CA2432474C - Fractions de fixation de la fibrine qui conviennent comme agents d'imagerie - Google Patents

Fractions de fixation de la fibrine qui conviennent comme agents d'imagerie Download PDF

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Publication number
CA2432474C
CA2432474C CA2432474A CA2432474A CA2432474C CA 2432474 C CA2432474 C CA 2432474C CA 2432474 A CA2432474 A CA 2432474A CA 2432474 A CA2432474 A CA 2432474A CA 2432474 C CA2432474 C CA 2432474C
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Canada
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cys
pro
trp
gly
glu
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Expired - Lifetime
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CA2432474A
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English (en)
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CA2432474A1 (fr
Inventor
Charles R. Wescott
James P. Beltzer
Aaron K. Sato
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Dyax Corp
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Dyax Corp
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Publication of CA2432474A1 publication Critical patent/CA2432474A1/fr
Application granted granted Critical
Publication of CA2432474C publication Critical patent/CA2432474C/fr
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Expired - Lifetime legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0056—Peptides, proteins, polyamino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0041—Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal
    • A61K49/0043—Fluorescein, used in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Optics & Photonics (AREA)
  • Molecular Biology (AREA)
  • Vascular Medicine (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La présente invention concerne des fractions de fixation de la fibrine qui possèdent diverses utilisations, que ce soit dans la détection, dans l'isolation ou dans la localisation de la fibrine, et plus particulièrement la fibrine en tant qu'opposé au fibrinogène, est intéressante. Cette invention concerne particulièrement des polypeptides isolés synthétiques capables de se fixer à la fibrine et de reconnaître la forme de la fibrine polymérisée trouvée dans les thrombi. Par ailleurs, ces polypeptides possèdent une vitesse de dissociation des thrombi faible, ce qui améliore leur capacité de former une image de contraste au niveau d'un site de caillot de fibrine et rend ces fractions de fixation particulièrement utiles comme agents d'imagerie pour les thrombi.
CA2432474A 2000-12-23 2001-12-21 Fractions de fixation de la fibrine qui conviennent comme agents d'imagerie Expired - Lifetime CA2432474C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US74740300A 2000-12-23 2000-12-23
US09/747,403 2000-12-23
PCT/US2001/049534 WO2002055544A2 (fr) 2000-12-23 2001-12-21 Fractions de fixation de la fibrine qui conviennent comme agents d'imagerie

Publications (2)

Publication Number Publication Date
CA2432474A1 CA2432474A1 (fr) 2002-07-18
CA2432474C true CA2432474C (fr) 2012-06-26

Family

ID=25004908

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2432474A Expired - Lifetime CA2432474C (fr) 2000-12-23 2001-12-21 Fractions de fixation de la fibrine qui conviennent comme agents d'imagerie

Country Status (5)

Country Link
EP (1) EP1348026A2 (fr)
JP (1) JP3991086B2 (fr)
AU (1) AU2002248222B2 (fr)
CA (1) CA2432474C (fr)
WO (1) WO2002055544A2 (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002353823A1 (en) * 2001-10-16 2003-04-28 Epix Medical, Inc. Detection and treatment of intravascular lesions
CA2510893C (fr) * 2002-12-20 2012-07-10 Amgen, Inc. Agents de liaison inhibant la myostatine
EP1590006B1 (fr) 2003-02-04 2010-09-08 Bracco Suisse SA Agents de contraste pour ultrasons et procede pour leur elaboration
US20050152836A1 (en) * 2003-05-22 2005-07-14 Euan Ashley Diagnostic markers and pharmacological targets in heart failure and related reagents and methods of use thereof
CA2547024C (fr) 2003-12-22 2013-12-17 Bracco Research Sa Systeme de microvesicule remplie de gaz pour l'imagerie de contraste
US20070189970A1 (en) * 2004-02-25 2007-08-16 Astellas Pharma Inc. Contrast medium for thrombus formation
CN1960707B (zh) 2004-06-03 2012-11-14 博莱科瑞士股份有限公司 用于治疗和/或诊断用途的脂质集合体
WO2006018433A1 (fr) 2004-08-18 2006-02-23 Bracco Research Sa Composition renfermant des microvesicules remplies de gaz, destinee a l'imagerie de contraste
EP1714642A1 (fr) 2005-04-18 2006-10-25 Bracco Research S.A. Formulation pharmaceutique comprenant des microcapsules remplies de gaz pour la délibération échographique
EP2510943B1 (fr) * 2006-02-06 2016-04-20 The Burnham Institute for Medical Research Procedes et compositions lies au ciblage detumeurs et de plaies
US9446156B2 (en) 2006-09-05 2016-09-20 Bracco Suisse S.A. Gas-filled microvesicles with polymer-modified lipids
JP5345945B2 (ja) * 2006-12-11 2013-11-20 ブラッコ・イメージング・ソシエタ・ペル・アチオニ フィブリン結合ペプチドおよびそのコンジュゲート
EP2117603A2 (fr) 2006-12-19 2009-11-18 Bracco International B.V. Composés de ciblage et composés thérapeutiques, et microvésicules remplies de gaz comprenant lesdits composés
JP2010514839A (ja) * 2007-01-03 2010-05-06 バーナム インスティテュート フォー メディカル リサーチ クロット結合化合物に関連する方法および組成物
IT1391546B1 (it) * 2008-09-05 2012-01-11 Univ Firenze Complessi di manganese e cobalto, loro preparazione ed uso
AU2009301141B2 (en) 2008-10-07 2015-08-27 Bracco Suisse S.A. Targeting construct comprising anti-polymer antibody and liposomes or microvesicles binding to the same
KR101474063B1 (ko) * 2012-05-23 2014-12-19 동국대학교 산학협력단 피브린 표적 펩타이드 서열이 결합된 글라이콜 키토산-금 나노입자를 포함하는 혈전 탐지용 ｃｔ 조영제
JP6313329B2 (ja) 2012-12-21 2018-04-18 ブラッコ・スイス・ソシエテ・アノニムＢｒａｃｃｏ Ｓｕｉｓｓｅ ＳＡ ガス封入マイクロベシクル
CN109127131A (zh) * 2018-07-18 2019-01-04 沛县育龙粮油工贸有限公司 一种高效重金属污染大米的清洗方法
US20200360289A1 (en) 2019-05-15 2020-11-19 Bracco Suisse Sa Freeze-dried product and gas-filled microvesicles suspension
US11717570B2 (en) 2019-05-15 2023-08-08 Bracco Suisse Sa Gas-filled microvesicles

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4219724A1 (de) 1992-06-13 1993-12-16 Schering Ag Verwendung von Mikrokapseln als Kontrastmittel für die Farbdoppler-Sonographie
AU3695589A (en) * 1988-06-03 1990-01-05 Celltech Limited Hybrid proteins
US5364612A (en) * 1991-05-06 1994-11-15 Immunomedics, Inc. Detection of cardiovascular lesions
JP2003508027A (ja) * 1999-07-29 2003-03-04 ダイアックス コーポレイション フィブリン結合性部分

Also Published As

Publication number Publication date
WO2002055544A3 (fr) 2003-03-27
AU2002248222B2 (en) 2006-04-27
JP3991086B2 (ja) 2007-10-17
CA2432474A1 (fr) 2002-07-18
WO2002055544A2 (fr) 2002-07-18
EP1348026A2 (fr) 2003-10-01
JP2004523514A (ja) 2004-08-05

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Effective date: 20211221