WO2002020017A3 - Verwendung von ectoin oder ectoin-derivaten zur stabilisierung von p53 - Google Patents

Verwendung von ectoin oder ectoin-derivaten zur stabilisierung von p53 Download PDF

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Publication number
WO2002020017A3
WO2002020017A3 PCT/EP2001/009670 EP0109670W WO0220017A3 WO 2002020017 A3 WO2002020017 A3 WO 2002020017A3 EP 0109670 W EP0109670 W EP 0109670W WO 0220017 A3 WO0220017 A3 WO 0220017A3
Authority
WO
WIPO (PCT)
Prior art keywords
alkyl
ectoin
radical
stabilizing
compound
Prior art date
Application number
PCT/EP2001/009670
Other languages
English (en)
French (fr)
Other versions
WO2002020017A2 (de
Inventor
Joachim Buenger
Francois Marchio
Original Assignee
Merck Patent Gmbh
Joachim Buenger
Francois Marchio
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh, Joachim Buenger, Francois Marchio filed Critical Merck Patent Gmbh
Priority to JP2002524501A priority Critical patent/JP2004508332A/ja
Priority to EP01962962A priority patent/EP1315498A2/de
Priority to AU2001284028A priority patent/AU2001284028A1/en
Priority to US10/363,469 priority patent/US20030199446A1/en
Publication of WO2002020017A2 publication Critical patent/WO2002020017A2/de
Publication of WO2002020017A3 publication Critical patent/WO2002020017A3/de

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
    • A61Q1/02—Preparations containing skin colorants, e.g. pigments
    • A61Q1/04—Preparations containing skin colorants, e.g. pigments for lips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/001—Preparations for care of the lips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/004—Aftersun preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/02—Preparations for cleaning the hair
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/06—Preparations for styling the hair, e.g. by temporary shaping or colouring

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Birds (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Die vorliegende Erfindung betrifft die Verwendung von mindestens einer Verbindung, gewählt aus einer Verbindung der Formel (1a, 1b), einem physiologisch verträglichen Salz davon und einer stereoisomeren Form davon, worin R1 H oder Alkyl, R2, H, COOH, COO-Alkyl oder CO-NH-R?5, R3 und R4¿ jeweils unabhängig voneinander H oder OH, n 1,2 oder 3, R5 H, Alkyl, einen Aminosäurerest, Dipeptidrest oder Tripeptidrest, und Alkyl einen Alkylrest mit 1 bis 4 Kohlenstoffatomen bedeuten, zur Stabilisierung von p53, insbesondere um die Apoptose auch bei Tumorzellen einzuleiten. Diese Verbindungen werden erfindungsgemäss üblicherweise in Form einer topischen Zusammensetzung verwendet.
PCT/EP2001/009670 2000-09-04 2001-08-21 Verwendung von ectoin oder ectoin-derivaten zur stabilisierung von p53 WO2002020017A2 (de)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2002524501A JP2004508332A (ja) 2000-09-04 2001-08-21 ｐ５３の安定化におけるエクトインまたはエクトイン誘導体の使用
EP01962962A EP1315498A2 (de) 2000-09-04 2001-08-21 Verwendung von ectoin oder ectoin-derivaten zur stabilisierung von p53
AU2001284028A AU2001284028A1 (en) 2000-09-04 2001-08-21 Use of ectoin or ectoin derivatives for stabilizing p53
US10/363,469 US20030199446A1 (en) 2000-09-04 2001-08-21 Use of ectoin or ectoin derivatives for stabilizing p53

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10043456A DE10043456A1 (de) 2000-09-04 2000-09-04 Verwendung von Ectoin oder Ectoin-Derivaten zur Stabilisierung von p53
DE10043456.8 2000-09-04

Publications (2)

Publication Number Publication Date
WO2002020017A2 WO2002020017A2 (de) 2002-03-14
WO2002020017A3 true WO2002020017A3 (de) 2003-03-13

Family

ID=7654866

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/009670 WO2002020017A2 (de) 2000-09-04 2001-08-21 Verwendung von ectoin oder ectoin-derivaten zur stabilisierung von p53

Country Status (6)

Country Link
US (1) US20030199446A1 (de)
EP (1) EP1315498A2 (de)
JP (1) JP2004508332A (de)
AU (1) AU2001284028A1 (de)
DE (1) DE10043456A1 (de)
WO (1) WO2002020017A2 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1414846A2 (de) * 2001-08-10 2004-05-06 Medical Research Council P53-stabilisierendes peptid
DE10214257A1 (de) * 2002-03-28 2003-10-16 Merck Patent Gmbh Verwendung von kompatiblen Soluten zur Inhibierung der Freisetzung von Ceramiden
TWI280136B (en) * 2003-05-30 2007-05-01 Lytone Enterprise Inc Composition containing dipeptide of histidine and alanine for reducing uric acid
US7425638B2 (en) 2003-06-17 2008-09-16 Hoffmann-La Roche Inc. Cis-imidazolines
RU2319696C2 (ru) * 2003-06-17 2008-03-20 Ф.Хоффманн-Ля Рош Аг Цис-2, 4, 5-триарил-имидазолины
RU2418633C2 (ru) 2004-04-08 2011-05-20 Байоматрика, Инк. Объединение процессов хранения образцов и управление образцами в медико-биологических науках
US20080176209A1 (en) * 2004-04-08 2008-07-24 Biomatrica, Inc. Integration of sample storage and sample management for life science
US20060286050A1 (en) * 2005-06-01 2006-12-21 L'oreal Moisturizing lipstick compositions
US8519125B2 (en) * 2009-05-11 2013-08-27 Biomatrica, Inc. Compositions and methods for biological sample storage
EP2598660B1 (de) 2010-07-26 2017-03-15 Biomatrica, INC. Zusammensetzungen zur stabilisierung von dna, rna und proteinen in blut- und anderen biologischen proben während des transports und der lagerung bei umgebungstemperaturen
EP2598661B1 (de) 2010-07-26 2017-09-27 Biomatrica, INC. Zusammensetzungen zur stabilisierung von dna, rna und proteinen in speichel- und anderen biologischen proben während des transports und der lagerung bei umgebungstemperaturen
US9725703B2 (en) 2012-12-20 2017-08-08 Biomatrica, Inc. Formulations and methods for stabilizing PCR reagents
WO2015191632A1 (en) 2014-06-10 2015-12-17 Biomatrica, Inc. Stabilization of thrombocytes at ambient temperatures
CN113588501A (zh) 2015-12-08 2021-11-02 生物马特里卡公司 降低红细胞沉降速率
US11304968B2 (en) 2018-11-16 2022-04-19 Janssen Pharmaceutica Nv Pharmaceutical compositions comprising a hydroxyethylquercetin glucuronide
US10639294B2 (en) 2018-10-02 2020-05-05 Janssen Pharmaceutica Nv Pharmaceutical compositions comprising a hydroxyethylquercetin glucuronide metabolite

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0553884A1 (de) * 1992-01-30 1993-08-04 Yeda Research And Development Co. Ltd. Gereinigte Tetrahydropyrimidinderivate und diese enthaltende pharmazeutische Zusammensetzungen
JPH09143167A (ja) * 1995-11-17 1997-06-03 Dainippon Pharmaceut Co Ltd 酵素の安定化法
DE19933460A1 (de) * 1998-07-10 2000-01-13 Beiersdorf Ag Verwendung von Ectoinen und sulfonierten UV-Filtern
WO2000007558A1 (de) * 1998-08-01 2000-02-17 Merck Patent Gmbh Verwendung von ectoin oder ectoin-derivaten in kosmetischen formulierungen
WO2000076528A2 (de) * 1999-06-12 2000-12-21 Bitop Gmbh Proteinenthaltende pharmazeutische zubereitung
WO2001058446A1 (de) * 2000-02-14 2001-08-16 bitop Aktiengesellschaft für biotechnische Optimierung Verwendung von kompatiblen soluten als inhibitoren des enzymatischen abbaus von makromolekularen biopolymeren
DE10006578A1 (de) * 2000-02-14 2001-08-23 Bitop Gmbh Verwendung von kompatiblen Soluten als Inhibitoren des enzymatischen Abbaus von makromolekularen Biopolymeren
WO2001072263A2 (de) * 2000-03-24 2001-10-04 Merck Patent Gmbh Verwendung von ectoin oder ectoin-derivaten zum schutz der stressprotein in der haut

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0553884A1 (de) * 1992-01-30 1993-08-04 Yeda Research And Development Co. Ltd. Gereinigte Tetrahydropyrimidinderivate und diese enthaltende pharmazeutische Zusammensetzungen
JPH09143167A (ja) * 1995-11-17 1997-06-03 Dainippon Pharmaceut Co Ltd 酵素の安定化法
DE19933460A1 (de) * 1998-07-10 2000-01-13 Beiersdorf Ag Verwendung von Ectoinen und sulfonierten UV-Filtern
WO2000007558A1 (de) * 1998-08-01 2000-02-17 Merck Patent Gmbh Verwendung von ectoin oder ectoin-derivaten in kosmetischen formulierungen
WO2000076528A2 (de) * 1999-06-12 2000-12-21 Bitop Gmbh Proteinenthaltende pharmazeutische zubereitung
WO2001058446A1 (de) * 2000-02-14 2001-08-16 bitop Aktiengesellschaft für biotechnische Optimierung Verwendung von kompatiblen soluten als inhibitoren des enzymatischen abbaus von makromolekularen biopolymeren
DE10006578A1 (de) * 2000-02-14 2001-08-23 Bitop Gmbh Verwendung von kompatiblen Soluten als Inhibitoren des enzymatischen Abbaus von makromolekularen Biopolymeren
WO2001072263A2 (de) * 2000-03-24 2001-10-04 Merck Patent Gmbh Verwendung von ectoin oder ectoin-derivaten zum schutz der stressprotein in der haut

Non-Patent Citations (6)

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Title
ADAMS, J. L. ET AL.: "cis-4-Carboxy-6-(mercaptomethyl)-3,4,5,6-tetrahydropyrimidin-2(1H)-one, a potent inhibitor of mammalian dihydroorotase", J. MED. CHEM., vol. 31, no. 7, 1988, pages 1355 - 1359, XP001074178 *
BEYER, N. ET AL: "Ectoin - a innovative, multi-functional active substance for the cosmetic industry", SOFW JOURNAL (2000), 126(12), 26,28-29, XP001041687 *
BUENGER J: "NEUE WIRKSTOFFKLASSE SCHUETZT UND PFLEGT DIE HAUT. ECTOINE STABILISIEREN BIOPOLYMERSTRUKTUREN", PARFUMERIE UND KOSMETIK, HUETHIG, HEIDELBERG, DE, vol. 79, no. 11, 1998, pages 32 - 34-35, XP000852629, ISSN: 0031-1952 *
DATABASE WPI Section Ch Week 199732, Derwent World Patents Index; Class B04, AN 1997-347460, XP002214202 *
KREZEL, I: "Antitumor activity of new derivatives of 1,3-diazaheterocycles", PHARMAZIE, vol. 53, no. 9, 1998, pages 614 - 617, XP001074183 *
SAUER T ET AL: "ECTOINE - BIOTECHNISCHE PRODUKTION UND MOEGLICHE ANWENDUNGSBEREICHE", GIT FACHZEITSCHRIFT FUER DAS LABORATORIUM, DARMSTADT, DE, vol. 39, no. 10, 1995, pages 892 - 896, XP000918716, ISSN: 0016-3538 *

Also Published As

Publication number Publication date
AU2001284028A1 (en) 2002-03-22
EP1315498A2 (de) 2003-06-04
US20030199446A1 (en) 2003-10-23
WO2002020017A2 (de) 2002-03-14
DE10043456A1 (de) 2002-03-14
JP2004508332A (ja) 2004-03-18

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