WO2002056896A2 - Solution de traitement pour soigner des plaies, ainsi que materiau pour pansement a utiliser avec cette solution de traitement - Google Patents

Solution de traitement pour soigner des plaies, ainsi que materiau pour pansement a utiliser avec cette solution de traitement Download PDF

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Publication number
WO2002056896A2
WO2002056896A2 PCT/DE2002/000031 DE0200031W WO02056896A2 WO 2002056896 A2 WO2002056896 A2 WO 2002056896A2 DE 0200031 W DE0200031 W DE 0200031W WO 02056896 A2 WO02056896 A2 WO 02056896A2
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WO
WIPO (PCT)
Prior art keywords
layer
dressing material
solution
chamber
material according
Prior art date
Application number
PCT/DE2002/000031
Other languages
German (de)
English (en)
Other versions
WO2002056896A3 (fr
Inventor
Thomas Riesinger
Original Assignee
Nawa-Heilmittel Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE20103716U external-priority patent/DE20103716U1/de
Priority claimed from DE10139398A external-priority patent/DE10139398A1/de
Application filed by Nawa-Heilmittel Gmbh filed Critical Nawa-Heilmittel Gmbh
Priority to US10/250,674 priority Critical patent/US20040076686A1/en
Priority to AU2002231596A priority patent/AU2002231596A1/en
Priority to EP02711764A priority patent/EP1383519A2/fr
Priority to KR10-2003-7009513A priority patent/KR20030076615A/ko
Priority to CA002435069A priority patent/CA2435069A1/fr
Priority to JP2002557403A priority patent/JP4285993B2/ja
Publication of WO2002056896A2 publication Critical patent/WO2002056896A2/fr
Publication of WO2002056896A3 publication Critical patent/WO2002056896A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/44—Medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/00051—Accessories for dressings
    • A61F13/00055—Saturation indicators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/00051—Accessories for dressings
    • A61F13/00063—Accessories for dressings comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive bandages or dressings
    • A61F13/0203—Adhesive bandages or dressings with fluid retention members
    • A61F13/022—Adhesive bandages or dressings with fluid retention members having more than one layer with different fluid retention characteristics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/30—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/06—Bandages or dressings; Absorbent pads specially adapted for feet or legs; Corn-pads; Corn-rings
    • A61F13/064—Bandages or dressings; Absorbent pads specially adapted for feet or legs; Corn-pads; Corn-rings for feet
    • A61F13/069—Decubitus ulcer bandages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F2013/00089—Wound bandages
    • A61F2013/00157—Wound bandages for burns or skin transplants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F2013/00089—Wound bandages
    • A61F2013/00246—Wound bandages in a special way pervious to air or vapours
    • A61F2013/00251—Wound bandages in a special way pervious to air or vapours with macroscopic openings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F2013/00361—Plasters
    • A61F2013/00365—Plasters use
    • A61F2013/00519—Plasters use for treating burn
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F2013/00361—Plasters
    • A61F2013/00544—Plasters form or structure
    • A61F2013/00604—Multilayer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F2013/00361—Plasters
    • A61F2013/00727—Plasters means for wound humidity control
    • A61F2013/00731—Plasters means for wound humidity control with absorbing pads
    • A61F2013/00744—Plasters means for wound humidity control with absorbing pads containing non-woven
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F2013/00361—Plasters
    • A61F2013/00855—Plasters pervious to air or vapours
    • A61F2013/00859—Plasters pervious to air or vapours with macroscopic openings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F2013/00361—Plasters
    • A61F2013/00855—Plasters pervious to air or vapours
    • A61F2013/00885—Plasters pervious to air or vapours impervious, i.e. occlusive bandage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F2013/00361—Plasters
    • A61F2013/00902—Plasters containing means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/606—Coatings
    • A61L2300/608—Coatings having two or more layers

Definitions

  • Treatment solution for wound care and dressing material for use with this treatment solution is
  • the invention relates to a treatment solution according to the preamble of claim 1 and to a dressing material according to the preamble of claim 7.
  • wounds can be improved by a moist environment, in particular media which support wound healing or which contain at least one medicament, for example solutions or gels, can also be used.
  • a currently practiced method is that the dressing material or a layer of this material consisting of an absorbent material is soaked with the relevant solution and then the dressing material is applied to the wound. The handling is cumbersome and especially when treating larger and deeper wounds and when dressings are changed frequently, a specially trained staff is necessary.
  • the object of the invention is to show a treatment medium and a dressing material which, with simplified use, enables an improvement in wound healing, in particular an improvement in the healing of chronic or postoperative wounds.
  • a treatment solution is designed according to claim 1.
  • a dressing material which is used for the care of wounds, in particular for the care of chronic or postoperative wounds (chronic or postoperative wound care) with the treatment solution, is designed according to claim 7.
  • the dressing material according to the invention has the advantage that, in the case of simple use, it allows in particular the care of chronic wounds or postoperative wound healing in a moist environment using the treatment medium which promotes wound healing, and also significantly increases the time period within which a dressing change must take place. For example, when using the dressing material according to the invention, it is possible to change the dressing only three days after the first treatment of a wound, ie at a point in time when a deep wound has already closed to such an extent that the risk of infections is substantially reduced.
  • This long residence time of the dressing material on the wound also ensures wound rest that is necessary for rapid healing, particularly within the first few days after the wound has been treated. This is possible because the chamber for the treatment medium has at least one connection led out of the dressing material for refilling and / or renewing the treatment medium.
  • the chamber is formed by at least one channel which extends in several sections and / or turns over the surface of the dressing material. This channel is then preferably at least one piece of hose.
  • Fig. 1 shows a schematic partial representation of the layer structure of a dressing material according to the invention, the individual actually in the dressing material interconnected layers for better clarity
  • FIG. 2 in a simplified schematic representation, a top view of the material of the
  • FIG. 1 shows a schematic partial representation of the layer structure of another
  • Dressing material according to the invention 4 - 7 different graphics relating to the time course of wound healing in animal experiments.
  • the dressing material generally designated 1 in the figures which is suitable for the care of chronic wounds, but also for the care of open, deep wounds, is essentially designed as a multilayer flat material, for example with a square or rectangular cut.
  • the dressing material 1 consists of a first, sterile layer 2 on the outside, which forms the support on the wound and is formed by a perforated flat material, for example perforated film or grid made of a suitable plastic, for example PVC.
  • the single-layer outer layer 2 is followed by a layer 3, which is formed by several layers of a sterile, absorbent and air and moisture-permeable material, for example a coarse fabric or a non-woven material.
  • the layer 3 consists of several layers of sterile gauze, for example four layers.
  • Layer 4 has semipermeable properties, ie it is not permeable to air and gases permeable but for liquid.
  • a lumen or tube piece 5 is fastened, which extends in a meandering manner almost over the entire area of layer 4 and thus over the entire area of dressing material 1 and forms two ends or connections 6, which are led out laterally from the dressing material 1, in the embodiment shown in such a way that these ends 6 protrude on two opposite circumferential sides 1 'and 1 "of the dressing material.
  • the tube piece 5 which forms a channel for receiving and distributing a treatment medium, in particular an aqueous treatment medium, is on its inside the dressing material 1, i.e. between the layers 3 and 4 extending length so that a finely divided outlet of the treatment medium present in the tube piece 5 is possible in the layer 3.
  • the piece of hose 5 is, for example, finely perforated.
  • the projecting ends 6 are preferably each formed by a tube length that does not have this perforation.
  • the individual layers 2, 3 and 4 with the tube piece 5 arranged between the layers 3 and 4 are connected to one another in a suitable manner, for example along the edge of the dressing material 1 and / or point-wise also within the dressing material 1.
  • the dressing material 1 is placed on the wound to be treated with the layer 2 and then fixed, for example, at the edge by means of an adhesive tape 7 or in some other way.
  • a solution suitable for wound treatment is supplied via one end 6, for example via the upper end in FIG. 2, and until such solution emerges at the other end or connection 6 and thus the entire, of the tube 5 formed chamber is filled with this treatment solution. Then both ends 6 are closed, for example with a suitable plug.
  • the treatment solution emerging from the tube piece 5 is finely distributed over the entire dressing material over the layer 3 and thus in particular also over the entire wound area.
  • the solution in the hose section 5 is renewed and replaced several times a day, for example twice a day.
  • the wound material is optimally kept occlusive and moist by the dressing material according to the invention, so that a significantly improved wound healing is achieved.
  • the particular advantage of the dressing material according to the invention is that a change of the dressing is only necessary after several days, for example only every three days, so that the first change of the dressing material usually takes place at a time when even a deep, open wound has already closed to such an extent that the risk of an additional infection when changing the dressing can be excluded.
  • the large time interval between the application of the dressing material and the first change of this dressing material ensures, in particular, that the wound is calm for the first healing process within the first days after the care of a wound.
  • the dressing material according to the invention thus combines the advantages of wound healing in a moist environment with the advantage of long wound rest, which promotes the healing process, particularly in the first few days.
  • FIG. 3 shows a further exemplary embodiment of the invention in a schematic representation and in section of a dressing material 1 a, which in turn has a multi-layer construction and also serves to improve wound healing in a moist environment.
  • the dressing material 1 a consists of a lower layer 10 with which this material is placed on a wound.
  • This layer 10 which is the sterile pad forms on the wound, is formed from a sterile perforated flat material, for example from a perforated or lattice-like film made from a suitable plastic, for example from PVC or silicone.
  • a layer 11 is provided on the layer 10, which serves as a distribution layer for the treatment liquid and for this purpose is made, for example, from a sterile soft and absorbent material, for example from gauze or from a non-woven material (fleece).
  • a layer 12 which contains the liquid treatment medium in encapsulated form, in such a way that the treatment medium is opened via the layer 11 by opening or breaking the layer 12 or the capsules there distributed to the underside of the dressing material and thus to the wound area.
  • a covering layer 13 is provided over the layer 12, which consists of a semi-permeable flat material, i.e. from a flat material which is not or largely impermeable to the liquid treatment medium, but permeable to air and gases.
  • the covering layer 1 3 also covers the dressing material 1 a or the various layers and layers of this dressing material from the side and is skin-compatible at the edge which is at the level of the underside of the layer 10 adhesive order 14 provided.
  • the dressing material 1 a is sterile closed with a removable cover layer 15 on the side with which it is applied to a wound. Layer 1 5 is subtracted if used.
  • the dressing material is placed on the wound with the then exposed layer 10 after the covering or protective layer 15 has been removed and fixed with the adhesive layer 14 around the wound.
  • the encapsulated treatment liquid is released.
  • the dressing material 1 a is preferably designed such that when a dressing is changed, the layer 10 of the existing dressing is separated from the adjacent layer 1 1 and the layer 10 thus remains on the wound, so that the rest of the wound and thus the healing process does not result from a dressing change be affected.
  • the fresh dressing material used when changing the dressing then corresponds to the dressing material 1 a, but without the layer 10, i.e. the training is then such that, in addition to the protective layer 1 5, the layer 10 can also be removed from the dressing material 1 a if necessary.
  • a solution which contains zinc and iron in aqueous solution, in addition to distilled water and sulfuric acid per liter of solution 10 - 100 mg Zn and 6.5 - 65 mg Fe, e.g. 1 5 - 45 mg Zn and 10 - 30 mg Fe, the proportion of sulfuric acid being chosen so that a pH value between 2.5 to 3.5, preferably 2.8. In a preferred embodiment, a 95-97% sulfuric acid is used.
  • the distilled water is a double distilled water according to DAB 10. Suitable raw materials are, for example, ZnCl 2 and FeS0 4 , namely about 20-209 mg ZnCl 2 and 32-325 mg FeS0 4 per liter of solution.
  • composition of the treatment solution is given below:
  • the low pH of the treatment medium not only creates an acidic and therefore optimal wound environment.
  • the acidic environment particularly stimulates the metabolism that promotes the healing process.
  • the treatment medium also has a microbacteriostatic effect due to the acid in connection with the iron content, i.e. this creates a milieu which prevents the growth of germs and bacteria and has a repulsive effect on them, so that inflammation caused by germs entering a wound and developing there is effectively prevented.
  • the treatment medium (solution) described above is also particularly suitable in connection with the dressing material 1 or 1 a for the treatment or care of chronic wounds and burns, as was found in animal experiments.
  • animal experiments were carried out on pigs using the treatment medium described above with a proportion of 30 mg zinc and 20 mg iron per liter solution (hereinafter 0.003% solution), with a comparison solution containing only 10 mg zinc and approximately Contained 7 mg iron per liter solution (hereinafter 0.001% solution), with a comparison solution containing 100 mg zinc and 66 mg iron per liter solution (hereinafter 0.01% solution).
  • a comparison solution containing 100 mg zinc and 66 mg iron per liter solution hereinafter 0.01% solution.
  • the results of these burn tests are also significant for the effectiveness in the care of chronic wounds, such as pressure ulcers, leg ulcers, wound healing disorders in diabetes mellitus, etc.
  • the results are shown in the graphics of FIGS. 4, 5, 6 and 7, specifically in FIG. 4 for the 0.001% solution, in FIG. 5 for the 0.01% solution, in FIG. 6 for the 0.003 % Solution and in Figure 7 for a wound only exposed to ambient air.
  • the illustrations show that the best healing results are achieved with the 0.003% solution.
  • the above-described treatment medium (solution) is furthermore particularly suitable in connection with the dressing material 1 or 1 a for the treatment of postoperative wounds and improves the healing process decisively, as was also proven by tests on pigs.
  • animal experiments were carried out on pigs using the treatment medium described above and the dressing material 1. In these experiments, compared to wound healing in ambient air, a significantly accelerated healing process (shortening the healing process by about 5 days) and a substantial reduction in scar formation were found.
  • 16 also denotes an indicator which, in the embodiment shown, consists of a substrate or strip of a flat material which is provided with an indicator material which is used when the dressing material 1 falls or dries out, ie when the moisture of this dressing material 1 falls below a predetermined value in use, the color changes.
  • the indicator 16 is integrated in the dressing material 1 so that it is visible when the dressing material 1 is applied.
  • the indicator 16 is located below that layer which closes the dressing material on the side facing away from the wound, ie in the case of the dressing material 1 between the layer 4 and the layer 5 and in the dressing material 1 a below the layer 1 3.
  • Suitable indicator materials which change their color depending on the moisture are known to the person skilled in the art.
  • an indicator material is also suitable in the invention, which changes color depending on the pH value, since the pH value changes when the dressing material dries out or falls dry.
  • an indicator can also be integrated into the dressing material 1 or 1 a, which displays an indication of a possible increased microbial contamination of the dressing material, so that the dressing material can be changed in good time .
  • This indicator is also designed in accordance with the indicator 16 and is preferably provided such that it is visible when the dressing is applied to the patient, and consists of a carrier material which is provided with a substance which changes color when there is an increased microbial load or contamination, for example, again due to a change in the pH value.
  • a dressing material ' 1 "peripheral edge layer of a sterile, perforated flat material made of plastic, for example made of PVC as a layer on the wound protective layer of a sterile, soft and absorbent
  • Material for example a gauze layer made of a semi-permeable material

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Materials Engineering (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne une solution de traitement servant au traitement ou aux soins de plaies chroniques ou postopératoires et contenant comme solution aqueuse par litre de solution, outre de l'eau et de l'acide, 10 à 100 mg de zinc (Zn) et 6,5 à 65 mg de fer (Fe). La part d'acide est sélectionnée de façon à obtenir une valeur du pH d'environ 2,5 à 3,5, de préférence de 2,8.
PCT/DE2002/000031 2001-01-18 2002-01-09 Solution de traitement pour soigner des plaies, ainsi que materiau pour pansement a utiliser avec cette solution de traitement WO2002056896A2 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
US10/250,674 US20040076686A1 (en) 2001-08-10 2002-01-09 Treatment solution used for caring wounds in addition to dressing material for use with said treatment solution
AU2002231596A AU2002231596A1 (en) 2001-01-18 2002-01-09 Treatment solution in addition to dressing material for caring for wounds
EP02711764A EP1383519A2 (fr) 2001-01-18 2002-01-09 Solution de traitement pour soigner des plaies, ainsi que materiau pour pansement a utiliser avec cette solution de traitement
KR10-2003-7009513A KR20030076615A (ko) 2001-01-18 2002-01-09 상처 치료용 치료 용액 및 상기 치료 용액과 함께사용하기 위한 드레싱 재료
CA002435069A CA2435069A1 (fr) 2001-01-18 2002-01-09 Solution de traitement pour soigner des plaies, ainsi que materiau pour pansement a utiliser avec cette solution de traitement
JP2002557403A JP4285993B2 (ja) 2001-01-18 2002-01-09 創傷用処置溶液および該溶液とともに用いられる包帯材

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
DE20103576 2001-01-18
DE20103576.6 2001-01-18
DE20103716U DE20103716U1 (de) 2001-01-18 2001-03-05 Verbandmaterial sowie Behandlungslösung zur Verwendung mit dem Verbandmaterial
DE20103716.5 2001-03-05
DE10139400.4 2001-08-10
DE10139398A DE10139398A1 (de) 2001-01-18 2001-08-10 Behandlungslösung für die chronische Wundversorgung sowie Verbandmaterial zur Verwendung mit dieser Behandlungslösung
DE10139398.9 2001-08-10
DE10139400A DE10139400A1 (de) 2001-01-18 2001-08-10 Behandlungslösung für die postoperative Wundversorgung sowie Verbandmaterial zur Verwendung mit dieser Behandlungslösung

Publications (2)

Publication Number Publication Date
WO2002056896A2 true WO2002056896A2 (fr) 2002-07-25
WO2002056896A3 WO2002056896A3 (fr) 2003-11-27

Family

ID=27438000

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2002/000031 WO2002056896A2 (fr) 2001-01-18 2002-01-09 Solution de traitement pour soigner des plaies, ainsi que materiau pour pansement a utiliser avec cette solution de traitement

Country Status (6)

Country Link
EP (1) EP1383519A2 (fr)
JP (1) JP4285993B2 (fr)
CN (1) CN1292802C (fr)
AU (1) AU2002231596A1 (fr)
CA (1) CA2435069A1 (fr)
WO (1) WO2002056896A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101889677B1 (ko) 2015-06-12 2018-08-17 제이에프이미네라르 가부시키가이샤 피부 창상 또는 피부 거침 치료제
CN107847522B (zh) * 2015-06-12 2021-07-09 杰富意矿物股份有限公司 皮肤创伤或皮肤粗糙治疗剂
EP3552610A4 (fr) 2016-12-09 2019-12-18 JFE Mineral Company, Ltd. Composition inorganique ayant d'excellentes propriétés de libération progressive d'ions zinc, et son procédé de production

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0363696A1 (fr) * 1988-09-22 1990-04-18 Siegfried Natterer Préparation pharmaceutique ainsi que procédé pour sa fabrication

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040076662A1 (en) * 2001-01-18 2004-04-22 Thomas Riesinger Dressing material in addition to treatment solution for use with said dressing material

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0363696A1 (fr) * 1988-09-22 1990-04-18 Siegfried Natterer Préparation pharmaceutique ainsi que procédé pour sa fabrication

Also Published As

Publication number Publication date
CN1538855A (zh) 2004-10-20
CN1292802C (zh) 2007-01-03
WO2002056896A3 (fr) 2003-11-27
JP2004534560A (ja) 2004-11-18
JP4285993B2 (ja) 2009-06-24
CA2435069A1 (fr) 2002-07-25
EP1383519A2 (fr) 2004-01-28
AU2002231596A1 (en) 2002-07-30

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