KR0121564B1 - Tooth whitening dentifrice composition - Google Patents

Abstract

The invention relates to a toothpaste composition for whitening teeth which contains 2-30wt% of zeolite, 0.5-30wt% of a protease and 1-40wt% of a peroxide, and optionally an abrasive and a fluoride. The toothpaste composition is excellent in removing stain of tooth surface and dental plaque in a short period of time.

Description

Toothpaste composition for teeth whitening

The present invention relates to a toothpaste composition for whitening teeth. More specifically, the present invention relates to a toothpaste composition excellent in tooth whitening effect by using zeolite, protease and peroxide.

In general, tooth discoloration may be classified into discoloration due to exogenous and discoloration due to endogenous. The cause of exogenousness may be caused by food waste, nicotine, coffee, tea, etc. deposited on the dentin of teeth by coloring on the tooth surface. In addition, tooth discoloration may occur due to dyeing of pigment components in tartar or soft deposits on the tooth surface, and may also be caused by bleeding of other pigmented bacteria or gingiva, excessive intake of fluorine, or inorganic metal dust or chemicals of a factory.

Another discoloration factor, endogenous discoloration, may occur when tooth nerves are affected, and silver amalgam, a prosthetic aid, may discolor the tooth structure to gray or black color, and tetracycline antibiotics If taken, it can be a major cause of endogenous tooth discoloration. Complete removal of such endogenous discolored teeth is difficult. As a method for treating tooth discoloration, a physical treatment method and a treatment method using medicinal agents have been developed. Representative tooth discoloration treatment methods include the temporary method of applying a jacket crown to discolored teeth and the treatment of stains by scaling through dental hygienists, but the treatment cost is high. Problems such as the hassle of visiting a dental hospital have been pointed out. Another method was to use a bristle toothbrush or a abrasive. Representative abrasives have been developed using physical methods using insoluble sodium triphosphate (Insoluble Natrium Metaphosphate), anhydrous calcium monohydrogen phosphate. However, when cleaning the teeth with a preparation containing these substances, enamel or alveolar areas on the surface of the teeth are worn or damaged, so that the exposed dentin is subjected to external stimulation such as mechanical or chemical irritation or temperature. It has been pointed out that the problem is that it is likely to be a pain-sensitive sensitive tooth and difficult to remove effective stains.

In order to improve this and to effectively treat tooth discoloration, US Patent No. 446045, No. 3885028, and European Patent No. 303520 have improved the discolored teeth using calcium peroxide and calcium perborate, but because they contain boron, Safety problems can occur because it can be absorbed into the oral tissue and damage the oral cavity and esophageal mucosa. In addition, US Pat. No. 5122365 attempts to improve discolored teeth using sodium benzoate, hydrogen peroxide, titanium oxide, etc., but in this case, there is a problem in use that is stored in a separate container and used over three steps. In addition, in US Pat. No. 4,897,901, citric acid, papain, and aluminum oxide are used to improve the tooth bleaching effect. However, when aluminum oxide is used, its feeling of inherent astringent taste may be degraded, and safety may occur.

On the other hand, European Patent No. 0279130 is intended to improve the tooth cleaning effect by using a powdered toothpaste using hydrogen peroxide and thickening, but in this case, the powder is deposited directly on the oral mucosa, which may cause scars and tissue damage. In addition, although US Patent Nos. 5084268, 4839157, and 44409999 use peroxides to enhance tooth bleaching effect, partial stain removal is possible, but the whitening effect on the entire tooth such as tartar is small. appear.

Accordingly, the present inventors have conducted extensive research and reviewed the zeolite component and protease, which are a kind of aluminosilicate which can effectively remove tartar, which is a poorly soluble salt such as calcium and magnesium, in saliva, together with peroxides and sodium bicarbonate. As a result, it was found that the tooth whitening effect was improved to an excellent level in a short time, and the present invention was completed.

The present invention relates to a toothpaste composition comprising 2 to 30% by weight of zeolite, 0.5 to 30% by weight of protease and 1 to 40% by weight of peroxide.

The toothpaste composition of the present invention may further comprise 2 to 70% by weight of the abrasive and 0 to 5% by weight of the fluorine compound.

Hereinafter, the present invention will be described in detail.

The zeolite used in the present invention uses A-type zeolite whose pH is adjusted to 6 to 8 so as to be suitable for oral use by treating with acid as powder or granule zeolite. Zeolites of the form A useful in the present invention consist of 0.9 to 1.1 molar ratio of Me ₂ O.Al ₂ O ₃ and 1.8 to 2.2 molar ratio of SiO ₂ .nH ₂ O, where Me is an alkali metal and n is an integer. Zeolite is preferred. In particular, the zeolites useful in the present invention are zeolites of the 4A form.

When using the zeolite used for this invention in powder form, an average particle diameter is 0.5-20 micrometers, Preferably 1-10 micrometers is 90% or more. In the case of granular zeolites, particle diameters are used having a size in the range of 30 to 300 mesh.

The zeolite content in the present invention is 2 to 30% by weight, preferably 5 to 20% by weight is appropriate. At this time, when the zeolite content is less than 2%, it is difficult to effectively remove stains in the teeth. When the zeolite content is more than 20% by weight, the product stability is lowered and the value of the product is lowered.

Proteolytic enzymes are papaya, dextran, glucose oxidase or glucose amylase. Particularly useful proteolytic enzymes in the present invention are papain composed of a polypeptide chain separated from green fruit latex and Carica Papaya L., and 400 units per milligram. Use the above activity. The content of protease is suitably 0.5 to 30% by weight, particularly preferably 0.5 to 20% by weight. When the amount is less than 0.5% by weight, the stain removal effect cannot be expected, and when the amount is more than 30% by weight, the efficacy is no longer improved. In some cases, by encapsulating papain in order to increase the efficacy of the composition, it may be used to suppress the decrease in titer that may be caused by other ingredients.

As the peroxide, it is suitable to use 1 to 40% by weight of urea peroxide or hydrogen peroxide (3 to 35%) free of metal ions, and preferably 3 to 30% by weight. When it is less than 1%, the stain removal effect is inferior, and when it is more than 40% by weight, the product stability is inferior.

Precipitating silica, sodium bicarbonate, and aluminosilicate are preferably used as the abrasive component, and in the case of silica, the average particle diameter is preferably 1 to 0 m and the BET specific surface area is preferably 100 to 500 m 2 / g.

In the case of medium bath, it is preferable to have a particle diameter of 60-250 micrometers, it is suitable to contain 2 to 70 weight% using these abrasive components mixed or single use, It is preferable to contain 2 to 50 weight% preferably. . If it is less than 2% by weight, product stability is inferior, and if it is more than 70% by weight, it is not preferable because it damages the teeth.

In addition, as a fluorine compound which is an agent for strengthening dental tissue, sodium fluoride and sodium primary phosphate are mixed or used alone, and the content thereof is appropriately 0 to 5.0% by weight. When it is more than 5.0% by weight, the use as an oral preparation is unsuitable because it may affect human stability.

Ointment compositions generally include wetting agents, foaming agents, flavoring agents, sweetening agents and other ingredients.

Wetting agent prevents solidification when exposed to air, and mainly uses 3 to 70% by weight of amorphous sorbitol liquid (70%), glycerin, polyethylene glycol, polypropylene glycol, and xylitol liquid alone or mixed. In the present invention, 3 to 60% by weight of these humectants are used in combination or singly for product stability.

In general, in the case of a paste toothpaste, a binder is essentially used to combine the solid and liquid components of the inorganic material to prevent the liquid from being separated over time and to maintain the state of the toothpaste. As the binder, carboxymethyl cellulose sodium, carrageenan, water-soluble polyvinyl acrylic resin, xanthan gum, sodium alginate, and the like are usually used, and these are preferably used in combination of 0.1 to 2% by weight.

The foaming agent helps to cleanse, speed up the dispersal and penetration of the drug, and reduce the interfacial tension, so that the foreign substances in the oral cavity easily fall off. As the foaming agent, sodium alkyl sulfates such as sodium lauryl sulfate and sodium lauroyl sulfate are mainly used as anionic surfactants, and polyoxyethylene, polyoxypropylene copolymer, polyoxyethylene hydrogenated castor oil and poly Oxyethylene sorbitan fatty acid esters, sugar fatty acid esters and the like are used. The amount of foaming agent is preferably 0.5 to 5% by weight of anionic or nonionic surfactants alone or in combination of two or more.

In addition to the components used are a whitening agent, preservatives and buffers, etc., wherein the buffer is used to adjust the pH of the toothpaste composition, sodium monophosphate, sodium diphosphate and sodium triphosphate, sodium pyrophosphate and Fatigue salt etc. can be used.

The pH of the composition of the present invention is preferably in the range of 5-9. If less than 5 damages the enamel and dentin, and if more than 9 it is not suitable because of poor stability of toothpaste.

In addition, flavoring and sweetening agents are used to improve the gargling in the composition of the present invention, the fragrance, such as peppermint, spearmint, winter green, sage, eucalyptol oil, methyl salicylate and other fruit extracts, etc. The ratio is 0.01 to 2% by weight. Examples of sweeteners include lactose, malose, aspartame, saccharin, and the like. Preferably, saccharin is used in an amount of 0.05 to 1% by weight.

The present invention will be described in more detail with reference to the following examples, but the technical scope of the present invention is not limited to these examples.

[Examples 1 to 5 and Comparative Examples 1 to 4]

Toothpaste compositions were prepared using the following weight percent components of Table 1, and the preparation method was prepared according to a known method.

Experimental Example 1: Calcium ion blockade test and evaluation of tartar suppression effect of the toothpaste composition of Examples 1 to 5 and Comparative Examples 1 to 4

The toothpaste of Examples and Comparative Examples was evaluated for the evaluation of calcium ion sequestration ability, which is a kind of stain removal evaluation test, and the tartar suppression effect.

1) Calcium ion blockade test

100 g of the compositions of Examples and Comparative Examples were each added, and 300 ml of water was added, followed by centrifugation (10,000 rpm, 30 minutes), the supernatant was collected, 5.0 ml of saturated ammonium oxalate solution was added, and titrated with a standard calcium solution. It was titrated until a white phosphorus precipitated. At this time, the blocked calcium ion blocking value was calculated from the consumption amount of standard calcium solution (ml) and is shown in Table 2 below.

Where 50.0 is the CaCo ₃ content in mg of standard calcium solution.

2) Test for inhibiting tartar formation

A supernatant obtained by centrifuging the toothpaste compositions of Examples and Comparative Examples was added to the reaction of artificially producing apatite, which is the main component of tartar, to suppress the tartar formation effect of these compositions by producing apatite [Ca ₃ (PO ₄ ) ₂ ]. In order to measure the inhibition time, 0.5 ml of 0.1 M sodium dihydrogen phosphate was added to a reaction flask containing 20 ml of distilled water, a nitric acid atmosphere was prepared, 5 g of the compositions of Examples and Comparative Examples were dispersed and dispersed in 50 ml of distilled water, followed by centrifugation. (10,000 rpm, 3 minutes), 10 ml of the supernatant was taken into the reaction flask, 1 ml of 0.1 M calcium chloride was added with continuous stirring, the pH was adjusted to 7.2 ± 0.1 with sodium hydroxide, and precipitation began to form. The time was measured and the results are shown in Table 2.

As shown in Table 2, it can be seen that both the calcium ion blocking power and the tartar formation inhibition time of the examples of the present invention are significantly superior to those of the comparative example.

Experimental Example 2 stain evaluation of the toothpaste composition of Examples 1 to 5 and Comparative Examples 1 to 4

(1) stain test for human teeth

In order to evaluate the stain removal effect of Examples 1 to 5 and Comparative Examples 1 to 4, the motor was mixed with tobacco, coffee, tea, sugar, calcium, and the like to make a gel and then rotated. The specimen was transferred to the bottom container of the equipped device, and a specimen prepared from a healthy person in their 20s to 30s was fixed to an epoxy resin to produce a specimen having an exposed area of width x length (2 mm x 2 mm). It was attached to the swivel plate and operated for 3 days to force staining. At this time, an incandescent lamp was installed at the center of the rotating plate to dry the stain attached to the specimen, thereby promoting the adhesion of the stain.

Remove the stained specimen on the last day, measure the whiteness using a color difference meter (Model: SZ, Nippon Denshoku), fix the specimen on a specially designed abrasive force meter to allow reciprocating motion, and then fix the soft bristles on the axis of motion. To rub against the specimen. At this time, put each Example and Comparative Example composition on the end of the bristles 0.5g equally and operated for 30 minutes to reciprocate 180 times per minute, then take out the specimen and measure the degree of improvement of the whiteness of the specimen using a colorimeter again. Calculated as shown in Table 3 below.

(2) Stain evaluation experiment using cotton cloth

The cotton cloth deposited with red wine was first measured using a colorimeter as in the method of (1), and then the cotton cloth was separated from the bottom at a predetermined height in a 200 ml beaker containing 100 ml of distilled water. 5 g of each composition was stirred for about 2 hours, the cotton cloth was taken out and dried, and the staining degree was again evaluated using a color difference meter as a percentage.

As shown in Table 3, it can be seen that the stain improvement effect on the human teeth and cotton cloth of the embodiment of the present invention is significantly superior to that of the comparative example.

Claims (19)

Toothpaste composition, characterized in that it contains 2 to 30% by weight of zeolite, 0.5 to 30% by weight of protease and 1 to 40% by weight of peroxide. The composition of claim 1, wherein the content of zeolite is 5 to 20% by weight. The composition of claim 1 wherein the zeolite is A type zeolite. The composition of claim 3 wherein the zeolite is a 4A type zeolite. The composition of claim 1 wherein the pH of the zeolite is adjusted to 6-8. The composition of claim 1 wherein the zeolite is in powder or granular form. The composition according to claim 6, wherein the average particle diameter of the powdered zeolite is 0.5 to 20 mu m. The composition according to claim 6, wherein the particle size of the granular zeolite is 30 to 300 mesh. The composition of claim 1, wherein the content of proteolytic enzyme is 0.5 to 20% by weight. The composition of claim 1 wherein the protease is papain. The composition of claim 10 wherein the titer of papain is at least 400 μ / mg. 10. The composition of claim 1 or 9, wherein the protease is encapsulated and used. The composition according to claim 1, wherein the content of peroxide is 3 to 30% by weight. The composition of claim 1 wherein the peroxide is hydrogen peroxide (3 to 35%) or urea peroxide. The composition according to claim 1, further comprising 2 to 70 wt% of the abrasive and 0 to 5 wt% of the fluorine compound. The composition of claim 15 wherein the abrasive comprises alone or mixed precipitated silica, sodium bicarbonate, aluminosilicate and silica gel. The composition according to claim 16, wherein the precipitated silica and silica gel have an average particle diameter of 1 to 10 mu m and a specific surface area of 100 to 500 m 2 / g. The composition according to claim 16, wherein the average particle diameter of the sodium bicarbonate is 60 to 250 mu m. The composition of claim 15 wherein the fluorine compound is sodium fluoride and / or sodium monofluorophosphate.