WO2002053157A1 - Derive de thiazolidine - Google Patents

Derive de thiazolidine Download PDF

Info

Publication number
WO2002053157A1
WO2002053157A1 PCT/US2001/050041 US0150041W WO02053157A1 WO 2002053157 A1 WO2002053157 A1 WO 2002053157A1 US 0150041 W US0150041 W US 0150041W WO 02053157 A1 WO02053157 A1 WO 02053157A1
Authority
WO
WIPO (PCT)
Prior art keywords
mmol
compound
calcd
found
added
Prior art date
Application number
PCT/US2001/050041
Other languages
English (en)
Inventor
Koji Hagihara
Hitoshi Arai
Akira Asai
Yoshinori Yamashita
Allison C. Chin
Mieczslaw A. Piatyszek
Original Assignee
Geron Corporation
Kyowa Hakko Kogyo Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Geron Corporation, Kyowa Hakko Kogyo Co., Ltd. filed Critical Geron Corporation
Publication of WO2002053157A1 publication Critical patent/WO2002053157A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Definitions

  • Alkyl refers to a moiety -R'-R" where R' is an alkylene group and R" is an aryl group as defined above. Specific examples of.the aralkyl include benzyl, phenethyl, phenylpropyl, naphthylmethyl, naphthylethyl, diphenylmethyl, and the like.
  • Heterocyclic group refers to a cyclic ring moiety having at least one nitrogen atom in the ring structure.
  • Exemplary pharmaceutically acceptable acid addition salts of Compound (I) include inorganic acid salts, e.g., hydrochlorides, sulfates, nitrates, and phosphates; and organic acid salts, e.g., acetates, maleates, fumarates, citrates, methanesulfonates, oxalates, malonates, succinates, and tartarates.
  • Exemplary pharmaceutically acceptable metal salts of Compound (I) include alkali metal salts, e.g., sodium salts and potassium salts; alkaline-earth metal salts, e.g., magnesium salts and calcium salts; aluminum salts; zinc salts; and the like.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des dérivés de thiazolidine utilisés dans le traitement de maladies liées à l'activité de télomerase, notamment des tumeurs malignes. Selon une variante, le dérivé de thiazolidine est de formule (I), dans laquelle A, X, Y?1 and Y2¿ sont tels que définis ici.
PCT/US2001/050041 2000-12-30 2001-12-28 Derive de thiazolidine WO2002053157A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25912300P 2000-12-30 2000-12-30
US60/259,123 2000-12-30

Publications (1)

Publication Number Publication Date
WO2002053157A1 true WO2002053157A1 (fr) 2002-07-11

Family

ID=22983619

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/050041 WO2002053157A1 (fr) 2000-12-30 2001-12-28 Derive de thiazolidine

Country Status (1)

Country Link
WO (1) WO2002053157A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1568698A1 (fr) * 2004-02-27 2005-08-31 Aventis Pharma Deutschland GmbH Dérivés de pyrrole en tant qu'inhibiteurs du facteur xa

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5143929A (en) * 1991-05-09 1992-09-01 Warner-Lambert Company 2-substituted thiazolidinone, oxazolidinone, and imidazolidinone derivatives of fenamates as antiinflammatory agents
US5326770A (en) * 1992-07-17 1994-07-05 The Du Pont Merck Pharmaceutical Company Monoamine oxidase-B (MAO-B) inhibitory 5-substituted 2,4-thiazolidinediones useful in treating memory disorders of mammals
US5925656A (en) * 1995-04-10 1999-07-20 Dr. Reddy's Research Foundation Compounds having antidiabetic, hypolipidemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5143929A (en) * 1991-05-09 1992-09-01 Warner-Lambert Company 2-substituted thiazolidinone, oxazolidinone, and imidazolidinone derivatives of fenamates as antiinflammatory agents
US5326770A (en) * 1992-07-17 1994-07-05 The Du Pont Merck Pharmaceutical Company Monoamine oxidase-B (MAO-B) inhibitory 5-substituted 2,4-thiazolidinediones useful in treating memory disorders of mammals
US5925656A (en) * 1995-04-10 1999-07-20 Dr. Reddy's Research Foundation Compounds having antidiabetic, hypolipidemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1568698A1 (fr) * 2004-02-27 2005-08-31 Aventis Pharma Deutschland GmbH Dérivés de pyrrole en tant qu'inhibiteurs du facteur xa
US7465806B2 (en) 2004-02-27 2008-12-16 Sanofi-Aventis Deutschland Gmbh Pyrrole-derivatives as factor Xa inhibitors

Similar Documents

Publication Publication Date Title
CN108516958B (zh) 稠环衍生物、其制备方法、中间体、药物组合物及应用
JP4417622B2 (ja) Ｐａｒｐの阻害剤として用いるためのチエノ［２，３−ｃ］イソキノリン
EP1309594B1 (fr) Derives de benzimidazole, leur preparation et leur application en therapeutique
JP6966423B2 (ja) 縮合環ピリミジンアミノ誘導体、その製造方法、中間体、薬学的組成物及び応用
JP2667987B2 (ja) ５−［２−（４−（ベンゾイソチアゾール−３−イル）−ピペラジン−１−イル）エチル］−６−クロロ−１，３−ジヒドロ−インドール−２−オンの製造方法及び製造用中間体
US20030149034A1 (en) Indazoles substituted with1,1-dioxoisothiazolidine useful as inhibitors of cell proliferation
US20040266755A1 (en) Prodrugs of 1-(1-hydroxy-5-isoquinolinesulfonyl) homopiperazine
SK16972002A3 (sk) Beta-karbolínové deriváty použiteľné ako inhibítory fosfodiesterázy
CA2176668C (fr) Nouveaux composes spiro heterocycliques, leur procede de preparation et les compositions pharmaceutiques les contenant
JPH0219112B2 (fr)
GB1588166A (en) Nitrogen-containing heterocyclic compounds
JP3939246B2 (ja) インドロキナゾリノン類
JPS61155358A (ja) ジアリール酪酸誘導体
HUE024989T2 (en) Azaindole derivatives as ABI and SRC protein kinase inhibitors
JP3044055B2 (ja) １，２―エタンジオール誘導体およびその塩
JPH0536436B2 (fr)
FR2753970A1 (fr) Derives de n-(benzothiazol-2-yl) piperidine-1-ethanamine, leur preparation et leur application en therapeutique
EP1541149A1 (fr) Inhibiteur de phosphodiesterase
JP2000503972A (ja) １―ピラゾール―３―イルエチル―４―インドール―３―イルピペリジン
JP2002322162A (ja) チアゾリジン誘導体
WO2002053157A1 (fr) Derive de thiazolidine
EA014236B1 (ru) Новые пиперазиновые производные диалкилоксиндолов
JPH06116273A (ja) 三環系化合物
CN109280028B (zh) 喹啉类化合物及其在dpp-4酶抑制剂的应用
JP2597731B2 (ja) Ｎ―（２―ヒドロキシエチル）―３―（４―ニトロフェニル）プロピルアミン及びその製造方法

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PH PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP