(A) pyrophosphate tetrasodium 0.8%

(B) Kantoretsu AN-119 1.0

(C) sodium lauryl sulfate 0.9

(D) 2- palm oil alkyl-N-carboxymethyl-N-hydroxyethylimidazoliniumbetaine sodium (* 1) 0.3

Silicic anhydride 30.0

70% Sorbit Liquid 20.0

85% Glycerin 10.0

Sodium Polyacrylate 1.5

Propylene Glycol 3.0

Saccharin Sodium 0.2

Sodium benzoate 0.3

Methyl paraoxybenzoate 0.1

Sodium Monofluorophosphate 0.76

Tocopherol Acetate 0.1

Spices 1.0

water Remainder

Total 100.0%

* 1: The 30% article was used and the compounding quantity converted into pure parts was shown.

(C) / (D) = 3

Tannin iron adhesion inhibitory effect: ○

Qualifications for the oral mucosa: ◎

Foaming during use Evaluation: ○

The dentifrice composition described above has an anti-adhesion effect on tannin iron stain, which is a representative tooth surface contamination, is hypoallergenic to the oral mucosa, and it is confirmed that foaming at the time of use is high.

Example 13 Liquid Toothpaste

(A) 1.0% sodium pyrophosphate

(B) Kantoretsu AN-139 2.0

(C) sodium lauryl sulfate 1.0

(D) Palm oil fatty acid amide propyl betaine (* 1) 0.4

Silicic anhydride 15.0

60% Sorbit Liquid 30.0

85% Glycerin 35.0

Xanthan Gum 0.2

Carrageenan 0.5

Sodium Alginate 1.0

Propylene Glycol 2.0.

Sodium Monofluorophosphate 0.76

Dextranase (1 million u / g) 0.5

Saccharin Sodium 0.1

Spices 1.0

water Remainder

Total 100.0%

* 1: The 30% article was used and the compounding quantity converted into pure parts was shown.

(C) / (D) = 2.5

Tannin iron stain suppression effect: ◎

Qualifications for the oral mucosa: ◎

Foaming during use Evaluation: ○

It was confirmed that the above toothpaste composition had an anti-adhesion effect on tannin iron stain, which is a representative tooth surface contamination, is hypoallergenic to the oral mucosa, and foaming during use was also high.

Example 14 Cream Toothpaste

(A) 1.0% sodium pyrophosphate

(B) Kantoretsu AN-169 1.2

(C) sodium lauryl sulfate 1.0

(D) 2- Palm oil alkyl-N-carboxymethyl-N-hydroxyethylimidazoliniumbetaine sodium (* 1) 0.5

Carboxymethylcellulose Sodium 1.2

70% Sorbet 30.0

Silicic anhydride 25.0

Propylene Glycol 2.5

Sodium Fluoride 0.21

Blue No. 1 0.0001

Spices 1.3

Aluminum oxide 2.0

4A zeolite 1.5

Saccharin Sodium 0.2

Titanium Oxide 0.2

water Remainder

Total 100.0%

* 1: The 30% article was used and the compounding quantity converted into pure parts was shown.

(C) / (D) = 2

Tannin iron stain suppression effect: ◎

Qualifications for the oral mucosa: ◎

Foaming rating when using: ◎

It was confirmed that the above toothpaste composition had an anti-adhesion effect on tannin iron stain, which is a representative tooth surface contamination, is hypoallergenic to the oral mucosa, and foaming during use was also high.

Example 15 Cream Toothpaste

(A) tetrasodium tetraphosphate 0.3%

(B) Kantoretsu AN-169 1.5

(C) sodium lauryl sulfate 1.2

(D) 2- Palm oil alkyl-N-carboxymethyl-N-hydroxyethylimidazoliniumbetaine sodium (* 1) 0.4

Silicic anhydride 25.0

70% Sorbet 30.0

Carboxymethylcellulose Sodium 1.2

Propylene Glycol 2.0

Saccharin Sodium 0.2

Sodium benzoate 0.3

Methyl paraoxybenzoate 0.1

Sodium Monofluorophosphate 0.76

Tocopherol Acetate 0.1

Spices 1.0

water Remainder

Total 100.0%

* 1: The 30% article was used and the compounding quantity converted into pure parts was shown.

(C) / (D) = 3

Tannin iron adhesion inhibitory effect: ○

Qualifications for the oral mucosa: ◎

Foaming rating when using: ◎

It was confirmed that the above toothpaste composition had an anti-adhesion effect on tannin iron stain, which is a representative tooth surface contamination, is hypoallergenic to the oral mucosa, and foaming during use was also high.

Claims (2)

(A) the general formula M _{n + 2} P _n O _{3n + 1,} at least one of a water soluble polyphosphate of a straight chain represented by the following (note that the formula, M represents Na or K, n is an integer of 2 or 3) species 0.3-1.2 mass%, (B) 0.1-2.0 mass% of the methylvinyl ether maleic anhydride copolymer whose viscosity of 2.0 mass% aqueous solution in 25 degreeC and pH7.0 is 5-1000 mPa * s, and (C) lauryl 0.6-2.0 mass% of sulfates, 0.2-1.0 mass% of (D) 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine, and also the combination of (C) / (D) Toothpaste composition, characterized in that the ratio is 1 to 4 by mass. The method of claim 1, In addition, dicalcium phosphate dihydrate, dicalcium phosphate anhydride, dibasic calcium phosphate, tricalcium phosphate, calcium pyrophosphate, calcium carbonate, aluminum hydroxide, alumina, magnesium carbonate, tertiary magnesium phosphate, insoluble sodium metaphosphate, 5 to 50% by mass of an abrasive selected from insoluble potassium metaphosphate, titanium oxide, zeolite, silicic anhydride, hydrous silicic acid, titanium silicate, zirconium silicate, and synthetic resin-based abrasives, sorbet, glycerin, propylene glycol, polyethylene glycol, 10 to 50 mass% of a viscous agent selected from xylitol, maltitol, lactol, 1,3-butylene glycol, polypropylene glycol, ethanol, modified ethanol, sugar alcohol reduced starch sugar saccharine, carrageenan, carboxymethyl cellulose sodium, Methyl cellulose, sodium hypogiethyl cellulose, sodium alginate, xanthan gum, tracant gum, karaya gum, gum arabic, locust beam gum 0.1-5 mass% of thickeners selected from polyvinyl alcohol, sodium polyacrylate, carboxyvinyl polymer, polyvinylpyrrolidone, carbopol, silica gel, aluminum silica gel, bee gum and laponite, (Iii) A toothpaste composition prepared as a composition.