WO2002086137A2 - Process for the production of l-amino acids by fermentation using coryneform bacteria - Google Patents

Process for the production of l-amino acids by fermentation using coryneform bacteria Download PDF

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Publication number
WO2002086137A2
WO2002086137A2 PCT/EP2002/003728 EP0203728W WO02086137A2 WO 2002086137 A2 WO2002086137 A2 WO 2002086137A2 EP 0203728 W EP0203728 W EP 0203728W WO 02086137 A2 WO02086137 A2 WO 02086137A2
Authority
WO
WIPO (PCT)
Prior art keywords
gene
coding
mqo
amino acid
coryneform bacteria
Prior art date
Application number
PCT/EP2002/003728
Other languages
English (en)
French (fr)
Other versions
WO2002086137A3 (en
Inventor
Mike Farwick
Brigitte Bathe
Thomas Hermann
Achim Marx
Walter Pfefferle
Original Assignee
Degussa Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Degussa Ag filed Critical Degussa Ag
Priority to AU2002316834A priority Critical patent/AU2002316834A1/en
Priority to HU0303926A priority patent/HUP0303926A3/hu
Priority to EP02745213A priority patent/EP1377674A2/de
Publication of WO2002086137A2 publication Critical patent/WO2002086137A2/en
Publication of WO2002086137A3 publication Critical patent/WO2002086137A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0036—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6)

Definitions

  • the E. coli expression vector pXK99Emob constructed was transferred by means of electroporation (Tauch et al . 1994, FEMS Microbiol Letters, 123: 343-347) into E. coli DH5 ⁇ mcr (Grant, 1990, Proceedings of the National Academy of Sciences U.S.A., 87:4645-4649). Selection of the transformants was carried out on LB Agar (Sambrook et al . , Molecular Cloning: A Laboratory Manual. 2 nd Ed., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y. , 1989), which had been supplemented with.50 mg/1 kanamycin.
  • the microorganism identified under L above was accompanied by:
  • microorganism identified under I above was received by this International Depositary Authority on (date of original deposit) and a request to convert the original deposit to a deposit under the Budapest Treaty was received by it on (date of receipt of request for conversion).
PCT/EP2002/003728 2001-04-10 2002-04-04 Process for the production of l-amino acids by fermentation using coryneform bacteria WO2002086137A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2002316834A AU2002316834A1 (en) 2001-04-10 2002-04-04 Process for the production of l-amino acids by fermentation using coryneform bacteria
HU0303926A HUP0303926A3 (en) 2001-04-10 2002-04-04 Process for the production of l-amino acids by fermentation using coryneform bacteria
EP02745213A EP1377674A2 (de) 2001-04-10 2002-04-04 Verfahren zur herstellung von l-aminosäuren durch fermentation von coryneformen bakterien

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10117816.6 2001-04-10
DE10117816A DE10117816A1 (de) 2001-04-10 2001-04-10 Verfahren zur fermentativen Herstellung von L-Aminosäuren unter Verwendung coryneformer Bakterien

Publications (2)

Publication Number Publication Date
WO2002086137A2 true WO2002086137A2 (en) 2002-10-31
WO2002086137A3 WO2002086137A3 (en) 2003-08-28

Family

ID=7681045

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/003728 WO2002086137A2 (en) 2001-04-10 2002-04-04 Process for the production of l-amino acids by fermentation using coryneform bacteria

Country Status (7)

Country Link
EP (1) EP1377674A2 (de)
KR (1) KR20040014489A (de)
CN (1) CN1231591C (de)
AU (1) AU2002316834A1 (de)
DE (1) DE10117816A1 (de)
HU (1) HUP0303926A3 (de)
WO (1) WO2002086137A2 (de)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006077004A3 (de) * 2005-01-19 2007-03-15 Degussa Allele des mqo-gens aus coryneformen bakterien
US7214526B2 (en) 2005-01-19 2007-05-08 Degussa Ag Alleles of the mqo gene from coryneform bacteria
WO2007141111A2 (de) * 2006-06-02 2007-12-13 Evonik Degussa Gmbh Verfahren zur herstellung eines l-lysin enthaltende futtermitteladditives
WO2008049769A1 (de) * 2006-10-26 2008-05-02 Evonik Degussa Gmbh Allele des prpd1-gens aus coryneformen bakterien
EP3498853A1 (de) 2017-12-14 2019-06-19 Evonik Degussa GmbH Verfahren zur fermentativen herstellung von l-lysin

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100786987B1 (ko) * 2004-01-30 2007-12-18 아지노모토 가부시키가이샤 Ｌ-아미노산 생산 미생물 및 ｌ-아미노산 생산 방법
DE102004011248A1 (de) * 2004-03-09 2005-09-22 Degussa Ag Verfahren zur Herstellung von L-Aminosäuren unter Verwendung coryneformer Bakterien
KR100789270B1 (ko) * 2005-11-30 2008-01-02 씨제이 주식회사 Ｌ-라이신 생산능이 향상된 코리네박테리움 속 미생물 및그를 이용하여 ｌ-라이신을 생산하는 방법
KR100733928B1 (ko) * 2005-11-30 2007-07-02 씨제이 주식회사 카나마이신 내성을 갖고 ｌ-라이신 생산능이 향상된코리네형 미생물 및 그를 이용하여 ｌ-라이신을 생산하는방법
KR101072708B1 (ko) 2008-12-17 2011-10-11 씨제이제일제당 (주) ５＇－크산틸산 생산능이 향상된 미생물 및 이를 이용한 ５＇－크산틸산의 생산방법
KR101072720B1 (ko) * 2008-12-17 2011-10-11 씨제이제일제당 (주) ５＇－구아닐산 생산능이 향상된 미생물 및 이를 이용한 ５＇－구아닐산의 생산방법
KR102572849B1 (ko) * 2022-07-11 2023-08-31 대상 주식회사 L-글루탐산을 생산하는 코리네박테리움 속 변이 미생물 및 이를 이용한 l-글루탐산의 생산 방법

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1038969A2 (de) * 1999-03-19 2000-09-27 Degussa-Hüls Aktiengesellschaft Verfahren zur fermentativen Herstellung von L-Aminosäuren unter Verwendung coryneformer Bakterien
EP1085091A1 (de) * 1999-09-01 2001-03-21 Degussa-Hüls Aktiengesellschaft Für das thrE-Gen codierende Nukleotidsequenzen und Verfahren zur fermentativen Herstellung von L-Threonin mit coryneformen Bakterien

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1038969A2 (de) * 1999-03-19 2000-09-27 Degussa-Hüls Aktiengesellschaft Verfahren zur fermentativen Herstellung von L-Aminosäuren unter Verwendung coryneformer Bakterien
EP1085091A1 (de) * 1999-09-01 2001-03-21 Degussa-Hüls Aktiengesellschaft Für das thrE-Gen codierende Nukleotidsequenzen und Verfahren zur fermentativen Herstellung von L-Threonin mit coryneformen Bakterien

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
MOLENAAR D ET AL: "BIOCHEMICAL AND GENETIC CHARACTERIZATION OF THE MEMBRANE-ASSOCIATEDMALATE DEHYDROGENASE (ACCEPTOR) FROM CORYNEBACTERIUM GLUTAMICUM" EUROPEAN JOURNAL OF BIOCHEMISTRY, BERLIN, DE, vol. 254, 1998, pages 395-403, XP000941422 ISSN: 0014-2956 cited in the application *
MOLENAAR DOUWE ET AL: "Functions of the membrane-associated and cytoplasmic malate dehydrogenases in the citric acid cycle of Corynebacterium glutamicum" JOURNAL OF BACTERIOLOGY, WASHINGTON, DC, US, vol. 182, no. 24, December 2000 (2000-12), pages 6884-6891, XP002182880 ISSN: 0021-9193 *
REST VAN DER M E ET AL: "Functions of the membrane-associated and cytoplasmic malate dehydrogenases in the citric acid cycle of Escherichia coli" JOURNAL OF BACTERIOLOGY, WASHINGTON, DC, US, vol. 182, no. 24, December 2000 (2000-12), pages 6892-6899, XP002179953 ISSN: 0021-9193 *

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006077004A3 (de) * 2005-01-19 2007-03-15 Degussa Allele des mqo-gens aus coryneformen bakterien
US7214526B2 (en) 2005-01-19 2007-05-08 Degussa Ag Alleles of the mqo gene from coryneform bacteria
US7618798B2 (en) 2005-01-19 2009-11-17 Evonik Degussa Gmbh Alginate gel scaffold having a plurality of continuous parallel microtubular copper capillaries
WO2007141111A2 (de) * 2006-06-02 2007-12-13 Evonik Degussa Gmbh Verfahren zur herstellung eines l-lysin enthaltende futtermitteladditives
WO2007141111A3 (de) * 2006-06-02 2008-03-06 Evonik Degussa Gmbh Verfahren zur herstellung eines l-lysin enthaltende futtermitteladditives
WO2008049769A1 (de) * 2006-10-26 2008-05-02 Evonik Degussa Gmbh Allele des prpd1-gens aus coryneformen bakterien
US7893231B2 (en) 2006-10-26 2011-02-22 Evonik Degussa Gmbh Alleles of the PRPD1 gene from coryneform bacteria
EP3498853A1 (de) 2017-12-14 2019-06-19 Evonik Degussa GmbH Verfahren zur fermentativen herstellung von l-lysin
EP3498854A1 (de) 2017-12-14 2019-06-19 Evonik Degussa GmbH Verfahren zur fermentativen herstellung von l-lysin

Also Published As

Publication number Publication date
HUP0303926A3 (en) 2005-12-28
HUP0303926A2 (hu) 2004-03-01
AU2002316834A1 (en) 2002-11-05
CN1501979A (zh) 2004-06-02
KR20040014489A (ko) 2004-02-14
AU2002316834A8 (en) 2005-10-13
DE10117816A1 (de) 2002-10-17
CN1231591C (zh) 2005-12-14
EP1377674A2 (de) 2004-01-07
WO2002086137A3 (en) 2003-08-28

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