JP5572346B2 - Oral composition - Google Patents

Description

  The present invention relates to an oral composition containing catechins.

It is known that cavity and periodontal disease are caused by oral bacteria. Therefore, in order to prevent cavity and periodontal disease, it is common to add a bactericidal agent to the oral composition to sterilize oral bacteria or suppress their activity. In particular, in recent years, natural ingredients have been attracting attention as fungicides as natural orientation has increased. For example, it is known that a green tea extract and a tea polyphenol compound (catechins or the like) that is a component thereof are effective in suppressing the growth of oral bacteria (for example, Patent Documents 1 to 3). According to these documents, the green tea extract and the like prevent the growth of Sterotococcus mutans, which is a causative agent of cavity, and Porphyromonas gingivalis, which is a causative agent of periodontal disease, so that the oral cavity effective in preventing cavity and periodontal disease. It is described that a composition can be provided.
However, since polyphenol compounds (catechins and the like) are oxidized and polymerized by contact with oxygen and change their color significantly, discoloration over time of the oral composition containing the same is inevitable.

  As a method for suppressing these discolorations, in addition to a general method of blending an antioxidant such as ascorbic acid, a plant extract containing polyphenol as described in Patent Document 4 is added to a sugar alcohol having 4 to 5 carbon atoms ( For example, a method of blending xylitol, erythritol and the like into oxygen-impermeable individual bags has been proposed. In addition, it has been reported that catechins can be stably retained by blending hydrogel particles encapsulating catechins in a polymer that forms a water-insoluble complex with catechins in an oral composition (Patent Literature). 5).

JP-A-1-90124 JP-A-2-25413 Japanese Patent Laid-Open No. 3-86814 JP 2000-297022 A JP 2008-24652 A

According to the methods described in Patent Documents 4 and 5, discoloration of the oral composition in a state stored in a container can be prevented. However, even if preventing the discoloration of the oral composition stored in the container, if the oral composition containing catechins is taken out of the container and used continuously for a long time, the used toothbrush and washstand will It has been found that catechins may cause coloring, and the coloring due to long-term use may not be sufficiently prevented even with the dentifrices of Patent Documents 4 and 5.
Therefore, the subject of this invention is providing the composition for oral cavity which contains catechins and can prevent the coloring of a toothbrush and a washstand by continuous use effectively.

  Therefore, the present inventor has conducted various studies on coloring prevention means by continuous use of the catechin-containing oral composition, and the coloring cannot be prevented even by an antioxidant such as ascorbic acid, but a certain amount of polyphosphoric acid or a salt thereof. It was found that the organic acid having a chelate effect is not more than a specific amount and can be remarkably prevented by adjusting to a specific pH.

That is, the present invention includes the following components (A) and (B):
(A) Catechin 0.002 to 2 mass%,
(B) Polyphosphoric acid or its salt 0.05-2 mass%
And the mass ratio (A: B) of the component (A) to the component (B) is 2: 1 to 1:25, and (C) does not contain an organic acid having a chelating effect and a salt thereof. The composition for oral cavity which contains 0.8 mass% or less and pH is 5-7 is provided.

  Even if it uses continuously, the composition for oral cavity of this invention prevents coloring of the used toothbrush and a washstand, and exhibits the bactericidal effect by catechins stably.

  The component (A) catechins used in the present invention are non-polymerizable catechins, for example, non-epimeric catechins such as catechin, gallocatechin, catechin gallate, gallocatechin gallate; epicatechin, epigallocatechin, epi Examples include epicatechins such as catechin gallate and epigallocatechin gallate. The catechins are preferably tea catechins and can be obtained by concentrating and purifying a green tea extract extracted from tea leaves with hot water or a water-soluble organic solvent. In addition, by using green tea extract concentrates such as commercially available Mitsui Norin Co., Ltd. “Polyphenone”, ITO EN Co., Ltd. “Theafuran”, Taiyo Kagaku Co., Ltd. “Sunphenon”, etc., by adjusting the components, A catechin suitable for the purpose can be obtained.

  The content of the catechins in the oral composition of the present invention is such that the catechins sufficiently act on the gums, and from the viewpoint of preventing flavoring of the oral composition and coloring of the toothbrush and the like, 0.002 to 2 masses %, Preferably 0.01 to 1.5% by mass, more preferably 0.02 to 1% by mass.

  Examples of (B) polyphosphoric acid used in the present invention include condensed polyphosphoric acid having 3 or more phosphoric acids, and tripolyphosphoric acid, tetrapolyphosphoric acid, pentapolyphosphoric acid, hexametaphosphoric acid, ultrapolyphosphoric acid and hydrates thereof. included. It is important that orthophosphoric acid is polyphosphoric acid because it cannot provide a sufficient anti-coloring effect on toothbrushes. Further, as the salt of polyphosphoric acid, alkali metal salts such as sodium salt and potassium salt are preferable, and sodium polyphosphate is particularly preferable from the viewpoint of coloring prevention effect on toothbrushes.

  The content of (B) polyphosphoric acid or a salt thereof in the oral cavity composition of the present invention is from 0.05 to 0.05 in terms of the effect of preventing coloration on toothbrushes and washstands and the flavor of the oral cavity composition (preventing the appearance of salty taste). 2 mass%, preferably 0.1 to 1.5 mass%, more preferably 0.15 to 1.2 mass%.

  Moreover, the mass ratio (A: B) of the component (A) and the component (B) in the oral cavity composition of the present invention is such that the bactericidal effect by catechins, the effect of preventing coloration on toothbrushes and the like (salt taste by polyphosphoric acid). From the viewpoint of balance, it is 2: 1 to 1:25, preferably 2: 1 to 1:10, and more preferably 1.5: 1 to 1: 5.

The composition for oral cavity of the present invention further does not contain (C) an organic acid having a chelating effect or a salt thereof, or 0.8% by mass or less. From the viewpoint of preventing the coloring of toothbrushes and the like and suppressing the discoloration of the oral composition by catechins, (C) the organic acid having a chelating effect or a salt thereof may contain 0.01 to 0.8% by mass. Preferably, it is more preferable to contain 0.01-0.4 mass%. Examples of organic acids having a chelating effect include malic acid, citric acid, lactic acid, succinic acid, tartaric acid, fumaric acid, gluconic acid and the like, and malic acid, citric acid, lactic acid, succinic acid, tartaric acid, fumaric acid in terms of flavor. Acids are preferred, and malic acid, lactic acid, and tartaric acid are particularly preferred.
Examples of these organic acid salts having a chelating effect include alkali metal salts such as sodium salts and potassium salts.

  In addition, the mass ratio (A: C) of the component (A) and the component (C) in the case of containing (C) an organic acid having a chelate effect or a salt thereof is the balance between the anti-coloring effect on the toothbrush and the flavor. From the point, 15: 1 to 1: 2.5 are preferable, and 10: 1 to 1: 2 are more preferable.

The composition for oral cavity of the present invention preferably contains an antioxidant from the viewpoint of suppressing discoloration of catechins. Antioxidants include antioxidant or reducing components that can be used in oral compositions such as L-ascorbic acid or salts thereof, erythorbic acid or salts thereof, rosemary extract, stevia extract, Sunflower seed extract, propyl gallate, dibutylhydroxytoluene, butylhydroxyanisole, L-cysteine hydrochloride, hydroquinone and its glycoside, nordihydroguaiaretic acid, ascorbic acid higher fatty acid ester (lauric acid ester, stearic acid ester) , Isostearic acid ester, palmitic acid ester, etc.), guaiac fat and the like. Examples of ascorbic acid salts include sodium salts and potassium salts, and examples of erythorbic acid salts include sodium salts, calcium salts, ferrous salts, and palmitic acid ester salts. These antioxidants may be used alone or in combination of two or more. The antioxidant is preferably ascorbic acid or a salt thereof from the viewpoint of flavor.
Content of antioxidant is 0.0005-5 mass% in the composition for oral cavity of this invention from the point of the discoloration suppression of the external color of the composition for oral cavity by catechins, Furthermore, 0.001-2 mass% In particular, 0.01 to 1% by mass is preferable.

  The pH of the composition for oral cavity of the present invention is preferably 5 to 7, more preferably 5 to 6.5. By adjusting the pH to 5 to 7, the catechins in the oral composition can be stabilized, the effect of preventing coloring to a toothbrush and the like can be obtained, and the flavor can be improved. In order to adjust pH to the said range, a pH adjuster can be used. As a pH adjuster, as long as it does not inhibit the discoloration suppressing effect of catechins and does not impair the usability, orthophosphoric acid, hydroxide such as sodium hydroxide, ammonia or aqueous ammonia, lower alkanolamines, arginine, lysine These may be used alone or in combination of two or more.

  In the oral composition of the present invention, other compounding ingredients that can be used in the oral composition, such as abrasives, foaming agents, wetting agents, sweeteners, flavoring agents, preservatives, various medicinal ingredients, water, ethanol Etc. may be appropriately blended within a range that does not impair the object of the present invention. Moreover, the composition for oral cavity of this invention suppresses discoloration of the external color of the composition for oral cavity by catechins, and from the viewpoint of making catechins act effectively, catechins are added to the hydrogel particles described in Patent Document 5. As described in Patent Document 4, a packaging form in which sugar alcohol having 4 to 5 carbon atoms (for example, xylitol, erythritol, etc.) is blended or sealed in an oxygen-impermeable individual bag is adopted. May be.

  Examples of the foaming agent include an anionic surfactant, a nonionic surfactant, a cationic surfactant, and an amphoteric surfactant.

Examples of the anionic surfactant include acyl amino acid salts such as sodium acyl glutamate and acyl sarcosine sodium, alkyl phosphates such as sodium alkyl phosphate, alkyl sulfate salts, higher fatty acid sulfonated monoglyceride salts, fatty acid esters of isethionic acid. Salt, N-methyl long chain acyl taurine sodium salt, polyoxyethylene monoalkyl phosphate and the like. The hydrophobic alkyl group and acyl group in these anionic surfactants preferably have 6 to 18 carbon atoms, particularly 10 to 14 carbon atoms. The salt is preferably a sodium salt. As the anionic surfactant, an alkyl sulfate ester salt is particularly preferable from the viewpoint of good foamability and availability at low cost.
It is preferable to contain 0-5 mass% of an anionic surfactant in the composition for oral cavity of this invention, More preferably, it is 0-2 mass%.

Nonionic surfactants include, for example, polyoxyalkylene addition surfactants, amine oxide surfactants, mono- or diethanolamide surfactants, sorbitan fatty acid esters, glycerin fatty acid esters, polyglycerin fatty acid esters, sucrose fatty acids. Mention may be made of esters. Among these, sorbitan fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, and sucrose fatty acid ester are preferable, and polyglycerin fatty acid ester such as monostearic acid decaglycerin and monomyristic acid pentaglycerin is particularly preferable. In the present invention, one or more of these can be used.
Content of a nonionic surfactant is 0.1-30 mass% in the composition for oral cavity of this invention, More preferably, it is 0.2-10 mass%.

  As the wetting agent, glycerin, sorbitol, polyethylene glycol, propylene glycol, 1,3-butylene glycol, xylitol, maltitol, lactitol, trehalose and the like are preferably used. In addition, erythritol is preferably used in terms of cooling and flavor.

  The oral composition of the present invention can be a toothpaste composition, a liquid toothpaste composition, a gel-like toothpaste composition, a mouthwash, or the like depending on its use.

  Unless otherwise specified,% in the examples is% by mass.

(Toothbrush coloring test with dentifrice)
A dentifrice having the formulation shown in Table 1 was produced, and a coloring test on a toothbrush was performed using this dentifrice. Specifically, using a toothbrush (Puola Compact Head) as a coloring model, the following treatments 1 to 5 were repeated 5 times for each dentifrice, and the colorability was evaluated. The flavor was evaluated.

1) The coloring model was set on a brushing machine, 1.5 g of a dentifrice was applied to the brushing area of the surface to be brushed in the brushing machine, 200 g of pressure was applied, and brushing was performed twice for 1 minute at 120 strokes / min. Before the second brushing, the brushing area dentifrice was centered with a spatula and an additional 0.5 g dentifrice was added.
2) After washing with water for 30 seconds, it was air-dried with an air blower at room temperature (25 ° C.) for 2 minutes.
3) The colored model is rinsed with an aqueous solution of 1% by weight calcium chloride. Specifically, taking out the colored model immediately after dipping is repeated five times. After rinsing, it was dried at room temperature (25 ° C.) until there was no moisture.
4) Test 1 was immersed in a 1% aqueous solution of albumin (BSA) for 1 minute.
Test 2 was immersed in an aqueous solution of albumin (BSA) 1% and sheep serum 1% for 1 minute.
(Albumin (BSA) was 95% purity manufactured by Wako Pure Chemical Industries, Ltd.)
5) Test 1 was dried overnight at room temperature (25 ° C).
Test 2 was dried overnight in a 50 ° C. thermostat.

Table 1 shows the coloring property of the coloring model by each dentifrice and the evaluation of the flavor of the dentifrice. The evaluation of flavor was carried out by three people, and an evaluation common to two or more people was adopted. The coloring evaluation was performed visually.
Evaluation of coloring 0: Almost not colored to 5: Clearly browned until the degree of coloring was evaluated with a numerical value of 1 to 5.
Evaluation of flavor A: Good B: Feels slightly salty but good C: Feels slightly salty D: Feels salty

  As is apparent from Table 1, Comparative Example 2 that did not contain tripolyphosphoric acid produced coloration. On the other hand, although the coloring of Comparative Example 1 containing tripolyphosphoric acid was suppressed, saltiness was confirmed because it contained 4% by mass. In Example 1, coloring of the toothbrush by tea catechin was suppressed, and the flavor was also good.

(Coloring test with mouthwash)
Mouthwashes with the formulations shown in Table 2 were prepared, and using this mouthwash, a color test on synthetic resin and ceramics was performed. Specifically, as a coloring model, test 3 uses a polyacetal resin (MISSUMI PASH-20-20-2.0), test 4 uses a tile (INAX JM-35 / 20B-D), and the mouthwash of Table 2 After the following treatments 1) to 5) were repeated 10 times, the colorability was evaluated, and the flavor of the mouthwash was also evaluated. The polyacetal resin used was that whose surface was scratched with abrasive paper (# 400).

1) The colored model was immersed in a 1% aqueous solution of albumin (BSA) for 1 minute. Albumin was the same as in the dentifrice coloring test.
2) The colored model was rinsed with artificial saliva. Specifically, the colored model was immersed in artificial saliva and immediately taken out five times.
3) The colored model was rinsed with the mouthwash of Table 2. Specifically, the colored model was immersed in a mouthwash and immediately taken out five times.
4) The colored model was dried with an air blower for 20 seconds.
5) The colored model was immersed in purified water for 5 minutes.

The colorability was evaluated using the L ^* a ^* b ^* color system (CIE 1976) based on the absolute value of the change amount Δb ^* of the b ^* value before and after the aforementioned color test. Specifically, coloring models before and after the coloring test were placed on a white plate, and L ^* a ^* b ^* was measured using a shade eye NCC (Matsukaze). Five points were measured for each model, and the average value of three points excluding the maximum and minimum values was taken as L ^* a ^* b ^* for each model. I caught a pre-colored test b ^* from the b ^* value after coloring test to determine the Δb ^*.
The flavor was evaluated in the same manner as the dentifrice.

  As is clear from Table 2, Comparative Examples 3 and 4 containing tea catechins and containing malic acid exceeding 0.8% by mass were colored on tiles despite containing tripolyphosphoric acid. However, saltiness was also felt. Further, in Comparative Example 5 in which the content of sodium tripolyphosphate was less than 1/2 by weight with respect to tea catechin (28% with respect to tea catechin), coloring to the tile could not be prevented. In addition, Comparative Example 6 in which the content of sodium tripolyphosphate was too large (3% by mass) had a strong salty taste. On the other hand, the mouthwash of the present invention containing a specific amount of tea catechin and tripolyphosphoric acid or a salt thereof and containing 0.8% by mass or less of malic acid having a chelating effect is prevented from coloring to tiles, etc. And the flavor was also good.

Claims (3)

The following components (A) and (B):
(A) Catechin 0.002 to 2 mass%,
(B) Condensed polyphosphoric acid or salt thereof selected from tripolyphosphoric acid, tetrapolyphosphoric acid, pentapolyphosphoric acid, hexametaphosphoric acid, ultrapolyphosphoric acid and salts thereof 0.05 to 1.5 % by mass
The mass ratio (A: B) of component (A) to component (B) is 2: 1 to 1:25,
(C) The composition for oral cavity which does not contain the organic acid which has a chelate effect, or its salt, or contains 0.8 mass% or less, and pH is 5-7.   The component (C) is at least one selected from malic acid, citric acid, lactic acid, succinic acid, tartaric acid, fumaric acid and salts thereof, and the content thereof is 0.01 to 0.8% by mass. The composition for oral cavity according to 1.   The composition for oral cavity according to claim 1 or 2, wherein the mass ratio (A: C) of the component (A) to the component (C) is 15: 1 to 1: 2.5.