EP1348026A2 - Fractions de fixation de la fibrine qui conviennent comme agents d'imagerie - Google Patents
Fractions de fixation de la fibrine qui conviennent comme agents d'imagerieInfo
- Publication number
- EP1348026A2 EP1348026A2 EP01997103A EP01997103A EP1348026A2 EP 1348026 A2 EP1348026 A2 EP 1348026A2 EP 01997103 A EP01997103 A EP 01997103A EP 01997103 A EP01997103 A EP 01997103A EP 1348026 A2 EP1348026 A2 EP 1348026A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- cys
- gly
- pro
- trp
- glu
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
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- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0041—Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal
- A61K49/0043—Fluorescein, used in vivo
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- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
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Landscapes
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Abstract
La présente invention concerne des fractions de fixation de la fibrine qui possèdent diverses utilisations, que ce soit dans la détection, dans l'isolation ou dans la localisation de la fibrine, et plus particulièrement la fibrine en tant qu'opposé au fibrinogène, est intéressante. Cette invention concerne particulièrement des polypeptides isolés synthétiques capables de se fixer à la fibrine et de reconnaître la forme de la fibrine polymérisée trouvée dans les thrombi. Par ailleurs, ces polypeptides possèdent une vitesse de dissociation des thrombi faible, ce qui améliore leur capacité de former une image de contraste au niveau d'un site de caillot de fibrine et rend ces fractions de fixation particulièrement utiles comme agents d'imagerie pour les thrombi.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74740300A | 2000-12-23 | 2000-12-23 | |
| US747403 | 2000-12-23 | ||
| PCT/US2001/049534 WO2002055544A2 (fr) | 2000-12-23 | 2001-12-21 | Fractions de fixation de la fibrine qui conviennent comme agents d'imagerie |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EP1348026A2 true EP1348026A2 (fr) | 2003-10-01 |
Family
ID=25004908
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP01997103A Withdrawn EP1348026A2 (fr) | 2000-12-23 | 2001-12-21 | Fractions de fixation de la fibrine qui conviennent comme agents d'imagerie |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1348026A2 (fr) |
| JP (1) | JP3991086B2 (fr) |
| AU (1) | AU2002248222B2 (fr) |
| CA (1) | CA2432474C (fr) |
| WO (1) | WO2002055544A2 (fr) |
Families Citing this family (21)
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| JP2005529839A (ja) * | 2001-10-16 | 2005-10-06 | エピックス メディカル， インコーポレイテッド | 脈管内病変の検出および処置 |
| MEP57508A (en) * | 2002-12-20 | 2011-05-10 | Amgen Inc | Binding agents which inhibit myostatin |
| US9364569B2 (en) | 2003-02-04 | 2016-06-14 | Bracco Suisse S.A. | Ultrasound contrast agents and process for the preparation thereof |
| EP1656560A2 (fr) * | 2003-05-22 | 2006-05-17 | Agilent Technologies, Inc. | Marqueurs de diagnostic et cibles pharmacologiques utilises dans l'insuffisance cardiaque, et reactifs connexes et leurs procedes d'utilisation |
| WO2005063305A1 (fr) | 2003-12-22 | 2005-07-14 | Bracco Research Sa | Systeme de microvesicule remplie de gaz pour l'imagerie de contraste |
| WO2005079863A1 (fr) * | 2004-02-25 | 2005-09-01 | Astellas Pharma Inc. | Produit de contraste pour la formation d'un thrombus |
| JP4773430B2 (ja) | 2004-06-03 | 2011-09-14 | ブラッコ・リサーチ・ソシエテ・アノニム | 治療および／または診断用途のためのリポソーム集合体 |
| EP1784228B1 (fr) | 2004-08-18 | 2016-10-05 | Bracco Suisse SA | Composition à base de microvésicules remplis de gaz pour l'imagerie de contraste |
| EP1714642A1 (fr) | 2005-04-18 | 2006-10-25 | Bracco Research S.A. | Formulation pharmaceutique comprenant des microcapsules remplies de gaz pour la délibération échographique |
| CA2638911C (fr) | 2006-02-06 | 2018-01-23 | Burnham Institute For Medical Research | Procedes et compositions lies au ciblage de tumeurs et de plaies |
| EP2061517B1 (fr) | 2006-09-05 | 2010-06-02 | Bracco Research S.A. | Microvesicules remplies de gaz contenant des lipides modifies par polymeres |
| EP2111237B1 (fr) | 2006-12-11 | 2015-03-18 | BRACCO IMAGING S.p.A. | Peptides se fixant à la fibrine, et conjugués correspondants |
| EP2117603A2 (fr) | 2006-12-19 | 2009-11-18 | Bracco International B.V. | Composés de ciblage et composés thérapeutiques, et microvésicules remplies de gaz comprenant lesdits composés |
| EP2117575A4 (fr) * | 2007-01-03 | 2013-06-05 | Burnham Inst Medical Research | Méthodes et compositions associées à des composés adhérant aux caillots |
| IT1391546B1 (it) * | 2008-09-05 | 2012-01-11 | Univ Firenze | Complessi di manganese e cobalto, loro preparazione ed uso |
| AU2009301141B2 (en) | 2008-10-07 | 2015-08-27 | Bracco Suisse S.A. | Targeting construct comprising anti-polymer antibody and liposomes or microvesicles binding to the same |
| KR101474063B1 (ko) * | 2012-05-23 | 2014-12-19 | 동국대학교 산학협력단 | 피브린 표적 펩타이드 서열이 결합된 글라이콜 키토산-금 나노입자를 포함하는 혈전 탐지용 ｃｔ 조영제 |
| CN105026030B (zh) | 2012-12-21 | 2017-04-12 | 博莱科瑞士股份有限公司 | 充气微泡 |
| CN109127131A (zh) * | 2018-07-18 | 2019-01-04 | 沛县育龙粮油工贸有限公司 | 一种高效重金属污染大米的清洗方法 |
| US11717570B2 (en) | 2019-05-15 | 2023-08-08 | Bracco Suisse Sa | Gas-filled microvesicles |
| US20200360289A1 (en) | 2019-05-15 | 2020-11-19 | Bracco Suisse Sa | Freeze-dried product and gas-filled microvesicles suspension |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4219724A1 (de) | 1992-06-13 | 1993-12-16 | Schering Ag | Verwendung von Mikrokapseln als Kontrastmittel für die Farbdoppler-Sonographie |
| WO1989012098A1 (fr) * | 1988-06-03 | 1989-12-14 | Celltech Limited | Proteines hybrides |
| US5364612A (en) * | 1991-05-06 | 1994-11-15 | Immunomedics, Inc. | Detection of cardiovascular lesions |
| TWI290146B (en) * | 1999-07-29 | 2007-11-21 | Dyax Corp | Binding moieties for fibrin |
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2001
- 2001-12-21 AU AU2002248222A patent/AU2002248222B2/en not_active Expired
- 2001-12-21 EP EP01997103A patent/EP1348026A2/fr not_active Withdrawn
- 2001-12-21 JP JP2002556612A patent/JP3991086B2/ja not_active Expired - Lifetime
- 2001-12-21 WO PCT/US2001/049534 patent/WO2002055544A2/fr active Application Filing
- 2001-12-21 CA CA2432474A patent/CA2432474C/fr not_active Expired - Lifetime
Non-Patent Citations (1)
| Title |
|---|
| See references of WO02055544A2 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002055544A2 (fr) | 2002-07-18 |
| JP3991086B2 (ja) | 2007-10-17 |
| CA2432474C (fr) | 2012-06-26 |
| CA2432474A1 (fr) | 2002-07-18 |
| WO2002055544A3 (fr) | 2003-03-27 |
| JP2004523514A (ja) | 2004-08-05 |
| AU2002248222B2 (en) | 2006-04-27 |
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