CA2432474C - Fractions de fixation de la fibrine qui conviennent comme agents d'imagerie - Google Patents
Fractions de fixation de la fibrine qui conviennent comme agents d'imagerie Download PDFInfo
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- CA2432474C CA2432474C CA2432474A CA2432474A CA2432474C CA 2432474 C CA2432474 C CA 2432474C CA 2432474 A CA2432474 A CA 2432474A CA 2432474 A CA2432474 A CA 2432474A CA 2432474 C CA2432474 C CA 2432474C
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- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
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Abstract
La présente invention concerne des fractions de fixation de la fibrine qui possèdent diverses utilisations, que ce soit dans la détection, dans l'isolation ou dans la localisation de la fibrine, et plus particulièrement la fibrine en tant qu'opposé au fibrinogène, est intéressante. Cette invention concerne particulièrement des polypeptides isolés synthétiques capables de se fixer à la fibrine et de reconnaître la forme de la fibrine polymérisée trouvée dans les thrombi. Par ailleurs, ces polypeptides possèdent une vitesse de dissociation des thrombi faible, ce qui améliore leur capacité de former une image de contraste au niveau d'un site de caillot de fibrine et rend ces fractions de fixation particulièrement utiles comme agents d'imagerie pour les thrombi.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74740300A | 2000-12-23 | 2000-12-23 | |
| US09/747,403 | 2000-12-23 | ||
| PCT/US2001/049534 WO2002055544A2 (fr) | 2000-12-23 | 2001-12-21 | Fractions de fixation de la fibrine qui conviennent comme agents d'imagerie |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2432474A1 CA2432474A1 (fr) | 2002-07-18 |
| CA2432474C true CA2432474C (fr) | 2012-06-26 |
Family
ID=25004908
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2432474A Expired - Lifetime CA2432474C (fr) | 2000-12-23 | 2001-12-21 | Fractions de fixation de la fibrine qui conviennent comme agents d'imagerie |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1348026A2 (fr) |
| JP (1) | JP3991086B2 (fr) |
| AU (1) | AU2002248222B2 (fr) |
| CA (1) | CA2432474C (fr) |
| WO (1) | WO2002055544A2 (fr) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002353823A1 (en) * | 2001-10-16 | 2003-04-28 | Epix Medical, Inc. | Detection and treatment of intravascular lesions |
| KR20140004805A (ko) * | 2002-12-20 | 2014-01-13 | 암겐 인코포레이티드 | 미오스타틴을 저해하는 결합제 |
| KR101076053B1 (ko) | 2003-02-04 | 2011-10-21 | 브라코 인터내셔날 비.브이. | 초음파 조영제 및 그것의 제조방법 |
| EP1656560A2 (fr) * | 2003-05-22 | 2006-05-17 | Agilent Technologies, Inc. | Marqueurs de diagnostic et cibles pharmacologiques utilises dans l'insuffisance cardiaque, et reactifs connexes et leurs procedes d'utilisation |
| CA2547024C (fr) | 2003-12-22 | 2013-12-17 | Bracco Research Sa | Systeme de microvesicule remplie de gaz pour l'imagerie de contraste |
| US20070189970A1 (en) * | 2004-02-25 | 2007-08-16 | Astellas Pharma Inc. | Contrast medium for thrombus formation |
| US7749485B2 (en) | 2004-06-03 | 2010-07-06 | Bracco Research S.A. | Liposomal assembly for therapeutic and/or diagnostic use |
| EP1784228B1 (fr) | 2004-08-18 | 2016-10-05 | Bracco Suisse SA | Composition à base de microvésicules remplis de gaz pour l'imagerie de contraste |
| EP1714642A1 (fr) | 2005-04-18 | 2006-10-25 | Bracco Research S.A. | Formulation pharmaceutique comprenant des microcapsules remplies de gaz pour la délibération échographique |
| US8815804B2 (en) | 2006-02-06 | 2014-08-26 | Sanford-Burnham Medical Research Institute | Methods and compositions related to targeting tumors and wounds |
| AU2007293888B2 (en) | 2006-09-05 | 2013-05-02 | Bracco Suisse S.A. | Gas-filled microvesicles with polymer-modified lipids |
| CN101573143B (zh) * | 2006-12-11 | 2013-04-24 | 伯拉考成像股份公司 | 纤维蛋白结合肽及其缀合体 |
| EP2117603A2 (fr) | 2006-12-19 | 2009-11-18 | Bracco International B.V. | Composés de ciblage et composés thérapeutiques, et microvésicules remplies de gaz comprenant lesdits composés |
| WO2008085794A2 (fr) * | 2007-01-03 | 2008-07-17 | Burnham Institute For Medical Research | Méthodes et compositions associées à des composés adhérant aux caillots |
| IT1391546B1 (it) * | 2008-09-05 | 2012-01-11 | Univ Firenze | Complessi di manganese e cobalto, loro preparazione ed uso |
| WO2010040772A2 (fr) | 2008-10-07 | 2010-04-15 | Bracco Research Sa | Construction de ciblage comprenant un anticorps anti-polymere et des liposomes ou des microvesicules se liant à ceux-ci |
| KR101474063B1 (ko) | 2012-05-23 | 2014-12-19 | 동국대학교 산학협력단 | 피브린 표적 펩타이드 서열이 결합된 글라이콜 키토산-금 나노입자를 포함하는 혈전 탐지용 ｃｔ 조영제 |
| EP2934740B1 (fr) | 2012-12-21 | 2019-12-11 | Bracco Suisse SA | Microvésicules remplies de gaz |
| CN109127131A (zh) * | 2018-07-18 | 2019-01-04 | 沛县育龙粮油工贸有限公司 | 一种高效重金属污染大米的清洗方法 |
| US20200360289A1 (en) | 2019-05-15 | 2020-11-19 | Bracco Suisse Sa | Freeze-dried product and gas-filled microvesicles suspension |
| US11717570B2 (en) | 2019-05-15 | 2023-08-08 | Bracco Suisse Sa | Gas-filled microvesicles |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4219724A1 (de) | 1992-06-13 | 1993-12-16 | Schering Ag | Verwendung von Mikrokapseln als Kontrastmittel für die Farbdoppler-Sonographie |
| JPH02504472A (ja) * | 1988-06-03 | 1990-12-20 | セルテック リミテッド | ハイブリッド蛋白 |
| US5364612A (en) * | 1991-05-06 | 1994-11-15 | Immunomedics, Inc. | Detection of cardiovascular lesions |
| AU768859B2 (en) * | 1999-07-29 | 2004-01-08 | Dyax Corp. | Binding moieties for fibrin |
-
2001
- 2001-12-21 JP JP2002556612A patent/JP3991086B2/ja not_active Expired - Lifetime
- 2001-12-21 WO PCT/US2001/049534 patent/WO2002055544A2/fr active Application Filing
- 2001-12-21 AU AU2002248222A patent/AU2002248222B2/en not_active Expired
- 2001-12-21 EP EP01997103A patent/EP1348026A2/fr not_active Withdrawn
- 2001-12-21 CA CA2432474A patent/CA2432474C/fr not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP3991086B2 (ja) | 2007-10-17 |
| WO2002055544A2 (fr) | 2002-07-18 |
| EP1348026A2 (fr) | 2003-10-01 |
| WO2002055544A3 (fr) | 2003-03-27 |
| JP2004523514A (ja) | 2004-08-05 |
| CA2432474A1 (fr) | 2002-07-18 |
| AU2002248222B2 (en) | 2006-04-27 |
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