JP5572346B2 - Oral composition - Google Patents
Oral composition Download PDFInfo
- Publication number
- JP5572346B2 JP5572346B2 JP2009196135A JP2009196135A JP5572346B2 JP 5572346 B2 JP5572346 B2 JP 5572346B2 JP 2009196135 A JP2009196135 A JP 2009196135A JP 2009196135 A JP2009196135 A JP 2009196135A JP 5572346 B2 JP5572346 B2 JP 5572346B2
- Authority
- JP
- Japan
- Prior art keywords
- acid
- mass
- composition
- coloring
- catechins
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 title claims description 41
- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 claims description 32
- 235000005487 catechin Nutrition 0.000 claims description 32
- 210000000214 mouth Anatomy 0.000 claims description 19
- 150000003839 salts Chemical class 0.000 claims description 19
- 230000000694 effects Effects 0.000 claims description 17
- 239000002253 acid Substances 0.000 claims description 9
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 9
- 229920000137 polyphosphoric acid Polymers 0.000 claims description 9
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 8
- 150000007524 organic acids Chemical class 0.000 claims description 7
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 6
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims description 6
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 6
- 239000001630 malic acid Substances 0.000 claims description 6
- 235000011090 malic acid Nutrition 0.000 claims description 6
- UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 claims description 6
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 claims description 5
- 229950001002 cianidanol Drugs 0.000 claims description 5
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 4
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 4
- 239000004310 lactic acid Substances 0.000 claims description 4
- 235000014655 lactic acid Nutrition 0.000 claims description 4
- 239000011975 tartaric acid Substances 0.000 claims description 4
- 235000002906 tartaric acid Nutrition 0.000 claims description 4
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims description 3
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 claims description 3
- 239000013522 chelant Substances 0.000 claims description 3
- 235000015165 citric acid Nutrition 0.000 claims description 3
- 239000001530 fumaric acid Substances 0.000 claims description 3
- 235000011087 fumaric acid Nutrition 0.000 claims description 3
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 3
- 235000002639 sodium chloride Nutrition 0.000 claims 1
- 238000004040 coloring Methods 0.000 description 31
- -1 polyphenol compound Chemical class 0.000 description 28
- 150000001765 catechin Chemical class 0.000 description 27
- 239000000796 flavoring agent Substances 0.000 description 15
- 238000012360 testing method Methods 0.000 description 15
- 235000019634 flavors Nutrition 0.000 description 14
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 12
- 239000000551 dentifrice Substances 0.000 description 12
- 235000014113 dietary fatty acids Nutrition 0.000 description 12
- 239000000194 fatty acid Substances 0.000 description 12
- 229930195729 fatty acid Natural products 0.000 description 12
- 238000002845 discoloration Methods 0.000 description 9
- 239000002324 mouth wash Substances 0.000 description 9
- 239000003963 antioxidant agent Substances 0.000 description 8
- 235000006708 antioxidants Nutrition 0.000 description 8
- 229940051866 mouthwash Drugs 0.000 description 8
- WMBWREPUVVBILR-WIYYLYMNSA-N (-)-Epigallocatechin-3-o-gallate Chemical compound O([C@@H]1CC2=C(O)C=C(C=C2O[C@@H]1C=1C=C(O)C(O)=C(O)C=1)O)C(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-WIYYLYMNSA-N 0.000 description 6
- 230000003078 antioxidant effect Effects 0.000 description 6
- 230000001680 brushing effect Effects 0.000 description 6
- 238000011156 evaluation Methods 0.000 description 6
- 102000009027 Albumins Human genes 0.000 description 5
- 108010088751 Albumins Proteins 0.000 description 5
- 239000003945 anionic surfactant Substances 0.000 description 5
- 229960005070 ascorbic acid Drugs 0.000 description 5
- 230000000052 comparative effect Effects 0.000 description 5
- 159000000000 sodium salts Chemical class 0.000 description 5
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 4
- 244000269722 Thea sinensis Species 0.000 description 4
- 239000007864 aqueous solution Substances 0.000 description 4
- 235000010323 ascorbic acid Nutrition 0.000 description 4
- 239000011668 ascorbic acid Substances 0.000 description 4
- 125000004432 carbon atom Chemical group C* 0.000 description 4
- 229940094952 green tea extract Drugs 0.000 description 4
- 235000020688 green tea extract Nutrition 0.000 description 4
- 208000028169 periodontal disease Diseases 0.000 description 4
- 235000013616 tea Nutrition 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 3
- 239000004386 Erythritol Substances 0.000 description 3
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- 229910019142 PO4 Inorganic materials 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 3
- 125000002252 acyl group Chemical group 0.000 description 3
- XMOCLSLCDHWDHP-IUODEOHRSA-N epi-Gallocatechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@H]2O)=CC(O)=C(O)C(O)=C1 XMOCLSLCDHWDHP-IUODEOHRSA-N 0.000 description 3
- 235000019414 erythritol Nutrition 0.000 description 3
- 229940009714 erythritol Drugs 0.000 description 3
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 description 3
- LVJJFMLUMNSUFN-UHFFFAOYSA-N gallocatechin gallate Natural products C1=C(O)C=C2OC(C=3C=C(O)C(O)=CC=3)C(O)CC2=C1OC(=O)C1=CC(O)=C(O)C(O)=C1 LVJJFMLUMNSUFN-UHFFFAOYSA-N 0.000 description 3
- 235000011187 glycerol Nutrition 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 239000002736 nonionic surfactant Substances 0.000 description 3
- 235000021317 phosphate Nutrition 0.000 description 3
- 235000011007 phosphoric acid Nutrition 0.000 description 3
- 235000013824 polyphenols Nutrition 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 239000004094 surface-active agent Substances 0.000 description 3
- 239000000606 toothpaste Substances 0.000 description 3
- 229940034610 toothpaste Drugs 0.000 description 3
- 239000000811 xylitol Substances 0.000 description 3
- 235000010447 xylitol Nutrition 0.000 description 3
- 229960002675 xylitol Drugs 0.000 description 3
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 3
- LSHVYAFMTMFKBA-PZJWPPBQSA-N (+)-catechin-3-O-gallate Chemical compound O([C@H]1CC2=C(O)C=C(C=C2O[C@@H]1C=1C=C(O)C(O)=CC=1)O)C(=O)C1=CC(O)=C(O)C(O)=C1 LSHVYAFMTMFKBA-PZJWPPBQSA-N 0.000 description 2
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- 239000000120 Artificial Saliva Substances 0.000 description 2
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 2
- WMBWREPUVVBILR-UHFFFAOYSA-N GCG Natural products C=1C(O)=C(O)C(O)=CC=1C1OC2=CC(O)=CC(O)=C2CC1OC(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-UHFFFAOYSA-N 0.000 description 2
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 description 2
- XMOCLSLCDHWDHP-UHFFFAOYSA-N L-Epigallocatechin Natural products OC1CC2=C(O)C=C(O)C=C2OC1C1=CC(O)=C(O)C(O)=C1 XMOCLSLCDHWDHP-UHFFFAOYSA-N 0.000 description 2
- 235000021314 Palmitic acid Nutrition 0.000 description 2
- 229930182556 Polyacetal Natural products 0.000 description 2
- ZTHYODDOHIVTJV-UHFFFAOYSA-N Propyl gallate Chemical compound CCCOC(=O)C1=CC(O)=C(O)C(O)=C1 ZTHYODDOHIVTJV-UHFFFAOYSA-N 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- 229910052783 alkali metal Inorganic materials 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 231100000676 disease causative agent Toxicity 0.000 description 2
- 235000012734 epicatechin Nutrition 0.000 description 2
- DZYNKLUGCOSVKS-UHFFFAOYSA-N epigallocatechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3cc(O)c(O)c(O)c3 DZYNKLUGCOSVKS-UHFFFAOYSA-N 0.000 description 2
- 239000004088 foaming agent Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000000017 hydrogel Substances 0.000 description 2
- SUMDYPCJJOFFON-UHFFFAOYSA-N isethionic acid Chemical compound OCCS(O)(=O)=O SUMDYPCJJOFFON-UHFFFAOYSA-N 0.000 description 2
- HCZKYJDFEPMADG-TXEJJXNPSA-N masoprocol Chemical compound C([C@H](C)[C@H](C)CC=1C=C(O)C(O)=CC=1)C1=CC=C(O)C(O)=C1 HCZKYJDFEPMADG-TXEJJXNPSA-N 0.000 description 2
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N n-hexadecanoic acid Natural products CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
- 239000003002 pH adjusting agent Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
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- 229920006324 polyoxymethylene Polymers 0.000 description 2
- 159000000001 potassium salts Chemical class 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
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- 235000019600 saltiness Nutrition 0.000 description 2
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- FSYKKLYZXJSNPZ-UHFFFAOYSA-N sarcosine Chemical compound C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 description 2
- 235000019832 sodium triphosphate Nutrition 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- 150000005846 sugar alcohols Chemical class 0.000 description 2
- 238000011282 treatment Methods 0.000 description 2
- 239000000080 wetting agent Substances 0.000 description 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 1
- XMOCLSLCDHWDHP-SWLSCSKDSA-N (+)-Epigallocatechin Natural products C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC(O)=C(O)C(O)=C1 XMOCLSLCDHWDHP-SWLSCSKDSA-N 0.000 description 1
- PFTAWBLQPZVEMU-ZFWWWQNUSA-N (+)-epicatechin Natural products C1([C@@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-ZFWWWQNUSA-N 0.000 description 1
- WMBWREPUVVBILR-GHTZIAJQSA-N (+)-gallocatechin gallate Chemical compound O([C@H]1CC2=C(O)C=C(C=C2O[C@@H]1C=1C=C(O)C(O)=C(O)C=1)O)C(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-GHTZIAJQSA-N 0.000 description 1
- PFTAWBLQPZVEMU-UKRRQHHQSA-N (-)-epicatechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-UKRRQHHQSA-N 0.000 description 1
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- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
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- 229930182470 glycoside Natural products 0.000 description 1
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- GNYGXCHYOXCZON-UHFFFAOYSA-N octadecanoic acid;propane-1,2,3-triol Chemical compound OCC(O)CO.OCC(O)CO.OCC(O)CO.OCC(O)CO.OCC(O)CO.OCC(O)CO.OCC(O)CO.OCC(O)CO.OCC(O)CO.OCC(O)CO.CCCCCCCCCCCCCCCCCC(O)=O GNYGXCHYOXCZON-UHFFFAOYSA-N 0.000 description 1
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- HELXLJCILKEWJH-NCGAPWICSA-N rebaudioside A Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HELXLJCILKEWJH-NCGAPWICSA-N 0.000 description 1
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Landscapes
- Cosmetics (AREA)
Description
本発明は、カテキン類を含む口腔用組成物に関する。 The present invention relates to an oral composition containing catechins.
むし歯や歯周病は、口腔内細菌が原因であることが知られている。従って、むし歯や歯周病を予防するために、口腔用組成物に殺菌剤を配合し、口腔内細菌を殺菌もしくはその活性を抑えることが一般的である。特に近年、天然志向が高まる中、殺菌剤として天然物由来の成分が注目されている。例えば、緑茶抽出物及びその成分である茶ポリフェノール化合物(カテキン類等)は口腔内細菌の増殖抑制に有効であることが知られている(例えば、特許文献1〜3等)。これらの文献によると、緑茶抽出物等は、むし歯の原因菌であるStereptcoccus mutansや歯周病の原因菌とされるPorphyromonas gingivalisの増殖を阻止するため、むし歯、歯周病の予防に有効な口腔用組成物を提供できることが記載されている。
しかしながら、ポリフェノール化合物(カテキン類等)は酸素に触れることにより酸化、重合がおこり、顕著に変色するため、それを配合した口腔用組成物自体の経時変色は避けられない。
It is known that cavity and periodontal disease are caused by oral bacteria. Therefore, in order to prevent cavity and periodontal disease, it is common to add a bactericidal agent to the oral composition to sterilize oral bacteria or suppress their activity. In particular, in recent years, natural ingredients have been attracting attention as fungicides as natural orientation has increased. For example, it is known that a green tea extract and a tea polyphenol compound (catechins or the like) that is a component thereof are effective in suppressing the growth of oral bacteria (for example, Patent Documents 1 to 3). According to these documents, the green tea extract and the like prevent the growth of Sterotococcus mutans, which is a causative agent of cavity, and Porphyromonas gingivalis, which is a causative agent of periodontal disease, so that the oral cavity effective in preventing cavity and periodontal disease. It is described that a composition can be provided.
However, since polyphenol compounds (catechins and the like) are oxidized and polymerized by contact with oxygen and change their color significantly, discoloration over time of the oral composition containing the same is inevitable.
これらの変色を抑制する方法として、アスコルビン酸等の酸化防止剤を配合する一般的な方法のほか、特許文献4に記載のようにポリフェノールを含む植物抽出物に炭素数4〜5の糖アルコール(例えばキシリトール、エリスリトール等)を配合し酸素不透過性の個袋に分封する方法が提案されている。また、カテキン類をカテキン類と水不溶性複合体を形成するポリマー中に内包したハイドロゲル粒子を口腔用組成物中に配合することにより、カテキン類を安定に保持できることが報告されている(特許文献5)。 As a method for suppressing these discolorations, in addition to a general method of blending an antioxidant such as ascorbic acid, a plant extract containing polyphenol as described in Patent Document 4 is added to a sugar alcohol having 4 to 5 carbon atoms ( For example, a method of blending xylitol, erythritol and the like into oxygen-impermeable individual bags has been proposed. In addition, it has been reported that catechins can be stably retained by blending hydrogel particles encapsulating catechins in a polymer that forms a water-insoluble complex with catechins in an oral composition (Patent Literature). 5).
前記特許文献4、5に記載の方法によれば、容器中に保存した状態における口腔用組成物の変色は防止できる。しかし、容器内に保存されている口腔用組成物の変色を防止したとしても、カテキン類を含有する口腔用組成物を容器から出して長期間使用し続けると、使用した歯ブラシや洗面台は、カテキン類が原因で着色する場合があることが判明し、当該長期間使用による着色は特許文献4及び5の歯磨剤でも十分防止できない場合があることが判明した。
従って、本発明の課題は、カテキン類を含有し、かつ継続使用による歯ブラシや洗面台の着色を効果的に防止することができる口腔用組成物を提供するものである。
According to the methods described in Patent Documents 4 and 5, discoloration of the oral composition in a state stored in a container can be prevented. However, even if preventing the discoloration of the oral composition stored in the container, if the oral composition containing catechins is taken out of the container and used continuously for a long time, the used toothbrush and washstand will It has been found that catechins may cause coloring, and the coloring due to long-term use may not be sufficiently prevented even with the dentifrices of Patent Documents 4 and 5.
Therefore, the subject of this invention is providing the composition for oral cavity which contains catechins and can prevent the coloring of a toothbrush and a washstand by continuous use effectively.
そこで本発明者は、カテキン類含有口腔用組成物の継続使用による着色防止手段について種々検討したところ、その着色は、アスコルビン酸等の酸化防止剤でも防止できないが、一定量のポリリン酸又はその塩を含有し、キレート効果を有する有機酸を特定量以下とし、特定のpHに調整することにより顕著に防止できることを見出した。 Therefore, the present inventor has conducted various studies on coloring prevention means by continuous use of the catechin-containing oral composition, and the coloring cannot be prevented even by an antioxidant such as ascorbic acid, but a certain amount of polyphosphoric acid or a salt thereof. It was found that the organic acid having a chelate effect is not more than a specific amount and can be remarkably prevented by adjusting to a specific pH.
すなわち、本発明は、次の成分(A)及び(B):
(A)カテキン類 0.002〜2質量%、
(B)ポリリン酸又はその塩 0.05〜2質量%
を含有し、成分(A)と成分(B)の質量比(A:B)が2:1〜1:25であって、(C)キレート効果のある有機酸及びその塩を含有しないか0.8質量%以下含有し、pHが5〜7である口腔用組成物を提供するものである。
That is, the present invention includes the following components (A) and (B):
(A) Catechin 0.002 to 2 mass%,
(B) Polyphosphoric acid or its salt 0.05-2 mass%
And the mass ratio (A: B) of the component (A) to the component (B) is 2: 1 to 1:25, and (C) does not contain an organic acid having a chelating effect and a salt thereof. The composition for oral cavity which contains 0.8 mass% or less and pH is 5-7 is provided.
本発明の口腔用組成物は、継続使用しても使用した歯ブラシや洗面台の着色を防止し、かつカテキン類による殺菌効果を安定して発揮する。 Even if it uses continuously, the composition for oral cavity of this invention prevents coloring of the used toothbrush and a washstand, and exhibits the bactericidal effect by catechins stably.
本発明に用いられる成分(A)カテキン類としては、非重合性カテキン類であって、例えばカテキン、ガロカテキン、カテキンガレート、ガロカテキンガレート等の非エピ体カテキン類;エピカテキン、エピガロカテキン、エピカテキンガレート、エピガロカテキンガレート等のエピ体カテキン類などが挙げられる。カテキン類は、茶カテキン類が好ましく、茶葉から熱水もしくは水溶性有機溶媒により抽出された緑茶抽出物を濃縮、精製等を行うことによって得ることができる。また、市販の三井農林(株)「ポリフェノン」、伊藤園(株)「テアフラン」、太陽化学(株)「サンフェノン」などの緑茶抽出物の濃縮物を用い、成分調整を行うことにより、本発明の目的に適うカテキン類を得ることができる。 The component (A) catechins used in the present invention are non-polymerizable catechins, for example, non-epimeric catechins such as catechin, gallocatechin, catechin gallate, gallocatechin gallate; epicatechin, epigallocatechin, epi Examples include epicatechins such as catechin gallate and epigallocatechin gallate. The catechins are preferably tea catechins and can be obtained by concentrating and purifying a green tea extract extracted from tea leaves with hot water or a water-soluble organic solvent. In addition, by using green tea extract concentrates such as commercially available Mitsui Norin Co., Ltd. “Polyphenone”, ITO EN Co., Ltd. “Theafuran”, Taiyo Kagaku Co., Ltd. “Sunphenon”, etc., by adjusting the components, A catechin suitable for the purpose can be obtained.
本発明の口腔用組成物におけるカテキン類の含有量は、カテキン類が歯ぐきに対して十分に作用し、口腔用組成物の香味及び歯ブラシ等への着色防止の観点から、0.002〜2質量%であって、0.01〜1.5質量%が好ましく、0.02〜1質量%がさらに好ましい。 The content of the catechins in the oral composition of the present invention is such that the catechins sufficiently act on the gums, and from the viewpoint of preventing flavoring of the oral composition and coloring of the toothbrush and the like, 0.002 to 2 masses %, Preferably 0.01 to 1.5% by mass, more preferably 0.02 to 1% by mass.
本発明に用いられる(B)ポリリン酸としては、リン酸を3個以上有する縮合ポリリン酸が挙げられ、トリポリリン酸、テトラポリリン酸、ペンタポリリン酸、ヘキサメタリン酸、ウルトラポリリン酸及びその水和物が含まれる。オルトリン酸では、十分な歯ブラシ等への着色防止効果が得られず、ポリリン酸であることが重要である。また、当該ポリリン酸の塩としては、ナトリウム塩、カリウム塩等のアルカリ金属塩が好ましく、特にポリリン酸ナトリウムを用いるのが歯ブラシ等への着色防止効果の点で好ましい。 Examples of (B) polyphosphoric acid used in the present invention include condensed polyphosphoric acid having 3 or more phosphoric acids, and tripolyphosphoric acid, tetrapolyphosphoric acid, pentapolyphosphoric acid, hexametaphosphoric acid, ultrapolyphosphoric acid and hydrates thereof. included. It is important that orthophosphoric acid is polyphosphoric acid because it cannot provide a sufficient anti-coloring effect on toothbrushes. Further, as the salt of polyphosphoric acid, alkali metal salts such as sodium salt and potassium salt are preferable, and sodium polyphosphate is particularly preferable from the viewpoint of coloring prevention effect on toothbrushes.
本発明口腔用組成物における(B)ポリリン酸又はその塩の含有量は、歯ブラシや洗面台への着色防止効果及び口腔用組成物の香味(塩味の出現防止)の点から、0.05〜2質量%であって、0.1〜1.5質量%が好ましく、さらに0.15〜1.2質量%が好ましい。 The content of (B) polyphosphoric acid or a salt thereof in the oral cavity composition of the present invention is from 0.05 to 0.05 in terms of the effect of preventing coloration on toothbrushes and washstands and the flavor of the oral cavity composition (preventing the appearance of salty taste). 2 mass%, preferably 0.1 to 1.5 mass%, more preferably 0.15 to 1.2 mass%.
また本発明口腔用組成物中の成分(A)と成分(B)の質量比(A:B)は、カテキン類による殺菌効果、歯ブラシ等への着色防止効果及び香味(ポリリン酸による塩味)のバランスの点から、2:1〜1:25であって、2:1〜1:10が好ましく、さらに1.5:1〜1:5が好ましい。 Moreover, the mass ratio (A: B) of the component (A) and the component (B) in the oral cavity composition of the present invention is such that the bactericidal effect by catechins, the effect of preventing coloration on toothbrushes and the like (salt taste by polyphosphoric acid). From the viewpoint of balance, it is 2: 1 to 1:25, preferably 2: 1 to 1:10, and more preferably 1.5: 1 to 1: 5.
本発明の口腔用組成物には、さらに(C)キレート効果を有する有機酸又はその塩を含有しないか又は0.8質量%以下含有する。歯ブラシ等への着色防止効果、及びカテキン類による口腔用組成物の変色抑制の観点から、(C)キレート効果を有する有機酸又はその塩は、0.01〜0.8質量%含有することが好ましく、さらに0.01〜0.4質量%含有することが好ましい。キレート効果を有する有機酸としては、リンゴ酸、クエン酸、乳酸、コハク酸、酒石酸、フマル酸、グルコン酸等が挙げられ、香味の点からリンゴ酸、クエン酸、乳酸、コハク酸、酒石酸、フマル酸が好ましく、特にリンゴ酸、乳酸、酒石酸が好ましい。
これらのキレート効果を有する有機酸の塩としては、ナトリウム塩、カリウム塩等のアルカリ金属塩が挙げられる。
The composition for oral cavity of the present invention further does not contain (C) an organic acid having a chelating effect or a salt thereof, or 0.8% by mass or less. From the viewpoint of preventing the coloring of toothbrushes and the like and suppressing the discoloration of the oral composition by catechins, (C) the organic acid having a chelating effect or a salt thereof may contain 0.01 to 0.8% by mass. Preferably, it is more preferable to contain 0.01-0.4 mass%. Examples of organic acids having a chelating effect include malic acid, citric acid, lactic acid, succinic acid, tartaric acid, fumaric acid, gluconic acid and the like, and malic acid, citric acid, lactic acid, succinic acid, tartaric acid, fumaric acid in terms of flavor. Acids are preferred, and malic acid, lactic acid, and tartaric acid are particularly preferred.
Examples of these organic acid salts having a chelating effect include alkali metal salts such as sodium salts and potassium salts.
また、(C)キレート効果を有する有機酸又はその塩を含有する場合の成分(A)と成分(C)の質量比(A:C)は、歯ブラシ等への着色防止効果及び香味のバランスの点から15:1〜1:2.5が好ましく、さらに10:1〜1:2が好ましい。 In addition, the mass ratio (A: C) of the component (A) and the component (C) in the case of containing (C) an organic acid having a chelate effect or a salt thereof is the balance between the anti-coloring effect on the toothbrush and the flavor. From the point, 15: 1 to 1: 2.5 are preferable, and 10: 1 to 1: 2 are more preferable.
本発明の口腔用組成物は、カテキン類の変色抑制の点から抗酸化剤を含有することが好ましい。抗酸化剤としては、抗酸化力又は還元力を有し、口腔用組成物に使用可能な成分、例えばL−アスコルビン酸又はその塩、エリソルビン酸又はその塩、ローズマリー抽出物、ステビア抽出物、ヒマワリ種子抽出物、没食子酸プロピル、ジブチルヒドロキシトルエン、ブチルヒドロキシアニソール、L−システイン塩酸塩、ハイドロキノン及びその配糖体、ノルジヒドログアヤレチン酸、アスコルビン酸高級脂肪酸エステル(ラウリン酸エステル、ステアリン酸エステル、イソステアリン酸エステル、パルミチン酸エステルなど)、グアヤク脂等が挙げられる。アスコルビン酸の塩としては、ナトリウム塩、カリウム塩等が挙げられ、エリソルビン酸の塩としては、ナトリウム塩、カルシウム塩、第一鉄の塩、パルミチン酸エステルの塩等が挙げられる。これら抗酸化剤は、単独で用いてもよく、2種以上を選択して用いてもよい。抗酸化剤は、香味の点からアスコルビン酸又はその塩が好ましい。
抗酸化剤の含有量は、カテキン類による口腔用組成物の外観色の変色抑制の点から、本発明の口腔用組成物中、0.0005〜5質量%、さらに0.001〜2質量%、特に0.01〜1質量%が好ましい。
The composition for oral cavity of the present invention preferably contains an antioxidant from the viewpoint of suppressing discoloration of catechins. Antioxidants include antioxidant or reducing components that can be used in oral compositions such as L-ascorbic acid or salts thereof, erythorbic acid or salts thereof, rosemary extract, stevia extract, Sunflower seed extract, propyl gallate, dibutylhydroxytoluene, butylhydroxyanisole, L-cysteine hydrochloride, hydroquinone and its glycoside, nordihydroguaiaretic acid, ascorbic acid higher fatty acid ester (lauric acid ester, stearic acid ester) , Isostearic acid ester, palmitic acid ester, etc.), guaiac fat and the like. Examples of ascorbic acid salts include sodium salts and potassium salts, and examples of erythorbic acid salts include sodium salts, calcium salts, ferrous salts, and palmitic acid ester salts. These antioxidants may be used alone or in combination of two or more. The antioxidant is preferably ascorbic acid or a salt thereof from the viewpoint of flavor.
Content of antioxidant is 0.0005-5 mass% in the composition for oral cavity of this invention from the point of the discoloration suppression of the external color of the composition for oral cavity by catechins, Furthermore, 0.001-2 mass% In particular, 0.01 to 1% by mass is preferable.
本発明の口腔用組成物のpHは、5〜7、さらに5〜6.5が好ましい。pHを5〜7に調整することにより、口腔用組成物中におけるカテキン類の安定化が図られ、歯ブラシ等への着色防止効果が得られ、かつ香味も良好になる。pHを上記範囲に調整するために、pH調整剤を用いることができる。pH調整剤としては、カテキン類の変色抑制効果を阻害せず、使用感を損なわない範囲で、オルトリン酸、水酸化ナトリウム等の水酸化物、アンモニア又はアンモニア水、低級アルカノールアミン類、アルギニン、リジン等の塩基性アミノ酸等が挙げられ、これらを単独又は2種以上組み合せて用いてもよい。 The pH of the composition for oral cavity of the present invention is preferably 5 to 7, more preferably 5 to 6.5. By adjusting the pH to 5 to 7, the catechins in the oral composition can be stabilized, the effect of preventing coloring to a toothbrush and the like can be obtained, and the flavor can be improved. In order to adjust pH to the said range, a pH adjuster can be used. As a pH adjuster, as long as it does not inhibit the discoloration suppressing effect of catechins and does not impair the usability, orthophosphoric acid, hydroxide such as sodium hydroxide, ammonia or aqueous ammonia, lower alkanolamines, arginine, lysine These may be used alone or in combination of two or more.
本発明の口腔用組成物には、口腔用組成物に使用可能なその他の配合成分、例えば、研磨剤、発泡剤、湿潤剤、甘味剤、香味料、保存剤、各種薬効成分、水、エタノールなどを、本発明の目的が阻害されない範囲で適宜配合してもよい。また、本発明の口腔用組成物は、カテキン類による口腔用組成物の外観色の変色を抑制し、カテキン類を有効に作用させる観点から、特許文献5に記載のハイドロゲル粒子にカテキン類を含有しても良いし、特許文献4に記載のように炭素数4〜5の糖アルコール(例えばキシリトール、エリスリトール等)を配合したり、酸素不透過性の個袋に分封する包装形態を採用しても良い。 In the oral composition of the present invention, other compounding ingredients that can be used in the oral composition, such as abrasives, foaming agents, wetting agents, sweeteners, flavoring agents, preservatives, various medicinal ingredients, water, ethanol Etc. may be appropriately blended within a range that does not impair the object of the present invention. Moreover, the composition for oral cavity of this invention suppresses discoloration of the external color of the composition for oral cavity by catechins, and from the viewpoint of making catechins act effectively, catechins are added to the hydrogel particles described in Patent Document 5. As described in Patent Document 4, a packaging form in which sugar alcohol having 4 to 5 carbon atoms (for example, xylitol, erythritol, etc.) is blended or sealed in an oxygen-impermeable individual bag is adopted. May be.
発泡剤としては、陰イオン界面活性剤、非イオン界面活性剤、陽イオン界面活性剤、及び両性界面活性剤が挙げられる。 Examples of the foaming agent include an anionic surfactant, a nonionic surfactant, a cationic surfactant, and an amphoteric surfactant.
陰イオン界面活性剤としては、例えばアシルグルタミン酸ナトリウム、アシルサルコシンナトリウム等のアシルアミノ酸塩、アルキルリン酸ナトリウム等のアルキルリン酸塩、アルキル硫酸エステル塩、高級脂肪酸スルホン化モノグリセリド塩、イセチオン酸の脂肪酸エステル塩、N−メチル長鎖アシルタウリンナトリウム塩、ポリオキシエチレンモノアルキルリン酸塩等が挙げられる。これらの陰イオン界面活性剤における疎水基のアルキル基、アシル基は炭素数6〜18、特に10〜14のものが好ましい。また、その塩としてはナトリウム塩が好ましい。陰イオン界面活性剤としては、発泡性が良く、また、安価に入手可能な点からアルキル硫酸エステル塩が特に好ましい。
陰イオン界面活性剤は、本発明の口腔用組成物中に0〜5質量%含有することが好ましく、より好ましくは0〜2質量%である。
Examples of the anionic surfactant include acyl amino acid salts such as sodium acyl glutamate and acyl sarcosine sodium, alkyl phosphates such as sodium alkyl phosphate, alkyl sulfate salts, higher fatty acid sulfonated monoglyceride salts, fatty acid esters of isethionic acid. Salt, N-methyl long chain acyl taurine sodium salt, polyoxyethylene monoalkyl phosphate and the like. The hydrophobic alkyl group and acyl group in these anionic surfactants preferably have 6 to 18 carbon atoms, particularly 10 to 14 carbon atoms. The salt is preferably a sodium salt. As the anionic surfactant, an alkyl sulfate ester salt is particularly preferable from the viewpoint of good foamability and availability at low cost.
It is preferable to contain 0-5 mass% of an anionic surfactant in the composition for oral cavity of this invention, More preferably, it is 0-2 mass%.
非イオン界面活性剤としては、例えばポリオキシアルキレン付加系界面活性剤、アミンオキサイド系界面活性剤、モノ又はジエタノールアミド系界面活性剤、ソルビタン脂肪酸エステル、グリセリン脂肪酸エステル、ポリグリセリン脂肪酸エステル、ショ糖脂肪酸エステルを挙げることができる。この中でもソルビタン脂肪酸エステル、グリセリン脂肪酸エステル、ポリグリセリン脂肪酸エステル、ショ糖脂肪酸エステルが好ましく、モノステアリン酸デカグリセリン、モノミリスチン酸ペンタグリセリン等のポリグリセリン脂肪酸エステルが特に好ましい。本発明ではこれらを1種以上用いることができる。
非イオン界面活性剤の含有量は、本発明の口腔用組成物中に0.1〜30質量%、より好ましくは0.2〜10質量%である。
Nonionic surfactants include, for example, polyoxyalkylene addition surfactants, amine oxide surfactants, mono- or diethanolamide surfactants, sorbitan fatty acid esters, glycerin fatty acid esters, polyglycerin fatty acid esters, sucrose fatty acids. Mention may be made of esters. Among these, sorbitan fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, and sucrose fatty acid ester are preferable, and polyglycerin fatty acid ester such as monostearic acid decaglycerin and monomyristic acid pentaglycerin is particularly preferable. In the present invention, one or more of these can be used.
Content of a nonionic surfactant is 0.1-30 mass% in the composition for oral cavity of this invention, More preferably, it is 0.2-10 mass%.
湿潤剤としては、グリセリン、ソルビトール、ポリエチレングリコール、プロピレングリコール、1,3−ブチレングリコール、キシリトール、マルチトール、ラクチトール、トレハロース等が好適に用いられる。また、清涼化と香味の点からエリスリトールが好適に用いられる。 As the wetting agent, glycerin, sorbitol, polyethylene glycol, propylene glycol, 1,3-butylene glycol, xylitol, maltitol, lactitol, trehalose and the like are preferably used. In addition, erythritol is preferably used in terms of cooling and flavor.
本発明の口腔用組成物は、その用途に応じて、練歯磨き組成物、液状歯磨き組成物、ゲル状歯磨き組成物、洗口剤などとすることができる。 The oral composition of the present invention can be a toothpaste composition, a liquid toothpaste composition, a gel-like toothpaste composition, a mouthwash, or the like depending on its use.
例中の%は、特記しない限り質量%である。 Unless otherwise specified,% in the examples is% by mass.
(歯磨き剤による歯ブラシの着色試験)
表1に示す処方の歯磨き剤を製造し、この歯磨き剤を用いて歯ブラシへの着色試験を行った。具体的には、着色モデルとして歯ブラシ(ピュオーラ コンパクトヘッド ふつう)を用い、表1の各歯磨き剤について以下の処理1〜5を5回繰り返して行った後に着色性を評価し、併せて歯磨き剤の香味を評価した。
(Toothbrush coloring test with dentifrice)
A dentifrice having the formulation shown in Table 1 was produced, and a coloring test on a toothbrush was performed using this dentifrice. Specifically, using a toothbrush (Puola Compact Head) as a coloring model, the following treatments 1 to 5 were repeated 5 times for each dentifrice, and the colorability was evaluated. The flavor was evaluated.
1)着色モデルをブラッシングマシーンにセットし、ブラッシングマシーンにおけるブラッシング対象面のブラッシング領域に歯磨き剤を1.5g塗布し、圧力200gをかけて、120ストローク/分で1分間ブラッシングを2回行った。2回目のブラッシング前に、ブラッシング領域の歯磨き剤をスパチュラで中央に寄せるとともに、0.5gの歯磨き剤をさらに加えた。
2)30秒間水洗いした後に、室温(25℃)にてエアブロアで2分間風乾させた。
3)着色モデルを塩化カルシウム1質量%の水溶液で濯ぐ。具体的には、着色モデルを浸漬した直後に取り出すことを5回繰り返す。濯いだ後に水分がなくなるまで室温(25℃)で乾燥させた。
4)試験1はアルブミン(BSA)1%水溶液に1分間浸した。
試験2はアルブミン(BSA)1%、羊血清1%の水溶液に1分間浸した。
(アルブミン(BSA)は和光純薬工業株式会社製の95%純度のものを用いた)
5)試験1は室温(25℃)で一晩乾燥させた。
試験2は50℃の恒温槽内で一晩乾燥させた。
1) The coloring model was set on a brushing machine, 1.5 g of a dentifrice was applied to the brushing area of the surface to be brushed in the brushing machine, 200 g of pressure was applied, and brushing was performed twice for 1 minute at 120 strokes / min. Before the second brushing, the brushing area dentifrice was centered with a spatula and an additional 0.5 g dentifrice was added.
2) After washing with water for 30 seconds, it was air-dried with an air blower at room temperature (25 ° C.) for 2 minutes.
3) The colored model is rinsed with an aqueous solution of 1% by weight calcium chloride. Specifically, taking out the colored model immediately after dipping is repeated five times. After rinsing, it was dried at room temperature (25 ° C.) until there was no moisture.
4) Test 1 was immersed in a 1% aqueous solution of albumin (BSA) for 1 minute.
Test 2 was immersed in an aqueous solution of albumin (BSA) 1% and sheep serum 1% for 1 minute.
(Albumin (BSA) was 95% purity manufactured by Wako Pure Chemical Industries, Ltd.)
5) Test 1 was dried overnight at room temperature (25 ° C).
Test 2 was dried overnight in a 50 ° C. thermostat.
各歯磨き剤による着色モデルの着色性、歯磨き剤の香味の評価を表1に示す。香味の評価は3名で行い、2名以上が共通する評価を採用した。着色評価は目視で行った。
着色評価
0:殆ど着色していない〜5:明らかに茶色に着色 までの間で、着色の程度を1〜5の数値で評価。
香味の評価
A:良好
B:わずかに塩味を感じるが良好
C:少し塩味を感じる
D:塩味を感じる
Table 1 shows the coloring property of the coloring model by each dentifrice and the evaluation of the flavor of the dentifrice. The evaluation of flavor was carried out by three people, and an evaluation common to two or more people was adopted. The coloring evaluation was performed visually.
Evaluation of coloring 0: Almost not colored to 5: Clearly browned until the degree of coloring was evaluated with a numerical value of 1 to 5.
Evaluation of flavor A: Good B: Feels slightly salty but good C: Feels slightly salty D: Feels salty
表1から明らかなように、トリポリリン酸を含有しなかった比較例2は着色を生じた。一方、トリポリリン酸を含有する比較例1は着色は抑制されたが、4質量%含有するために塩味が確認された。実施例1は、茶カテキンによる歯ブラシの着色が抑制され、かつ、香味も良好であった。 As is apparent from Table 1, Comparative Example 2 that did not contain tripolyphosphoric acid produced coloration. On the other hand, although the coloring of Comparative Example 1 containing tripolyphosphoric acid was suppressed, saltiness was confirmed because it contained 4% by mass. In Example 1, coloring of the toothbrush by tea catechin was suppressed, and the flavor was also good.
(洗口剤による着色試験)
表2に示す処方の洗口剤を調製し、この洗口剤を用いて合成樹脂と陶器への着色試験を行った。具体的には、着色モデルとして試験3はポリアセタール樹脂(MISUMI PASH−20−20−2.0)、試験4はタイル(INAX JM−35/20B−D)を用い、表2の洗口剤による以下の1)〜5)の処理を10回繰り返した後に着色性を評価し、併せて洗口剤の香味を評価した。なお、ポリアセタール樹脂は、表面を研磨紙(♯400)で傷つけたものを用いた。
(Coloring test with mouthwash)
Mouthwashes with the formulations shown in Table 2 were prepared, and using this mouthwash, a color test on synthetic resin and ceramics was performed. Specifically, as a coloring model, test 3 uses a polyacetal resin (MISSUMI PASH-20-20-2.0), test 4 uses a tile (INAX JM-35 / 20B-D), and the mouthwash of Table 2 After the following treatments 1) to 5) were repeated 10 times, the colorability was evaluated, and the flavor of the mouthwash was also evaluated. The polyacetal resin used was that whose surface was scratched with abrasive paper (# 400).
1)着色モデルをアルブミン(BSA)1%水溶液に1分間浸漬した。アルブミンは歯磨き剤の着色試験と同じものを用いた。
2)着色モデルを人工唾液で濯いだ。具体的には、着色モデルを人工唾液に浸漬させて直ちに取り出すことを5回繰り返した。
3)着色モデルを表2の洗口剤で濯いだ。具体的には、着色モデルを洗口剤に浸漬させて直ちに取り出すことを5回繰り返した。
4)着色モデルをエアブロアで20秒間乾燥させた。
5)着色モデルを精製水に5分間浸した。
1) The colored model was immersed in a 1% aqueous solution of albumin (BSA) for 1 minute. Albumin was the same as in the dentifrice coloring test.
2) The colored model was rinsed with artificial saliva. Specifically, the colored model was immersed in artificial saliva and immediately taken out five times.
3) The colored model was rinsed with the mouthwash of Table 2. Specifically, the colored model was immersed in a mouthwash and immediately taken out five times.
4) The colored model was dried with an air blower for 20 seconds.
5) The colored model was immersed in purified water for 5 minutes.
着色性の評価はL*a*b*表色系(CIE1976)を用いて前述の着色試験の前と後のb*値の変化量Δb*の絶対値により評価した。具体的には、着色試験前後の着色モデルを白板の上に置き、シェードアイNCC(松風)を用いてL*a*b*を測定した。各モデルについて5点測定を行い、最大値、最小値を除いた3点の平均値を各モデルのL*a*b*とした。着色試験後のb*値から着色試験前のb*をひいてΔb*を求めた。
香味の評価は、歯磨き剤と同様に評価した。
The colorability was evaluated using the L * a * b * color system (CIE 1976) based on the absolute value of the change amount Δb * of the b * value before and after the aforementioned color test. Specifically, coloring models before and after the coloring test were placed on a white plate, and L * a * b * was measured using a shade eye NCC (Matsukaze). Five points were measured for each model, and the average value of three points excluding the maximum and minimum values was taken as L * a * b * for each model. I caught a pre-colored test b * from the b * value after coloring test to determine the Δb *.
The flavor was evaluated in the same manner as the dentifrice.
表2から明らかなように、茶カテキンを含有し、リンゴ酸の含有量が0.8質量%を超える比較例3及び4は、トリポリリン酸を含有しているにもかかわらず、タイルへの着色が防止できず、また塩味も感じられた。また、トリポリリン酸ナトリウムの含有量が茶カテキンに対して重量比で1/2より少ない(茶カテキンに対して28%である)比較例5は、タイルへの着色を防止できなかった。また、トリポリリン酸ナトリウムの含有量が多すぎる(3質量%)比較例6は、塩味が強くなった。これらに対し、茶カテキン及びトリポリリン酸又はその塩を特定量含有し、キレート効果を有するリンゴ酸を0.8質量%以下含有する本発明の洗口剤は、タイル等への着色が防止され、かつ香味も良好であった。 As is clear from Table 2, Comparative Examples 3 and 4 containing tea catechins and containing malic acid exceeding 0.8% by mass were colored on tiles despite containing tripolyphosphoric acid. However, saltiness was also felt. Further, in Comparative Example 5 in which the content of sodium tripolyphosphate was less than 1/2 by weight with respect to tea catechin (28% with respect to tea catechin), coloring to the tile could not be prevented. In addition, Comparative Example 6 in which the content of sodium tripolyphosphate was too large (3% by mass) had a strong salty taste. On the other hand, the mouthwash of the present invention containing a specific amount of tea catechin and tripolyphosphoric acid or a salt thereof and containing 0.8% by mass or less of malic acid having a chelating effect is prevented from coloring to tiles, etc. And the flavor was also good.
Claims (3)
(A)カテキン類 0.002〜2質量%、
(B)トリポリリン酸、テトラポリリン酸、ペンタポリリン酸、ヘキサメタリン酸、ウルトラポリリン酸及びその塩から選ばれる縮合ポリリン酸又はその塩 0.05〜1.5質量%
を含有し、成分(A)と成分(B)の質量比(A:B)が2:1〜1:25であって、
(C)キレート効果を有する有機酸又はその塩を含有しないか0.8質量%以下含有し、pHが5〜7である口腔用組成物。 The following components (A) and (B):
(A) Catechin 0.002 to 2 mass%,
(B) Condensed polyphosphoric acid or salt thereof selected from tripolyphosphoric acid, tetrapolyphosphoric acid, pentapolyphosphoric acid, hexametaphosphoric acid, ultrapolyphosphoric acid and salts thereof 0.05 to 1.5 % by mass
The mass ratio (A: B) of component (A) to component (B) is 2: 1 to 1:25,
(C) The composition for oral cavity which does not contain the organic acid which has a chelate effect, or its salt, or contains 0.8 mass% or less, and pH is 5-7.
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Free format text: JAPANESE INTERMEDIATE CODE: R250 |
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R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
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R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |