Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
  • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
  • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
  • A61L2/18—Liquid substances or solutions comprising solids or dissolved gases
  • A61L2/186—Peroxide solutions
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
  • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
  • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
  • A61L2/08—Radiation
  • A61L2/10—Ultraviolet radiation
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
  • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
  • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
  • A61L2/18—Liquid substances or solutions comprising solids or dissolved gases
  • A61L2/183—Ozone dissolved in a liquid
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
  • A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
  • A61L2202/20—Targets to be treated
  • A61L2202/24—Medical instruments, e.g. endoscopes, catheters, sharps

Definitions

• the present invention comprises an agent for the treatment of surfaces, in particular medical instruments, obtainable by artificial UV irradiation of a disinfectant solution and a method for the sterilizing treatment of surfaces, in particular medical instruments without and with sterile water rinsing.
• the present invention includes a system for the sterilizing treatment of surfaces, in particular medical instruments, consisting of a UV source and a disinfectant.
• US 4,731,222 and US 4,992,706 deal with the sterilization of medical instruments using liquid disinfectants.
• the medical instruments are rinsed free of the residues of the disinfectant by rinsing with sterile water, generated by filtering, for example, tap water through a sterile filter.
• US Pat. No. 6,103,189 discloses a method in which sterile water as rinse water is dispensed with by rinsing with a sterilizing solution which is free of non-disintegrating components. According to the example in column 5, lines 16 to 18, the conditions must be selected so that the tap water used is sterilized.
• the present invention accordingly relates to agents for treating surfaces, in particular medical instruments, obtainable by artificial UV irradiation of an aqueous solution which contains a chemical disinfectant, optionally together with corrosion inhibitors, buffer components, complexing agents, wetting agents and / or other auxiliaries or active ingredients , wherein the chemical disinfectant is preferably selected from ozone, chlorine dioxide, sodium hypochlorite, hypochlorous acid, hydrogen peroxide, organic or inorganic peracids or mixtures thereof, optionally together with other auxiliaries or active substances and / or water.
• a chemical disinfectant is preferably selected from ozone, chlorine dioxide, sodium hypochlorite, hypochlorous acid, hydrogen peroxide, organic or inorganic peracids or mixtures thereof, optionally together with other auxiliaries or active substances and / or water.
• the invention can be used wherever disinfection or sterilization is to be carried out under similar conditions.
• the application is conceivable to increase the antimicrobial effectiveness of aqueous chain lubricant solutions in the field of conveyor belt lubrication in food manufacturing companies. This can reduce occurring microbiological problems.
• an aqueous antimicrobial substance is usually already present in the aqueous solution.
• these are C8-C20-alkylpropylenediamines, quaternary ammonium compounds, amphoteric substances.
• foam disinfectants containing peracetic acid which are usually applied to the surfaces to be disinfected after dilution and are present there as foam.
• activation of the biocidal performance is also achieved by applying the teaching according to the invention.
• R 2 -0 2 C- (CH 2 ) ⁇ -CO 3 H (I) wherein R 2 is hydrogen or an alkyl group of 1 to 4 carbon atoms and x is a number from 1 to 4, and / or b) the phthalimido-percarboxylic acids (II), in which the percarboxylic acid content contains 1 to 18 carbon atoms, and / or c) the compounds of the formula III
• the agent according to the invention contains a) peracids according to the general formula I as peracids in which R 2 is hydrogen or a methyl group, and / or b) contains phthalimido peracids as peracids in which the percarboxylic acid portion contains 1 to 8 carbon atoms, and / or c) as peracids according to the general formula III, peracids with an alkyl or alkenyl group with 1 to 12 carbon atoms are contained.
• the agent according to the invention contains, as peracid, one or more compounds selected from peracetic acid, perpropionic acid, peroctanoic acid, phthalimidoperhexanoic acid, phthalimidoperoctanoic acid, persuccinic acid, persuccinic acid monomethyl ester, perglutaric acid, perglutaric acid monomethyl ester, peradipic acid, peradipic acid, peradipic acid, peradipic acid Monosuccinic acid monomethyl ester, the selection of these components highlighting the peracetic acid.
• the agent according to the invention preferably additionally contains fatty acids with 8 to 12 carbon atoms and / or anionic surfactants selected from the C 8 -C 8 alkyl sulfates, C 8 -C ⁇ 8 - alkyl ether sulfates, C 8 -Ci 8 alkanesulfonates, C 8 -C 18 - ⁇ -olefin sulfonates, sulfonated C 8 -C 18 fatty acids, C 8 -C ⁇ 8 alkylbenzenesulfonates, sulfonic succinic acid mono- and -di-CrCi 2 - Alkyl esters, C 8 -C 8 -alkylpolyglycol ether carboxylates, C 8 -C 8 -N-acyl acids, C 8 -C 8 -N-sarcosinates, C 8 -C
• the agent according to the invention by UV irradiation of a solution which, apart from water and the decomposition products of the disinfectant mentioned in the solution, is free of non-disintegrating constituents.
• constituents of the composition are those which are intentionally added and remain stable under the conditions described. Accordingly, inadvertently added ingredients, such as salts, which get into the agent when using tap water, are not to be taken into account in this connection.
• Non-disintegrating constituents are still present in the initial concentration after a substantial period of time, for example after a day or after a week.
• the solution to be treated by UV radiation contains 0.0001 to 0.2% by weight. Disinfectant, based on the entire solution.
• the solution to be treated by UV radiation is 0.0002 to 0.01% by weight, particularly preferably 0.001 to 0.005 and very particularly preferably contains no more than 0.03% by weight of disinfectant, based on the total solution.
• Another object of the present invention is a method for the sterilizing treatment of microbiologically contaminated surfaces, in particular medical instruments, in which the surfaces are brought into contact with an agent according to the invention, if necessary after a cleaning step, and then rinsed with sterile water.
• the present invention also relates to a method for the sterilizing treatment of microbiologically contaminated surfaces, in particular medical instruments, without the need for rinsing with sterile water, in which a) the solution of a chemical disinfectant, optionally together with corrosion inhibitors, buffer components, complexing agents, wetting agents and / or other auxiliary or active substances in water and b) the surfaces mentioned are decontaminated with the solution according to a), and then c) the surfaces mentioned are treated with a further aqueous solution of a liquid chemical disinfectant which is free from non-decomposing constituents, characterized in that as a further aqueous solution the embodiment of the agent according to the invention is used, with the preferred proviso that the proportion of the disinfectant present in the solution to be treated for the preparation of the agent used is 0.002 to 0.01% by weight, based on the total solution.
• Another object of the present invention is a method for the sterilizing treatment of microbiologically contaminated surfaces, in particular medical instruments, without rinsing with pure sterile water, in which a) the surfaces mentioned are decontaminated with a first agent according to the invention and then b) the surfaces mentioned another agent according to the invention are treated, the proportion of disinfectant in the further agent according to the invention being less than the proportion of disinfectant in the first agent according to the invention.
• the proportion of disinfectant in the further agent is chosen so that this proportion would not be sufficient without the additional use of UV light under the chosen process conditions, such as time and temperature, for certain pathogenic groups of germs, such as mycobacteria or Kill spores.
• Another object of the present invention is a system for the sterilizing treatment of surfaces, in particular medical instruments, possibly without using sterile water, containing a) a UV source and b) a chemical disinfectant selected from ozone, chlorine dioxide, sodium hypochlorite, hypochlorous acid, hydrogen peroxide, organic or inorganic peracids or mixtures thereof, optionally together with other auxiliaries or active substances and / or water and optionally c) corrosion inhibitors and / or d) buffer components and / or e) complexing agents and / or f) wetting agents and / or g) other auxiliaries or active substances.
• a UV source and b) a chemical disinfectant selected from ozone, chlorine dioxide, sodium hypochlorite, hypochlorous acid, hydrogen peroxide, organic or inorganic peracids or mixtures thereof, optionally together with other auxiliaries or active substances and / or water and optionally c) corrosion inhibitors and / or d) buffer components and / or
• a disinfectant solution DES1 was used in the context of the present invention, which, according to the recipe, represents a mixture of 61.1% by weight of deionized water, 28.7% by weight of hydrogen peroxide and 10.2% by weight of acetic acid , The resulting proportion of peracetic acid in the DES1 is 4.5% by weight, based on the total DES1.
• DSM 939 Pseudomonas aeruginosa
• ATCC6633 Bacillus subtilis
• the water to be used was contaminated with the test germs in the following concentrations:
• the test was carried out with the UV system switched on and baked on (lead time 30 min.) First in one pass with contaminated water without DES1 and then with contaminated water and enough DES1 that in the solution in one experiment approximately 30 and in another experiment approximately 10 ppm peracetic acid were present. The system was rinsed with water between each run and disinfected so that any test germs that remained could not falsify the result of the next run.
• a UV system suitable for the disinfection of liquid humans in a flow-through method was used as the UV system.
• Artificial UV-C radiation is generated by low-pressure mercury lamps. On the wavelength of 254 nm is approximately 80% of the total radiation from a UV lamp (the absorption curve of DNA shows a maximum at 260 nm).
• the flow rate through the UV system mentioned is preferably between 640 and 800 l / h.
• test germ Pseudomonas aeruginosa which is also one of the most important water germs, is significantly reduced in the plant in the presence of the product DES1.
• the necessary for the germ reduction DES1 concentration can be significantly reduced.
• the results are shown in the tables. With this test germ, however, UV treatment alone only leads to a slight reduction in germs.
• the information "per 100 ml” refers to test results, where even after processing 100 ml only the specified number of germs was detected.

Landscapes

• Health & Medical Sciences (AREA)
• Epidemiology (AREA)
• Life Sciences & Earth Sciences (AREA)
• Animal Behavior & Ethology (AREA)
• General Health & Medical Sciences (AREA)
• Public Health (AREA)
• Veterinary Medicine (AREA)
• Chemical & Material Sciences (AREA)
• Chemical Kinetics & Catalysis (AREA)
• General Chemical & Material Sciences (AREA)
• Apparatus For Disinfection Or Sterilisation (AREA)
• Agricultural Chemicals And Associated Chemicals (AREA)
• Materials For Medical Uses (AREA)

Priority Applications (5)

Applications Claiming Priority (2)

Publications (1)

Family

ID=7685645

Family Applications (1)

Country Status (8)

Cited By (3)

Families Citing this family (8)

Citations (12)

Family Cites Families (9)

• 2001
  • 2001-05-21 DE DE10124817A patent/DE10124817A1/de not_active Ceased
• 2002
  • 2002-05-11 BR BRPI0209846A patent/BRPI0209846B8/pt not_active IP Right Cessation
  • 2002-05-11 US US10/478,099 patent/US20040146426A1/en not_active Abandoned
  • 2002-05-11 EP EP02732710A patent/EP1389908B1/de not_active Expired - Lifetime
  • 2002-05-11 WO PCT/EP2002/005199 patent/WO2002102154A1/de not_active Ceased
  • 2002-05-11 JP JP2003504751A patent/JP2005500291A/ja active Pending
  • 2002-05-11 AU AU2002304626A patent/AU2002304626B2/en not_active Expired
• 2003
  • 2003-09-29 ZA ZA200307562A patent/ZA200307562B/en unknown

Patent Citations (12)

Non-Patent Citations (1)

Also Published As

Similar Documents

Legal Events