WO2002080753A2 - Induction powered in vivo imaging device - Google Patents

Induction powered in vivo imaging device Download PDF

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Publication number
WO2002080753A2
WO2002080753A2 PCT/IL2002/000283 IL0200283W WO02080753A2 WO 2002080753 A2 WO2002080753 A2 WO 2002080753A2 IL 0200283 W IL0200283 W IL 0200283W WO 02080753 A2 WO02080753 A2 WO 02080753A2
Authority
WO
WIPO (PCT)
Prior art keywords
energy
imaging device
receiving unit
image sensor
vivo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IL2002/000283
Other languages
English (en)
French (fr)
Other versions
WO2002080753A3 (en
Inventor
Arkady Glukhovsky
Gavriel J. Iddan
Gavriel Meron
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Given Imaging Ltd
Original Assignee
Given Imaging Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Given Imaging Ltd filed Critical Given Imaging Ltd
Priority to JP2002578793A priority Critical patent/JP2004528890A/ja
Priority to EP02759837A priority patent/EP1418845A4/en
Priority to IL15442002A priority patent/IL154420A0/xx
Priority to AU2002307759A priority patent/AU2002307759A1/en
Publication of WO2002080753A2 publication Critical patent/WO2002080753A2/en
Anticipated expiration legal-status Critical
Publication of WO2002080753A3 publication Critical patent/WO2002080753A3/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
    • A61B1/041—Capsule endoscopes for imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00002—Operational features of endoscopes
    • A61B1/00025—Operational features of endoscopes characterised by power management
    • A61B1/00027—Operational features of endoscopes characterised by power management characterised by power supply
    • A61B1/00029—Operational features of endoscopes characterised by power management characterised by power supply externally powered, e.g. wireless
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/07—Endoradiosondes
    • A61B5/073—Intestinal transmitters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00002—Operational features of endoscopes
    • A61B1/00011—Operational features of endoscopes characterised by signal transmission
    • A61B1/00016—Operational features of endoscopes characterised by signal transmission using wireless means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00002—Operational features of endoscopes
    • A61B1/0002—Operational features of endoscopes provided with data storages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
    • A61B1/042—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances characterised by a proximal camera, e.g. a CCD camera
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
    • A61B2560/02—Operational features
    • A61B2560/0204—Operational features of power management
    • A61B2560/0214—Operational features of power management of power generation or supply
    • A61B2560/0219—Operational features of power management of power generation or supply of externally powered implanted units
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
    • A61B5/0031—Implanted circuitry

Definitions

  • the present invention relates to induction powered in vivo devices, specifically to externally powered in vivo imaging devices.
  • Physiological sensors and medical devices such as cochlear prosthesis, artificial hearts and defibrillators may be implanted for performing in vivo.
  • the implanted devices may contain a battery or may be powered externally.
  • External energy transmission to implants increases the power efficiency and operative hours of the implanted devices.
  • External wireless energy transmission to implants also contributes to patient motility and to the elimination of the potential of infection.
  • Transcutaneous coupling of power to implanted devices is one alternative for external energy transmission.
  • Another alternative is described in WO 98/29030, which relates to an implantable stent for measuring fluid flow that can be powered by electrical energy received from a source out side the body.
  • the stent circuitry can be activated by a time varying magnetic field that is generated in the vicinity of the stent coil and that is generally aligned with the central axis of the stent.
  • the present invention provides an induction powered in vivo imaging device.
  • the imaging device according to an embodiment of the invention may be moved through body lumens and thus may have an inconstant axis orientation.
  • the imaging device includes an image sensor, optionally an illumination source and an energy receiving unit.
  • the energy receiving unit is configured for receiving electromagnetic energy and for converting the received electromagnetic energy to energy for powering at least one electrical component of the image sensor.
  • electromagnetic energy may refer to energy generated by an electromagnetic wave or by a magnetic field.
  • the energy receiving unit may include at least one coil configured to receive electromagnetic energy and an element, coupled to the coil, configured for converting the received electromagnetic energy to energy for powering the electrical components of the device, such as the image sensor, illumination source etc.
  • the energy receiving unit may further be configured for storing the voltage, such as by including a capacitor or chargeable battery.
  • the imaging device images in vivo sites that are illuminated by the illumination source.
  • the images may be stored in the imaging device or may be transmitted to an external receiving system.
  • the device of the invention may further include a storing device, such as a solid state memory chip for the collected images.
  • the device may include a transmitter for transmitting signals to an external receiving system.
  • the system includes an in vivo imaging device and an external energy source for induction of the imaging device.
  • the in vivo imaging device contains an image sensor, an illumination source and an energy receiving unit.
  • the device may further include a transmitter for transmitting signals to an external receiving system.
  • the external energy source for induction of the imaging device is typically a magnetic field generator capable of generating a time varying magnetic field around the in vivo imaging device.
  • the varying magnetic field can be generated by an AC induction coil or by a rotating magnetic circuit.
  • the magnetic field generator may be in communication with or may include a localizing device for localizing the in vivo imaging device in a patient's body.
  • the magnetic filed generator can then be moved along the patient's body in accordance with the in vivo imaging device location, as determined by the localizing device, thus optimizing the energy transfer from the external energy source to the in vivo imaging device.
  • the in vivo imaging device contains at least one complementary metal oxide semiconductor (CMOS) imaging camera, at least one light emitting diode (LED) and a transmitter for transmitting video signals from the CMOS imaging camera to an external receiving system.
  • CMOS complementary metal oxide semiconductor
  • LED light emitting diode
  • the energy receiving unit contains a three axial coil assembly and a corresponding selector rectifier circuit that is able to convert magnetically induced AC voltage to a desired DC voltage that is available for powering the electrical components of the in vivo imaging device.
  • the external energy source is a magnetic field generator containing a low frequency AC induction coil or a rotating magnetic circuit.
  • the energy receiving unit contains a single coil and the external energy source is a magnetic field generator having three alternating orthogonal components.
  • the magnetic field generator may be in communication with or may include a localizing device for localizing the in vivo imaging device in a body lumen.
  • the magnetic filed generator can then be moved along a patient's body in accordance with the in vivo imaging device location, as determined by the localizing device for optimizing the energy transfer from the external energy source to the in vivo imaging device.
  • the device and system of the invention can be used for imaging body lumens, such as the gastrointestinal (GI) tract.
  • the device according to an embodiment of the invention may be contained within a swallowable capsule that is capable of passing through and obtaining images of substantially the entire GI tract.
  • the device of the invention may be attached onto any device suitable for being inserted into and moved through body lumens, such as needles, stents, catheters and endoscopes.
  • the method includes the step of: externally powering an in vivo imaging device to obtain images in vivo, the in vivo imaging device including at least one image sensor, optionally an illumination source and an energy receiving unit.
  • the energy receiving unit is configured for receiving electromagnetic energy and for converting the received electromagnetic energy to energy for powering at least one electrical component of the image sensor.
  • Externally powering the in vivo imaging device can be done by generating a magnetic field around the in vivo imaging device.
  • the magnetic field which, according to some embodiments, may be unidirectional or having three orthogonal components, is generated around an area of the patient's body that contains the in vivo imaging device.
  • the method may further include the step of localizing the in vivo imaging device, optionally, prior to the step of externally powering the in vivo imaging device and the step of moving an external energy source, for example, a magnetic field generator, to correlate with the location of the in vivo imaging device in the patient's body.
  • an external energy source for example, a magnetic field generator
  • the method may be useful for imaging the GI tract and the in vivo imaging device may be contained in a swallowable capsule that can pass through substantially the entire GI tract.
  • Figure 1A is a schematic illustration of the in vivo imaging device in accordance with an embodiment of the invention.
  • Figure IB is an electric block diagram of the energy receiving unit included in the in vivo imaging device illustrated in Fig. 1A, according to an embodiment of the invention
  • FIG. 2A is a schematic illustration of the energy receiving unit in accordance with an embodiment of the invention.
  • Figure 2B is an electric block diagram of the energy receiving unit illustrated in Fig. 2A, according to an embodiment of the invention.
  • FIG. 3 is a schematic illustration of the energy receiving unit in accordance with another embodiment of the invention.
  • FIG. 4 is a schematic illustration of the system in accordance with an embodiment of the invention.
  • the device according to an embodiment of the present invention is an induction powered in vivo imaging device.
  • the device may be introduced into a patient's body and the electrical components of the device may be powered by an external energy source that is applied to the patient's body.
  • the device may not be dependent for its operation on a battery having a limited shelf life and a limited amount of operational hours.
  • the in vivo imaging device can be used to obtain images from within body lumens, inter alia, by being moved through the body lumen.
  • the device can be attached onto a medical instrument designed to be inserted and/or moved in a body lumen, such as a swallowable capsule, needle, stent, catheter, endoscope, etc.
  • the device is contained within a swallowable capsule, such as the capsule described in WO 01/65995, which is assigned to the common assignee of the present invention and which is hereby incorporated by reference in its entirety.
  • the swallowable capsule 10 consists of an optical window 12 behind which are positioned at least one solid state imaging chip such as a CCD or CMOS imaging camera 14 for obtaining images of the GI tract and at least one LED 13 for illuminating the GI tract.
  • the CMOS imaging camera 14 is connected to a transmitter 15 that transmits the video signals obtained by the CMOS imaging camera 14 to an external receiving system (not shown).
  • the transmitter 15, CMOS imaging camera 14 and LEDs 13 are all connected to and powered by energy receiving unit 16.
  • Energy receiving unit 16 consists of an element 18, for example a conductive coil, configured for receiving energy from an external energy source, a rectifier circuit 19 for converting AC voltage to DC voltage and a capacitor 17.
  • a capacitor ranging from several mili-Farads to a few hundred mili-Farads may be used or alternatively, a chargeable battery could be used for storage of the voltage required for operation of the electrical components of the capsule 10.
  • a capacitor of about 10 Farad and 5 mWatt is suitable for use in the present invention.
  • FIG. IB A block diagram of the energy receiving unit 16 is illustrated in Fig. IB.
  • a single receiving inductor L converts a time varying magnetic field into alternating electrical current which is rectified by diode bridge B.
  • Capacitor C serves as an energy storing and ripple damping element.
  • Energy receiving unit 26 includes a capacitor or any other suitable energy storing component (not shown), a rectifier circuit for converting AC voltage to DC voltage (not shown) and a three axial coil assembly 28 or possibly, three or more separate orthogonal elements configured for receiving energy from an external energy source.
  • the three axial coil assembly 28 ensures that energy will be produced from a unidirectional magnetic field independently of the directionality of the energy receiving unit 26 (as will be further discussed below).
  • FIG. 2B A block diagram of the energy receiving unit 26 is illustrated in Fig. 2B.
  • Three orthogonal coils Lx, Ly and Lz convert a time varying magnetic field into alternating electrical current which is rectified by diode bridges B.
  • Capacitor C serves as an energy storing and ripple damping element.
  • Energy receiving unit 36 which includes a three axial coil assembly 38, a capacitor (not shown) and a rectifier circuit for converting AC voltage to DC voltage (not shown), is connected to a circuit 34 capable of selecting the coil having the maximal voltage, rectifying and stabilizing it to a desired voltage by methods known in the art. Energy transfer to a device which includes energy receiving unit 36, coil assembly 38 and circuit 34 is thus optimized.
  • FIG. 4 an embodiment of the system of the invention is schematically illustrated.
  • a medical instrument 40 containing the device 42 of the invention such as the capsule described in Fig. 1, is introduced into a patient's body 44.
  • a varying magnetic field 46 is generated by magnetic field generator 43 around the patient's body 44, in the area containing the medical instrument 40.
  • Magnetic field generator 43 can include an AC induction coil 45, typically a low frequency AC induction coil (about 60Hz) or may have a rotating magnetic circuit to generate a varying magnetic field.
  • AC induction coil 45 typically a low frequency AC induction coil (about 60Hz) or may have a rotating magnetic circuit to generate a varying magnetic field.
  • the practical frequency range will typically be from several tens of Hz to several tens of KHz.
  • the magnetic field 46 is received by an element configured for receiving energy in device 42.
  • the magnetic field 46 induces a current in the element which can be received (and stored) by a capacitor for powering the electrical components of the medical instrument 40.
  • Magnetic field 46 may be generated by three orthogonal coils surrounding the patient's body 44. This configuration enables the receiving element in device 42 to have an arbitrary orientation in the patient's body 44 and yet to be able to pick up energy from the generated magnetic field 46.
  • three orthogonal external coils may be operated simultaneously, with the same phase, adding up to a linear magnetic field.
  • the coils may be operated either sequentially or with a phase shift between them, resulting in a magnetic field with time-varying orientation.
  • Induction of an electromagnetic field in the receiving element may be most efficient when the long axis of the receiving element and the magnetic field 46 axis are orthogonal to each other.
  • medical instrument 40 may move through a body lumen, sometimes rotating or tumbling through the lumen, the directionality of the device 42 (and of the element in it) is not always permanent and not necessarily known, making it difficult to keep the magnetic field and the axis of the element in a fixed position relative to each other.
  • the element configured for receiving energy comprises a three axial coil array or the magnetic field includes a three axial arrangement, such that for any directionality of the medical instrument 40, and of the device 42 in it, there is a magnetic field basically orthogonal to the long axis of the energy receiving element.
  • the location of the medical instrument 40 can be determined and the magnetic field generator 43 can be moved to correlate with the location of the medical instrument 40 in the patient's body 44.
  • the system may include a reception system located externally, typically comprising an antenna array wrapped around the central portion of the patient's trunk; other reception systems are possible.
  • the antennas are located so as to be able to determine from their output the location of the medical instrument 40 within the patient's body 44.
  • the output of the antennas can be used to determine the location of the medical instrument 40 by triangulation or any other suitable method known in the art. For example, a method for determining the location of a swallowable capsule in a patient's GI tract is described in US 5,604,531. US 5,604,531, which is assigned to the common assignee of the present application, is hereby incorporated by reference in its entirety.
  • the determined location of medical instrument 40 can be displayed two- or three-dimensionally on a position monitor, typically, though not necessarily, as an overlay to a drawing of the body lumen it is in, such as the digestive tract.
  • the magnetic field generator 43 may be in communication with the position monitor such that the location of the magnetic field generator 43 can be correlated to that of the medical instrument 40 in the patient's body 44.
  • the magnetic field generator 43 may include a localizing device for localizing the medical device 40 in the patient's body 44, in a similar manner to that described above. The magnetic filed generator 43 can then be moved along the patient's body 44 in accordance with the location of the medical device 40, thus optimizing the energy transfer from the external energy source to the medical instrument 40.

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  • Optics & Photonics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
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PCT/IL2002/000283 2001-04-04 2002-04-04 Induction powered in vivo imaging device Ceased WO2002080753A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2002578793A JP2004528890A (ja) 2001-04-04 2002-04-04 誘導動力式生体内撮像装置
EP02759837A EP1418845A4 (en) 2001-04-04 2002-04-04 IMAGING DEVICE IN VIVO WITH INDUCTION DRIVE
IL15442002A IL154420A0 (en) 2001-04-04 2002-04-04 Induction powered in vivo imaging device
AU2002307759A AU2002307759A1 (en) 2001-04-04 2002-04-04 Induction powered in vivo imaging device

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28101301P 2001-04-04 2001-04-04
US60/281,013 2001-04-04

Publications (2)

Publication Number Publication Date
WO2002080753A2 true WO2002080753A2 (en) 2002-10-17
WO2002080753A3 WO2002080753A3 (en) 2004-03-18

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PCT/IL2002/000283 Ceased WO2002080753A2 (en) 2001-04-04 2002-04-04 Induction powered in vivo imaging device

Country Status (6)

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US (2) US20020165592A1 (enExample)
EP (1) EP1418845A4 (enExample)
JP (1) JP2004528890A (enExample)
AU (1) AU2002307759A1 (enExample)
IL (1) IL154420A0 (enExample)
WO (1) WO2002080753A2 (enExample)

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US20020165592A1 (en) 2002-11-07
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