WO2002020495A3 - Inhibiteurs de glycogene-synthase kinase 3 - Google Patents
Inhibiteurs de glycogene-synthase kinase 3 Download PDFInfo
- Publication number
- WO2002020495A3 WO2002020495A3 PCT/US2001/042081 US0142081W WO0220495A3 WO 2002020495 A3 WO2002020495 A3 WO 2002020495A3 US 0142081 W US0142081 W US 0142081W WO 0220495 A3 WO0220495 A3 WO 0220495A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- gsk3
- glycogen synthase
- synthase kinase
- disorders
- compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Pain & Pain Management (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU9502601A AU9502601A (en) | 2000-09-06 | 2001-09-06 | Inhibitors of glycogen synthase kinase 3 |
JP2002525117A JP2004514656A (ja) | 2000-09-06 | 2001-09-06 | グリコゲンシンターゼキナーゼ3のインヒビター |
KR1020037003327A KR100816769B1 (ko) | 2000-09-06 | 2001-09-06 | 글리코겐 합성효소 키나아제 3의 억제제 |
AU2001295026A AU2001295026B2 (en) | 2000-09-06 | 2001-09-06 | Inhibitors of glycogen synthase kinase 3 |
EP01975734A EP1317433A2 (fr) | 2000-09-06 | 2001-09-06 | Inhibiteurs de glycogene-synthase kinase 3 |
HK05104683.9A HK1072936A1 (en) | 2000-09-06 | 2005-06-03 | Inhibitors of glycogen synthase kinase 3 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23048000P | 2000-09-06 | 2000-09-06 | |
US60/230,480 | 2000-09-06 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2002020495A2 WO2002020495A2 (fr) | 2002-03-14 |
WO2002020495A3 true WO2002020495A3 (fr) | 2002-06-20 |
Family
ID=22865391
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2001/042081 WO2002020495A2 (fr) | 2000-09-06 | 2001-09-06 | Inhibiteurs de glycogene-synthase kinase 3 |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP1317433A2 (fr) |
JP (1) | JP2004514656A (fr) |
KR (2) | KR100816769B1 (fr) |
CN (1) | CN100506801C (fr) |
AU (2) | AU2001295026B2 (fr) |
HK (1) | HK1072936A1 (fr) |
WO (1) | WO2002020495A2 (fr) |
Families Citing this family (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE416175T1 (de) * | 2001-02-20 | 2008-12-15 | Astrazeneca Ab | 2-arylaminopyrimidine zur behandlung von mit gsk3 in zusammenhang stehenden erkrankungen |
EP1373257B9 (fr) | 2001-03-29 | 2008-10-15 | Vertex Pharmaceuticals Incorporated | Inhibiteurs de kinases n-terminales c-jun (jnk) et autres proteineskinases |
TWI330183B (fr) | 2001-10-22 | 2010-09-11 | Eisai R&D Man Co Ltd | |
CA2487948A1 (fr) | 2002-06-14 | 2003-12-24 | Applied Research Systems Ars Holding N.V. | Derives de cyanure d'azole methylidene et leur utilisation comme modulateurs de proteine kinase |
US7304071B2 (en) * | 2002-08-14 | 2007-12-04 | Vertex Pharmaceuticals Incorporated | Protein kinase inhibitors and uses thereof |
CN1717391A (zh) | 2002-10-21 | 2006-01-04 | 希龙公司 | 糖元合成酶激酶3的抑制剂 |
ATE454378T1 (de) * | 2002-11-01 | 2010-01-15 | Vertex Pharma | Verbindungen, die sich als inhibitoren vonjak und anderen proteinkinasen eignen |
ES2289349T3 (es) * | 2002-11-04 | 2008-02-01 | Vertex Pharmaceuticals Incorporated | Derivados de heteroaril-pirimidina como inhibidores de jak. |
JP2006508107A (ja) * | 2002-11-05 | 2006-03-09 | バーテックス ファーマシューティカルズ インコーポレイテッド | Jakおよび他のプロテインキナーゼのインヒビターとして有用な化合物 |
MXPA05005477A (es) * | 2002-11-21 | 2005-07-25 | Chiron Corp | Pirimidinas 2,4,6-trisustituidas como inhibidores de fosfotidilinositol (pi) 3-cinasa y su uso en el tratamiento del cancer. |
JPWO2004054617A1 (ja) * | 2002-12-13 | 2006-04-20 | 協和醗酵工業株式会社 | 中枢疾患の予防および/または治療剤 |
CA2524161C (fr) | 2003-05-08 | 2013-01-15 | Applied Research Systems Ars Holding N.V. | Acetonitriles de pyridinyle |
TWI334868B (en) * | 2003-06-03 | 2010-12-21 | Nippon Kayaku Kk | [1,2,4] triazoro [1,5-a] pyrimidine-2-ylurea derivative and use thereof |
AU2004272306A1 (en) * | 2003-09-12 | 2005-03-24 | Merck Serono Sa | Benzimidazole acetonitriles |
EP1668004A1 (fr) * | 2003-09-12 | 2006-06-14 | Applied Research Systems ARS Holding N.V. | Derives de benzoxazole-acetonitrile |
US20070129383A1 (en) * | 2003-10-17 | 2007-06-07 | Hiroshi Kuramochi | Substituted 2-amino-[1,2,4]triazolo[1,5-a]pyrimidine derivative and use thereof |
GB0324551D0 (en) * | 2003-10-21 | 2003-11-26 | Karobio Ab | Novel compounds |
WO2005040135A1 (fr) * | 2003-10-24 | 2005-05-06 | Ono Pharmaceutical Co., Ltd. | Medicament antistress et usage medical correspondant |
ZA200602664B (en) * | 2003-12-03 | 2007-06-27 | Cytopia Res Pty Ltd | Tubulin inhibitors |
HUP0400405A3 (en) * | 2004-02-10 | 2009-03-30 | Sanofi Synthelabo | Pyrimidine derivatives, process for producing them, their use, pharmaceutical compositions containing them and their intermediates |
EP1768679B1 (fr) * | 2004-07-09 | 2012-08-22 | Agency for Science, Technology and Research | Modulation de gsk-3beta et procede de traitement des maladies proliferatives |
WO2006066172A1 (fr) | 2004-12-17 | 2006-06-22 | Amgen, Inc. | Composes d'aminopyrimidine et procedes d'utilisation correspondants |
US7759342B2 (en) | 2005-01-13 | 2010-07-20 | Signal Pharmaceuticals, Llc | Methods of treatment and prevention using haloaryl substituted aminopurines |
US7723340B2 (en) | 2005-01-13 | 2010-05-25 | Signal Pharmaceuticals, Llc | Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith |
US7521446B2 (en) | 2005-01-13 | 2009-04-21 | Signal Pharmaceuticals, Llc | Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith |
US9101722B2 (en) | 2005-02-28 | 2015-08-11 | Novo Nordisk A/S | Dose setting mechanism for an injection device capable of presetting a maximum dose |
ES2270715B1 (es) | 2005-07-29 | 2008-04-01 | Laboratorios Almirall S.A. | Nuevos derivados de pirazina. |
WO2007025177A2 (fr) | 2005-08-26 | 2007-03-01 | Braincells, Inc. | Neurogenese par modulation du recepteur muscarinique |
EP2258359A3 (fr) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenèse par modulation des récepteurs muscariniques avec sabcomeline |
ES2274712B1 (es) | 2005-10-06 | 2008-03-01 | Laboratorios Almirall S.A. | Nuevos derivados imidazopiridina. |
WO2007047978A2 (fr) | 2005-10-21 | 2007-04-26 | Braincells, Inc. | Modulation de la neurogenese par inhibition de la pde |
US20070112017A1 (en) | 2005-10-31 | 2007-05-17 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
JO2660B1 (en) | 2006-01-20 | 2012-06-17 | نوفارتيس ايه جي | Pi-3 inhibitors and methods of use |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
WO2007117399A2 (fr) | 2006-03-31 | 2007-10-18 | Janssen Pharmaceutica N.V. | Benzoimidazol-2-yl pyrimidines et pyrazines modulatrices du récepteur de l'histamine h4 |
EP2004188B1 (fr) | 2006-03-31 | 2010-09-01 | Janssen Pharmaceutica NV | Benzoimidazol-2-yl pyridines modulatrices du récepteur de l'histamine h4 |
JP2009536669A (ja) | 2006-05-09 | 2009-10-15 | ブレインセルス,インコーポレイティド | アンジオテンシン調節による神経新生 |
KR20090115866A (ko) | 2007-03-05 | 2009-11-09 | 교와 핫꼬 기린 가부시키가이샤 | 의약 조성물 |
US8084466B2 (en) | 2007-12-18 | 2011-12-27 | Janssen Pharmaceutica Nv | Bicyclic heteroaryl-substituted imidazoles as modulators of the histamine H4 receptor |
US9371311B2 (en) | 2008-06-30 | 2016-06-21 | Janssen Pharmaceutica Nv | Benzoimidazol-2-yl pyrimidine derivatives |
DE102008035552A1 (de) * | 2008-07-30 | 2010-02-04 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Pyridine und ihre Verwendung |
WO2010099217A1 (fr) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation de neurogenèse à l'aide de combinaisons de d-cyclosérine |
DK2401010T3 (en) | 2009-02-26 | 2018-07-23 | Shl Group Ab | DOSE ADJUSTMENT MECHANISM |
WO2011082268A2 (fr) | 2009-12-30 | 2011-07-07 | Arqule Inc. | Composés naphthalényl-pyrimidine substitués |
WO2012175711A1 (fr) | 2011-06-24 | 2012-12-27 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Procédé pour prédire la réponse à une chimiothérapie d'un patient atteint d'un ostéosarcome |
EP2554662A1 (fr) | 2011-08-05 | 2013-02-06 | M Maria Pia Cosma | Procédés pour le traitement de maladies rétiniennes dégénératives |
MX342326B (es) | 2011-09-27 | 2016-09-26 | Novartis Ag | 3-pirimidin-4-il-oxazolidin-2-onas como inhibidoras de idh mutante. |
UY34632A (es) | 2012-02-24 | 2013-05-31 | Novartis Ag | Compuestos de oxazolidin- 2- ona y usos de los mismos |
BR112015007182A2 (pt) * | 2012-10-05 | 2017-07-04 | Rigel Pharmaceuticals Inc | inibidores de gdf-8 |
US9296733B2 (en) | 2012-11-12 | 2016-03-29 | Novartis Ag | Oxazolidin-2-one-pyrimidine derivative and use thereof for the treatment of conditions, diseases and disorders dependent upon PI3 kinases |
UY35370A (es) | 2013-03-06 | 2014-09-30 | Janssen Pharmaceutica Nv | Moduladores benzoimidazol-2-il pirimidina del receptor de histamina h4 |
WO2014141104A1 (fr) | 2013-03-14 | 2014-09-18 | Novartis Ag | 3-pyrimidin-4-yl-oxazolidin-2-ones comme inhibiteurs d'idh mutante |
GB201312800D0 (en) | 2013-07-17 | 2013-08-28 | Heptares Therapeutics Ltd | mGlu5 modulators |
WO2015155738A2 (fr) | 2014-04-09 | 2015-10-15 | Christopher Rudd | Utilisation d'inhibiteurs ou d'activateurs de gsk -3 qui modulent l'expression de pd -1 ou de t-bet pour moduler l'immunité due aux lymphocytes t |
EP3313420B1 (fr) | 2015-06-25 | 2024-03-13 | The Children's Medical Center Corporation | Procédés et compositions se rapportant à l'expansion, l'enrichissement et la conservation de cellules souches hématopoïétiques |
AU2017235461B2 (en) | 2016-03-15 | 2023-02-23 | Children's Medical Center Corporation | Methods and compositions relating to hematopoietic stem cell expansion |
EP3231434A1 (fr) | 2016-04-14 | 2017-10-18 | Fundacio Centre de Regulacio Genomica | Procédé de traitement de la maladie de parkinson |
US11331313B2 (en) | 2017-05-22 | 2022-05-17 | Whitehead Institute For Biomedical Research | KCC2 expression enhancing compounds and uses thereof |
EP3920885A1 (fr) | 2019-02-08 | 2021-12-15 | Frequency Therapeutics, Inc. | Composés d'acide valproïque et agonistes wnt pour le traitement de troubles de l'oreille |
CN113293046B (zh) * | 2021-05-26 | 2021-11-30 | 安徽博洋润滑科技有限公司 | 一种低发尘润滑脂及其制备方法 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0710659A1 (fr) * | 1994-11-02 | 1996-05-08 | Takeda Chemical Industries, Ltd. | Dérivés d'oxazolidinedione, leur fabrication et leur application |
US5741796A (en) * | 1994-05-27 | 1998-04-21 | Merck & Co., Inc. | Pyridyl and naphthyridyl compounds for inhibiting osteoclast-mediated bone resorption |
WO1998024782A2 (fr) * | 1996-12-05 | 1998-06-11 | Amgen Inc. | Composes pyrimidines substitues et leur utilisation |
WO1999065897A1 (fr) * | 1998-06-19 | 1999-12-23 | Chiron Corporation | Inhibiteurs de glycogene synthase kinase 3 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3627922A1 (de) * | 1986-08-18 | 1988-03-03 | Henkel Kgaa | Neue tetraaminopyrimidin-derivate und deren verwendung in haarfaerbemitteln |
ZA959204B (en) * | 1994-11-02 | 1997-04-30 | Takeda Chemical Industries Ltd | Oxazolidinedioe derivatives their production and use |
NZ335997A (en) * | 1996-12-05 | 2001-08-31 | Amgen Inc | Substituted pyrimidine compounds for treating TNF and interleukin diseases |
-
2001
- 2001-09-06 EP EP01975734A patent/EP1317433A2/fr not_active Withdrawn
- 2001-09-06 JP JP2002525117A patent/JP2004514656A/ja active Pending
- 2001-09-06 KR KR1020037003327A patent/KR100816769B1/ko not_active IP Right Cessation
- 2001-09-06 KR KR1020087001887A patent/KR100860827B1/ko not_active IP Right Cessation
- 2001-09-06 AU AU2001295026A patent/AU2001295026B2/en not_active Ceased
- 2001-09-06 WO PCT/US2001/042081 patent/WO2002020495A2/fr active Application Filing
- 2001-09-06 CN CNB018184251A patent/CN100506801C/zh not_active Expired - Fee Related
- 2001-09-06 AU AU9502601A patent/AU9502601A/xx active Pending
-
2005
- 2005-06-03 HK HK05104683.9A patent/HK1072936A1/xx not_active IP Right Cessation
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5741796A (en) * | 1994-05-27 | 1998-04-21 | Merck & Co., Inc. | Pyridyl and naphthyridyl compounds for inhibiting osteoclast-mediated bone resorption |
EP0710659A1 (fr) * | 1994-11-02 | 1996-05-08 | Takeda Chemical Industries, Ltd. | Dérivés d'oxazolidinedione, leur fabrication et leur application |
WO1998024782A2 (fr) * | 1996-12-05 | 1998-06-11 | Amgen Inc. | Composes pyrimidines substitues et leur utilisation |
WO1999065897A1 (fr) * | 1998-06-19 | 1999-12-23 | Chiron Corporation | Inhibiteurs de glycogene synthase kinase 3 |
Non-Patent Citations (1)
Title |
---|
S.C.CONNOR: "ANTIDIABETIC EFFICACY OF BRL 49653", J. PHARM. PHARMACOL., vol. 49, no. 3, 1 March 1997 (1997-03-01), ENGL., pages 336 - 344, XP002080751 * |
Also Published As
Publication number | Publication date |
---|---|
EP1317433A2 (fr) | 2003-06-11 |
KR20080013026A (ko) | 2008-02-12 |
KR100860827B1 (ko) | 2008-09-30 |
AU9502601A (en) | 2002-03-22 |
HK1072936A1 (en) | 2005-09-16 |
JP2004514656A (ja) | 2004-05-20 |
KR20040030404A (ko) | 2004-04-09 |
CN1592743A (zh) | 2005-03-09 |
KR100816769B1 (ko) | 2008-03-26 |
AU2001295026B2 (en) | 2008-04-03 |
WO2002020495A2 (fr) | 2002-03-14 |
CN100506801C (zh) | 2009-07-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2002020495A3 (fr) | Inhibiteurs de glycogene-synthase kinase 3 | |
AU4956699A (en) | Inhibitors of glycogen synthase kinase 3 | |
WO2001044246A8 (fr) | Inhibiteurs bicycliques de synthase kinase 3 de glycogene | |
PT1237880E (pt) | Inibidores baseados em pirazina da cinase 3 da glicogénio sintase | |
AU2003268184A1 (en) | Pyrrole based inhibitors of glycogen synthase kinase 3 | |
WO2004078116A3 (fr) | Inhibiteurs de la p 38 et leurs procedes d'utilisation | |
WO2007041365A3 (fr) | Composes organiques | |
IL161829A (en) | 1,2,4 - thiadiazole derivatives, some of which are novel and pharmaceutical compositions comprising the same for treating disorders mediated by melanocortin receptor modulators | |
WO2007056163A3 (fr) | Aminopyrimidines utiles en tant qu'inhibiteurs de kinases | |
WO2006034235A3 (fr) | Inhibiteurs quinoline et quinazoline a substitution inhibant la quinone reductase 2 | |
WO2007079214A3 (fr) | Antagonistes du recepteur de la prokineticine 2 | |
WO2004078747A8 (fr) | Nouveaux derives de cyanopyridine utiles dans le traitement du cancer et d'autres troubles | |
WO2000006085A3 (fr) | Composes et procedes | |
WO2002096361A3 (fr) | Derives de 5-aralkylsulfonyl-3-(pyrrol-2-ylmethylidene)-2-indolinone utilises comme inhibiteurs de kinase | |
WO2004058769A3 (fr) | Compositions utiles en tant qu'inhibiteurs des proteine kinases | |
WO2001012199A3 (fr) | Effet synergique de la methoxyamide sur l'activite anticancereuse de la temozolomide | |
WO2005086656A3 (fr) | Derives d'heteroarylaminopyrazole utilises pour traiter le diabete | |
WO2004009549A3 (fr) | Piperidines utiles pour traiter des maladies du systeme nerveux central | |
WO2007079163A3 (fr) | Antagonistes du recepteur de la prokineticine 1 | |
WO2006034491A3 (fr) | Composes a base de quinoleine et de quinazoline a substitution phenylique pour le traitement du diabete | |
WO2002078745A3 (fr) | Compositions et utilisations d'antagonistes de mglur5 | |
WO2003020280A3 (fr) | Compositions et methodes de traitement du cancer | |
WO2007022305A3 (fr) | 2-aminoimidazopyridines destinees a traiter des maladies neurodegeneratives | |
WO2003057149A3 (fr) | Heteropyrimidines et hetero-4-pyrimidones fusionnees substituees en position 4, compositions pharmaceutiques les contenant et leur utilisation dans le traitement ou la prevention de maladies et de troubles a mediation par de7¿b? | |
WO2005121102A3 (fr) | Inhibiteur du facteur viia |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PH PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
AK | Designated states |
Kind code of ref document: A3 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PH PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A3 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
WWE | Wipo information: entry into national phase |
Ref document number: 2002525117 Country of ref document: JP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 277/KOLNP/2003 Country of ref document: IN |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1020037003327 Country of ref document: KR |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2001295026 Country of ref document: AU |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2001975734 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 018184251 Country of ref document: CN |
|
WWP | Wipo information: published in national office |
Ref document number: 2001975734 Country of ref document: EP |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
WWP | Wipo information: published in national office |
Ref document number: 1020037003327 Country of ref document: KR |