FR2463613A1 - NEW COMPOSITIONS FOR THE REVELATION OF THE DENTAL PLATE - Google Patents
NEW COMPOSITIONS FOR THE REVELATION OF THE DENTAL PLATE Download PDFInfo
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- FR2463613A1 FR2463613A1 FR7920929A FR7920929A FR2463613A1 FR 2463613 A1 FR2463613 A1 FR 2463613A1 FR 7920929 A FR7920929 A FR 7920929A FR 7920929 A FR7920929 A FR 7920929A FR 2463613 A1 FR2463613 A1 FR 2463613A1
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- dental plaque
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/43—Guanidines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
- A61K8/411—Aromatic amines, i.e. where the amino group is directly linked to the aromatic nucleus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/42—Colour properties
- A61K2800/43—Pigments; Dyes
Abstract
Description
La présente invention a pour objet de nouvelles compositions pour le traitement et l'hygiène dentaire,ayant,entre autres buts, celui de révéler la plaque dentaire. The present invention relates to new compositions for dental treatment and hygiene, having, among other aims, that of revealing dental plaque.
Il convient de rappeler qu'on désigne par plaque dentaire un film se déposant à la surface des dents et qui s'interpose entre celles-ci et le milieu buccal.Elle est essentielle,aent constituée par une couche de protélnes naturelles et salivaires plus ou moins dénaturées,de mucine salivaire et de microorganismes divers vivants ou morts.Sur le plan physico-chimique,la plaque dentaire présente des propriétés liées à sa haute teneur en protélnes.Ce film largement protéinique constitue donc un barrage entre les dents et le volume buccal dans lequel la salive libre est légèrement acide ou sensiblement neutre(pII de 5,6 à 7,6 le plus généralement).Elle a tendance à être plutôt acide au repos qu'en période active.Or,en l'absence de plaque dentaire,qui,comme les os,sont sujettes à déminéralisation,entrent en échange ionique avec la salive,solution colloldale aqueuse de sels minéraux en présence de mucine et douée de propriétés enzymatiques.La plaque dentaire empêche donc en tout ou partie ces échanges et constitue une source d'anomalies pouvant s'aggraver avec le temps.Elle joue surtout un roule cariogène désormais bien connu(cS,par exemple,Dechaume et Brunel"Reflexions sur la prophylaxie de la carie dentaire",Revue de Stomatologie,juillet et août 1956). It should be remembered that dental plaque designates a film depositing on the surface of the teeth and which is interposed between them and the oral environment. It is essential, aent constituted by a layer of natural and salivary proteins more or less denatured, salivary mucin and various living or dead microorganisms. Physico-chemically, dental plaque has properties related to its high content of proteins. This largely protein film therefore constitutes a barrier between the teeth and the oral volume. in which the free saliva is slightly acidic or appreciably neutral (pII of 5.6 to 7.6 most generally). It tends to be more acidic at rest than in active period. , which, like bones, are subject to demineralization, enter into ion exchange with saliva, an aqueous colloidal solution of mineral salts in the presence of mucin and endowed with enzymatic properties. Dental plaque therefore prevents all or part of these changes and is a source of anomalies that can worsen over time. It plays mainly a cariogenic roll now well known (cS, for example, Dechaume and Brunel "Reflexions on the prophylaxis of dental caries", Revue de Stomatologie, July and August 1956).
Or,il n'est pas aisé pour un non-spécialiste de mesurer l'étendue de la plaque dentaire et,donc,des dangers encourus.La présente invention a donc pour but,lorsque l'utilisateur le désire,et notamment lorsqu'il se lave les dents,de lui permettre de voir ap paraltre,gr ce à une coloration,nette,ladite plaque dentaire,coloration ensuite éliminée aisément par le lavage et/ou brossage classique effectués généralement à l'aide de dentifrice. However, it is not easy for a non-specialist to measure the extent of dental plaque and, therefore, of the dangers incurred. The present invention therefore aims, when the user wishes, and in particular when washes the teeth, allowing it to see ap paraltre, thanks to a clear coloring, said dental plaque, coloring then easily removed by washing and / or conventional brushing generally carried out using toothpaste.
On conçoit donc qu'il est possible,soit d'utiliser les compositions révélatrices de la plaque dentaire conformes à l'invention seules,ce qui nécessite une élimination ultérieure,soit de recourir à une composition unique incluant celle conforme à l'invention révélant la plaque dentaire par coloration,et les constituants de tout dentifrice classique.Ce-tte dernière solution étant la plus simple,on insistera sur elle dans les exemples qui suivent,sans que cela limite la portée de l'invention.I1 y a donc addition ou,dans certains combinaisons des effets révélateurs et dentifrices,dans le cas de ces compositions uniques. It is therefore understandable that it is possible either to use the compositions revealing dental plaque according to the invention alone, which requires subsequent elimination, or to use a single composition including that according to the invention revealing the dental plaque by coloring, and the constituents of any conventional toothpaste. This last solution being the simplest, we will insist on it in the examples which follow, without this limiting the scope of the invention. There is therefore addition or , in certain combinations of the revealing and toothpaste effects, in the case of these unique compositions.
Les compositions conformes à la présente invention contiennent donc au moins un corps ci-après appelé révélateur qui apporte. à la plaque dentaire une coloration qui n'apparut pas ou apparait dif féremment sur les autres surfaces de la cavité buccale.Cette coloration de la plaque dentaire peut être obtenue à l'aide de tout produit qui,en concentration suffisante,fixe,par voie physique, chimique et/ou biologique,une couche,un film ou des particules, le temps nécessaire à l'observation,et pouvant être ensuite aisé- ment éliminés.Il importe donc que la coloration soit apparente lors de cette observation, de sorte qu'elle peut n'apparattre qu'au mo-. The compositions according to the present invention therefore contain at least one body hereinafter called developer which provides. a dental stain that does not appear or appears differently on other surfaces of the oral cavity. This staining of dental plaque can be obtained using any product which, in sufficient concentration, fixes, by physical, chemical and / or biological, a layer, a film or particles, the time necessary for the observation, and which can then be easily removed. It is therefore important that the coloration is apparent during this observation, so that 'it can only appear at least.
ment de la mise en contact entre révélateur et piaque dentaire,par interaction physique chimique et/ou biologique entre le ou les révélateurs et un ou plusieurs constituants de la plaque dentaire.ment of the contact between dental developer and piac, by physical chemical and / or biological interaction between the developer (s) and one or more constituents of dental plaque.
On remarquera,à ce sujet,que certaines matières colorantes sont déjà en usage dans les produits dentifrices traditionnels mais à des concentrations insuffisantes pour apporter à la plaque dentaire une apparence contrastant nettement avec les surfaces avoisinantes, le rôle de ces colorants de l'art antérieur étant essentiellement d'ordre,sinon esthétique,du moins commercial au sens ou l'entend le droit des marques,c'est-à-dire comme signe distinctif,sans effet technique.It will be noted, in this regard, that certain coloring materials are already in use in traditional toothpaste products but at concentrations insufficient to bring to dental plaque an appearance which clearly contrasts with the neighboring surfaces, the role of these coloring agents of the prior art being essentially of an order, if not aesthetic, at least commercial in the sense or understood by trademark law, that is to say as a distinctive sign, without technical effect.
Par rapport à l'art antérieur,la mise en évidence de la plaque dentaire est donc entièrement nouvelle avec des composants autorisés par les diverses législations et des produits finis accessibles au grand public. Compared to the prior art, the highlighting of dental plaque is therefore entirely new with components authorized by the various legislations and finished products accessible to the general public.
Pour mieux faire comprendre les caractéristiques techniques et les avantages de la présente invention,on va en décrire des exemples de réalisation,étant entendu que ceux-ci ne sont pas limitatifs quant à leur mode de mise en oeuvre et aux applications qu'on peut en faire. To better understand the technical characteristics and advantages of the present invention, we will describe embodiments, it being understood that these are not limiting as to their mode of implementation and to the applications that can be made of them. to do.
Exemple 1
On prépare un dentifrice révélateur sur la base de la composition pondérale suivante donnée en pourcentage,avec mention de la propriété considérée généralement comme la plus caractéristique dans le cadre de la présente invention: Dihydroxyallantolnate de sodium 0,02 cicatrisant
Erythrosine 5 révélateur
Fluorure d'ammonium 0,15 anticarie
Acide borique 0,20 antiseptique
Chloroforme (éventuellement) 2 anesthésique Rinocléato de sodium 2 coadjuvant @@@
Nipagine(parahydroxybenzoate de méthyle) 0,08 conservateur
Nipasol(parahydroxybenzoate de propyle) 0,07 conservateur
Glycérine(ou propylène-glycol) 1 lubrifiant
Hydroxyde d'aluminium 3 agent abrasif
Saccarinate de sodium 0,03 édlcorant
Mélange de silice 22 excipient
Kylitol(ou sorbitol) 20 excipient
Essence de spearminth 0,80 parfum @enthol 0,05 parfum
Oxyde ae titane 0,50 agent blanchissant
Alcool aurique sultane < coadjuvant au q.s. pour 100
On remarquera que la quantité d'érythrosine indiquée ci-dessus n'est pas limitative puisque des résultats satisfaisants peuvent hêtre obtenus avec des teneurs comprises entre 0,1 et 10%.Example 1
A revealing toothpaste is prepared on the basis of the following weight composition given in percentage, with mention of the property generally considered to be the most characteristic in the context of the present invention: Sodium dihydroxyallantolnate 0.02 healing
Erythrosine 5 developer
0.15 anti-caries ammonium fluoride
Boric acid 0.20 antiseptic
Chloroform (possibly) 2 anesthetic Rinocléato sodium 2 coadjuvant @@@
Nipagine (methyl parahydroxybenzoate) 0.08 preservative
Nipasol (propyl parahydroxybenzoate) 0.07 preservative
Glycerin (or propylene glycol) 1 lubricant
Aluminum hydroxide 3 abrasive agent
0.03 sodium sweetener
Mixture of silica 22 excipient
Kylitol (or sorbitol) 20 excipient
Essence of spearminth 0.80 scent @enthol 0.05 scent
Titanium oxide 0.50 whitening agent
Sultana auric alcohol <coadjuvant at qs per 100
It will be noted that the amount of erythrosine indicated above is not limiting since satisfactory results can be obtained with contents of between 0.1 and 10%.
Cette composition peut entre préparée de la façon suivante, et cec; pour une tonne de produit fini:
On dissout dans 20 litres d'eau purifiée, le fluorure d'ammo- nium,ce qui donne la solution ci-après appelée solution A.This composition can between prepared in the following manner, and cec; for a ton of finished product:
Ammonium fluoride is dissolved in 20 liters of purified water, which gives the solution hereinafter called solution A.
Dans une autre cuve,on dissout dans 100 litres d'eau purifiée et sous agitation électrique,le rinocléate de sodium,le saccarina- te de sodium et le dihydroxyallantoïnate de sodium,ce qui donne la solution dite B. In another tank, sodium rinocléate, sodium saccarina and sodium dihydroxyallantoinate are dissolved in 100 liters of purified water and with electric stirring, which gives the solution called B.
Dans un disperseur on introduit la quantité suffisante d'eau purifiée avec le mélange de silice,le xylitol, l'oxyde de titane et l'hydroxyde d'aluminium. On laisse l'appareil homogénéiser le mélan Oe.On ajoute ensuite la solution B en filtrat,et par pompage,puis l'acide borique, l'alcool laurique sulfane et l'éventuel chloroforme.Après quelques minutes,on ajoute la solution A ainsi que les essences de parfum dans lesquelles on a préalablement dissous les conservateurs.0n laisse tourner l'appareillage jusqu'à bonne homo- généité,puis on incorpore l'érythrosine et l'on tourne jusqu'à parfaite homogénéité soit pendant une trentaine de minutes.On désaère ensuite sous vide pendant un quart d'heure. A sufficient quantity of purified water is introduced into a disperser with the mixture of silica, xylitol, titanium oxide and aluminum hydroxide. The apparatus is left to homogenize the melan Oe, then solution B is added as a filtrate, and by pumping, then boric acid, lauric alcohol sulfane and any chloroform. After a few minutes, solution A is added as well only the fragrance essences in which the preservatives have been dissolved beforehand. The apparatus is allowed to rotate until it is homogeneous, then the erythrosine is incorporated and it is turned to perfect homogeneity, that is to say for about thirty minutes. Then deaerated under vacuum for a quarter of an hour.
La pâte ainsi obtenue est broyée et stockée en cuve 43heures. The dough thus obtained is ground and stored in a tank for 43 hours.
Cette composition conforme à l'invention,comme celles données ci-dessous,est utilisable corme un dentifrice,la plaque dentaire étant,dans une première phase,directement colorée,ici grâce essentiellement à l'érythrosine,le dentifrice agissant,dans une seconde phase en faisant disparaitre la coloration avec tout ou partie de la plaque dentaire. This composition according to the invention, like those given below, can be used as a toothpaste, the dental plaque being, in a first phase, directly colored, here mainly thanks to erythrosine, the toothpaste acting, in a second phase by removing the color with all or part of the dental plaque.
Exemples 2
On peut préparer des compositions comme à l'exemple 1,en remplaçant l'érythrosine par un ou plusieurs composés réagissant avec les protides.On peut également associer ces divers types de révélateurs entre eux et avec ceux qui seront mentionnés dans les exemples suivants.Examples 2
Compositions can be prepared as in Example 1, by replacing erythrosine with one or more compounds which react with proteins. It is also possible to associate these various types of developer with each other and with those which will be mentioned in the following examples.
Parmi les révélateurs réagissant avec les protides,on a obtenu d'excellents résultats avec les produits suivants:
Iodure de potassium iodé
Eosine en solution aqueuse
Réactif de Mi lion
Solution d'alloxane à 1%
Sel de sodium et/ou de potassium de la tétraiodoBluorescéine
Rose Bengale
Phloxine
Mercurochrome
Exemples 3
De même,on peut recourir comme révélateur à des composés réagissant à la mucine,tels que les suivants avec lesquels des résultats particulièrement satisfaisants ont été obtenus::
Violet de méthyle
Bleu de toluidine
Bleu polychrome
Exemple 4
On peut aussi utiliser comme révélateurs,dans une formule du type de celle de l'exemple l,des composés développant une réaction physique,chimique et/ou biologique avec les microorganismes vivants ou morts présents dans la plaquekdentaire,tels que le Rouge Neutre qui vire en milieu acide.Among the developers reacting with proteins, excellent results have been obtained with the following products:
Iodized potassium iodide
Eosin in aqueous solution
Mi lion reagent
1% alloxane solution
Sodium and / or potassium salt of tetraiodoBluorescein
Bengal rose
Phloxine
Mercurochrome
Examples 3
Likewise, it is possible to use, as a developer, compounds which react to mucin, such as the following with which particularly satisfactory results have been obtained:
Methyl violet
Toluidine blue
Full color blue
Example 4
It is also possible to use, as developers, in a formula of the type of that of Example 1, compounds developing a physical, chemical and / or biological reaction with living or dead microorganisms present in the dental plaque, such as Neutral Red which turns in an acid medium.
Exemple 5
On peut de même fabriquer une composition à rôle essentiellement révélateur nécessitant ensuite un brossage ci'élininationet/ou un lavage avec un éventuel dentifrice.Cette formulation peut se baser sur les gammes de proportions pondérales suivantes:
Gélifiants 5 à 40%
Erythrosine et/ou révélateurs équivalents 0,01 à l0oi0/
Parums(tels qu'essence de menthe) 0,1 à 1%
Stabilisants et/ou conservateurs(tels que
Nipogine et/ou Nipasol) 0,1 à 0,2'J
Dans tous les exemples qui précèdent,on a mentionné un certain nombre de composants et notamment des colorants ou produits entral- nant une coloration.0n rappellera que le choix de tel ou tel compo sant est soumis,en plus des impératifs biologiques,physiques et/ou chimiques tels que ceux définis ci-dessus,a des rêlementations qui tendent à s'étendre.Ainsi,dans la cavité buccale la règlementation européenne en matière de colorants autorise de façon que l'on eut en pratique considérer comme limitative telle gamme de produits pour telle gamme de couleurs:par exemple,en rouge,sont autorisés à l'heure actuelle:E120,122 à 127,162,163,172,180 et 420.Il est donc nécessaire d'en tenir compte.Example 5
We can similarly make a composition with an essentially revealing role, then requiring a brushing and / or washing with a possible toothpaste. This formulation can be based on the following ranges of weight proportions:
Gelling agents 5 to 40%
Erythrosine and / or developer equivalent 0.01 to 10oi0 /
Parum (such as mint essence) 0.1 to 1%
Stabilizers and / or preservatives (such as
Nipogine and / or Nipasol) 0.1 to 0.2'J
In all of the foregoing examples, a certain number of components have been mentioned, in particular dyes or products involving coloring. It will be recalled that the choice of such and such a component is subject, in addition to the biological, physical and / or chemicals such as those defined above, has regulations which tend to extend. Thus, in the oral cavity the European regulation as regards dyes authorizes so that one had in practice to consider as limiting such range of products for such a range of colors: for example, in red, the following are currently authorized: E120,122 to 127,162,163,172,180 and 420. It is therefore necessary to take this into account.
Dans les exemples ci-dessus de 1 à 4,on obtient des compositions à la fois révélatrices et dentiBrices.L'exemple 5 se limite plus particulièrement au roule révélateur de la plaque dentaire d'où l'usage ultérieur du brossage accompagné ou non d'un lavage avec un dentifrice éliminant coloration et tout ou partie de la plaque.Lans tous les cas.Une répétition des opérations doit entraîner une com plète élimination de la plaque dentaire. In the above examples from 1 to 4, compositions are obtained which are both revealing and sensitive. Example 5 is more particularly limited to the revealing roll of dental plaque, hence the subsequent use of brushing with or without d '' wash with toothpaste to remove color and all or part of the plaque. In all cases. Repeated operations must lead to complete removal of plaque.
Un usage classique de ces diverses compositions conformes à l'invention en quantité et en fréquence équivalentes à celles des dentifrices classiques n'a pas révélé chez les cinquante sujets soumis à l'expérimentation de phénomènes appréciables sur les divers plans de la toxicité orale,de l'inocuité et de la tolérance. A conventional use of these various compositions in accordance with the invention in quantity and in frequency equivalent to those of conventional toothpastes did not reveal in the fifty subjects subjected to the experiment of phenomena appreciable on the various levels of oral toxicity, safety and tolerance.
Comme il a été dit ci-dessus à propos du choix des composants,il est nécessaire de tenir compte de l'éventuelle évolution des règlementations souvent plus strictes que les conclusions expérimentales
Dans tout ce qui précède on a parlé de réaction physique chimique et/ou biologique entre révélateurs et au moins l'un des constituants de la plaque dentaire.Il est évident que les mots réaction et réagir doivent être pris ici dans un sens plus large que le sens chimique classique dès lors que les révélateurs peuvent être ce que l'on appelle classiquement en chimie des réactifs colorés,mais plus généralement des corps qui,déjà colorés eux-mêmes ou non colorés ou autrement colorés vont,au contact de la plaque avec au moins l'un des constituants de la plaque ou grâce à sa présence provoquer une coloration,au moins en suface de cette plaque.Il y a donc généralement une interaction entre au moins l'un des révélateurs et au moins l'un des constituants de la plaque dentaire. As it was said above about the choice of components, it is necessary to take into account the possible evolution of the regulations often stricter than the experimental conclusions
In all of the above, we have spoken of a physical chemical and / or biological reaction between developers and at least one of the constituents of dental plaque. It is obvious that the words reaction and react must be taken here in a broader sense than the conventional chemical meaning since the developers can be what is conventionally called in chemistry colored reagents, but more generally bodies which, already colored themselves or not colored or otherwise colored, come into contact with the plate with at least one of the constituents of the plate or thanks to its presence cause coloring, at least on the surface of this plate. There is therefore generally an interaction between at least one of the developers and at least one of the constituents of dental plaque.
Claims (9)
Priority Applications (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7920929A FR2463613A1 (en) | 1979-08-20 | 1979-08-20 | NEW COMPOSITIONS FOR THE REVELATION OF THE DENTAL PLATE |
| PCT/FR1980/000131 WO1981000513A1 (en) | 1979-08-20 | 1980-08-13 | New compositions for detecting dental plaque |
| AU62230/80A AU6223080A (en) | 1979-08-20 | 1980-08-13 | New composition for detecting dental plaque |
| JP55501817A JPS57501280A (en) | 1979-08-20 | 1980-08-13 | |
| PT71709A PT71709B (en) | 1979-08-20 | 1980-08-19 | PROCESS FOR THE PREPARATION OF NEW DENTIFRING COMPOSITIONS FOR THE DETECTION OF THE PRESENCE AND THE INHIBITION OF DENTAL TARTAR |
| BE0/201807A BE884850A (en) | 1979-08-20 | 1980-08-20 | NEW COMPOSITIONS FOR REVELATION AND INHIBITION OF DENTAL PLATE |
| GR62709A GR82353B (en) | 1979-08-20 | 1980-08-20 | |
| EP80901502A EP0034595A1 (en) | 1979-08-20 | 1981-03-09 | New compositions for detecting dental plaque |
| NO811325A NO811325L (en) | 1979-08-20 | 1981-04-15 | PREPARATIONS FOR DISCLOSURE AND INHIBITION OF DENTAL PLAQUE |
| OA57380A OA07365A (en) | 1979-08-20 | 1981-04-20 | New compositions for the detection and inhibition of dental plaque. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7920929A FR2463613A1 (en) | 1979-08-20 | 1979-08-20 | NEW COMPOSITIONS FOR THE REVELATION OF THE DENTAL PLATE |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2463613A1 true FR2463613A1 (en) | 1981-02-27 |
| FR2463613B1 FR2463613B1 (en) | 1983-01-28 |
Family
ID=9228939
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7920929A Granted FR2463613A1 (en) | 1979-08-20 | 1979-08-20 | NEW COMPOSITIONS FOR THE REVELATION OF THE DENTAL PLATE |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0034595A1 (en) |
| JP (1) | JPS57501280A (en) |
| AU (1) | AU6223080A (en) |
| BE (1) | BE884850A (en) |
| FR (1) | FR2463613A1 (en) |
| GR (1) | GR82353B (en) |
| NO (1) | NO811325L (en) |
| OA (1) | OA07365A (en) |
| PT (1) | PT71709B (en) |
| WO (1) | WO1981000513A1 (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003000215A1 (en) * | 2001-06-21 | 2003-01-03 | Herbariorum Medicaminum Officina Alta Badiae S.N.C. | Tooth-paste composition having anti-plaque properties |
| WO2005025528A1 (en) * | 2003-09-11 | 2005-03-24 | The Procter & Gamble Company | Dye composition and method for detection of demineralized lesions in teeth |
| WO2013074080A1 (en) * | 2011-11-15 | 2013-05-23 | Colgate-Palmolive Company | Oral care gel dispenser systems |
| WO2013074079A1 (en) * | 2011-11-15 | 2013-05-23 | Colgate-Palmolive Company | Oral care gels |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01246214A (en) * | 1988-03-28 | 1989-10-02 | Shiseido Co Ltd | Composition for oral cavity |
| FR2791890B1 (en) * | 1999-04-12 | 2004-12-10 | Gilbert Lab | COLORED ALCOHOLIC CHLORHEXIDINE SOLUTION AND MANUFACTURING METHOD THEREOF |
| JP5366553B2 (en) | 2005-11-09 | 2013-12-11 | クロックス テクノロジーズ インコーポレイテッド | Teeth whitening composition and method |
| US20100266989A1 (en) | 2006-11-09 | 2010-10-21 | Klox Technologies Inc. | Teeth whitening compositions and methods |
| NZ631218A (en) | 2008-11-07 | 2016-03-31 | Klox Technologies Inc | Combination of an oxidant and a photoactivator for the healing of wounds |
| DE102009017090A1 (en) * | 2009-04-15 | 2010-11-11 | Festo Ag & Co. Kg | Method for determining controller parameters of a control device for controlling the drive of a drive system |
| SG10201401823RA (en) | 2009-07-17 | 2014-08-28 | Klox Technologies Inc | Combination of an oxidant, a photosensitizer and a wound healing agent for oral disinfection and treatment of oral disease |
| US11116841B2 (en) | 2012-04-20 | 2021-09-14 | Klox Technologies Inc. | Biophotonic compositions, kits and methods |
| US20130281913A1 (en) | 2012-04-20 | 2013-10-24 | Klox Technologies Inc. | Biophotonic compositions and methods for providing biophotonic treatment |
| MX351267B (en) | 2012-09-14 | 2017-10-06 | Valeant Pharmaceuticals Int Inc | Compositions and methods for teeth whitening. |
| US20140276354A1 (en) | 2013-03-14 | 2014-09-18 | Klox Technologies Inc. | Biophotonic materials and uses thereof |
| RU2016103321A (en) | 2013-07-03 | 2017-08-08 | Клокс Текнолоджиз Инк. | COMPOSITIONS AND METHODS FOR TREATING NON-HEALING RAS |
| MX2016012933A (en) | 2014-04-01 | 2016-12-07 | Klox Tech Inc | Tissue filler compositions and methods of use. |
| KR20170077153A (en) | 2014-10-31 | 2017-07-05 | 클록스 테크놀로지스 인크. | Photoactivatable fibers and fabric media |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3723613A (en) * | 1971-01-22 | 1973-03-27 | J Derdivanis | Dental plaque disclosing agent |
| AU6703974A (en) * | 1973-03-30 | 1975-09-25 | Selwyn S L | Dental plaque disclosing agents |
| US4080441A (en) * | 1976-12-27 | 1978-03-21 | Colgate-Palmolive Company | Antibacterial oral composition |
-
1979
- 1979-08-20 FR FR7920929A patent/FR2463613A1/en active Granted
-
1980
- 1980-08-13 JP JP55501817A patent/JPS57501280A/ja active Pending
- 1980-08-13 AU AU62230/80A patent/AU6223080A/en not_active Abandoned
- 1980-08-13 WO PCT/FR1980/000131 patent/WO1981000513A1/en not_active Application Discontinuation
- 1980-08-19 PT PT71709A patent/PT71709B/en unknown
- 1980-08-20 BE BE0/201807A patent/BE884850A/en unknown
- 1980-08-20 GR GR62709A patent/GR82353B/el unknown
-
1981
- 1981-03-09 EP EP80901502A patent/EP0034595A1/en not_active Withdrawn
- 1981-04-15 NO NO811325A patent/NO811325L/en unknown
- 1981-04-20 OA OA57380A patent/OA07365A/en unknown
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003000215A1 (en) * | 2001-06-21 | 2003-01-03 | Herbariorum Medicaminum Officina Alta Badiae S.N.C. | Tooth-paste composition having anti-plaque properties |
| WO2005025528A1 (en) * | 2003-09-11 | 2005-03-24 | The Procter & Gamble Company | Dye composition and method for detection of demineralized lesions in teeth |
| WO2013074080A1 (en) * | 2011-11-15 | 2013-05-23 | Colgate-Palmolive Company | Oral care gel dispenser systems |
| WO2013074079A1 (en) * | 2011-11-15 | 2013-05-23 | Colgate-Palmolive Company | Oral care gels |
| US9775788B2 (en) | 2011-11-15 | 2017-10-03 | Colgate-Palmolive Company | Oral care gels |
| US10278796B2 (en) | 2011-11-15 | 2019-05-07 | Colgate-Palmolive Company | Oral care gel dispenser systems |
Also Published As
| Publication number | Publication date |
|---|---|
| PT71709A (en) | 1980-09-01 |
| AU6223080A (en) | 1981-03-18 |
| BE884850A (en) | 1980-12-16 |
| EP0034595A1 (en) | 1981-09-02 |
| OA07365A (en) | 1984-06-30 |
| FR2463613B1 (en) | 1983-01-28 |
| PT71709B (en) | 1981-06-17 |
| NO811325L (en) | 1981-04-15 |
| JPS57501280A (en) | 1982-07-22 |
| WO1981000513A1 (en) | 1981-03-05 |
| GR82353B (en) | 1984-12-13 |
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