WO2002055544A2 - Fractions de fixation de la fibrine qui conviennent comme agents d'imagerie - Google Patents
Fractions de fixation de la fibrine qui conviennent comme agents d'imagerie Download PDFInfo
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- WO2002055544A2 WO2002055544A2 PCT/US2001/049534 US0149534W WO02055544A2 WO 2002055544 A2 WO2002055544 A2 WO 2002055544A2 US 0149534 W US0149534 W US 0149534W WO 02055544 A2 WO02055544 A2 WO 02055544A2
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- A61K49/001—Preparation for luminescence or biological staining
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- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0041—Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal
- A61K49/0043—Fluorescein, used in vivo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/75—Fibrinogen
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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Landscapes
- Health & Medical Sciences (AREA)
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
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- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Abstract
La présente invention concerne des fractions de fixation de la fibrine qui possèdent diverses utilisations, que ce soit dans la détection, dans l'isolation ou dans la localisation de la fibrine, et plus particulièrement la fibrine en tant qu'opposé au fibrinogène, est intéressante. Cette invention concerne particulièrement des polypeptides isolés synthétiques capables de se fixer à la fibrine et de reconnaître la forme de la fibrine polymérisée trouvée dans les thrombi. Par ailleurs, ces polypeptides possèdent une vitesse de dissociation des thrombi faible, ce qui améliore leur capacité de former une image de contraste au niveau d'un site de caillot de fibrine et rend ces fractions de fixation particulièrement utiles comme agents d'imagerie pour les thrombi.
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002556612A JP3991086B2 (ja) | 2000-12-23 | 2001-12-21 | 造影剤として有用なフィブリン結合部分 |
| CA2432474A CA2432474C (fr) | 2000-12-23 | 2001-12-21 | Fractions de fixation de la fibrine qui conviennent comme agents d'imagerie |
| EP01997103A EP1348026A2 (fr) | 2000-12-23 | 2001-12-21 | Fractions de fixation de la fibrine qui conviennent comme agents d'imagerie |
| AU2002248222A AU2002248222B2 (en) | 2000-12-23 | 2001-12-21 | Fibrin binding polypeptides useful inter alia in medical imaging processes |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74740300A | 2000-12-23 | 2000-12-23 | |
| US09/747,403 | 2000-12-23 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2002055544A2 true WO2002055544A2 (fr) | 2002-07-18 |
| WO2002055544A3 WO2002055544A3 (fr) | 2003-03-27 |
Family
ID=25004908
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US2001/049534 WO2002055544A2 (fr) | 2000-12-23 | 2001-12-21 | Fractions de fixation de la fibrine qui conviennent comme agents d'imagerie |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1348026A2 (fr) |
| JP (1) | JP3991086B2 (fr) |
| AU (1) | AU2002248222B2 (fr) |
| CA (1) | CA2432474C (fr) |
| WO (1) | WO2002055544A2 (fr) |
Cited By (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1443953A2 (fr) * | 2001-10-16 | 2004-08-11 | Epix Medical, Inc. | Detection et traitement de lesions intravasculaires |
| WO2005029066A2 (fr) * | 2003-05-22 | 2005-03-31 | Agilent Technologies, Inc. | Marqueurs de diagnostic et cibles pharmacologiques utilises dans l'insuffisance cardiaque, et reactifs connexes et leurs procedes d'utilisation |
| WO2005079863A1 (fr) * | 2004-02-25 | 2005-09-01 | Astellas Pharma Inc. | Produit de contraste pour la formation d'un thrombus |
| JP2006524034A (ja) * | 2002-12-20 | 2006-10-26 | アムジェン インコーポレイテッド | ミオスタチンを阻害する結合剤 |
| WO2008071679A1 (fr) | 2006-12-11 | 2008-06-19 | Bracco Imaging Spa | Conjugués peptidiques se liant à la fibrine pour des applications de diagnostic et thérapeutiques |
| ITFI20080173A1 (it) * | 2008-09-05 | 2010-03-06 | Univ Firenze | Complessi di manganese e cobalto, loro preparazione ed uso |
| US7749485B2 (en) | 2004-06-03 | 2010-07-06 | Bracco Research S.A. | Liposomal assembly for therapeutic and/or diagnostic use |
| US8293214B2 (en) | 2006-12-19 | 2012-10-23 | Bracco Suisse S.A. | Targeting and therapeutic compounds and gas-filled microvesicles comprising said compounds |
| US8815804B2 (en) | 2006-02-06 | 2014-08-26 | Sanford-Burnham Medical Research Institute | Methods and compositions related to targeting tumors and wounds |
| US9192685B2 (en) | 2008-10-07 | 2015-11-24 | Bracco Suisse S.A. | Targeting construct comprising anti-polymer antibody and contrast/therapeutic agents binding to the same |
| US9248204B2 (en) | 2004-08-18 | 2016-02-02 | Bracco Suisse S.A. | Gas-filled microvesicles composition for contrast imaging |
| US9364569B2 (en) | 2003-02-04 | 2016-06-14 | Bracco Suisse S.A. | Ultrasound contrast agents and process for the preparation thereof |
| US9375397B2 (en) | 2005-04-18 | 2016-06-28 | Bracco Suisse S.A. | Composition comprising gas-filled microcapsules for ultrasound mediated delivery |
| US9446156B2 (en) | 2006-09-05 | 2016-09-20 | Bracco Suisse S.A. | Gas-filled microvesicles with polymer-modified lipids |
| US9750821B2 (en) | 2003-12-22 | 2017-09-05 | Bracco Suisse S.A. | Gas-filled microvesicle assembly for contrast imaging |
| US10010630B2 (en) | 2012-12-21 | 2018-07-03 | Bracco Suisse S.A. | Gas-filled microvesicles |
| CN109127131A (zh) * | 2018-07-18 | 2019-01-04 | 沛县育龙粮油工贸有限公司 | 一种高效重金属污染大米的清洗方法 |
| WO2020229642A1 (fr) | 2019-05-15 | 2020-11-19 | Bracco Suisse Sa | Produit lyophilisé et suspension de microvésicules remplies de gaz |
| US11717570B2 (en) | 2019-05-15 | 2023-08-08 | Bracco Suisse Sa | Gas-filled microvesicles |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2117575A4 (fr) * | 2007-01-03 | 2013-06-05 | Burnham Inst Medical Research | Méthodes et compositions associées à des composés adhérant aux caillots |
| KR101474063B1 (ko) | 2012-05-23 | 2014-12-19 | 동국대학교 산학협력단 | 피브린 표적 펩타이드 서열이 결합된 글라이콜 키토산-금 나노입자를 포함하는 혈전 탐지용 ｃｔ 조영제 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993025241A1 (fr) | 1992-06-13 | 1993-12-23 | Schering Aktiengesellschaft | Utilisation de microcapsules comme agents de contraste pour la sonographie doppler en couleurs |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR900702017A (ko) * | 1988-06-03 | 1990-12-05 | 존 로버트 버쉬 | 혼성 단백질(bybrid proteins) |
| US5364612A (en) * | 1991-05-06 | 1994-11-15 | Immunomedics, Inc. | Detection of cardiovascular lesions |
| EP1203026A4 (fr) * | 1999-07-29 | 2005-03-16 | Dyax Corp | Fractions se liant la fibrine |
-
2001
- 2001-12-21 JP JP2002556612A patent/JP3991086B2/ja not_active Expired - Lifetime
- 2001-12-21 AU AU2002248222A patent/AU2002248222B2/en not_active Expired
- 2001-12-21 WO PCT/US2001/049534 patent/WO2002055544A2/fr active Application Filing
- 2001-12-21 EP EP01997103A patent/EP1348026A2/fr not_active Withdrawn
- 2001-12-21 CA CA2432474A patent/CA2432474C/fr not_active Expired - Lifetime
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993025241A1 (fr) | 1992-06-13 | 1993-12-23 | Schering Aktiengesellschaft | Utilisation de microcapsules comme agents de contraste pour la sonographie doppler en couleurs |
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| WO2005029066A2 (fr) * | 2003-05-22 | 2005-03-31 | Agilent Technologies, Inc. | Marqueurs de diagnostic et cibles pharmacologiques utilises dans l'insuffisance cardiaque, et reactifs connexes et leurs procedes d'utilisation |
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| CN101573143B (zh) * | 2006-12-11 | 2013-04-24 | 伯拉考成像股份公司 | 纤维蛋白结合肽及其缀合体 |
| EP2111237A2 (fr) * | 2006-12-11 | 2009-10-28 | BRACCO IMAGING S.p.A. | Peptides se fixant à la fibrine, et conjugués correspondants |
| WO2008071679A1 (fr) | 2006-12-11 | 2008-06-19 | Bracco Imaging Spa | Conjugués peptidiques se liant à la fibrine pour des applications de diagnostic et thérapeutiques |
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| EP2111237A4 (fr) * | 2006-12-11 | 2011-04-13 | Bracco Imaging Spa | Peptides se fixant à la fibrine, et conjugués correspondants |
| US8293214B2 (en) | 2006-12-19 | 2012-10-23 | Bracco Suisse S.A. | Targeting and therapeutic compounds and gas-filled microvesicles comprising said compounds |
| WO2010026545A1 (fr) | 2008-09-05 | 2010-03-11 | Universita' Degli Studi Di Firenze | Complexes de manganèse et de cobalt, leur synthèse et leur application |
| ITFI20080173A1 (it) * | 2008-09-05 | 2010-03-06 | Univ Firenze | Complessi di manganese e cobalto, loro preparazione ed uso |
| US9192685B2 (en) | 2008-10-07 | 2015-11-24 | Bracco Suisse S.A. | Targeting construct comprising anti-polymer antibody and contrast/therapeutic agents binding to the same |
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| CN109127131A (zh) * | 2018-07-18 | 2019-01-04 | 沛县育龙粮油工贸有限公司 | 一种高效重金属污染大米的清洗方法 |
| WO2020229642A1 (fr) | 2019-05-15 | 2020-11-19 | Bracco Suisse Sa | Produit lyophilisé et suspension de microvésicules remplies de gaz |
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Also Published As
| Publication number | Publication date |
|---|---|
| AU2002248222B2 (en) | 2006-04-27 |
| JP3991086B2 (ja) | 2007-10-17 |
| WO2002055544A3 (fr) | 2003-03-27 |
| CA2432474A1 (fr) | 2002-07-18 |
| JP2004523514A (ja) | 2004-08-05 |
| EP1348026A2 (fr) | 2003-10-01 |
| CA2432474C (fr) | 2012-06-26 |
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